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Spero Therapeutics, Inc. (SPRO) Stock Price History

Historical prices from 2017 to 2026

Current Price

$2.51

-0.02 (-0.79%)

All-Time High

$23.64

Dec 28, 2020

-89.4% from ATH

All-Time Low

$0.51

Apr 9, 2025

Avg Volume (50D)

387K

Daily average

52-Week Range$0.57 — $3.22

LowCurrent: $2.51High

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SPRO Historical Performance

1 YearTotal Return

+334.3%

Price: +334.3%

3 YearsTotal Return

+32.1%

CAGR: +9.7%

Price: +32.1%

5 YearsTotal Return

-81.3%

CAGR: -28.5%

Price: -81.3%

YTD

+6.8%

Short-Term Returns

1D-0.8%

1W+0.0%

1M-6.0%

3M+6.4%

6M+2.0%

SPRO Stock Price Trajectory (2017–2026)

As of May 8, 2026, Spero Therapeutics, Inc. (SPRO) trades at $2.51, representing a +334.3% return over the past year. The stock has delivered a -81.3% total return over five years (-28.5% CAGR), reflecting challenging market conditions.

The stock reached its all-time high of $23.64 on December 28, 2020. From this peak, SPRO has corrected -89.4%, currently trading 9% above its 200-day moving average, indicating continued institutional support.

When compared to Healthcare sector peers VNDA (+45.9% 1Y), PRAX (+775.0% 1Y), and NAOV (-95.7% 1Y), SPRO has underperformed the peer group average. Compare SPRO vs VNDA →

SPRO Historical Price Data (2025–2026)

Showing 30 of 2,139 records

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Date	Open	High	Low	Close	Volume	Change %
2026-05-07	2.59	2.62	2.50	2.51	566K	-0.79%
2026-05-06	2.44	2.56	2.44	2.53	617K	+4.55%
2026-05-05	2.51	2.58	2.41	2.42	502K	-3.20%
2026-05-04	2.49	2.61	2.46	2.50	461K	+0.81%
2026-05-01	2.54	2.63	2.48	2.48	453K	-1.20%
2026-04-30	2.50	2.58	2.50	2.51	364K	-0.79%
2026-04-29	2.65	2.66	2.47	2.53	825K	-5.24%
2026-04-28	2.67	2.73	2.67	2.67	214K	0.00%
2026-04-27	2.75	2.75	2.67	2.67	312K	-2.55%
2026-04-24	2.82	2.82	2.74	2.74	341K	-2.14%
2026-04-23	2.86	2.91	2.79	2.80	292K	-2.10%
2026-04-22	2.84	2.92	2.84	2.86	316K	+2.14%
2026-04-21	2.82	2.82	2.73	2.80	256K	-1.41%
2026-04-20	2.73	2.86	2.71	2.84	386K	+3.27%
2026-04-17	2.73	2.78	2.65	2.75	381K	+2.61%
2026-04-16	2.64	2.71	2.62	2.68	550K	+1.52%
2026-04-15	2.78	2.80	2.63	2.64	694K	-5.04%
2026-04-14	2.85	2.88	2.76	2.78	402K	0.00%
2026-04-13	2.67	2.86	2.67	2.78	514K	+4.12%
2026-04-10	2.80	2.80	2.63	2.67	669K	-3.96%
2026-04-09	2.72	2.80	2.67	2.78	445K	+2.21%
2026-04-08	2.73	2.75	2.60	2.72	411K	+1.87%
2026-04-07	2.59	2.69	2.48	2.67	687K	+2.30%
2026-04-06	2.44	2.61	2.44	2.61	471K	+7.41%
2026-04-02	2.40	2.45	2.38	2.43	214K	-0.82%
2026-04-01	2.35	2.48	2.35	2.45	400K	+4.70%
2026-03-31	2.29	2.35	2.21	2.34	483K	+4.46%
2026-03-30	2.35	2.43	2.23	2.24	307K	-3.86%
2026-03-27	2.34	2.44	2.28	2.33	492K	-1.69%
2026-03-26	2.39	2.48	2.34	2.37	443K	-1.66%

SPRO — Frequently Asked Questions

Quick answers to the most common questions about buying SPRO stock.

How has SPRO stock performed recently?

SPRO returned +334.3% over the past year, beating its 5-year annualized CAGR of -28.5%. The stock trades above its 200-day moving average, confirming the uptrend.

What is SPRO's all-time high price?

Spero Therapeutics, Inc. reached $23.64 on 2020-12-28. The 52-week high is $3.22. Current 1-year return of +334.3% places the stock closer to historical peaks.

Where can I download SPRO historical price data?

This page provides SPRO daily OHLCV data with 50-day MA, 200-day MA, and RSI indicators. Data spans 2017-2026, downloadable in CSV format.

SPRO Stock Price Trajectory (2017–2026)

When compared to Healthcare sector peers VNDA (+45.9% 1Y), PRAX (+775.0% 1Y), and NAOV (-95.7% 1Y), SPRO has underperformed the peer group average. Compare SPRO vs VNDA →

Date

Open

High

Low

Volume

Change %

2026-05-07

2.59

2.62

2.50

2.51

566K

-0.79%

2026-05-06

2.44

2.56

2.44

2.53

617K

+4.55%

2026-05-05

2.51

2.58

2.41

2.42

502K

-3.20%

2026-05-04

2.49

2.61

2.46

2.50

461K

+0.81%

2026-05-01

2.54

2.63

2.48

453K

-1.20%

2026-04-30

2.50

2.58

2.50

2.51

364K

-0.79%

2026-04-29

2.65

2.66

2.47

2.53

825K

-5.24%

2026-04-28

2.67

2.73

2.67

214K

0.00%

2026-04-27

2.75

2.67

312K

-2.55%

2026-04-24

2.82

2.74

341K

-2.14%

2026-04-23

2.86

2.91

2.79

2.80

292K

-2.10%

2026-04-22

2.84

2.92

2.84

2.86

316K

+2.14%

2026-04-21

2.82

2.73

2.80

256K

-1.41%

2026-04-20

2.73

2.86

2.71

2.84

386K

+3.27%

2026-04-17

2.73

2.78

2.65

2.75

381K

+2.61%

2026-04-16

2.64

2.71

2.62

2.68

550K

+1.52%

2026-04-15

2.78

2.80

2.63

2.64

694K

-5.04%

2026-04-14

2.85

2.88

2.76

2.78

402K

0.00%

2026-04-13

2.67

2.86

2.67

2.78

514K

+4.12%

2026-04-10

2.80

2.63

2.67

669K

-3.96%

2026-04-09

2.72

2.80

2.67

2.78

445K

+2.21%

2026-04-08

2.73

2.75

2.60

2.72

411K

+1.87%

2026-04-07

2.59

2.69

2.48

2.67

687K

+2.30%

2026-04-06

2.44

2.61

2.44

2.61

471K

+7.41%

2026-04-02

2.40

2.45

2.38

2.43

214K

-0.82%

2026-04-01

2.35

2.48

2.35

2.45

400K

+4.70%

2026-03-31

2.29

2.35

2.21

2.34

483K

+4.46%

2026-03-30

2.35

2.43

2.23

2.24

307K

-3.86%

2026-03-27

2.34

2.44

2.28

2.33

492K

-1.69%

2026-03-26

2.39

2.48

2.34

2.37

443K

-1.66%

Spero Therapeutics, Inc. (SPRO) Stock Price History

SPRO Historical Performance

Short-Term Returns

Download Historical Data

SPRO Stock Price Trajectory (2017–2026)

SPRO Historical Price Data (2025–2026)

See SPRO's True Return

Is SPRO Undervalued?

Compare SPRO vs DBVT

Spero Therapeutics, Inc. (SPRO) Stock Price History

SPRO Historical Performance

Short-Term Returns

Download Historical Data

SPRO Stock Price Trajectory (2017–2026)

SPRO Historical Price Data (2025–2026)

See SPRO's True Return

Is SPRO Undervalued?

Compare SPRO vs DBVT