Spero Therapeutics, Inc. (SPRO) Stock Price History

Historical prices from 2017 to 2026

$2.21-0.07 (-3.07%)close Jun 22

Returns

1M: -11.6%
3M: -7.3%
YTD: -3.0%
1Y: -22.4%
3Y: +14.2%
5Y: -31.1%

ATH$23.64Dec 2020-90.7%

ATL$0.51Apr 2025pre-split

Avg Vol (50D)1.0M/ day

52-Week Range$1.80 — $3.22

LowCurrent: $2.21High

Loading 10-year price history...

SPRO Historical Performance

1 YearTotal Return

-22.4%

Price: -22.4%

3 YearsTotal Return

+49.0%

CAGR: +14.2%

Price: +49.0%

5 YearsTotal Return

-84.5%

CAGR: -31.1%

Price: -84.5%

YTD

-3.0%

SPRO Annual Returns

Year-by-year price performance · 2017–2026

Best+115.7%2025

Worst-88.6%2022

Up years4/10

2017+2.2%

2018-49.3%

2019+53.7%

2020+96.5%

2021-10.7%

2022-88.6%

2023-15.5%

2024-32.2%

2025+115.7%

2026-7.7%

2017 annual price return: +2.2%
2018 annual price return: -49.3%
2019 annual price return: +53.7%
2020 annual price return: +96.5%
2021 annual price return: -10.7%
2022 annual price return: -88.6%
2023 annual price return: -15.5%
2024 annual price return: -32.2%
2025 annual price return: +115.7%
2026 annual price return: -7.7%

LessMore

SPRO Stock Price Trajectory (2017–2026)

As of June 23, 2026, Spero Therapeutics, Inc. (SPRO) trades at $2.21, representing a -22.4% return over the past year. The stock has delivered a -84.5% total return over five years (-31.1% CAGR), reflecting challenging market conditions.

The stock reached its all-time high of $23.64 on December 28, 2020. From this peak, SPRO has corrected -90.7%, currently trading 8% below its 200-day moving average, suggesting potential weakness.

When compared to Healthcare sector peers VNDA (+28.0% 1Y), PRAX (+557.0% 1Y), and NAOV (-80.1% 1Y), SPRO has underperformed the peer group average. Compare SPRO vs VNDA →

SPRO Historical Price Data · from 2017

Rows 1–50 of 2,169

Date	Open	High	Low	Close	Volume	Change %
2026-06-22	2.29	2.36	2.16	2.21	2.21M	-3.07%
2026-06-18	2.50	2.51	2.15	2.28	7.11M	+8.06%
2026-06-17	2.87	3.05	1.95	2.11	10.79M	-23.83%
2026-06-16	2.95	2.98	2.75	2.77	1.42M	-4.81%
2026-06-15	2.93	2.97	2.85	2.91	920K	+2.11%
2026-06-12	2.72	2.85	2.70	2.85	621K	+5.56%
2026-06-11	2.52	2.76	2.48	2.70	1.13M	+6.30%
2026-06-10	2.58	2.63	2.50	2.54	757K	-1.17%
2026-06-09	2.78	2.81	2.53	2.57	1.13M	-6.20%
2026-06-08	2.84	2.87	2.73	2.74	645K	-2.84%
2026-06-05	2.96	2.96	2.77	2.82	751K	-5.37%
2026-06-04	2.79	3.07	2.78	2.98	994K	+6.43%
2026-06-03	2.85	2.86	2.77	2.80	770K	-1.06%
2026-06-02	2.83	2.87	2.76	2.83	605K	0.00%
2026-06-01	2.81	2.89	2.79	2.83	644K	0.00%
2026-05-29	2.92	2.92	2.75	2.83	1.33M	-2.41%
2026-05-28	2.93	3.00	2.90	2.90	790K	-1.02%
2026-05-27	2.86	3.08	2.81	2.93	1.77M	+2.45%
2026-05-26	2.80	2.94	2.77	2.86	1.51M	+3.62%
2026-05-22	2.70	2.85	2.70	2.76	545K	+2.60%
2026-05-21	2.63	2.71	2.56	2.69	432K	+2.28%
2026-05-20	2.59	2.65	2.55	2.63	316K	+1.54%
2026-05-19	2.52	2.62	2.50	2.59	316K	+0.39%
2026-05-18	2.77	2.79	2.57	2.58	909K	-7.53%
2026-05-15	2.71	2.88	2.69	2.79	931K	+1.09%
2026-05-14	2.39	2.76	2.38	2.76	1.60M	+13.11%
2026-05-13	2.56	2.56	2.42	2.44	668K	-3.94%
2026-05-12	2.51	2.56	2.48	2.54	351K	-0.39%
2026-05-11	2.60	2.67	2.54	2.55	416K	-0.39%
2026-05-08	2.52	2.58	2.49	2.56	350K	+1.99%
2026-05-07	2.59	2.62	2.50	2.51	566K	-0.79%
2026-05-06	2.44	2.56	2.44	2.53	617K	+4.55%
2026-05-05	2.51	2.58	2.41	2.42	502K	-3.20%
2026-05-04	2.49	2.61	2.46	2.50	461K	+0.81%
2026-05-01	2.54	2.63	2.48	2.48	453K	-1.20%
2026-04-30	2.50	2.58	2.50	2.51	364K	-0.79%
2026-04-29	2.65	2.66	2.47	2.53	825K	-5.24%
2026-04-28	2.67	2.73	2.67	2.67	214K	0.00%
2026-04-27	2.75	2.75	2.67	2.67	312K	-2.55%
2026-04-24	2.82	2.82	2.74	2.74	341K	-2.14%
2026-04-23	2.86	2.91	2.79	2.80	292K	-2.10%
2026-04-22	2.84	2.92	2.84	2.86	316K	+2.14%
2026-04-21	2.82	2.82	2.73	2.80	256K	-1.41%
2026-04-20	2.73	2.86	2.71	2.84	386K	+3.27%
2026-04-17	2.73	2.78	2.65	2.75	381K	+2.61%
2026-04-16	2.64	2.71	2.62	2.68	550K	+1.52%
2026-04-15	2.78	2.80	2.63	2.64	694K	-5.04%
2026-04-14	2.85	2.88	2.76	2.78	402K	0.00%
2026-04-13	2.67	2.86	2.67	2.78	514K	+4.12%
2026-04-10	2.80	2.80	2.63	2.67	669K	-3.96%

Consensus-Based Analysis Tools

Intrinsic Valuation

DCF models, multiple analysis, and analyst estimates.

Check Valuation

Historical Returns

10-year return with dividends reinvested.

Calculate

DCA Calculator

See how regular investing compounds over time.

Run Numbers

Peer Comparison

Compare growth, multiples, and margins vs sector.

Compare

SPRO — Frequently Asked Questions

Quick answers to the most common questions about buying SPRO stock.

How has SPRO stock performed recently?

SPRO declined -22.4% over the past year, below its 5-year annualized CAGR of -31.1%. The stock trades below its 200-day moving average, reflecting the downtrend.

What is SPRO's all-time high price?

Spero Therapeutics, Inc. reached $23.64 on 2020-12-28. The 52-week high is $3.22. Current 1-year return of -22.4% places the stock further from historical peaks.

Where can I download SPRO historical price data?

This page provides SPRO daily OHLCV data with 50-day MA, 200-day MA, and RSI indicators. Data spans 2017-2026, downloadable in CSV format.

SPRO Stock Price Trajectory (2017–2026)

When compared to Healthcare sector peers VNDA (+28.0% 1Y), PRAX (+557.0% 1Y), and NAOV (-80.1% 1Y), SPRO has underperformed the peer group average. Compare SPRO vs VNDA →

Date

Open

High

Low

Volume

Change %

2026-06-22

2.29

2.36

2.16

2.21

2.21M

-3.07%

2026-06-18

2.50

2.51

2.15

2.28

7.11M

+8.06%

2026-06-17

2.87

3.05

1.95

2.11

10.79M

-23.83%

2026-06-16

2.95

2.98

2.75

2.77

1.42M

-4.81%

2026-06-15

2.93

2.97

2.85

2.91

920K

+2.11%

2026-06-12

2.72

2.85

2.70

2.85

621K

+5.56%

2026-06-11

2.52

2.76

2.48

2.70

1.13M

+6.30%

2026-06-10

2.58

2.63

2.50

2.54

757K

-1.17%

2026-06-09

2.78

2.81

2.53

2.57

1.13M

-6.20%

2026-06-08

2.84

2.87

2.73

2.74

645K

-2.84%

2026-06-05

2.96

2.77

2.82

751K

-5.37%

2026-06-04

2.79

3.07

2.78

2.98

994K

+6.43%

2026-06-03

2.85

2.86

2.77

2.80

770K

-1.06%

2026-06-02

2.83

2.87

2.76

2.83

605K

0.00%

2026-06-01

2.81

2.89

2.79

2.83

644K

0.00%

2026-05-29

2.92

2.75

2.83

1.33M

-2.41%

2026-05-28

2.93

3.00

2.90

790K

-1.02%

2026-05-27

2.86

3.08

2.81

2.93

1.77M

+2.45%

2026-05-26

2.80

2.94

2.77

2.86

1.51M

+3.62%

2026-05-22

2.70

2.85

2.70

2.76

545K

+2.60%

2026-05-21

2.63

2.71

2.56

2.69

432K

+2.28%

2026-05-20

2.59

2.65

2.55

2.63

316K

+1.54%

2026-05-19

2.52

2.62

2.50

2.59

316K

+0.39%

2026-05-18

2.77

2.79

2.57

2.58

909K

-7.53%

2026-05-15

2.71

2.88

2.69

2.79

931K

+1.09%

2026-05-14

2.39

2.76

2.38

2.76

1.60M

+13.11%

2026-05-13

2.56

2.42

2.44

668K

-3.94%

2026-05-12

2.51

2.56

2.48

2.54

351K

-0.39%

2026-05-11

2.60

2.67

2.54

2.55

416K

-0.39%

2026-05-08

2.52

2.58

2.49

2.56

350K

+1.99%

2026-05-07

2.59

2.62

2.50

2.51

566K

-0.79%

2026-05-06

2.44

2.56

2.44

2.53

617K

+4.55%

2026-05-05

2.51

2.58

2.41

2.42

502K

-3.20%

2026-05-04

2.49

2.61

2.46

2.50

461K

+0.81%

2026-05-01

2.54

2.63

2.48

453K

-1.20%

2026-04-30

2.50

2.58

2.50

2.51

364K

-0.79%

2026-04-29

2.65

2.66

2.47

2.53

825K

-5.24%

2026-04-28

2.67

2.73

2.67

214K

0.00%

2026-04-27

2.75

2.67

312K

-2.55%

2026-04-24

2.82

2.74

341K

-2.14%

2026-04-23

2.86

2.91

2.79

2.80

292K

-2.10%

2026-04-22

2.84

2.92

2.84

2.86

316K

+2.14%

2026-04-21

2.82

2.73

2.80

256K

-1.41%

2026-04-20

2.73

2.86

2.71

2.84

386K

+3.27%

2026-04-17

2.73

2.78

2.65

2.75

381K

+2.61%

2026-04-16

2.64

2.71

2.62

2.68

550K

+1.52%

2026-04-15

2.78

2.80

2.63

2.64

694K

-5.04%

2026-04-14

2.85

2.88

2.76

2.78

402K

0.00%

2026-04-13

2.67

2.86

2.67

2.78

514K

+4.12%

2026-04-10

2.80

2.63

2.67

669K

-3.96%

Spero Therapeutics, Inc. (SPRO) Stock Price History

SPRO Historical Performance

SPRO Annual Returns

Download Historical Data

SPRO Stock Price Trajectory (2017–2026)

SPRO Historical Price Data · from 2017

Intrinsic Valuation

Historical Returns

DCA Calculator

Peer Comparison

Spero Therapeutics, Inc. (SPRO) Stock Price History

SPRO Historical Performance

SPRO Annual Returns

Download Historical Data

SPRO Stock Price Trajectory (2017–2026)

SPRO Historical Price Data · from 2017

Intrinsic Valuation

Historical Returns

DCA Calculator

Peer Comparison