Spero Therapeutics, Inc. (SPRO) Stock Price History
Historical prices from 2017 to 2026
- 1M
- -2.5%
- 3M
- -45.9%
- YTD
- -49.4%
- 1Y
- -41.4%
- 3Y
- +0.0%
- 5Y
- -42.0%
Loading 10-year price history...
SPRO Historical Performance
SPRO Annual Returns
Year-by-year price performance · 2017–2026
- 2017 annual price return
- +2.2%
- 2018 annual price return
- -49.3%
- 2019 annual price return
- +53.7%
- 2020 annual price return
- +96.5%
- 2021 annual price return
- -10.7%
- 2022 annual price return
- -88.6%
- 2023 annual price return
- -15.5%
- 2024 annual price return
- -32.2%
- 2025 annual price return
- +115.7%
- 2026 annual price return
- -50.2%
SPRO Stock Price Trajectory (2017–2026)
As of October 3, 2026, Spero Therapeutics, Inc. (SPRO) trades at $1.19, representing a -41.4% return over the past year. The stock has delivered a -93.4% total return over five years (-42.0% CAGR), reflecting challenging market conditions.
The stock reached its all-time high of $23.64 on December 28, 2020. From this peak, SPRO has corrected -95.0%, currently trading 44% below its 200-day moving average, suggesting potential weakness.
When compared to Healthcare sector peers VNDA (-10.3% 1Y), PRAX (+435.4% 1Y), and NAOV (-69.4% 1Y), SPRO has underperformed the peer group average. Compare SPRO vs VNDA →
SPRO Historical Price Data · from 2017
Rows 1–50 of 2,240| Date | Open | High | Low | Close | Volume | Change % |
|---|---|---|---|---|---|---|
| 2026-10-02 | 1.26 | 1.26 | 1.18 | 1.19 | 907K | -5.56% |
| 2026-10-01 | 1.22 | 1.31 | 1.20 | 1.26 | 1.04M | +4.13% |
| 2026-09-30 | 1.21 | 1.29 | 1.20 | 1.21 | 558K | +0.83% |
| 2026-09-29 | 1.20 | 1.21 | 1.17 | 1.20 | 335K | +0.84% |
| 2026-09-28 | 1.22 | 1.22 | 1.18 | 1.19 | 393K | -3.25% |
| 2026-09-25 | 1.27 | 1.27 | 1.21 | 1.23 | 538K | -1.60% |
| 2026-09-24 | 1.25 | 1.28 | 1.24 | 1.25 | 473K | -0.79% |
| 2026-09-23 | 1.36 | 1.39 | 1.24 | 1.26 | 1.40M | -7.35% |
| 2026-09-22 | 1.30 | 1.44 | 1.28 | 1.36 | 7.75M | +19.30% |
| 2026-09-21 | 1.14 | 1.15 | 1.13 | 1.14 | 319K | +0.88% |
| 2026-09-18 | 1.12 | 1.16 | 1.11 | 1.13 | 501K | +0.89% |
| 2026-09-17 | 1.12 | 1.14 | 1.11 | 1.12 | 176K | +0.90% |
| 2026-09-16 | 1.12 | 1.14 | 1.10 | 1.11 | 440K | -1.77% |
| 2026-09-15 | 1.14 | 1.15 | 1.11 | 1.13 | 222K | -0.88% |
| 2026-09-14 | 1.14 | 1.16 | 1.13 | 1.14 | 266K | +0.88% |
| 2026-09-11 | 1.14 | 1.15 | 1.13 | 1.13 | 309K | +0.89% |
| 2026-09-10 | 1.18 | 1.18 | 1.12 | 1.12 | 568K | -4.27% |
| 2026-09-09 | 1.20 | 1.20 | 1.17 | 1.17 | 367K | -1.68% |
| 2026-09-08 | 1.21 | 1.21 | 1.19 | 1.19 | 348K | -1.65% |
| 2026-09-04 | 1.21 | 1.22 | 1.19 | 1.21 | 363K | -0.82% |
| 2026-09-03 | 1.23 | 1.23 | 1.20 | 1.22 | 193K | 0.00% |
| 2026-09-02 | 1.24 | 1.24 | 1.21 | 1.22 | 170K | +1.67% |
| 2026-09-01 | 1.22 | 1.22 | 1.19 | 1.20 | 382K | -1.64% |
| 2026-08-31 | 1.23 | 1.23 | 1.20 | 1.22 | 330K | +1.67% |
| 2026-08-28 | 1.21 | 1.21 | 1.19 | 1.20 | 306K | -0.83% |
| 2026-08-27 | 1.22 | 1.23 | 1.18 | 1.21 | 538K | -0.82% |
| 2026-08-26 | 1.22 | 1.22 | 1.20 | 1.22 | 156K | -0.81% |
| 2026-08-25 | 1.23 | 1.26 | 1.23 | 1.23 | 646K | +0.82% |
| 2026-08-24 | 1.22 | 1.24 | 1.20 | 1.22 | 367K | 0.00% |
| 2026-08-21 | 1.22 | 1.25 | 1.21 | 1.22 | 359K | +0.83% |
| 2026-08-20 | 1.22 | 1.27 | 1.20 | 1.21 | 559K | -1.63% |
| 2026-08-19 | 1.20 | 1.24 | 1.19 | 1.23 | 480K | +2.50% |
| 2026-08-18 | 1.20 | 1.20 | 1.18 | 1.20 | 477K | +0.84% |
| 2026-08-17 | 1.21 | 1.24 | 1.19 | 1.19 | 299K | -3.25% |
| 2026-08-14 | 1.26 | 1.26 | 1.19 | 1.23 | 745K | -0.81% |
| 2026-08-13 | 1.26 | 1.30 | 1.21 | 1.24 | 1.29M | +4.20% |
| 2026-08-12 | 1.24 | 1.25 | 1.19 | 1.19 | 775K | -3.25% |
| 2026-08-11 | 1.24 | 1.25 | 1.21 | 1.23 | 364K | 0.00% |
| 2026-08-10 | 1.25 | 1.28 | 1.23 | 1.23 | 351K | -2.38% |
| 2026-08-07 | 1.27 | 1.28 | 1.24 | 1.26 | 459K | -0.79% |
| 2026-08-06 | 1.26 | 1.27 | 1.23 | 1.27 | 975K | +0.79% |
| 2026-08-05 | 1.25 | 1.28 | 1.21 | 1.26 | 575K | +2.44% |
| 2026-08-04 | 1.15 | 1.25 | 1.15 | 1.23 | 752K | +6.96% |
| 2026-08-03 | 1.19 | 1.22 | 1.13 | 1.15 | 1.37M | -1.71% |
| 2026-07-31 | 1.20 | 1.21 | 1.17 | 1.17 | 825K | -2.50% |
| 2026-07-30 | 1.20 | 1.22 | 1.18 | 1.20 | 488K | +0.84% |
| 2026-07-29 | 1.20 | 1.21 | 1.16 | 1.19 | 1.06M | -0.83% |
| 2026-07-28 | 1.18 | 1.28 | 1.15 | 1.20 | 1.60M | +1.69% |
| 2026-07-27 | 1.20 | 1.23 | 1.16 | 1.18 | 1.35M | -0.84% |
| 2026-07-24 | 1.14 | 1.23 | 1.08 | 1.19 | 11.77M | +2.59% |
SPRO Chart Terminal
Live VCP patterns, Cup & Handle overlays, support/resistance, and AI trade plans.
Live Breakouts Feed
High-probability breakout stocks crossing their pivot across 5 pattern engines.
Intrinsic Valuation
DCF models, multiple analysis, and analyst estimates.
Historical Returns
10-year return with dividends reinvested.
Peer Comparison
Compare growth, multiples, and margins vs sector.
SPRO — Frequently Asked Questions
Quick answers to the most common questions about buying SPRO stock.
How has SPRO stock performed recently?
SPRO declined -41.4% over the past year, below its 5-year annualized CAGR of -42.0%. The stock trades below its 200-day moving average, reflecting the downtrend.
What is SPRO's all-time high price?
Spero Therapeutics, Inc. reached $23.64 on 2020-12-28. The 52-week high is $3.08. Current 1-year return of -41.4% places the stock further from historical peaks.
Where can I download SPRO historical price data?
This page provides SPRO daily OHLCV data with 50-day MA, 200-day MA, and RSI indicators. Data spans 2017-2026, downloadable in CSV format.