REPL vs CGEN

Analysts rate Replimune Group, Inc.

(REPL) a "Buy" — based on 15 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.

Over the past 5 years, Compugen Ltd.

(CGEN) delivered a total return of -62. 3%, compared to -90. 7% for Replimune Group, Inc. (REPL). Over 10 years, the gap is even starker: CGEN returned -57. 2% versus REPL's -78. 0%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.

By beta (market sensitivity over 5 years), Replimune Group, Inc.

(REPL) is the lower-risk stock at 0. 83β versus Compugen Ltd. 's 1. 68β — meaning CGEN is approximately 102% more volatile than REPL relative to the S&P 500. On balance sheet safety, Compugen Ltd. (CGEN) carries a lower debt/equity ratio of 5% versus 18% for Replimune Group, Inc. — giving it more financial flexibility in a downturn.

On earnings-per-share growth, the picture is similar: Compugen Ltd.

grew EPS 23. 8% year-over-year, compared to 5. 2% for Replimune Group, Inc.. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.

Replimune Group, Inc.

(REPL) is the more profitable company, earning 0. 0% net margin versus -51. 1% for Compugen Ltd. — meaning it keeps 0. 0% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: REPL leads at 0. 0% versus -53. 4% for CGEN. At the gross margin level — before operating expenses — CGEN leads at 71. 5%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.

None of the stocks in this comparison currently pay a material dividend.

All are effectively zero-yield and should be held for capital appreciation rather than income.

For long-horizon retirement investors, Replimune Group, Inc.

(REPL) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0. 83)). Compugen Ltd. (CGEN) carries a higher beta of 1. 68 — meaning larger drawdowns in market downturns, which matters significantly when you cannot wait years for a recovery. Both have compounded well over 10 years (REPL: -78. 0%, CGEN: -57. 2%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.

Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both.

These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.