Biotechnology
Compare Stocks
4 / 10Stock Comparison
ABUS vs HBIO vs ITRN vs REPL
Revenue, margins, valuation, and 5-year total return — side by side.
Medical - Instruments & Supplies
Communication Equipment
Biotechnology
ABUS vs HBIO vs ITRN vs REPL — Key Financials
Market cap, revenue, margins, and valuation side-by-side.
| Company Snapshot | ||||
|---|---|---|---|---|
| Industry | Biotechnology | Medical - Instruments & Supplies | Communication Equipment | Biotechnology |
| Market Cap | $838M | $304M | $1.38B | $266M |
| Revenue (TTM) | $14M | $87M | $359M | $0.00 |
| Net Income (TTM) | $-34M | $-57M | $58M | $-315M |
| Gross Margin | 2.8% | 53.0% | 49.7% | — |
| Operating Margin | -271.0% | -0.7% | 21.4% | — |
| Forward P/E | — | — | 17.8x | — |
| Total Debt | $746K | $36M | $5M | $76M |
| Cash & Equiv. | $18M | $9M | $108M | $111M |
ABUS vs HBIO vs ITRN vs REPL — Long-Term Stock Performance
Price return indexed to 100 at period start. Dividends excluded.
| Stock | May 20 | May 26 | Return |
|---|---|---|---|
| Arbutus Biopharma C… (ABUS) | 100 | 200.5 | +100.5% |
| Harvard Bioscience,… (HBIO) | 100 | 25.7 | -74.3% |
| Ituran Location and… (ITRN) | 100 | 344.5 | +244.5% |
| Replimune Group, In… (REPL) | 100 | 17.8 | -82.2% |
Price return only. Dividends and distributions are not included.
Quick Verdict: ABUS vs HBIO vs ITRN vs REPL
Each card shows where this stock fits in a portfolio — not just who wins on paper.
ABUS is the #2 pick in this set and the best alternative if growth exposure is your priority.
- Rev growth 128.2%, EPS growth 55.3%, 3Y rev CAGR -28.8%
- 128.2% revenue growth vs REPL's -39.7%
HBIO is the clearest fit if your priority is momentum.
- +126.3% vs REPL's -53.4%
ITRN carries the broadest edge in this set and is the clearest fit for income & stability and long-term compounding.
- Dividend streak 3 yrs, beta 1.18, yield 3.2%
- 233.6% 10Y total return vs ABUS's 1.4%
- Better valuation composite
- 16.1% margin vs ABUS's -237.9%
REPL is the clearest fit if your priority is sleep-well-at-night and defensive.
- Lower volatility, beta 0.83, Low D/E 18.3%, current ratio 7.95x
- Beta 0.83, current ratio 7.95x
- Beta 0.83 vs HBIO's 2.03, lower leverage
See the full category breakdown
| Category | Winner | Why |
|---|---|---|
| Growth | 128.2% revenue growth vs REPL's -39.7% | |
| Value | Better valuation composite | |
| Quality / Margins | 16.1% margin vs ABUS's -237.9% | |
| Stability / Safety | Beta 0.83 vs HBIO's 2.03, lower leverage | |
| Dividends | 3.2% yield; 3-year raise streak; the other 3 pay no meaningful dividend | |
| Momentum (1Y) | +126.3% vs REPL's -53.4% | |
| Efficiency (ROA) | 15.8% ROA vs REPL's -94.4%, ROIC 47.2% vs -51.9% |
ABUS vs HBIO vs ITRN vs REPL — Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
ABUS vs HBIO vs ITRN vs REPL — Financial Metrics
Side-by-side numbers across 4 stocks — who leads on profitability, valuation, growth, and risk.
Who Leads Where
ITRN leads in 5 of 6 categories
ABUS leads 0 • HBIO leads 0 • REPL leads 0 • 1 tied
Explore the data ↓Income & Cash Flow (Last 12 Months)
ITRN leads this category, winning 4 of 6 comparable metrics.
Income & Cash Flow (Last 12 Months)
ITRN and REPL operate at a comparable scale, with $359M and $0 in trailing revenue. ITRN is the more profitable business, keeping 16.1% of every revenue dollar as net income compared to ABUS's -2.4%. On growth, ITRN holds the edge at +12.8% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | ||||
|---|---|---|---|---|
| RevenueTrailing 12 months | $14M | $87M | $359M | $0 |
| EBITDAEarnings before interest/tax | -$37M | $5M | $96M | -$323M |
| Net IncomeAfter-tax profit | -$34M | -$57M | $58M | -$315M |
| Free Cash FlowCash after capex | -$40M | $5M | $71M | -$283M |
| Gross MarginGross profit ÷ Revenue | +2.8% | +53.0% | +49.7% | — |
| Operating MarginEBIT ÷ Revenue | -2.7% | -0.7% | +21.4% | — |
| Net MarginNet income ÷ Revenue | -2.4% | -65.5% | +16.1% | — |
| FCF MarginFCF ÷ Revenue | -2.8% | +5.9% | +19.7% | — |
| Rev. Growth (YoY)Latest quarter vs prior year | -33.2% | -3.3% | +12.8% | — |
| EPS Growth (YoY)Latest quarter vs prior year | +80.6% | — | +10.0% | +2.5% |
Valuation Metrics
ITRN leads this category, winning 2 of 5 comparable metrics.
Valuation Metrics
On an enterprise value basis, ITRN's 13.3x EV/EBITDA is more attractive than HBIO's 62.2x.
| Metric | ||||
|---|---|---|---|---|
| Market CapShares × price | $838M | $304M | $1.4B | $266M |
| Enterprise ValueMkt cap + debt − cash | $820M | $331M | $1.3B | $231M |
| Trailing P/EPrice ÷ TTM EPS | -25.59x | -5.30x | 20.19x | -1.09x |
| Forward P/EPrice ÷ next-FY EPS est. | — | — | 17.84x | — |
| PEG RatioP/E ÷ EPS growth rate | — | — | 0.66x | — |
| EV / EBITDAEnterprise value multiple | — | 62.25x | 13.33x | — |
| Price / SalesMarket cap ÷ Revenue | 59.47x | 3.51x | 3.85x | — |
| Price / BookPrice ÷ Book value/share | 10.88x | 21.95x | 5.22x | 0.65x |
| Price / FCFMarket cap ÷ FCF | — | 54.08x | 20.72x | — |
Profitability & Efficiency
ITRN leads this category, winning 7 of 9 comparable metrics.
Profitability & Efficiency
ITRN delivers a 27.3% return on equity — every $100 of shareholder capital generates $27 in annual profit, vs $-4 for HBIO. ABUS carries lower financial leverage with a 0.01x debt-to-equity ratio, signaling a more conservative balance sheet compared to HBIO's 2.61x. On the Piotroski fundamental quality scale (0–9), ITRN scores 7/9 vs REPL's 2/9, reflecting strong financial health.
| Metric | ||||
|---|---|---|---|---|
| ROE (TTM)Return on equity | -42.4% | -3.9% | +27.3% | -149.5% |
| ROA (TTM)Return on assets | -32.5% | -71.3% | +15.8% | -94.4% |
| ROICReturn on invested capital | -47.1% | -0.7% | +47.2% | -51.9% |
| ROCEReturn on capital employed | -37.3% | -1.0% | +29.5% | -55.9% |
| Piotroski ScoreFundamental quality 0–9 | 4 | 4 | 7 | 2 |
| Debt / EquityFinancial leverage | 0.01x | 2.61x | 0.02x | 0.18x |
| Net DebtTotal debt minus cash | -$17M | $27M | -$103M | -$35M |
| Cash & Equiv.Liquid assets | $18M | $9M | $108M | $111M |
| Total DebtShort + long-term debt | $746,000 | $36M | $5M | $76M |
| Interest CoverageEBIT ÷ Interest expense | -129.55x | -0.13x | 32.28x | -48.62x |
Total Returns (Dividends Reinvested)
ITRN leads this category, winning 5 of 6 comparable metrics.
Total Returns (Dividends Reinvested)
A $10,000 investment in ITRN five years ago would be worth $28,016 today (with dividends reinvested), compared to $925 for HBIO. Over the past 12 months, HBIO leads with a +126.3% total return vs REPL's -53.4%. The 3-year compound annual growth rate (CAGR) favors ITRN at 45.2% vs HBIO's -51.4% — a key indicator of consistent wealth creation.
| Metric | ||||
|---|---|---|---|---|
| YTD ReturnYear-to-date | -8.8% | +4.1% | +42.2% | -62.5% |
| 1-Year ReturnPast 12 months | +32.2% | +126.3% | +76.7% | -53.4% |
| 3-Year ReturnCumulative with dividends | +66.7% | -88.5% | +206.4% | -81.5% |
| 5-Year ReturnCumulative with dividends | +54.8% | -90.7% | +180.2% | -90.7% |
| 10-Year ReturnCumulative with dividends | +1.4% | -76.2% | +233.6% | -78.0% |
| CAGR (3Y)Annualised 3-year return | +18.6% | -51.4% | +45.2% | -43.0% |
Risk & Volatility
Evenly matched — ITRN and REPL each lead in 1 of 2 comparable metrics.
Risk & Volatility
REPL is the less volatile stock with a 0.83 beta — it tends to amplify market swings less than HBIO's 2.03 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. ITRN currently trades 98.5% from its 52-week high vs REPL's 25.2% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | ||||
|---|---|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 1.39x | 2.03x | 1.18x | 0.83x |
| 52-Week HighHighest price in past year | $5.10 | $9.46 | $59.84 | $13.24 |
| 52-Week LowLowest price in past year | $2.94 | $0.59 | $32.71 | $1.50 |
| % of 52W HighCurrent price vs 52-week peak | +85.3% | +71.8% | +98.5% | +25.2% |
| RSI (14)Momentum oscillator 0–100 | 52.6 | 65.8 | 68.3 | 46.3 |
| Avg Volume (50D)Average daily shares traded | 2.3M | 59K | 118K | 5.6M |
Analyst Outlook
ITRN leads this category, winning 1 of 1 comparable metric.
Analyst Outlook
Analyst consensus: ABUS as "Buy", HBIO as "Buy", ITRN as "Hold", REPL as "Buy". Consensus price targets imply 274.3% upside for REPL (target: $13) vs -11.6% for HBIO (target: $6). ITRN is the only dividend payer here at 3.21% yield — a key consideration for income-focused portfolios.
| Metric | ||||
|---|---|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Buy | Buy | Hold | Buy |
| Price TargetConsensus 12-month target | $8.50 | $6.00 | $56.00 | $12.50 |
| # AnalystsCovering analysts | 10 | 5 | 5 | 15 |
| Dividend YieldAnnual dividend ÷ price | — | — | +3.2% | — |
| Dividend StreakConsecutive years of raises | 0 | 0 | 3 | — |
| Dividend / ShareAnnual DPS | — | — | $1.89 | — |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | 0.0% | +0.2% | 0.0% |
ITRN leads in 5 of 6 categories — strongest in Income & Cash Flow and Valuation Metrics. 1 category is tied.
ABUS vs HBIO vs ITRN vs REPL: Key Questions Answered
9 questions · data-driven answers · updated daily
01Is ABUS or HBIO or ITRN or REPL a better buy right now?
For growth investors, Arbutus Biopharma Corporation (ABUS) is the stronger pick with 128.
2% revenue growth year-over-year, versus -8. 1% for Harvard Bioscience, Inc. (HBIO). Ituran Location and Control Ltd. (ITRN) offers the better valuation at 20. 2x trailing P/E (17. 8x forward), making it the more compelling value choice. Analysts rate Arbutus Biopharma Corporation (ABUS) a "Buy" — based on 10 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — ABUS or HBIO or ITRN or REPL?
Over the past 5 years, Ituran Location and Control Ltd.
(ITRN) delivered a total return of +180. 2%, compared to -90. 7% for Harvard Bioscience, Inc. (HBIO). Over 10 years, the gap is even starker: ITRN returned +233. 6% versus REPL's -78. 0%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — ABUS or HBIO or ITRN or REPL?
By beta (market sensitivity over 5 years), Replimune Group, Inc.
(REPL) is the lower-risk stock at 0. 83β versus Harvard Bioscience, Inc. 's 2. 03β — meaning HBIO is approximately 144% more volatile than REPL relative to the S&P 500. On balance sheet safety, Arbutus Biopharma Corporation (ABUS) carries a lower debt/equity ratio of 1% versus 3% for Harvard Bioscience, Inc. — giving it more financial flexibility in a downturn.
04Which is growing faster — ABUS or HBIO or ITRN or REPL?
By revenue growth (latest reported year), Arbutus Biopharma Corporation (ABUS) is pulling ahead at 128.
2% versus -8. 1% for Harvard Bioscience, Inc. (HBIO). On earnings-per-share growth, the picture is similar: Arbutus Biopharma Corporation grew EPS 55. 3% year-over-year, compared to -357. 1% for Harvard Bioscience, Inc.. Over a 3-year CAGR, ITRN leads at 7. 0% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.
05Which has better profit margins — ABUS or HBIO or ITRN or REPL?
Ituran Location and Control Ltd.
(ITRN) is the more profitable company, earning 16. 1% net margin versus -237. 9% for Arbutus Biopharma Corporation — meaning it keeps 16. 1% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: ITRN leads at 21. 4% versus -271. 0% for ABUS. At the gross margin level — before operating expenses — HBIO leads at 53. 0%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
06Is ABUS or HBIO or ITRN or REPL more undervalued right now?
Analyst consensus price targets imply the most upside for REPL: 274.
3% to $12. 50.
07Which pays a better dividend — ABUS or HBIO or ITRN or REPL?
In this comparison, ITRN (3.
2% yield) pays a dividend. ABUS, HBIO, REPL do not pay a meaningful dividend and should not be held primarily for income.
08Is ABUS or HBIO or ITRN or REPL better for a retirement portfolio?
For long-horizon retirement investors, Ituran Location and Control Ltd.
(ITRN) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 1. 18), 3. 2% yield, +233. 6% 10Y return). Harvard Bioscience, Inc. (HBIO) carries a higher beta of 2. 03 — meaning larger drawdowns in market downturns, which matters significantly when you cannot wait years for a recovery. Both have compounded well over 10 years (ITRN: +233. 6%, HBIO: -76. 2%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
09What are the main differences between ABUS and HBIO and ITRN and REPL?
These companies operate in different sectors (ABUS (Healthcare) and HBIO (Healthcare) and ITRN (Technology) and REPL (Healthcare)), which means they face different economic cycles, regulatory environments, and macro sensitivities — making direct comparison nuanced.
In terms of investment character: ABUS is a small-cap high-growth stock; HBIO is a small-cap quality compounder stock; ITRN is a small-cap income-oriented stock; REPL is a small-cap quality compounder stock. ITRN pays a dividend while ABUS, HBIO, REPL do not, making them suitable for different income and tax situations. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
Find Stocks Like These
Explore pre-built screens for each stock's profile, or build a custom screen to find stocks that outperform all of them.
You Might Also Compare
Based on how these companies actually compete and overlap — not just which sector they're filed under.