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BCTX vs CRIS vs NKTR vs IMVT vs RCUS

Revenue, margins, valuation, and 5-year total return — side by side.

Live fundamentals10-year financials5-year price chart
BCTX
BriaCell Therapeutics Corp.

Biotechnology

HealthcareNASDAQ • CA
Market Cap$5M
5Y Perf.-13.3%
CRIS
Curis, Inc.

Biotechnology

HealthcareNASDAQ • US
Market Cap$74M
5Y Perf.-96.6%
NKTR
Nektar Therapeutics

Biotechnology

HealthcareNASDAQ • US
Market Cap$1.66B
5Y Perf.-74.8%
IMVT
Immunovant, Inc.

Biotechnology

HealthcareNASDAQ • US
Market Cap$5.88B
5Y Perf.+12.8%
RCUS
Arcus Biosciences, Inc.

Biotechnology

HealthcareNYSE • US
Market Cap$2.55B
5Y Perf.-19.1%

BCTX vs CRIS vs NKTR vs IMVT vs RCUS — Key Financials

Market cap, revenue, margins, and valuation side-by-side.

Company Snapshot
BCTX logoBCTX
CRIS logoCRIS
NKTR logoNKTR
IMVT logoIMVT
RCUS logoRCUS
IndustryBiotechnologyBiotechnologyBiotechnologyBiotechnologyBiotechnology
Market Cap$5M$74M$1.66B$5.88B$2.55B
Revenue (TTM)$0.00$9M$56M$0.00$236M
Net Income (TTM)$-38M$-8M$-158M$-464M$-369M
Gross Margin99.5%80.1%90.7%
Operating Margin-348.4%-226.3%-168.6%
Total Debt$0.00$2M$149M$98K$99M
Cash & Equiv.$14M$5M$15M$714M$222M

BCTX vs CRIS vs NKTR vs IMVT vs RCUSLong-Term Stock Performance

Price return indexed to 100 at period start. Dividends excluded.

BCTX
CRIS
NKTR
IMVT
RCUS
StockMay 20May 26Return
BriaCell Therapeuti… (BCTX)10086.7-13.3%
Curis, Inc. (CRIS)1003.4-96.6%
Nektar Therapeutics (NKTR)10025.2-74.8%
Immunovant, Inc. (IMVT)100112.8+12.8%
Arcus Biosciences, … (RCUS)10080.9-19.1%

Price return only. Dividends and distributions are not included.

Quick Verdict: BCTX vs CRIS vs NKTR vs IMVT vs RCUS

Each card shows where this stock fits in a portfolio — not just who wins on paper.

Bottom line: IMVT leads in 2 of 6 categories (5-stock set), making it the strongest pick for profitability and margin quality and capital preservation and lower volatility. Curis, Inc. is the stronger pick specifically for operational efficiency and capital deployment. NKTR and RCUS also each lead in at least one category. As sector peers, any of these can serve as alternatives in the same allocation.
BCTX
BriaCell Therapeutics Corp.
The Healthcare Pick

Among these 5 stocks, BCTX doesn't own a clear edge in any measured category.

Best for: healthcare exposure
CRIS
Curis, Inc.
The Niche Pick

CRIS is the #2 pick in this set and the best alternative if efficiency is your priority.

  • -26.1% ROA vs BCTX's -153.6%
Best for: efficiency
NKTR
Nektar Therapeutics
The Momentum Pick

NKTR ranks third and is worth considering specifically for momentum.

  • +7.8% vs BCTX's -86.8%
Best for: momentum
IMVT
Immunovant, Inc.
The Income Pick

IMVT carries the broadest edge in this set and is the clearest fit for income & stability and long-term compounding.

  • beta 1.36
  • 190.9% 10Y total return vs RCUS's 49.2%
  • Lower volatility, beta 1.36, Low D/E 0.0%, current ratio 11.16x
  • Beta 1.36, current ratio 11.16x
Best for: income & stability and long-term compounding
RCUS
Arcus Biosciences, Inc.
The Growth Play

RCUS is the clearest fit if your priority is growth exposure.

  • Rev growth -4.3%, EPS growth -4.8%, 3Y rev CAGR 30.2%
  • -4.3% revenue growth vs BCTX's -136.6%
Best for: growth exposure
See the full category breakdown
CategoryWinnerWhy
GrowthRCUS logoRCUS-4.3% revenue growth vs BCTX's -136.6%
Quality / MarginsIMVT logoIMVT3.2% margin vs NKTR's -284.2%
Stability / SafetyIMVT logoIMVTBeta 1.36 vs CRIS's 1.92, lower leverage
DividendsTieNone of these 5 stocks pay a meaningful dividend
Momentum (1Y)NKTR logoNKTR+7.8% vs BCTX's -86.8%
Efficiency (ROA)CRIS logoCRIS-26.1% ROA vs BCTX's -153.6%

BCTX vs CRIS vs NKTR vs IMVT vs RCUS — Revenue Breakdown by Segment

How each company's revenue is distributed across its business units

BCTXBriaCell Therapeutics Corp.

Segment breakdown not available.

CRISCuris, Inc.
FY 2025
Reportable Segment
100.0%$9M
NKTRNektar Therapeutics
FY 2025
Non Cash Royalty Revenue Related To Sale Of Future Royalties
99.5%$55M
License Collaboration And Other Revenue
0.5%$300,000
IMVTImmunovant, Inc.

Segment breakdown not available.

RCUSArcus Biosciences, Inc.
FY 2025
License And Development Services
87.4%$221M
Development Services
6.7%$17M
R&D Services
3.2%$8M
License
2.8%$7M

BCTX vs CRIS vs NKTR vs IMVT vs RCUS — Financial Metrics

Side-by-side numbers across 5 stocks — who leads on profitability, valuation, growth, and risk.

BEST OVERALLIMVTLAGGINGRCUS

Income & Cash Flow (Last 12 Months)

CRIS leads this category, winning 3 of 6 comparable metrics.

RCUS and IMVT operate at a comparable scale, with $236M and $0 in trailing revenue. Profitability is closely matched — net margins range from -80.3% (CRIS) to -2.8% (NKTR). On growth, NKTR holds the edge at +3.8% YoY revenue growth, suggesting stronger near-term business momentum.

MetricBCTX logoBCTXBriaCell Therapeu…CRIS logoCRISCuris, Inc.NKTR logoNKTRNektar Therapeuti…IMVT logoIMVTImmunovant, Inc.RCUS logoRCUSArcus Biosciences…
RevenueTrailing 12 months$0$9M$56M$0$236M
EBITDAEarnings before interest/tax-$43M-$33M-$125M-$487M-$391M
Net IncomeAfter-tax profit-$38M-$8M-$158M-$464M-$369M
Free Cash FlowCash after capex-$37M-$27M-$160M-$423M-$489M
Gross MarginGross profit ÷ Revenue+99.5%+80.1%+90.7%
Operating MarginEBIT ÷ Revenue-3.5%-2.3%-168.6%
Net MarginNet income ÷ Revenue-80.3%-2.8%-156.4%
FCF MarginFCF ÷ Revenue-2.9%-2.9%-2.1%
Rev. Growth (YoY)Latest quarter vs prior year-66.0%+3.8%-39.3%
EPS Growth (YoY)Latest quarter vs prior year+92.3%+198.4%+49.7%+19.7%+10.5%
CRIS leads this category, winning 3 of 6 comparable metrics.

Valuation Metrics

Evenly matched — BCTX and CRIS and IMVT each lead in 1 of 3 comparable metrics.
MetricBCTX logoBCTXBriaCell Therapeu…CRIS logoCRISCuris, Inc.NKTR logoNKTRNektar Therapeuti…IMVT logoIMVTImmunovant, Inc.RCUS logoRCUSArcus Biosciences…
Market CapShares × price$5M$74M$1.7B$5.9B$2.6B
Enterprise ValueMkt cap + debt − cash-$9M$70M$1.8B$5.2B$2.4B
Trailing P/EPrice ÷ TTM EPS-0.05x-0.97x-8.42x-10.60x-7.71x
Forward P/EPrice ÷ next-FY EPS est.
PEG RatioP/E ÷ EPS growth rate
EV / EBITDAEnterprise value multiple
Price / SalesMarket cap ÷ Revenue7.82x30.09x10.34x
Price / BookPrice ÷ Book value/share0.33x13.52x15.38x6.20x4.32x
Price / FCFMarket cap ÷ FCF
Evenly matched — BCTX and CRIS and IMVT each lead in 1 of 3 comparable metrics.

Profitability & Efficiency

IMVT leads this category, winning 3 of 9 comparable metrics.

IMVT delivers a -47.1% return on equity — every $100 of shareholder capital generates $-47 in annual profit, vs $-194 for BCTX. IMVT carries lower financial leverage with a 0.00x debt-to-equity ratio, signaling a more conservative balance sheet compared to NKTR's 1.66x. On the Piotroski fundamental quality scale (0–9), CRIS scores 3/9 vs RCUS's 0/9, reflecting mixed financial health.

MetricBCTX logoBCTXBriaCell Therapeu…CRIS logoCRISCuris, Inc.NKTR logoNKTRNektar Therapeuti…IMVT logoIMVTImmunovant, Inc.RCUS logoRCUSArcus Biosciences…
ROE (TTM)Return on equity-193.8%-138.8%-87.0%-47.1%-69.0%
ROA (TTM)Return on assets-153.6%-26.1%-40.7%-44.1%-35.3%
ROICReturn on invested capital-12.6%-57.2%-64.1%
ROCEReturn on capital employed-3.4%-2.3%-55.7%-66.1%-42.1%
Piotroski ScoreFundamental quality 0–913220
Debt / EquityFinancial leverage0.30x1.66x0.00x0.16x
Net DebtTotal debt minus cash-$14M-$3M$134M-$714M-$123M
Cash & Equiv.Liquid assets$14M$5M$15M$714M$222M
Total DebtShort + long-term debt$0$2M$149M$98,000$99M
Interest CoverageEBIT ÷ Interest expense-796.67x-107.35x-6.23x-13.38x
IMVT leads this category, winning 3 of 9 comparable metrics.

Total Returns (Dividends Reinvested)

NKTR leads this category, winning 4 of 6 comparable metrics.

A $10,000 investment in IMVT five years ago would be worth $18,445 today (with dividends reinvested), compared to $29 for CRIS. Over the past 12 months, NKTR leads with a +782.4% total return vs BCTX's -86.8%. The 3-year compound annual growth rate (CAGR) favors NKTR at 92.1% vs BCTX's -84.3% — a key indicator of consistent wealth creation.

MetricBCTX logoBCTXBriaCell Therapeu…CRIS logoCRISCuris, Inc.NKTR logoNKTRNektar Therapeuti…IMVT logoIMVTImmunovant, Inc.RCUS logoRCUSArcus Biosciences…
YTD ReturnYear-to-date-41.6%-42.8%+88.6%+11.7%+8.9%
1-Year ReturnPast 12 months-86.8%-73.3%+782.4%+102.4%+197.3%
3-Year ReturnCumulative with dividends-99.6%-96.5%+609.0%+49.8%+27.8%
5-Year ReturnCumulative with dividends-99.1%-99.7%-72.3%+84.4%-12.1%
10-Year ReturnCumulative with dividends-99.7%-59.8%+190.9%+49.2%
CAGR (3Y)Annualised 3-year return-84.3%-67.3%+92.1%+14.4%+8.5%
NKTR leads this category, winning 4 of 6 comparable metrics.

Risk & Volatility

IMVT leads this category, winning 2 of 2 comparable metrics.

IMVT is the less volatile stock with a 1.36 beta — it tends to amplify market swings less than CRIS's 1.92 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. IMVT currently trades 96.2% from its 52-week high vs BCTX's 11.3% drawdown — a narrower gap to the peak suggests stronger recent price momentum.

MetricBCTX logoBCTXBriaCell Therapeu…CRIS logoCRISCuris, Inc.NKTR logoNKTRNektar Therapeuti…IMVT logoIMVTImmunovant, Inc.RCUS logoRCUSArcus Biosciences…
Beta (5Y)Sensitivity to S&P 5001.56x1.92x1.80x1.36x1.84x
52-Week HighHighest price in past year$37.20$3.13$109.00$30.09$28.72
52-Week LowLowest price in past year$3.60$0.49$7.99$13.36$7.72
% of 52W HighCurrent price vs 52-week peak+11.3%+17.9%+75.1%+96.2%+88.3%
RSI (14)Momentum oscillator 0–10048.443.650.550.652.9
Avg Volume (50D)Average daily shares traded183K446K977K1.4M1.2M
IMVT leads this category, winning 2 of 2 comparable metrics.

Analyst Outlook

Insufficient data to determine a leader in this category.

Analyst consensus: NKTR as "Buy", IMVT as "Buy", RCUS as "Buy". Consensus price targets imply 79.9% upside for NKTR (target: $147) vs 18.3% for RCUS (target: $30).

MetricBCTX logoBCTXBriaCell Therapeu…CRIS logoCRISCuris, Inc.NKTR logoNKTRNektar Therapeuti…IMVT logoIMVTImmunovant, Inc.RCUS logoRCUSArcus Biosciences…
Analyst RatingConsensus buy/hold/sellBuyBuyBuy
Price TargetConsensus 12-month target$147.33$45.50$30.00
# AnalystsCovering analysts332318
Dividend YieldAnnual dividend ÷ price
Dividend StreakConsecutive years of raises
Dividend / ShareAnnual DPS
Buyback YieldShare repurchases ÷ mkt cap0.0%0.0%0.0%0.0%0.0%
Insufficient data to determine a leader in this category.
Key Takeaway

IMVT leads in 2 of 6 categories (Profitability & Efficiency, Risk & Volatility). CRIS leads in 1 (Income & Cash Flow). 1 tied.

Best OverallImmunovant, Inc. (IMVT)Leads 2 of 6 categories
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BCTX vs CRIS vs NKTR vs IMVT vs RCUS: Key Questions Answered

8 questions · data-driven answers · updated daily

01

Is BCTX or CRIS or NKTR or IMVT or RCUS a better buy right now?

For growth investors, Arcus Biosciences, Inc.

(RCUS) is the stronger pick with -4. 3% revenue growth year-over-year, versus -43. 9% for Nektar Therapeutics (NKTR). Analysts rate Nektar Therapeutics (NKTR) a "Buy" — based on 33 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.

02

Which is the better long-term investment — BCTX or CRIS or NKTR or IMVT or RCUS?

Over the past 5 years, Immunovant, Inc.

(IMVT) delivered a total return of +84. 4%, compared to -99. 7% for Curis, Inc. (CRIS). Over 10 years, the gap is even starker: IMVT returned +190. 9% versus CRIS's -99. 7%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.

03

Which is safer — BCTX or CRIS or NKTR or IMVT or RCUS?

By beta (market sensitivity over 5 years), Immunovant, Inc.

(IMVT) is the lower-risk stock at 1. 36β versus Curis, Inc. 's 1. 92β — meaning CRIS is approximately 41% more volatile than IMVT relative to the S&P 500. On balance sheet safety, Immunovant, Inc. (IMVT) carries a lower debt/equity ratio of 0% versus 166% for Nektar Therapeutics — giving it more financial flexibility in a downturn.

04

Which is growing faster — BCTX or CRIS or NKTR or IMVT or RCUS?

By revenue growth (latest reported year), Arcus Biosciences, Inc.

(RCUS) is pulling ahead at -4. 3% versus -43. 9% for Nektar Therapeutics (NKTR). On earnings-per-share growth, the picture is similar: Curis, Inc. grew EPS 91. 6% year-over-year, compared to -45. 2% for Immunovant, Inc.. Over a 3-year CAGR, RCUS leads at 30. 2% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.

05

Which has better profit margins — BCTX or CRIS or NKTR or IMVT or RCUS?

BriaCell Therapeutics Corp.

(BCTX) is the more profitable company, earning 0. 0% net margin versus -297. 1% for Nektar Therapeutics — meaning it keeps 0. 0% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: BCTX leads at 0. 0% versus -348. 4% for CRIS. At the gross margin level — before operating expenses — NKTR leads at 100. 0%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.

06

Which pays a better dividend — BCTX or CRIS or NKTR or IMVT or RCUS?

None of the stocks in this comparison currently pay a material dividend.

All are effectively zero-yield and should be held for capital appreciation rather than income.

07

Is BCTX or CRIS or NKTR or IMVT or RCUS better for a retirement portfolio?

For long-horizon retirement investors, Immunovant, Inc.

(IMVT) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (+190. 9% 10Y return). Curis, Inc. (CRIS) carries a higher beta of 1. 92 — meaning larger drawdowns in market downturns, which matters significantly when you cannot wait years for a recovery. Both have compounded well over 10 years (IMVT: +190. 9%, CRIS: -99. 7%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.

08

What are the main differences between BCTX and CRIS and NKTR and IMVT and RCUS?

Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both.

These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.

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