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BCTX vs NKTR vs IMVT vs ADCT vs CRIS

Revenue, margins, valuation, and 5-year total return — side by side.

Live fundamentals10-year financials5-year price chart
BCTX
BriaCell Therapeutics Corp.

Biotechnology

HealthcareNASDAQ • CA
Market Cap$5M
5Y Perf.-15.1%
NKTR
Nektar Therapeutics

Biotechnology

HealthcareNASDAQ • US
Market Cap$1.69B
5Y Perf.-74.4%
IMVT
Immunovant, Inc.

Biotechnology

HealthcareNASDAQ • US
Market Cap$5.53B
5Y Perf.+6.1%
ADCT
ADC Therapeutics S.A.

Biotechnology

HealthcareNYSE • CH
Market Cap$478M
5Y Perf.-89.8%
CRIS
Curis, Inc.

Biotechnology

HealthcareNASDAQ • US
Market Cap$76M
5Y Perf.-96.5%

BCTX vs NKTR vs IMVT vs ADCT vs CRIS — Key Financials

Market cap, revenue, margins, and valuation side-by-side.

Company Snapshot
BCTX logoBCTX
NKTR logoNKTR
IMVT logoIMVT
ADCT logoADCT
CRIS logoCRIS
IndustryBiotechnologyBiotechnologyBiotechnologyBiotechnologyBiotechnology
Market Cap$5M$1.69B$5.53B$478M$76M
Revenue (TTM)$0.00$55M$0.00$79M$9M
Net Income (TTM)$-38M$-164M$-464M$-137M$-8M
Gross Margin99.6%90.7%99.5%
Operating Margin-237.9%-149.6%-348.4%
Total Debt$0.00$149M$98K$439M$2M
Cash & Equiv.$14M$15M$714M$261M$5M

BCTX vs NKTR vs IMVT vs ADCT vs CRISLong-Term Stock Performance

Price return indexed to 100 at period start. Dividends excluded.

BCTX
NKTR
IMVT
ADCT
CRIS
StockMay 20May 26Return
BriaCell Therapeuti… (BCTX)10084.9-15.1%
Nektar Therapeutics (NKTR)10025.6-74.4%
Immunovant, Inc. (IMVT)100106.1+6.1%
ADC Therapeutics S.… (ADCT)10010.2-89.8%
Curis, Inc. (CRIS)1003.5-96.5%

Price return only. Dividends and distributions are not included.

Quick Verdict: BCTX vs NKTR vs IMVT vs ADCT vs CRIS

Each card shows where this stock fits in a portfolio — not just who wins on paper.

Bottom line: IMVT leads in 2 of 6 categories (5-stock set), making it the strongest pick for profitability and margin quality and capital preservation and lower volatility. Nektar Therapeutics is the stronger pick specifically for recent price momentum and sentiment. ADCT and CRIS also each lead in at least one category. As sector peers, any of these can serve as alternatives in the same allocation.
BCTX
BriaCell Therapeutics Corp.
The Healthcare Pick

Among these 5 stocks, BCTX doesn't own a clear edge in any measured category.

Best for: healthcare exposure
NKTR
Nektar Therapeutics
The Momentum Pick

NKTR is the #2 pick in this set and the best alternative if momentum is your priority.

  • +8.2% vs BCTX's -87.5%
Best for: momentum
IMVT
Immunovant, Inc.
The Income Pick

IMVT carries the broadest edge in this set and is the clearest fit for income & stability and long-term compounding.

  • beta 1.37
  • 173.6% 10Y total return vs NKTR's -59.1%
  • Lower volatility, beta 1.37, Low D/E 0.0%, current ratio 11.16x
  • Beta 1.37, current ratio 11.16x
Best for: income & stability and long-term compounding
ADCT
ADC Therapeutics S.A.
The Growth Leader

ADCT ranks third and is worth considering specifically for growth.

  • 14.9% revenue growth vs BCTX's -136.6%
Best for: growth
CRIS
Curis, Inc.
The Growth Play

CRIS is the clearest fit if your priority is growth exposure.

  • Rev growth -13.4%, EPS growth 91.6%, 3Y rev CAGR -2.4%
  • -26.1% ROA vs BCTX's -153.6%
Best for: growth exposure
See the full category breakdown
CategoryWinnerWhy
GrowthADCT logoADCT14.9% revenue growth vs BCTX's -136.6%
Quality / MarginsIMVT logoIMVT3.2% margin vs NKTR's -297.1%
Stability / SafetyIMVT logoIMVTBeta 1.37 vs ADCT's 1.89
DividendsTieNone of these 5 stocks pay a meaningful dividend
Momentum (1Y)NKTR logoNKTR+8.2% vs BCTX's -87.5%
Efficiency (ROA)CRIS logoCRIS-26.1% ROA vs BCTX's -153.6%

BCTX vs NKTR vs IMVT vs ADCT vs CRIS — Revenue Breakdown by Segment

How each company's revenue is distributed across its business units

BCTXBriaCell Therapeutics Corp.

Segment breakdown not available.

NKTRNektar Therapeutics
FY 2025
Non Cash Royalty Revenue Related To Sale Of Future Royalties
99.5%$55M
License Collaboration And Other Revenue
0.5%$300,000
IMVTImmunovant, Inc.

Segment breakdown not available.

ADCTADC Therapeutics S.A.
FY 2025
Product
90.4%$74M
License Revenues
6.1%$5M
Royalty Revenue
3.4%$3M
CRISCuris, Inc.
FY 2025
Reportable Segment
100.0%$9M

BCTX vs NKTR vs IMVT vs ADCT vs CRIS — Financial Metrics

Side-by-side numbers across 5 stocks — who leads on profitability, valuation, growth, and risk.

BEST OVERALLNKTRLAGGINGCRIS

Income & Cash Flow (Last 12 Months)

ADCT leads this category, winning 3 of 6 comparable metrics.

ADCT and IMVT operate at a comparable scale, with $79M and $0 in trailing revenue. Profitability is closely matched — net margins range from -80.3% (CRIS) to -3.0% (NKTR). On growth, ADCT holds the edge at -9.5% YoY revenue growth, suggesting stronger near-term business momentum.

MetricBCTX logoBCTXBriaCell Therapeu…NKTR logoNKTRNektar Therapeuti…IMVT logoIMVTImmunovant, Inc.ADCT logoADCTADC Therapeutics …CRIS logoCRISCuris, Inc.
RevenueTrailing 12 months$0$55M$0$79M$9M
EBITDAEarnings before interest/tax-$43M-$130M-$487M-$117M-$33M
Net IncomeAfter-tax profit-$38M-$164M-$464M-$137M-$8M
Free Cash FlowCash after capex-$37M-$209M-$423M-$115M-$27M
Gross MarginGross profit ÷ Revenue+99.6%+90.7%+99.5%
Operating MarginEBIT ÷ Revenue-2.4%-149.6%-3.5%
Net MarginNet income ÷ Revenue-3.0%-173.0%-80.3%
FCF MarginFCF ÷ Revenue-3.8%-144.7%-2.9%
Rev. Growth (YoY)Latest quarter vs prior year-25.3%-9.5%-66.0%
EPS Growth (YoY)Latest quarter vs prior year+92.3%-4.5%+19.7%+41.7%+198.4%
ADCT leads this category, winning 3 of 6 comparable metrics.

Valuation Metrics

Evenly matched — BCTX and IMVT and ADCT each lead in 1 of 3 comparable metrics.
MetricBCTX logoBCTXBriaCell Therapeu…NKTR logoNKTRNektar Therapeuti…IMVT logoIMVTImmunovant, Inc.ADCT logoADCTADC Therapeutics …CRIS logoCRISCuris, Inc.
Market CapShares × price$5M$1.7B$5.5B$478M$76M
Enterprise ValueMkt cap + debt − cash-$9M$1.8B$4.8B$656M$73M
Trailing P/EPrice ÷ TTM EPS-0.05x-8.57x-9.97x-3.36x-0.99x
Forward P/EPrice ÷ next-FY EPS est.
PEG RatioP/E ÷ EPS growth rate
EV / EBITDAEnterprise value multiple
Price / SalesMarket cap ÷ Revenue30.64x5.88x8.04x
Price / BookPrice ÷ Book value/share0.32x15.66x5.83x13.91x
Price / FCFMarket cap ÷ FCF
Evenly matched — BCTX and IMVT and ADCT each lead in 1 of 3 comparable metrics.

Profitability & Efficiency

Evenly matched — IMVT and ADCT each lead in 3 of 9 comparable metrics.

IMVT delivers a -47.1% return on equity — every $100 of shareholder capital generates $-47 in annual profit, vs $-4 for NKTR. IMVT carries lower financial leverage with a 0.00x debt-to-equity ratio, signaling a more conservative balance sheet compared to NKTR's 1.66x. On the Piotroski fundamental quality scale (0–9), ADCT scores 4/9 vs BCTX's 1/9, reflecting mixed financial health.

MetricBCTX logoBCTXBriaCell Therapeu…NKTR logoNKTRNektar Therapeuti…IMVT logoIMVTImmunovant, Inc.ADCT logoADCTADC Therapeutics …CRIS logoCRISCuris, Inc.
ROE (TTM)Return on equity-193.8%-4.0%-47.1%-138.8%
ROA (TTM)Return on assets-153.6%-62.8%-44.1%-44.7%-26.1%
ROICReturn on invested capital-12.6%-57.2%
ROCEReturn on capital employed-3.4%-55.7%-66.1%-43.8%-2.3%
Piotroski ScoreFundamental quality 0–912243
Debt / EquityFinancial leverage1.66x0.00x0.30x
Net DebtTotal debt minus cash-$14M$134M-$714M$178M-$3M
Cash & Equiv.Liquid assets$14M$15M$714M$261M$5M
Total DebtShort + long-term debt$0$149M$98,000$439M$2M
Interest CoverageEBIT ÷ Interest expense-796.67x-4.74x-1.72x-107.35x
Evenly matched — IMVT and ADCT each lead in 3 of 9 comparable metrics.

Total Returns (Dividends Reinvested)

NKTR leads this category, winning 4 of 6 comparable metrics.

A $10,000 investment in IMVT five years ago would be worth $16,241 today (with dividends reinvested), compared to $28 for CRIS. Over the past 12 months, NKTR leads with a +818.2% total return vs BCTX's -87.5%. The 3-year compound annual growth rate (CAGR) favors NKTR at 93.3% vs BCTX's -84.4% — a key indicator of consistent wealth creation.

MetricBCTX logoBCTXBriaCell Therapeu…NKTR logoNKTRNektar Therapeuti…IMVT logoIMVTImmunovant, Inc.ADCT logoADCTADC Therapeutics …CRIS logoCRISCuris, Inc.
YTD ReturnYear-to-date-42.8%+92.0%+5.1%+6.8%-41.1%
1-Year ReturnPast 12 months-87.5%+818.2%+96.1%+196.1%-72.0%
3-Year ReturnCumulative with dividends-99.6%+621.8%+40.9%+77.4%-96.4%
5-Year ReturnCumulative with dividends-99.2%-72.3%+62.4%-84.1%-99.7%
10-Year ReturnCumulative with dividends-59.1%+173.6%-87.3%-99.7%
CAGR (3Y)Annualised 3-year return-84.4%+93.3%+12.1%+21.0%-67.0%
NKTR leads this category, winning 4 of 6 comparable metrics.

Risk & Volatility

IMVT leads this category, winning 2 of 2 comparable metrics.

IMVT is the less volatile stock with a 1.37 beta — it tends to amplify market swings less than ADCT's 1.89 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. IMVT currently trades 90.5% from its 52-week high vs BCTX's 11.0% drawdown — a narrower gap to the peak suggests stronger recent price momentum.

MetricBCTX logoBCTXBriaCell Therapeu…NKTR logoNKTRNektar Therapeuti…IMVT logoIMVTImmunovant, Inc.ADCT logoADCTADC Therapeutics …CRIS logoCRISCuris, Inc.
Beta (5Y)Sensitivity to S&P 5001.56x1.85x1.37x1.89x1.87x
52-Week HighHighest price in past year$37.20$109.00$30.09$4.97$3.13
52-Week LowLowest price in past year$3.60$7.99$13.36$1.23$0.49
% of 52W HighCurrent price vs 52-week peak+11.0%+76.5%+90.5%+75.7%+18.4%
RSI (14)Momentum oscillator 0–10050.053.460.248.048.9
Avg Volume (50D)Average daily shares traded185K991K1.4M946K444K
IMVT leads this category, winning 2 of 2 comparable metrics.

Analyst Outlook

Insufficient data to determine a leader in this category.

Analyst consensus: NKTR as "Buy", IMVT as "Buy", ADCT as "Buy". Consensus price targets imply 99.5% upside for ADCT (target: $8) vs 59.3% for NKTR (target: $133).

MetricBCTX logoBCTXBriaCell Therapeu…NKTR logoNKTRNektar Therapeuti…IMVT logoIMVTImmunovant, Inc.ADCT logoADCTADC Therapeutics …CRIS logoCRISCuris, Inc.
Analyst RatingConsensus buy/hold/sellBuyBuyBuy
Price TargetConsensus 12-month target$132.83$45.50$7.50
# AnalystsCovering analysts332312
Dividend YieldAnnual dividend ÷ price
Dividend StreakConsecutive years of raises
Dividend / ShareAnnual DPS
Buyback YieldShare repurchases ÷ mkt cap0.0%0.0%0.0%0.0%0.0%
Insufficient data to determine a leader in this category.
Key Takeaway

ADCT leads in 1 of 6 categories (Income & Cash Flow). NKTR leads in 1 (Total Returns). 2 tied.

Best OverallNektar Therapeutics (NKTR)Leads 1 of 6 categories
Loading custom metrics...

BCTX vs NKTR vs IMVT vs ADCT vs CRIS: Key Questions Answered

8 questions · data-driven answers · updated daily

01

Is BCTX or NKTR or IMVT or ADCT or CRIS a better buy right now?

For growth investors, ADC Therapeutics S.

A. (ADCT) is the stronger pick with 14. 9% revenue growth year-over-year, versus -43. 9% for Nektar Therapeutics (NKTR). Analysts rate Nektar Therapeutics (NKTR) a "Buy" — based on 33 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.

02

Which is the better long-term investment — BCTX or NKTR or IMVT or ADCT or CRIS?

Over the past 5 years, Immunovant, Inc.

(IMVT) delivered a total return of +62. 4%, compared to -99. 7% for Curis, Inc. (CRIS). Over 10 years, the gap is even starker: IMVT returned +173. 6% versus CRIS's -99. 7%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.

03

Which is safer — BCTX or NKTR or IMVT or ADCT or CRIS?

By beta (market sensitivity over 5 years), Immunovant, Inc.

(IMVT) is the lower-risk stock at 1. 37β versus ADC Therapeutics S. A. 's 1. 89β — meaning ADCT is approximately 37% more volatile than IMVT relative to the S&P 500. On balance sheet safety, Immunovant, Inc. (IMVT) carries a lower debt/equity ratio of 0% versus 166% for Nektar Therapeutics — giving it more financial flexibility in a downturn.

04

Which is growing faster — BCTX or NKTR or IMVT or ADCT or CRIS?

By revenue growth (latest reported year), ADC Therapeutics S.

A. (ADCT) is pulling ahead at 14. 9% versus -43. 9% for Nektar Therapeutics (NKTR). On earnings-per-share growth, the picture is similar: Curis, Inc. grew EPS 91. 6% year-over-year, compared to -45. 2% for Immunovant, Inc.. Over a 3-year CAGR, CRIS leads at -2. 4% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.

05

Which has better profit margins — BCTX or NKTR or IMVT or ADCT or CRIS?

BriaCell Therapeutics Corp.

(BCTX) is the more profitable company, earning 0. 0% net margin versus -297. 1% for Nektar Therapeutics — meaning it keeps 0. 0% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: BCTX leads at 0. 0% versus -348. 4% for CRIS. At the gross margin level — before operating expenses — NKTR leads at 100. 0%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.

06

Which pays a better dividend — BCTX or NKTR or IMVT or ADCT or CRIS?

None of the stocks in this comparison currently pay a material dividend.

All are effectively zero-yield and should be held for capital appreciation rather than income.

07

Is BCTX or NKTR or IMVT or ADCT or CRIS better for a retirement portfolio?

For long-horizon retirement investors, Immunovant, Inc.

(IMVT) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (+173. 6% 10Y return). ADC Therapeutics S. A. (ADCT) carries a higher beta of 1. 89 — meaning larger drawdowns in market downturns, which matters significantly when you cannot wait years for a recovery. Both have compounded well over 10 years (IMVT: +173. 6%, ADCT: -87. 3%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.

08

What are the main differences between BCTX and NKTR and IMVT and ADCT and CRIS?

Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both.

These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.

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