Biotechnology
Compare Stocks
5 / 10Stock Comparison
CBUS vs OFIX vs NVCR vs PGEN vs FATE
Revenue, margins, valuation, and 5-year total return — side by side.
Medical - Devices
Medical - Instruments & Supplies
Biotechnology
Biotechnology
CBUS vs OFIX vs NVCR vs PGEN vs FATE — Key Financials
Market cap, revenue, margins, and valuation side-by-side.
| Company Snapshot | |||||
|---|---|---|---|---|---|
| Industry | Biotechnology | Medical - Devices | Medical - Instruments & Supplies | Biotechnology | Biotechnology |
| Market Cap | $686M | $488M | $1.92B | $1.22B | $280M |
| Revenue (TTM) | $4M | $825M | $674M | $6M | $7M |
| Net Income (TTM) | $-127M | $-60M | $-173M | $-247M | $-136M |
| Gross Margin | 23.9% | 69.0% | 75.2% | 23.0% | — |
| Operating Margin | -26.8% | -4.0% | -27.2% | -18.6% | -22.2% |
| Total Debt | $33M | $229M | $290M | $6M | $78M |
| Cash & Equiv. | $10M | $82M | $103M | $30M | $47M |
CBUS vs OFIX vs NVCR vs PGEN vs FATE — Long-Term Stock Performance
Price return indexed to 100 at period start. Dividends excluded.
| Stock | May 20 | May 26 | Return |
|---|---|---|---|
| Cibus, Inc. (CBUS) | 100 | 0.7 | -99.3% |
| Orthofix Medical In… (OFIX) | 100 | 35.4 | -64.6% |
| NovoCure Limited (NVCR) | 100 | 25.0 | -75.0% |
| Precigen, Inc. (PGEN) | 100 | 188.6 | +88.6% |
| Fate Therapeutics, … (FATE) | 100 | 7.5 | -92.5% |
Price return only. Dividends and distributions are not included.
Quick Verdict: CBUS vs OFIX vs NVCR vs PGEN vs FATE
Each card shows where this stock fits in a portfolio — not just who wins on paper.
CBUS is the clearest fit if your priority is growth exposure.
- Rev growth -14.6%, EPS growth 74.3%, 3Y rev CAGR 185.1%
OFIX carries the broadest edge in this set and is the clearest fit for income & stability.
- beta 1.21
- -7.3% margin vs PGEN's -39.1%
- Beta 1.21 vs CBUS's 3.12, lower leverage
- -7.0% ROA vs PGEN's -144.1%, ROIC -8.6% vs -152.8%
NVCR is the #2 pick in this set and the best alternative if growth is your priority.
- 8.3% revenue growth vs FATE's -51.2%
PGEN ranks third and is worth considering specifically for sleep-well-at-night and defensive.
- Lower volatility, beta 1.44, Low D/E 14.3%, current ratio 4.76x
- Beta 1.44, current ratio 4.76x
- +207.4% vs CBUS's -40.0%
FATE is the clearest fit if your priority is long-term compounding.
- 40.5% 10Y total return vs NVCR's 30.3%
See the full category breakdown
| Category | Winner | Why |
|---|---|---|
| Growth | 8.3% revenue growth vs FATE's -51.2% | |
| Quality / Margins | -7.3% margin vs PGEN's -39.1% | |
| Stability / Safety | Beta 1.21 vs CBUS's 3.12, lower leverage | |
| Dividends | Tie | None of these 5 stocks pay a meaningful dividend |
| Momentum (1Y) | +207.4% vs CBUS's -40.0% | |
| Efficiency (ROA) | -7.0% ROA vs PGEN's -144.1%, ROIC -8.6% vs -152.8% |
CBUS vs OFIX vs NVCR vs PGEN vs FATE — Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
CBUS vs OFIX vs NVCR vs PGEN vs FATE — Financial Metrics
Side-by-side numbers across 5 stocks — who leads on profitability, valuation, growth, and risk.
Who Leads Where
OFIX leads in 3 of 6 categories
PGEN leads 1 • CBUS leads 0 • NVCR leads 0 • FATE leads 0 • 1 tied
Explore the data ↓Income & Cash Flow (Last 12 Months)
OFIX leads this category, winning 4 of 6 comparable metrics.
Income & Cash Flow (Last 12 Months)
OFIX is the larger business by revenue, generating $825M annually — 226.8x CBUS's $4M. OFIX is the more profitable business, keeping -7.3% of every revenue dollar as net income compared to PGEN's -39.1%. On growth, PGEN holds the edge at +2.1% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | |||||
|---|---|---|---|---|---|
| RevenueTrailing 12 months | $4M | $825M | $674M | $6M | $7M |
| EBITDAEarnings before interest/tax | -$92M | $102M | -$165M | -$115M | -$148M |
| Net IncomeAfter-tax profit | -$127M | -$60M | -$173M | -$247M | -$136M |
| Free Cash FlowCash after capex | -$51M | -$4M | -$48M | -$76M | -$88M |
| Gross MarginGross profit ÷ Revenue | +23.9% | +69.0% | +75.2% | +23.0% | — |
| Operating MarginEBIT ÷ Revenue | -26.8% | -4.0% | -27.2% | -18.6% | -22.2% |
| Net MarginNet income ÷ Revenue | -34.9% | -7.3% | -25.7% | -39.1% | -20.5% |
| FCF MarginFCF ÷ Revenue | -14.1% | -0.4% | -7.1% | -12.0% | -13.2% |
| Rev. Growth (YoY)Latest quarter vs prior year | -12.8% | +1.6% | +12.3% | +2.1% | -26.4% |
| EPS Growth (YoY)Latest quarter vs prior year | +55.2% | +61.5% | -100.0% | -11.7% | +38.6% |
Valuation Metrics
OFIX leads this category, winning 2 of 3 comparable metrics.
Valuation Metrics
| Metric | |||||
|---|---|---|---|---|---|
| Market CapShares × price | $686M | $488M | $1.9B | $1.2B | $280M |
| Enterprise ValueMkt cap + debt − cash | $709M | $635M | $2.1B | $1.2B | $312M |
| Trailing P/EPrice ÷ TTM EPS | -0.54x | -5.29x | -13.80x | -8.83x | -2.11x |
| Forward P/EPrice ÷ next-FY EPS est. | — | — | — | — | — |
| PEG RatioP/E ÷ EPS growth rate | — | — | — | — | — |
| EV / EBITDAEnterprise value multiple | — | — | — | — | — |
| Price / SalesMarket cap ÷ Revenue | 188.61x | 0.59x | 2.92x | 309.66x | 42.18x |
| Price / BookPrice ÷ Book value/share | 31.44x | 1.07x | 5.51x | 28.85x | 1.39x |
| Price / FCFMarket cap ÷ FCF | — | — | — | — | — |
Profitability & Efficiency
OFIX leads this category, winning 4 of 9 comparable metrics.
Profitability & Efficiency
OFIX delivers a -13.4% return on equity — every $100 of shareholder capital generates $-13 in annual profit, vs $-6 for PGEN. PGEN carries lower financial leverage with a 0.14x debt-to-equity ratio, signaling a more conservative balance sheet compared to CBUS's 1.51x. On the Piotroski fundamental quality scale (0–9), NVCR scores 5/9 vs FATE's 2/9, reflecting solid financial health.
| Metric | |||||
|---|---|---|---|---|---|
| ROE (TTM)Return on equity | -2.3% | -13.4% | -50.8% | -5.9% | -65.8% |
| ROA (TTM)Return on assets | -38.6% | -7.0% | -16.5% | -144.1% | -42.7% |
| ROICReturn on invested capital | -61.5% | -8.6% | -16.4% | -152.8% | -36.5% |
| ROCEReturn on capital employed | -21.8% | -9.7% | -28.9% | -107.2% | -43.1% |
| Piotroski ScoreFundamental quality 0–9 | 2 | 4 | 5 | 3 | 2 |
| Debt / EquityFinancial leverage | 1.51x | 0.51x | 0.85x | 0.14x | 0.38x |
| Net DebtTotal debt minus cash | $23M | $147M | $187M | -$24M | $31M |
| Cash & Equiv.Liquid assets | $10M | $82M | $103M | $30M | $47M |
| Total DebtShort + long-term debt | $33M | $229M | $290M | $6M | $78M |
| Interest CoverageEBIT ÷ Interest expense | -2.49x | -4.97x | -96.80x | -273.83x | — |
Total Returns (Dividends Reinvested)
PGEN leads this category, winning 4 of 6 comparable metrics.
Total Returns (Dividends Reinvested)
A $10,000 investment in PGEN five years ago would be worth $6,346 today (with dividends reinvested), compared to $69 for CBUS. Over the past 12 months, PGEN leads with a +207.4% total return vs CBUS's -40.0%. The 3-year compound annual growth rate (CAGR) favors PGEN at 49.2% vs CBUS's -54.4% — a key indicator of consistent wealth creation.
| Metric | |||||
|---|---|---|---|---|---|
| YTD ReturnYear-to-date | -20.2% | -18.7% | +28.3% | -3.0% | +145.5% |
| 1-Year ReturnPast 12 months | -40.0% | +0.4% | +1.1% | +207.4% | +143.0% |
| 3-Year ReturnCumulative with dividends | -90.5% | -35.1% | -75.7% | +232.0% | -55.4% |
| 5-Year ReturnCumulative with dividends | -99.3% | -72.7% | -91.3% | -36.5% | -96.8% |
| 10-Year ReturnCumulative with dividends | -99.7% | -72.0% | +30.3% | -84.6% | +40.5% |
| CAGR (3Y)Annualised 3-year return | -54.4% | -13.4% | -37.6% | +49.2% | -23.6% |
Risk & Volatility
Evenly matched — OFIX and FATE each lead in 1 of 2 comparable metrics.
Risk & Volatility
OFIX is the less volatile stock with a 1.21 beta — it tends to amplify market swings less than CBUS's 3.12 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. FATE currently trades 98.6% from its 52-week high vs CBUS's 35.8% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | |||||
|---|---|---|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 3.12x | 1.21x | 2.20x | 1.44x | 2.17x |
| 52-Week HighHighest price in past year | $4.19 | $16.99 | $20.06 | $5.23 | $2.46 |
| 52-Week LowLowest price in past year | $1.09 | $10.24 | $9.82 | $1.23 | $0.91 |
| % of 52W HighCurrent price vs 52-week peak | +35.8% | +71.0% | +83.9% | +79.3% | +98.6% |
| RSI (14)Momentum oscillator 0–100 | 45.8 | 50.4 | 69.8 | 62.7 | 81.0 |
| Avg Volume (50D)Average daily shares traded | 603K | 274K | 1.5M | 4.3M | 1.9M |
Analyst Outlook
Insufficient data to determine a leader in this category.
Analyst Outlook
Analyst consensus: CBUS as "Buy", OFIX as "Hold", NVCR as "Buy", PGEN as "Buy", FATE as "Buy". Consensus price targets imply 1525.5% upside for FATE (target: $40) vs 44.6% for PGEN (target: $6).
| Metric | |||||
|---|---|---|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Buy | Hold | Buy | Buy | Buy |
| Price TargetConsensus 12-month target | $11.50 | $18.00 | $33.50 | $6.00 | $39.50 |
| # AnalystsCovering analysts | 4 | 17 | 15 | 16 | 31 |
| Dividend YieldAnnual dividend ÷ price | — | — | — | — | — |
| Dividend StreakConsecutive years of raises | 1 | — | — | — | — |
| Dividend / ShareAnnual DPS | — | — | — | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% |
OFIX leads in 3 of 6 categories (Income & Cash Flow, Valuation Metrics). PGEN leads in 1 (Total Returns). 1 tied.
CBUS vs OFIX vs NVCR vs PGEN vs FATE: Key Questions Answered
8 questions · data-driven answers · updated daily
01Is CBUS or OFIX or NVCR or PGEN or FATE a better buy right now?
For growth investors, NovoCure Limited (NVCR) is the stronger pick with 8.
3% revenue growth year-over-year, versus -51. 2% for Fate Therapeutics, Inc. (FATE). Analysts rate Cibus, Inc. (CBUS) a "Buy" — based on 4 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — CBUS or OFIX or NVCR or PGEN or FATE?
Over the past 5 years, Precigen, Inc.
(PGEN) delivered a total return of -36. 5%, compared to -99. 3% for Cibus, Inc. (CBUS). Over 10 years, the gap is even starker: FATE returned +40. 5% versus CBUS's -99. 7%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — CBUS or OFIX or NVCR or PGEN or FATE?
By beta (market sensitivity over 5 years), Orthofix Medical Inc.
(OFIX) is the lower-risk stock at 1. 21β versus Cibus, Inc. 's 3. 12β — meaning CBUS is approximately 157% more volatile than OFIX relative to the S&P 500. On balance sheet safety, Precigen, Inc. (PGEN) carries a lower debt/equity ratio of 14% versus 151% for Cibus, Inc. — giving it more financial flexibility in a downturn.
04Which is growing faster — CBUS or OFIX or NVCR or PGEN or FATE?
By revenue growth (latest reported year), NovoCure Limited (NVCR) is pulling ahead at 8.
3% versus -51. 2% for Fate Therapeutics, Inc. (FATE). On earnings-per-share growth, the picture is similar: Cibus, Inc. grew EPS 74. 3% year-over-year, compared to -20. 5% for Precigen, Inc.. Over a 3-year CAGR, CBUS leads at 185. 1% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.
05Which has better profit margins — CBUS or OFIX or NVCR or PGEN or FATE?
Orthofix Medical Inc.
(OFIX) is the more profitable company, earning -11. 2% net margin versus -34. 9% for Cibus, Inc. — meaning it keeps -11. 2% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: OFIX leads at -8. 3% versus -34. 4% for PGEN. At the gross margin level — before operating expenses — NVCR leads at 74. 5%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
06Which pays a better dividend — CBUS or OFIX or NVCR or PGEN or FATE?
None of the stocks in this comparison currently pay a material dividend.
All are effectively zero-yield and should be held for capital appreciation rather than income.
07Is CBUS or OFIX or NVCR or PGEN or FATE better for a retirement portfolio?
For long-horizon retirement investors, Orthofix Medical Inc.
(OFIX) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 1. 21)). Cibus, Inc. (CBUS) carries a higher beta of 3. 12 — meaning larger drawdowns in market downturns, which matters significantly when you cannot wait years for a recovery. Both have compounded well over 10 years (OFIX: -72. 0%, CBUS: -99. 7%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
08What are the main differences between CBUS and OFIX and NVCR and PGEN and FATE?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both.
These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
Find Stocks Like These
Explore pre-built screens for each stock's profile, or build a custom screen to find stocks that outperform all of them.
You Might Also Compare
Based on how these companies actually compete and overlap — not just which sector they're filed under.