Biotechnology
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COCP vs GILD vs ABBV vs REGN
Revenue, margins, valuation, and 5-year total return — side by side.
Drug Manufacturers - General
Drug Manufacturers - General
Biotechnology
COCP vs GILD vs ABBV vs REGN — Key Financials
Market cap, revenue, margins, and valuation side-by-side.
| Company Snapshot | ||||
|---|---|---|---|---|
| Industry | Biotechnology | Drug Manufacturers - General | Drug Manufacturers - General | Biotechnology |
| Market Cap | $18M | $166.40B | $358.42B | $73.68B |
| Revenue (TTM) | $0.00 | $29.73B | $61.16B | $14.92B |
| Net Income (TTM) | $-10M | $9.22B | $4.23B | $4.42B |
| Gross Margin | — | 63.0% | 70.2% | 84.5% |
| Operating Margin | — | 38.2% | 26.7% | 24.3% |
| Forward P/E | — | 15.7x | 14.3x | 15.3x |
| Total Debt | $2M | $24.59B | $69.07B | $2.71B |
| Cash & Equiv. | $10M | $7.56B | $5.23B | $3.12B |
COCP vs GILD vs ABBV vs REGN — Long-Term Stock Performance
Price return indexed to 100 at period start. Dividends excluded.
| Stock | May 20 | May 26 | Return |
|---|---|---|---|
| Cocrystal Pharma, I… (COCP) | 100 | 11.9 | -88.1% |
| Gilead Sciences, In… (GILD) | 100 | 172.2 | +72.2% |
| AbbVie Inc. (ABBV) | 100 | 218.7 | +118.7% |
| Regeneron Pharmaceu… (REGN) | 100 | 115.7 | +15.7% |
Price return only. Dividends and distributions are not included.
Quick Verdict: COCP vs GILD vs ABBV vs REGN
Each card shows where this stock fits in a portfolio — not just who wins on paper.
COCP is the clearest fit if your priority is growth.
- 48.4% revenue growth vs REGN's 1.0%
GILD carries the broadest edge in this set and is the clearest fit for growth exposure and valuation efficiency.
- Rev growth 2.4%, EPS growth 16.8%, 3Y rev CAGR 2.6%
- PEG 0.15 vs REGN's 2.43
- PEG 0.15 vs 2.43
- 31.0% margin vs COCP's 4.0%
ABBV is the #2 pick in this set and the best alternative if income & stability and long-term compounding is your priority.
- Dividend streak 13 yrs, beta 0.34, yield 3.2%
- 295.5% 10Y total return vs GILD's 87.8%
- Beta 0.34, yield 3.2%, current ratio 0.67x
- Beta 0.34 vs COCP's 1.36
REGN is the clearest fit if your priority is sleep-well-at-night.
- Lower volatility, beta 0.81, Low D/E 8.7%, current ratio 4.13x
See the full category breakdown
| Category | Winner | Why |
|---|---|---|
| Growth | 48.4% revenue growth vs REGN's 1.0% | |
| Value | PEG 0.15 vs 2.43 | |
| Quality / Margins | 31.0% margin vs COCP's 4.0% | |
| Stability / Safety | Beta 0.34 vs COCP's 1.36 | |
| Dividends | 3.2% yield, 13-year raise streak, vs GILD's 2.4%, (1 stock pays no dividend) | |
| Momentum (1Y) | +38.8% vs COCP's -11.5% | |
| Efficiency (ROA) | 16.1% ROA vs COCP's -92.6%, ROIC 23.4% vs -8.0% |
COCP vs GILD vs ABBV vs REGN — Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
COCP vs GILD vs ABBV vs REGN — Financial Metrics
Side-by-side numbers across 4 stocks — who leads on profitability, valuation, growth, and risk.
Who Leads Where
GILD leads in 2 of 6 categories
ABBV leads 1 • COCP leads 0 • REGN leads 0 • 3 tied
Explore the data ↓Income & Cash Flow (Last 12 Months)
GILD leads this category, winning 3 of 6 comparable metrics.
Income & Cash Flow (Last 12 Months)
ABBV and COCP operate at a comparable scale, with $61.2B and $0 in trailing revenue. GILD is the more profitable business, keeping 31.0% of every revenue dollar as net income compared to ABBV's 6.9%. On growth, REGN holds the edge at +19.0% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | ||||
|---|---|---|---|---|
| RevenueTrailing 12 months | $0 | $29.7B | $61.2B | $14.9B |
| EBITDAEarnings before interest/tax | -$10M | $12.1B | $24.5B | $4.2B |
| Net IncomeAfter-tax profit | -$10M | $9.2B | $4.2B | $4.4B |
| Free Cash FlowCash after capex | -$10M | $10.3B | $18.7B | $4.2B |
| Gross MarginGross profit ÷ Revenue | — | +63.0% | +70.2% | +84.5% |
| Operating MarginEBIT ÷ Revenue | — | +38.2% | +26.7% | +24.3% |
| Net MarginNet income ÷ Revenue | — | +31.0% | +6.9% | +29.6% |
| FCF MarginFCF ÷ Revenue | — | +34.8% | +30.6% | +27.9% |
| Rev. Growth (YoY)Latest quarter vs prior year | — | +4.4% | +10.0% | +19.0% |
| EPS Growth (YoY)Latest quarter vs prior year | +61.2% | +54.8% | +57.4% | -7.2% |
Valuation Metrics
Evenly matched — COCP and GILD and ABBV each lead in 2 of 7 comparable metrics.
Valuation Metrics
At 17.1x trailing earnings, REGN trades at a 80% valuation discount to ABBV's 85.5x P/E. Adjusting for growth (PEG ratio), GILD offers better value at 0.15x vs REGN's 2.70x — a lower PEG means you pay less per unit of expected earnings growth.
| Metric | ||||
|---|---|---|---|---|
| Market CapShares × price | $18M | $166.4B | $358.4B | $73.7B |
| Enterprise ValueMkt cap + debt − cash | $10M | $183.4B | $422.3B | $73.3B |
| Trailing P/EPrice ÷ TTM EPS | -0.81x | 19.77x | 85.50x | 17.09x |
| Forward P/EPrice ÷ next-FY EPS est. | — | 15.69x | 14.28x | 15.35x |
| PEG RatioP/E ÷ EPS growth rate | — | 0.15x | — | 2.70x |
| EV / EBITDAEnterprise value multiple | — | 16.95x | 14.96x | 17.78x |
| Price / SalesMarket cap ÷ Revenue | — | 5.65x | 5.86x | 5.14x |
| Price / BookPrice ÷ Book value/share | 1.49x | 7.44x | — | 2.46x |
| Price / FCFMarket cap ÷ FCF | — | 17.60x | 20.12x | 18.06x |
Profitability & Efficiency
Evenly matched — GILD and REGN each lead in 3 of 9 comparable metrics.
Profitability & Efficiency
ABBV delivers a 62.1% return on equity — every $100 of shareholder capital generates $62 in annual profit, vs $-126 for COCP. REGN carries lower financial leverage with a 0.09x debt-to-equity ratio, signaling a more conservative balance sheet compared to GILD's 1.09x. On the Piotroski fundamental quality scale (0–9), GILD scores 9/9 vs COCP's 1/9, reflecting strong financial health.
| Metric | ||||
|---|---|---|---|---|
| ROE (TTM)Return on equity | -126.1% | +42.3% | +62.1% | +14.3% |
| ROA (TTM)Return on assets | -92.6% | +16.1% | +3.1% | +11.1% |
| ROICReturn on invested capital | -8.0% | +23.4% | +23.9% | +8.9% |
| ROCEReturn on capital employed | -91.6% | +25.1% | +21.5% | +10.2% |
| Piotroski ScoreFundamental quality 0–9 | 1 | 9 | 6 | 5 |
| Debt / EquityFinancial leverage | 0.19x | 1.09x | — | 0.09x |
| Net DebtTotal debt minus cash | -$8M | $17.0B | $63.8B | -$412M |
| Cash & Equiv.Liquid assets | $10M | $7.6B | $5.2B | $3.1B |
| Total DebtShort + long-term debt | $2M | $24.6B | $69.1B | $2.7B |
| Interest CoverageEBIT ÷ Interest expense | — | 8.87x | 3.28x | 108.44x |
Total Returns (Dividends Reinvested)
GILD leads this category, winning 4 of 6 comparable metrics.
Total Returns (Dividends Reinvested)
A $10,000 investment in GILD five years ago would be worth $22,418 today (with dividends reinvested), compared to $878 for COCP. Over the past 12 months, GILD leads with a +38.8% total return vs COCP's -11.5%. The 3-year compound annual growth rate (CAGR) favors GILD at 22.2% vs COCP's -20.4% — a key indicator of consistent wealth creation.
| Metric | ||||
|---|---|---|---|---|
| YTD ReturnYear-to-date | +40.4% | +10.9% | -10.1% | -8.5% |
| 1-Year ReturnPast 12 months | -11.5% | +38.8% | +11.3% | +27.1% |
| 3-Year ReturnCumulative with dividends | -49.6% | +82.4% | +50.4% | -5.1% |
| 5-Year ReturnCumulative with dividends | -91.2% | +124.2% | +101.3% | +43.6% |
| 10-Year ReturnCumulative with dividends | -99.4% | +87.8% | +295.5% | +90.0% |
| CAGR (3Y)Annualised 3-year return | -20.4% | +22.2% | +14.6% | -1.7% |
Risk & Volatility
Evenly matched — ABBV and REGN each lead in 1 of 2 comparable metrics.
Risk & Volatility
ABBV is the less volatile stock with a 0.34 beta — it tends to amplify market swings less than COCP's 1.36 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. REGN currently trades 86.4% from its 52-week high vs COCP's 52.1% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | ||||
|---|---|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 1.36x | 0.66x | 0.34x | 0.81x |
| 52-Week HighHighest price in past year | $2.67 | $157.29 | $244.81 | $821.11 |
| 52-Week LowLowest price in past year | $0.86 | $95.30 | $176.57 | $476.49 |
| % of 52W HighCurrent price vs 52-week peak | +52.1% | +85.2% | +82.8% | +86.4% |
| RSI (14)Momentum oscillator 0–100 | 54.0 | 52.6 | 46.8 | 44.9 |
| Avg Volume (50D)Average daily shares traded | 2.9M | 5.8M | 5.8M | 631K |
Analyst Outlook
ABBV leads this category, winning 2 of 2 comparable metrics.
Analyst Outlook
Analyst consensus: GILD as "Buy", ABBV as "Buy", REGN as "Buy". Consensus price targets imply 26.6% upside for ABBV (target: $257) vs 20.8% for GILD (target: $162). For income investors, ABBV offers the higher dividend yield at 3.24% vs REGN's 0.48%.
| Metric | ||||
|---|---|---|---|---|
| Analyst RatingConsensus buy/hold/sell | — | Buy | Buy | Buy |
| Price TargetConsensus 12-month target | — | $161.88 | $256.64 | $865.68 |
| # AnalystsCovering analysts | — | 58 | 41 | 48 |
| Dividend YieldAnnual dividend ÷ price | — | +2.4% | +3.2% | +0.5% |
| Dividend StreakConsecutive years of raises | — | 11 | 13 | 1 |
| Dividend / ShareAnnual DPS | — | $3.19 | $6.57 | $3.41 |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | +1.2% | +0.3% | +5.4% |
GILD leads in 2 of 6 categories (Income & Cash Flow, Total Returns). ABBV leads in 1 (Analyst Outlook). 3 tied.
COCP vs GILD vs ABBV vs REGN: Key Questions Answered
10 questions · data-driven answers · updated daily
01Is COCP or GILD or ABBV or REGN a better buy right now?
For growth investors, AbbVie Inc.
(ABBV) is the stronger pick with 8. 6% revenue growth year-over-year, versus 1. 0% for Regeneron Pharmaceuticals, Inc. (REGN). Regeneron Pharmaceuticals, Inc. (REGN) offers the better valuation at 17. 1x trailing P/E (15. 3x forward), making it the more compelling value choice. Analysts rate Gilead Sciences, Inc. (GILD) a "Buy" — based on 58 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which has the better valuation — COCP or GILD or ABBV or REGN?
On trailing P/E, Regeneron Pharmaceuticals, Inc.
(REGN) is the cheapest at 17. 1x versus AbbVie Inc. at 85. 5x. On forward P/E, AbbVie Inc. is actually cheaper at 14. 3x — notably different from the trailing picture, reflecting expected earnings growth.
03Which is the better long-term investment — COCP or GILD or ABBV or REGN?
Over the past 5 years, Gilead Sciences, Inc.
(GILD) delivered a total return of +124. 2%, compared to -91. 2% for Cocrystal Pharma, Inc. (COCP). Over 10 years, the gap is even starker: ABBV returned +295. 5% versus COCP's -99. 4%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
04Which is safer — COCP or GILD or ABBV or REGN?
By beta (market sensitivity over 5 years), AbbVie Inc.
(ABBV) is the lower-risk stock at 0. 34β versus Cocrystal Pharma, Inc. 's 1. 36β — meaning COCP is approximately 303% more volatile than ABBV relative to the S&P 500. On balance sheet safety, Regeneron Pharmaceuticals, Inc. (REGN) carries a lower debt/equity ratio of 9% versus 109% for Gilead Sciences, Inc. — giving it more financial flexibility in a downturn.
05Which is growing faster — COCP or GILD or ABBV or REGN?
By revenue growth (latest reported year), AbbVie Inc.
(ABBV) is pulling ahead at 8. 6% versus 1. 0% for Regeneron Pharmaceuticals, Inc. (REGN). On earnings-per-share growth, the picture is similar: Gilead Sciences, Inc. grew EPS 1684% year-over-year, compared to -0. 8% for AbbVie Inc.. Over a 3-year CAGR, REGN leads at 5. 6% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.
06Which has better profit margins — COCP or GILD or ABBV or REGN?
Regeneron Pharmaceuticals, Inc.
(REGN) is the more profitable company, earning 31. 4% net margin versus 0. 0% for Cocrystal Pharma, Inc. — meaning it keeps 31. 4% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: GILD leads at 40. 1% versus 0. 0% for COCP. At the gross margin level — before operating expenses — GILD leads at 86. 7%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
07Is COCP or GILD or ABBV or REGN more undervalued right now?
On forward earnings alone, AbbVie Inc.
(ABBV) trades at 14. 3x forward P/E versus 15. 7x for Gilead Sciences, Inc. — 1. 4x cheaper on a one-year earnings basis. Analyst consensus price targets imply the most upside for ABBV: 26. 6% to $256. 64.
08Which pays a better dividend — COCP or GILD or ABBV or REGN?
In this comparison, ABBV (3.
2% yield), GILD (2. 4% yield), REGN (0. 5% yield) pay a dividend. COCP does not pay a meaningful dividend and should not be held primarily for income.
09Is COCP or GILD or ABBV or REGN better for a retirement portfolio?
For long-horizon retirement investors, AbbVie Inc.
(ABBV) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0. 34), 3. 2% yield, +295. 5% 10Y return). Both have compounded well over 10 years (ABBV: +295. 5%, COCP: -99. 4%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
10What are the main differences between COCP and GILD and ABBV and REGN?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both.
In terms of investment character: COCP is a small-cap quality compounder stock; GILD is a mid-cap quality compounder stock; ABBV is a large-cap income-oriented stock; REGN is a mid-cap deep-value stock. GILD, ABBV pay a dividend while COCP, REGN do not, making them suitable for different income and tax situations. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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