GPCR
Structure Therapeutics Inc.
Biotechnology
Market Cap$2.25B
5Y Perf.+53.2%
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Stock Comparison
GPCR vs CHRS vs IMVT vs PRGO
Revenue, margins, valuation, and 5-year total return — side by side.
CHRS
Coherus Oncology, Inc.
Biotechnology
Market Cap$213M
5Y Perf.-74.0%
IMVT
Immunovant, Inc.
Biotechnology
Market Cap$5.53B
5Y Perf.+55.8%
PRGO
Perrigo Company plc
Drug Manufacturers - Specialty & Generic
Market Cap$1.61B
5Y Perf.-68.9%
GPCR vs CHRS vs IMVT vs PRGO — Key Financials
Market cap, revenue, margins, and valuation side-by-side.
| Company Snapshot | GPCR | CHRS | IMVT | PRGO |
|---|---|---|---|---|
| Industry | Biotechnology | Biotechnology | Biotechnology | Drug Manufacturers - Specialty & Generic |
| Market Cap | $2.25B | $213M | $5.53B | $1.61B |
| Revenue (TTM) | $0.00 | $42M | $0.00 | $4.18B |
| Net Income (TTM) | $-170M | $168M | $-464M | $-1.82B |
| Gross Margin | — | -37.3% | — | 34.2% |
| Operating Margin | — | -429.5% | — | -4.1% |
| Forward P/E | — | 1.2x | — | 5.6x |
| Total Debt | $6M | $1M | $98K | $3.97B |
| Cash & Equiv. | $800M | $89M | $714M | $532M |
GPCR vs CHRS vs IMVT vs PRGO — Long-Term Stock Performance
Price return indexed to 100 at period start. Dividends excluded.
GPCR
CHRS
IMVT
PRGO
| Stock | Feb 23 | May 26 | Return |
|---|---|---|---|
| Structure Therapeut… (GPCR) | 100 | 153.2 | +53.2% |
| Coherus Oncology, I… (CHRS) | 100 | 26.0 | -74.0% |
| Immunovant, Inc. (IMVT) | 100 | 155.8 | +55.8% |
| Perrigo Company plc (PRGO) | 100 | 31.1 | -68.9% |
Price return only. Dividends and distributions are not included.
Quick Verdict: GPCR vs CHRS vs IMVT vs PRGO
Each card shows where this stock fits in a portfolio — not just who wins on paper.
Bottom line: CHRS leads in 3 of 7 categories, making it the strongest pick for valuation and capital efficiency and profitability and margin quality. Perrigo Company plc is the stronger pick specifically for growth and revenue expansion and dividend income and shareholder returns. GPCR and IMVT also each lead in at least one category. As sector peers, any of these can serve as alternatives in the same allocation.
GPCR
Structure Therapeutics Inc.
The Income Pick
GPCR is the clearest fit if your priority is income & stability and sleep-well-at-night.
- beta 0.96
- Lower volatility, beta 0.96, Low D/E 0.4%, current ratio 24.81x
- Beta 0.96, current ratio 24.81x
- Beta 0.96 vs CHRS's 2.29, lower leverage
Best for: income & stability and sleep-well-at-night
CHRS
Coherus Oncology, Inc.
The Value Play
CHRS carries the broadest edge in this set and is the clearest fit for value and quality.
- Lower P/E (1.2x vs 5.6x)
- 398.4% margin vs PRGO's -43.5%
- 42.4% ROA vs IMVT's -44.1%
Best for: value and quality
IMVT
Immunovant, Inc.
The Long-Run Compounder
IMVT is the clearest fit if your priority is long-term compounding.
- 173.6% 10Y total return vs GPCR's 50.6%
- +96.1% vs PRGO's -51.2%
Best for: long-term compounding
PRGO
Perrigo Company plc
The Growth Play
PRGO is the #2 pick in this set and the best alternative if growth exposure is your priority.
- Rev growth -2.8%, EPS growth -7.2%, 3Y rev CAGR -1.5%
- -2.8% revenue growth vs CHRS's -84.2%
- 9.8% yield; 10-year raise streak; the other 3 pay no meaningful dividend
Best for: growth exposure
See the full category breakdown
| Category | Winner | Why |
|---|---|---|
| Growth | PRGO | -2.8% revenue growth vs CHRS's -84.2% |
| Value | CHRS | Lower P/E (1.2x vs 5.6x) |
| Quality / Margins | CHRS | 398.4% margin vs PRGO's -43.5% |
| Stability / Safety | GPCR | Beta 0.96 vs CHRS's 2.29, lower leverage |
| Dividends | PRGO | 9.8% yield; 10-year raise streak; the other 3 pay no meaningful dividend |
| Momentum (1Y) | IMVT | +96.1% vs PRGO's -51.2% |
| Efficiency (ROA) | CHRS | 42.4% ROA vs IMVT's -44.1% |
GPCR vs CHRS vs IMVT vs PRGO — Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
FY 2025
Segment breakdown not available.
FY 2025
GPCR vs CHRS vs IMVT vs PRGO — Financial Metrics
Side-by-side numbers across 4 stocks — who leads on profitability, valuation, growth, and risk.
BEST OVERALLPRGOLAGGINGCHRS
Who Leads Where
PRGO leads in 3 of 6 categories
IMVT leads 1 • GPCR leads 0 • CHRS leads 0 • 1 tied
Explore the data ↓CHRSCoherus Oncology, Inc.
0leads
GPCRStructure Therapeutic…
0leads
IMVTImmunovant, Inc.
1leads
PRGOPerrigo Company plc
3leads
6 Total Categories
CATEGORYLEADERvs IMVTvs GPCRMETRICS WON
Income & Cash FlowRevenue, margins, and cash flow strength
PRGO4/6
Valuation MetricsMultiples, price ratios, and targets
PRGO2/3
Profitability & EfficiencyROE, ROIC, leverage, and quality scores
PRGO4/9
Total Returns1Y, 3Y, 5Y total returns with dividends
IMVT3/6
Risk & VolatilityBeta, volatility, and downside exposure
Tied
—
Analyst OutlookRatings, price targets, and dividends
—
—
Income & Cash Flow (Last 12 Months)
PRGO leads this category, winning 4 of 6 comparable metrics.
Income & Cash Flow (Last 12 Months)
PRGO and IMVT operate at a comparable scale, with $4.2B and $0 in trailing revenue. CHRS is the more profitable business, keeping 4.0% of every revenue dollar as net income compared to PRGO's -43.5%. On growth, PRGO holds the edge at -7.2% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | GPCRStructure Therape… | CHRSCoherus Oncology,… | IMVTImmunovant, Inc. | PRGOPerrigo Company p… |
|---|---|---|---|---|
| RevenueTrailing 12 months | $0 | $42M | $0 | $4.2B |
| EBITDAEarnings before interest/tax | -$209M | -$184M | -$487M | $58M |
| Net IncomeAfter-tax profit | -$170M | $168M | -$464M | -$1.8B |
| Free Cash FlowCash after capex | -$159M | -$139M | -$423M | $108M |
| Gross MarginGross profit ÷ Revenue | — | -37.3% | — | +34.2% |
| Operating MarginEBIT ÷ Revenue | — | -4.3% | — | -4.1% |
| Net MarginNet income ÷ Revenue | — | +4.0% | — | -43.5% |
| FCF MarginFCF ÷ Revenue | — | -3.3% | — | +2.6% |
| Rev. Growth (YoY)Latest quarter vs prior year | — | -76.5% | — | -7.2% |
| EPS Growth (YoY)Latest quarter vs prior year | -29.6% | +29.5% | +19.7% | -56.4% |
PRGO leads this category, winning 4 of 6 comparable metrics.
Valuation Metrics
PRGO leads this category, winning 2 of 3 comparable metrics.
Valuation Metrics
| Metric | GPCRStructure Therape… | CHRSCoherus Oncology,… | IMVTImmunovant, Inc. | PRGOPerrigo Company p… |
|---|---|---|---|---|
| Market CapShares × price | $2.3B | $213M | $5.5B | $1.6B |
| Enterprise ValueMkt cap + debt − cash | $1.5B | $126M | $4.8B | $5.1B |
| Trailing P/EPrice ÷ TTM EPS | -16.31x | 1.23x | -9.97x | -1.14x |
| Forward P/EPrice ÷ next-FY EPS est. | — | — | — | 5.56x |
| PEG RatioP/E ÷ EPS growth rate | — | — | — | — |
| EV / EBITDAEnterprise value multiple | — | — | — | 7.42x |
| Price / SalesMarket cap ÷ Revenue | — | 5.06x | — | 0.38x |
| Price / BookPrice ÷ Book value/share | 1.53x | 3.47x | 5.83x | 0.55x |
| Price / FCFMarket cap ÷ FCF | — | — | — | 11.12x |
PRGO leads this category, winning 2 of 3 comparable metrics.
Profitability & Efficiency
PRGO leads this category, winning 4 of 9 comparable metrics.
Profitability & Efficiency
CHRS delivers a 7.9% return on equity — every $100 of shareholder capital generates $8 in annual profit, vs $-51 for PRGO. IMVT carries lower financial leverage with a 0.00x debt-to-equity ratio, signaling a more conservative balance sheet compared to PRGO's 1.35x. On the Piotroski fundamental quality scale (0–9), CHRS scores 4/9 vs IMVT's 2/9, reflecting mixed financial health.
| Metric | GPCRStructure Therape… | CHRSCoherus Oncology,… | IMVTImmunovant, Inc. | PRGOPerrigo Company p… |
|---|---|---|---|---|
| ROE (TTM)Return on equity | -15.1% | +7.9% | -47.1% | -50.7% |
| ROA (TTM)Return on assets | -14.4% | +42.4% | -44.1% | -19.8% |
| ROICReturn on invested capital | -30.3% | — | — | +3.7% |
| ROCEReturn on capital employed | -24.1% | -127.8% | -66.1% | +4.3% |
| Piotroski ScoreFundamental quality 0–9 | 3 | 4 | 2 | 4 |
| Debt / EquityFinancial leverage | 0.00x | 0.02x | 0.00x | 1.35x |
| Net DebtTotal debt minus cash | -$793M | -$87M | -$714M | $3.4B |
| Cash & Equiv.Liquid assets | $800M | $89M | $714M | $532M |
| Total DebtShort + long-term debt | $6M | $1M | $98,000 | $4.0B |
| Interest CoverageEBIT ÷ Interest expense | — | -28.88x | — | -7.20x |
PRGO leads this category, winning 4 of 9 comparable metrics.
Total Returns (Dividends Reinvested)
IMVT leads this category, winning 3 of 6 comparable metrics.
Total Returns (Dividends Reinvested)
A $10,000 investment in IMVT five years ago would be worth $16,241 today (with dividends reinvested), compared to $1,229 for CHRS. Over the past 12 months, IMVT leads with a +96.1% total return vs PRGO's -51.2%. The 3-year compound annual growth rate (CAGR) favors GPCR at 17.7% vs CHRS's -40.0% — a key indicator of consistent wealth creation.
| Metric | GPCRStructure Therape… | CHRSCoherus Oncology,… | IMVTImmunovant, Inc. | PRGOPerrigo Company p… |
|---|---|---|---|---|
| YTD ReturnYear-to-date | -42.5% | +28.5% | +5.1% | -13.5% |
| 1-Year ReturnPast 12 months | +47.2% | +86.0% | +96.1% | -51.2% |
| 3-Year ReturnCumulative with dividends | +63.1% | -78.4% | +40.9% | -58.1% |
| 5-Year ReturnCumulative with dividends | +50.6% | -87.7% | +62.4% | -60.1% |
| 10-Year ReturnCumulative with dividends | +50.6% | -90.8% | +173.6% | -77.7% |
| CAGR (3Y)Annualised 3-year return | +17.7% | -40.0% | +12.1% | -25.2% |
IMVT leads this category, winning 3 of 6 comparable metrics.
Risk & Volatility
Evenly matched — GPCR and IMVT each lead in 1 of 2 comparable metrics.
Risk & Volatility
GPCR is the less volatile stock with a 0.96 beta — it tends to amplify market swings less than CHRS's 2.29 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. IMVT currently trades 90.5% from its 52-week high vs PRGO's 41.2% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | GPCRStructure Therape… | CHRSCoherus Oncology,… | IMVTImmunovant, Inc. | PRGOPerrigo Company p… |
|---|---|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 0.96x | 2.29x | 1.37x | 1.18x |
| 52-Week HighHighest price in past year | $94.90 | $2.62 | $30.09 | $28.44 |
| 52-Week LowLowest price in past year | $15.80 | $0.71 | $13.36 | $9.23 |
| % of 52W HighCurrent price vs 52-week peak | +41.3% | +67.3% | +90.5% | +41.2% |
| RSI (14)Momentum oscillator 0–100 | 30.2 | 48.5 | 60.2 | 60.9 |
| Avg Volume (50D)Average daily shares traded | 953K | 1.1M | 1.4M | 3.4M |
Evenly matched — GPCR and IMVT each lead in 1 of 2 comparable metrics.
Analyst Outlook
Insufficient data to determine a leader in this category.
Analyst Outlook
Analyst consensus: GPCR as "Buy", CHRS as "Buy", IMVT as "Buy", PRGO as "Hold". Consensus price targets imply 242.0% upside for CHRS (target: $6) vs 67.2% for IMVT (target: $46). PRGO is the only dividend payer here at 9.81% yield — a key consideration for income-focused portfolios.
| Metric | GPCRStructure Therape… | CHRSCoherus Oncology,… | IMVTImmunovant, Inc. | PRGOPerrigo Company p… |
|---|---|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Buy | Buy | Buy | Hold |
| Price TargetConsensus 12-month target | $114.75 | $6.02 | $45.50 | $20.00 |
| # AnalystsCovering analysts | 14 | 16 | 23 | 36 |
| Dividend YieldAnnual dividend ÷ price | — | — | — | +9.8% |
| Dividend StreakConsecutive years of raises | — | — | — | 10 |
| Dividend / ShareAnnual DPS | — | — | — | $1.15 |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | 0.0% | 0.0% | 0.0% |
Insufficient data to determine a leader in this category.
Key Takeaway
PRGO leads in 3 of 6 categories (Income & Cash Flow, Valuation Metrics). IMVT leads in 1 (Total Returns). 1 tied.
Best OverallPerrigo Company plc (PRGO)Leads 3 of 6 categories
Loading custom metrics...
GPCR vs CHRS vs IMVT vs PRGO: Key Questions Answered
9 questions · data-driven answers · updated daily
01Is GPCR or CHRS or IMVT or PRGO a better buy right now?
For growth investors, Perrigo Company plc (PRGO) is the stronger pick with -2.
8% revenue growth year-over-year, versus -84. 2% for Coherus Oncology, Inc. (CHRS). Coherus Oncology, Inc. (CHRS) offers the better valuation at 1. 2x trailing P/E, making it the more compelling value choice. Analysts rate Structure Therapeutics Inc. (GPCR) a "Buy" — based on 14 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — GPCR or CHRS or IMVT or PRGO?
Over the past 5 years, Immunovant, Inc.
(IMVT) delivered a total return of +62. 4%, compared to -87. 7% for Coherus Oncology, Inc. (CHRS). Over 10 years, the gap is even starker: IMVT returned +173. 6% versus CHRS's -90. 8%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — GPCR or CHRS or IMVT or PRGO?
By beta (market sensitivity over 5 years), Structure Therapeutics Inc.
(GPCR) is the lower-risk stock at 0. 96β versus Coherus Oncology, Inc. 's 2. 29β — meaning CHRS is approximately 139% more volatile than GPCR relative to the S&P 500. On balance sheet safety, Immunovant, Inc. (IMVT) carries a lower debt/equity ratio of 0% versus 135% for Perrigo Company plc — giving it more financial flexibility in a downturn.
04Which is growing faster — GPCR or CHRS or IMVT or PRGO?
By revenue growth (latest reported year), Perrigo Company plc (PRGO) is pulling ahead at -2.
8% versus -84. 2% for Coherus Oncology, Inc. (CHRS). On earnings-per-share growth, the picture is similar: Coherus Oncology, Inc. grew EPS 472. 0% year-over-year, compared to -723. 2% for Perrigo Company plc. Over a 3-year CAGR, PRGO leads at -1. 5% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.
05Which has better profit margins — GPCR or CHRS or IMVT or PRGO?
Coherus Oncology, Inc.
(CHRS) is the more profitable company, earning 398. 4% net margin versus -33. 5% for Perrigo Company plc — meaning it keeps 398. 4% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: PRGO leads at 8. 1% versus -429. 5% for CHRS. At the gross margin level — before operating expenses — PRGO leads at 35. 1%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
06Is GPCR or CHRS or IMVT or PRGO more undervalued right now?
Analyst consensus price targets imply the most upside for CHRS: 242.
0% to $6. 02.
07Which pays a better dividend — GPCR or CHRS or IMVT or PRGO?
In this comparison, PRGO (9.
8% yield) pays a dividend. GPCR, CHRS, IMVT do not pay a meaningful dividend and should not be held primarily for income.
08Is GPCR or CHRS or IMVT or PRGO better for a retirement portfolio?
For long-horizon retirement investors, Perrigo Company plc (PRGO) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 1.
18), 9. 8% yield). Coherus Oncology, Inc. (CHRS) carries a higher beta of 2. 29 — meaning larger drawdowns in market downturns, which matters significantly when you cannot wait years for a recovery. Both have compounded well over 10 years (PRGO: -77. 7%, CHRS: -90. 8%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
09What are the main differences between GPCR and CHRS and IMVT and PRGO?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both.
In terms of investment character: GPCR is a small-cap quality compounder stock; CHRS is a small-cap deep-value stock; IMVT is a small-cap quality compounder stock; PRGO is a small-cap income-oriented stock. PRGO pays a dividend while GPCR, CHRS, IMVT do not, making them suitable for different income and tax situations. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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