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GPCRStructure Therapeutics Inc.
$35.95$2.1B
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GPCR logo

Structure Therapeutics Inc.

GPCR
NASDAQ · Biotechnology
$35.95
At close - Sep 23, 4:00 PM EDT - USD
Market Cap$2.07B
P/E-15.0x
52W High$94.90
Volume891.02K
OverviewTerminalAnalysisFinancialsValuationEarningsBreakoutsOwnership
VCP Research Verdict2026Q2

Accelerating R&D Burn Threatens Two-Year Cash Runway

Structure Therapeutics is a pre-revenue clinical-stage biotech whose valuation hinges entirely on the successful advancement of its oral GLP-1 pipeline. R&D investment surged 50% year-over-year to $100.1M in 2026Q2, driving operating losses to $118.6M and cons...

GrowthDecelerating
ProfitabilityNegative
ValuationReview
TechnicalsWeak
Explore valuation models
MARKET ACTION

GPCR price & volume

Price trend, volume and key moving averages

Launch Terminal
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Decision Checklist4 Core Signals

What matters now

The signals most likely to change the investment case.

01

Earnings momentum

5/12 Beats

EPS beat 5 of last 12 quarters

02

Valuation risk

-176% Peers

P/E is 176% below peer median

03

Market leadership

RS 13 · Lag

Laggard (Underperforming 87% of market)

04

Weak Trend

Below 200DMA

Price < 200DMA

Next CatalystConfirmed earnings · Nov 5

Market performance

Price History →

Trailing total returns as of 9/24/2026, which may include dividends or other distributions. Benchmark is S&P 500 (^GSPC).

YTD Return
GPCR-47.23%
S&P 500 (^GSPC)+12.39%
1-Year Return
GPCR+49.73%
S&P 500 (^GSPC)+15.77%
3-Year Return
GPCR+8.12%
S&P 500 (^GSPC)+77.03%
5-Year Return
GPCR+38.27%
S&P 500 (^GSPC)+68.92%

Growth & profitability

Annual revenue & EPS trend
Revenue
-
Net income
-$141M-15.2% YoY
Free cash flow
-$226M-91.5% YoY
Operating margin
-
ROIC (TTM)-30.3%
Avg ROIC 5Y-
ROE (TTM)-11.9%
Piotroski Score3 / 9
Financial Statements →
03

Monitor what changed

Recent results and news deserve attention only when they alter the forward view.

OPERATING RESULTS

Recent Earnings

Earnings History
EPS Beat Rate5/12 (42%)
QuarterEPS (Act vs Est)Revenue (Act vs Est)
Q3 2026Latest
Aug 6, 2026
-$0.49-25.6%
vs -$0.39
—
vs —
Q2 2026
May 7, 2026
-$0.35+10.3%
vs -$0.39
—
vs $11M
Q1 2026
Feb 26, 2026
-$0.49-40.0%
vs -$0.35
—
vs $9M
Q4 2025
Nov 6, 2025
-$0.37-2.8%
vs -$0.36
—
vs —
Historical baseline: 12 quarters analyzedGAAP / Adjusted
MARKET COVERAGE

Latest News

5 Stories
Zacks Investment Research·6d ago
LLY Stock Down Around 7% in a Month: Buy the Dip or Stay Cautious?

LLY's GLP-1 momentum, Foundayo launch and retatrutide pipeline support growth, but premium valuation and rising competition weigh on the stock.

Seeking Alpha·Sep 16, 2026
Structure Therapeutics Inc. (GPCR) Presents at Morgan Stanley 24th Annual Global Healthcare Conference Transcript

Structure Therapeutics Inc. (GPCR) Presents at Morgan Stanley 24th Annual Global Healthcare Conference Transcript

Seeking Alpha·Sep 9, 2026
Structure Therapeutics: The Amylin Data Changes The Math

Structure Therapeutics remains a Strong Buy, with recent data de-risking its lead oral obesity drug, aleniglipron. Aleniglipron's 72-week open-label data showed 16.2% weight loss, low AE discontinuations, and no DILI, though Phase 3 efficacy and safety monitoring remain key. ACCG-2671, an oral amylin agonist, now has human data and offers potential for combination therapy, further differentiating GPCR's pipeline.

Seeking Alpha·Sep 8, 2026
Structure Therapeutics Inc. (GPCR) Discusses Positive Clinical Data Updates for Oral Small Molecule Amylin and GLP-1 Programs in Chronic Weight Management Transcript

Structure Therapeutics Inc. (GPCR) Discusses Positive Clinical Data Updates for Oral Small Molecule Amylin and GLP-1 Programs in Chronic Weight Management Transcript

Filtered for Structure Therapeutics Inc.More Headlines
04

Compare before deciding

Benchmark GPCR against direct peers instead of judging its metrics in isolation.

Peers Comparison

Key metrics vs top competitors for Structure Therapeutics Inc. (GPCR)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
GPCR logoGPCRStructure Therapeutics Inc.Current
$35.95$2.07B-14.98——-11.86%—
CHRS logoCHRSCoherus Oncology, Inc.
$1.26$154.24M-0.87-84.2%-257.1%-181.73%—
RVMD logoRVMDRevolution Medicines, Inc.
$190.74$40.55B-32.06——-96.44%—
KYMR logoKYMRKymera Therapeutics, Inc.
$115.47$9.5B-31.29-16.72%-285.41%-21.5%—
ARWR logoARWRArrowhead Pharmaceuticals, Inc.
$66.96$9.43B-5488.5223258.15%-47.79%-60.05%—
CGEM logoCGEMCullinan Therapeutics, Inc.
$16.87$1.04B-4.53——-52.89%—

Compare GPCR vs Peers

Structure Therapeutics Inc. (GPCR) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs CHRS

Most directly comparable listed peer for GPCR.

Scale Benchmark

vs LLY

Larger-name benchmark to compare GPCR against a more recognizable public peer.

Peer Set

Compare Top 5

vs CHRS, RVMD, KYMR, ARWR

05

Keep researching

Verify the primary filings, follow material updates, and answer the remaining questions.

GPCR SEC Filings & Documents

Structure Therapeutics Inc. (GPCR) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Aug 6, 2026·SEC

Material company update

Jun 18, 2026·SEC

Material company update

May 7, 2026·SEC

10-K Annual Reports

4
FY 2026

Feb 26, 2026·SEC

FY 2025

Feb 27, 2025·SEC

FY 2024

Mar 8, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

Aug 6, 2026·SEC

FY 2026

May 7, 2026·SEC

FY 2025

Nov 6, 2025·SEC

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GPCR Frequently Asked Questions

Structure Therapeutics Inc. (GPCR) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
Is GPCR profitable?

Structure Therapeutics Inc. (GPCR) reported a net loss of $215.1M for fiscal year 2025.

Dividend & Returns
What is GPCR's return on equity?

Structure Therapeutics Inc. (GPCR) has a return on equity (ROE) of -11.9%. Negative ROE indicates the company is unprofitable.

What is Structure Therapeutics Inc.'s free cash flow?

Structure Therapeutics Inc. (GPCR) had negative free cash flow of $224.5M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in GPCR back in 2020?

Total return calculator · dividends reinvested · 6+ years of data

See returns →