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GPCR
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GPCRStructure Therapeutics Inc.
$20.35$1.2B
Overview & Tools
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Valuation & Forecasts
Valuation ModelsEstimatesDCF Model
Price & Analyst Data
Analyst TargetsPrice History
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GPCR logo

Structure Therapeutics Inc.

GPCR
NASDAQ · Metabolic & Cardiovascular Biotech
$20.35
At close - Nov 6, 4:00 PM EST - USD
Market Cap$1.17B
P/E-6.9x
52W High$94.90
Volume1.62M
OverviewTerminalAnalysisFinancialsValuationEarningsBreakoutsOwnership
VCP Research Verdict2026Q2

Accelerating R&D Burn Threatens Two-Year Cash Runway

Structure Therapeutics is a pre-revenue clinical-stage biotech whose valuation hinges entirely on the successful advancement of its oral GLP-1 pipeline.

GrowthDecelerating
ProfitabilityNegative
ValuationReview
TechnicalsWeak
Explore valuation models
MARKET ACTION

GPCR price & volume

Price trend, volume and key moving averages

Launch Terminal
Loading chart...
Decision Checklist4 Core Signals

What matters now

The signals most likely to change the investment case.

01

Earnings momentum

5/12 Beats

EPS beat 5 of last 12 quarters

02

Valuation risk

-126% Peers

P/E is 126% below peer median

03

Market leadership

RS 7 · Lag

Laggard (Underperforming 93% of market)

04

Weak Trend

Below 200DMA

Price < 200DMA

Next CatalystEstimated earnings · Nov 6

Market performance

Price History →

Trailing total returns as of 11/8/2026, which may include dividends or other distributions. Benchmark is S&P 500 (^GSPC).

YTD Return
GPCR-70.13%
S&P 500 (^GSPC)+7.63%
1-Year Return
GPCR-39.20%
S&P 500 (^GSPC)+9.69%
3-Year Return
GPCR-70.30%
S&P 500 (^GSPC)+74.87%
5-Year Return
GPCR-21.73%
S&P 500 (^GSPC)+65.74%

Growth & profitability

Annual revenue & EPS trend
Revenue FY25
-
Net income FY25
-$141M-15.2% YoY
Free cash flow FY25
-$226M-91.5% YoY
Operating margin FY25
-
ROIC (FY25)-30.3%
Avg ROIC 5Y-45.2%
ROE (TTM)-16.9%
Piotroski Score3 / 9
Financial Statements →
03

Monitor what changed

Recent results and news deserve attention only when they alter the forward view.

OPERATING RESULTS

Recent Earnings

Earnings History
EPS Beat Rate5/12 (42%)
QuarterEPS (Act vs Est)Revenue (Act vs Est)
Q3 2026Latest
Aug 6, 2026
-$0.49-25.6%
vs -$0.39
—
vs —
Q2 2026
May 7, 2026
-$0.35+10.3%
vs -$0.39
—
vs $11M
Q1 2026
Feb 26, 2026
-$0.49-40.0%
vs -$0.35
—
vs $9M
Q4 2025
Nov 6, 2025
-$0.37-2.8%
vs -$0.36
—
vs —
Historical baseline: 12 quarters analyzedGAAP / Adjusted
MARKET COVERAGE

Latest News

4 Stories
GlobeNewsWire·4d ago
Structure Therapeutics to Participate in the Jefferies Global Healthcare Conference

SAN FRANCISCO, Nov. 04, 2026 (GLOBE NEWSWIRE) -- Structure Therapeutics Inc. (NASDAQ: GPCR), a clinical-stage global biopharmaceutical company developing novel oral small molecule therapeutics for metabolic diseases, with a focus on chronic weight management, today announced that management will participate in the Jefferies Global Healthcare Conference being held November 16-19, 2026 in London, UK. Jefferies Global Healthcare Conference Date: Tuesday, November 17Format: Fireside chat and 1x1 meetingsTime: 12:00 PM GMTLocation: London, UK The live and archived webcasts will be accessible from the company's website at  https://ir.structuretx.com/events-presentations/events  and replays will be available for at least 90 days.

Defense World·Oct 21, 2026
Structure Therapeutics Inc. Sponsored ADR (NASDAQ:GPCR) Stock Has Consensus Price Target of $110.91 According to Brokerages

Structure Therapeutics Inc. Sponsored ADR (NASDAQ: GPCR - Get Free Report) has earned a consensus rating of "Moderate Buy" from the sixteen ratings firms that are presently covering the stock, Marketbeat reports. One investment analyst has rated the stock with a sell rating, one has given a hold rating, twelve have issued a buy rating and

GlobeNewsWire·Oct 19, 2026
Structure Therapeutics Announces Multiple Upcoming Presentations at ObesityWeek® 2026

SAN FRANCISCO, Oct. 19, 2026 (GLOBE NEWSWIRE) -- Structure Therapeutics Inc. (NASDAQ: GPCR), a clinical-stage global biopharmaceutical company developing novel oral small molecule therapeutics for metabolic diseases, with a focus on chronic weight management, today announced multiple upcoming poster presentations at The Obesity Society's Annual Meeting, ObesityWeek®, taking place from November 14–17, 2026 in National Harbor, MD. Title: Aleniglipron in Participants Living with Overweight or Obesity: ACCESS Trial Open-Label Extension Date/Time: November 15, 2026, 2:30 p.m.

Defense World·Oct 16, 2026
Structure Therapeutics (NASDAQ:GPCR) Sets New 52-Week Low – Here’s Why

Structure Therapeutics Inc. Sponsored ADR (NASDAQ: GPCR - Get Free Report) hit a new 52-week low during mid-day trading on Wednesday. The company traded as low as $22.10 and last traded at $22.31, with a volume of 1,434,790 shares changing hands. The stock had previously closed at $23.91. Wall Street Analyst Weigh In Several analysts recently

Filtered for Structure Therapeutics Inc.More Headlines
04

Compare before deciding

Benchmark GPCR against direct peers instead of judging its metrics in isolation.

Peers Comparison

Key metrics vs top competitors for Structure Therapeutics Inc. (GPCR)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
GPCR logoGPCRStructure Therapeutics Inc.Current
$20.35$1.17B-6.87——-16.91%—
CHRS logoCHRSCoherus Oncology, Inc.
$0.77$94.26M-0.91-84.2%-257.1%-181.73%—
RVMD logoRVMDRevolution Medicines, Inc.
$192.28$40.88B-22.10—-946.82%-91.93%—
KYMR logoKYMRKymera Therapeutics, Inc.
$131.73$10.84B-37.73-16.72%-341.87%-22.39%—
ARWR logoARWRArrowhead Pharmaceuticals, Inc.
$58.16$8.19B-26.0623258.15%-47.79%-60.05%—
CGEM logoCGEMCullinan Therapeutics, Inc.
$11.31$695.09M-3.40——-52.89%—

Compare GPCR vs Peers

Structure Therapeutics Inc. (GPCR) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs CHRS

Most directly comparable listed peer for GPCR.

Scale Benchmark

vs LLY

Larger-name benchmark to compare GPCR against a more recognizable public peer.

Peer Set

Compare Top 5

vs CHRS, RVMD, KYMR, ARWR

05

Keep researching

Verify the primary filings, follow material updates, and answer the remaining questions.

GPCR SEC Filings & Documents

Structure Therapeutics Inc. (GPCR) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Aug 6, 2026·SEC

Material company update

Jun 18, 2026·SEC

Material company update

May 7, 2026·SEC

10-K Annual Reports

4
FY 2026

Feb 26, 2026·SEC

FY 2025

Feb 27, 2025·SEC

FY 2024

Mar 8, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

Aug 6, 2026·SEC

FY 2026

May 7, 2026·SEC

FY 2025

Nov 6, 2025·SEC

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GPCR Frequently Asked Questions

Structure Therapeutics Inc. (GPCR) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
Is GPCR profitable?

No. Structure Therapeutics Inc. (GPCR) reported a net loss of $215.1M over the trailing twelve months.

Dividend & Returns
What is GPCR's return on equity?

Structure Therapeutics Inc. (GPCR) had a return on equity (ROE) of -16.9% over the trailing twelve months. A negative ROE means the company lost money over the period.

What is Structure Therapeutics Inc.'s free cash flow?

Structure Therapeutics Inc. (GPCR) had negative free cash flow of $224.5M over the trailing twelve months.

What if you invested $1,000 in GPCR back in 2020?

Total return calculator · dividends reinvested · 6+ years of data

See returns →