Drug Manufacturers - General
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GRFS vs DBVT vs HALO vs REGN
Revenue, margins, valuation, and 5-year total return — side by side.
Biotechnology
Biotechnology
Biotechnology
GRFS vs DBVT vs HALO vs REGN — Key Financials
Market cap, revenue, margins, and valuation side-by-side.
| Company Snapshot | ||||
|---|---|---|---|---|
| Industry | Drug Manufacturers - General | Biotechnology | Biotechnology | Biotechnology |
| Market Cap | $6.82B | $1712.35T | $7.68B | $73.68B |
| Revenue (TTM) | $7.51B | $0.00 | $1.40B | $14.92B |
| Net Income (TTM) | $401M | $-168M | $317M | $4.42B |
| Gross Margin | 38.4% | — | 81.9% | 84.5% |
| Operating Margin | 17.0% | — | 58.4% | 24.3% |
| Forward P/E | 9.4x | — | 8.1x | 15.3x |
| Total Debt | $8.74B | $22M | $0.00 | $2.71B |
| Cash & Equiv. | $825M | $194M | $134M | $3.12B |
GRFS vs DBVT vs HALO vs REGN — Long-Term Stock Performance
Price return indexed to 100 at period start. Dividends excluded.
| Stock | May 20 | May 26 | Return |
|---|---|---|---|
| Grifols, S.A. (GRFS) | 100 | 42.8 | -57.2% |
| DBV Technologies S.… (DBVT) | 100 | 40.7 | -59.3% |
| Halozyme Therapeuti… (HALO) | 100 | 264.2 | +164.2% |
| Regeneron Pharmaceu… (REGN) | 100 | 116.7 | +16.7% |
Price return only. Dividends and distributions are not included.
Quick Verdict: GRFS vs DBVT vs HALO vs REGN
Each card shows where this stock fits in a portfolio — not just who wins on paper.
GRFS is the #2 pick in this set and the best alternative if income & stability is your priority.
- Dividend streak 2 yrs, beta 1.12, yield 2.6%
- 2.6% yield, 2-year raise streak, vs REGN's 0.5%, (2 stocks pay no dividend)
DBVT is the clearest fit if your priority is momentum.
- +110.4% vs HALO's -7.1%
HALO carries the broadest edge in this set and is the clearest fit for growth exposure and long-term compounding.
- Rev growth 37.6%, EPS growth -25.4%, 3Y rev CAGR 28.4%
- 5.7% 10Y total return vs REGN's 90.0%
- PEG 0.35 vs REGN's 2.43
- Beta 0.56, current ratio 4.66x
REGN is the clearest fit if your priority is sleep-well-at-night.
- Lower volatility, beta 0.81, Low D/E 8.7%, current ratio 4.13x
- 29.6% margin vs DBVT's 0.3%
See the full category breakdown
| Category | Winner | Why |
|---|---|---|
| Growth | 37.6% revenue growth vs DBVT's -100.0% | |
| Value | Lower P/E (8.1x vs 15.3x), PEG 0.35 vs 2.43 | |
| Quality / Margins | 29.6% margin vs DBVT's 0.3% | |
| Stability / Safety | Beta 0.56 vs DBVT's 1.26 | |
| Dividends | 2.6% yield, 2-year raise streak, vs REGN's 0.5%, (2 stocks pay no dividend) | |
| Momentum (1Y) | +110.4% vs HALO's -7.1% | |
| Efficiency (ROA) | 12.5% ROA vs DBVT's -89.0% |
GRFS vs DBVT vs HALO vs REGN — Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
GRFS vs DBVT vs HALO vs REGN — Financial Metrics
Side-by-side numbers across 4 stocks — who leads on profitability, valuation, growth, and risk.
Who Leads Where
HALO leads in 3 of 6 categories
GRFS leads 1 • DBVT leads 0 • REGN leads 0 • 2 tied
Explore the data ↓Income & Cash Flow (Last 12 Months)
HALO leads this category, winning 3 of 6 comparable metrics.
Income & Cash Flow (Last 12 Months)
REGN and DBVT operate at a comparable scale, with $14.9B and $0 in trailing revenue. REGN is the more profitable business, keeping 29.6% of every revenue dollar as net income compared to GRFS's 5.3%. On growth, HALO holds the edge at +51.6% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | ||||
|---|---|---|---|---|
| RevenueTrailing 12 months | $7.5B | $0 | $1.4B | $14.9B |
| EBITDAEarnings before interest/tax | $1.6B | -$112M | $945M | $4.2B |
| Net IncomeAfter-tax profit | $401M | -$168M | $317M | $4.4B |
| Free Cash FlowCash after capex | $772M | -$151M | $645M | $4.2B |
| Gross MarginGross profit ÷ Revenue | +38.4% | — | +81.9% | +84.5% |
| Operating MarginEBIT ÷ Revenue | +17.0% | — | +58.4% | +24.3% |
| Net MarginNet income ÷ Revenue | +5.3% | — | +22.7% | +29.6% |
| FCF MarginFCF ÷ Revenue | +10.3% | — | +46.2% | +27.9% |
| Rev. Growth (YoY)Latest quarter vs prior year | -0.6% | — | +51.6% | +19.0% |
| EPS Growth (YoY)Latest quarter vs prior year | +40.0% | +91.5% | -2.1% | -7.2% |
Valuation Metrics
Evenly matched — GRFS and HALO each lead in 3 of 7 comparable metrics.
Valuation Metrics
At 12.0x trailing earnings, GRFS trades at a 53% valuation discount to HALO's 25.5x P/E. Adjusting for growth (PEG ratio), HALO offers better value at 1.11x vs REGN's 2.70x — a lower PEG means you pay less per unit of expected earnings growth.
| Metric | ||||
|---|---|---|---|---|
| Market CapShares × price | $6.8B | $1712.35T | $7.7B | $73.7B |
| Enterprise ValueMkt cap + debt − cash | $16.1B | $1712.35T | $7.5B | $73.3B |
| Trailing P/EPrice ÷ TTM EPS | 12.03x | -0.76x | 25.46x | 17.09x |
| Forward P/EPrice ÷ next-FY EPS est. | 9.35x | — | 8.09x | 15.35x |
| PEG RatioP/E ÷ EPS growth rate | — | — | 1.11x | 2.70x |
| EV / EBITDAEnterprise value multiple | 8.47x | — | 8.34x | 17.78x |
| Price / SalesMarket cap ÷ Revenue | 0.80x | — | 5.50x | 5.14x |
| Price / BookPrice ÷ Book value/share | 0.61x | 0.66x | 165.47x | 2.46x |
| Price / FCFMarket cap ÷ FCF | 7.72x | — | 11.91x | 18.06x |
Profitability & Efficiency
HALO leads this category, winning 5 of 9 comparable metrics.
Profitability & Efficiency
HALO delivers a 6.5% return on equity — every $100 of shareholder capital generates $6 in annual profit, vs $-130 for DBVT. REGN carries lower financial leverage with a 0.09x debt-to-equity ratio, signaling a more conservative balance sheet compared to GRFS's 1.15x. On the Piotroski fundamental quality scale (0–9), GRFS scores 6/9 vs DBVT's 4/9, reflecting solid financial health.
| Metric | ||||
|---|---|---|---|---|
| ROE (TTM)Return on equity | +5.2% | -130.2% | +6.5% | +14.3% |
| ROA (TTM)Return on assets | +2.0% | -89.0% | +12.5% | +11.1% |
| ROICReturn on invested capital | +5.4% | — | +73.4% | +8.9% |
| ROCEReturn on capital employed | +6.4% | -145.7% | +38.2% | +10.2% |
| Piotroski ScoreFundamental quality 0–9 | 6 | 4 | 5 | 5 |
| Debt / EquityFinancial leverage | 1.15x | 0.13x | — | 0.09x |
| Net DebtTotal debt minus cash | $7.9B | -$172M | -$134M | -$412M |
| Cash & Equiv.Liquid assets | $825M | $194M | $134M | $3.1B |
| Total DebtShort + long-term debt | $8.7B | $22M | $0 | $2.7B |
| Interest CoverageEBIT ÷ Interest expense | 2.05x | -189.82x | 46.08x | 108.44x |
Total Returns (Dividends Reinvested)
HALO leads this category, winning 3 of 6 comparable metrics.
Total Returns (Dividends Reinvested)
A $10,000 investment in REGN five years ago would be worth $14,365 today (with dividends reinvested), compared to $3,090 for DBVT. Over the past 12 months, DBVT leads with a +110.4% total return vs HALO's -7.1%. The 3-year compound annual growth rate (CAGR) favors HALO at 29.1% vs REGN's -1.7% — a key indicator of consistent wealth creation.
| Metric | ||||
|---|---|---|---|---|
| YTD ReturnYear-to-date | -12.8% | +4.9% | -7.3% | -8.5% |
| 1-Year ReturnPast 12 months | +12.5% | +110.4% | -7.1% | +27.1% |
| 3-Year ReturnCumulative with dividends | +8.9% | +19.7% | +115.3% | -5.1% |
| 5-Year ReturnCumulative with dividends | -52.8% | -69.1% | +37.0% | +43.6% |
| 10-Year ReturnCumulative with dividends | -35.4% | -87.0% | +570.7% | +90.0% |
| CAGR (3Y)Annualised 3-year return | +2.9% | +6.2% | +29.1% | -1.7% |
Risk & Volatility
Evenly matched — HALO and REGN each lead in 1 of 2 comparable metrics.
Risk & Volatility
HALO is the less volatile stock with a 0.56 beta — it tends to amplify market swings less than DBVT's 1.26 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. REGN currently trades 86.4% from its 52-week high vs GRFS's 72.4% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | ||||
|---|---|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 1.10x | 1.26x | 0.51x | 0.77x |
| 52-Week HighHighest price in past year | $11.14 | $26.18 | $82.22 | $821.11 |
| 52-Week LowLowest price in past year | $7.09 | $7.53 | $47.50 | $476.49 |
| % of 52W HighCurrent price vs 52-week peak | +72.4% | +76.3% | +79.3% | +86.4% |
| RSI (14)Momentum oscillator 0–100 | 54.6 | 48.1 | 52.4 | 44.9 |
| Avg Volume (50D)Average daily shares traded | 714K | 252K | 1.4M | 631K |
Analyst Outlook
GRFS leads this category, winning 2 of 2 comparable metrics.
Analyst Outlook
Analyst consensus: GRFS as "Buy", DBVT as "Buy", HALO as "Buy", REGN as "Buy". Consensus price targets imply 131.8% upside for DBVT (target: $46) vs 20.2% for HALO (target: $78). For income investors, GRFS offers the higher dividend yield at 2.63% vs REGN's 0.48%.
| Metric | ||||
|---|---|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Buy | Buy | Buy | Buy |
| Price TargetConsensus 12-month target | — | $46.33 | $78.33 | $865.68 |
| # AnalystsCovering analysts | 8 | 15 | 27 | 48 |
| Dividend YieldAnnual dividend ÷ price | +2.6% | — | — | +0.5% |
| Dividend StreakConsecutive years of raises | 2 | 0 | — | 1 |
| Dividend / ShareAnnual DPS | $0.18 | — | — | $3.41 |
| Buyback YieldShare repurchases ÷ mkt cap | +2.1% | 0.0% | +4.5% | +5.4% |
HALO leads in 3 of 6 categories (Income & Cash Flow, Profitability & Efficiency). GRFS leads in 1 (Analyst Outlook). 2 tied.
GRFS vs DBVT vs HALO vs REGN: Key Questions Answered
10 questions · data-driven answers · updated daily
01Is GRFS or DBVT or HALO or REGN a better buy right now?
For growth investors, Halozyme Therapeutics, Inc.
(HALO) is the stronger pick with 37. 6% revenue growth year-over-year, versus 0. 2% for Grifols, S. A. (GRFS). Grifols, S. A. (GRFS) offers the better valuation at 12. 0x trailing P/E (9. 4x forward), making it the more compelling value choice. Analysts rate Grifols, S. A. (GRFS) a "Buy" — based on 8 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which has the better valuation — GRFS or DBVT or HALO or REGN?
On trailing P/E, Grifols, S.
A. (GRFS) is the cheapest at 12. 0x versus Halozyme Therapeutics, Inc. at 25. 5x. On forward P/E, Halozyme Therapeutics, Inc. is actually cheaper at 8. 1x — notably different from the trailing picture, reflecting expected earnings growth. The PEG ratio (P/E divided by earnings growth rate) is the most growth-adjusted single valuation metric: Halozyme Therapeutics, Inc. wins at 0. 35x versus Regeneron Pharmaceuticals, Inc. 's 2. 43x — a PEG below 1. 0 traditionally signals the market is underpricing earnings growth.
03Which is the better long-term investment — GRFS or DBVT or HALO or REGN?
Over the past 5 years, Regeneron Pharmaceuticals, Inc.
(REGN) delivered a total return of +43. 6%, compared to -69. 1% for DBV Technologies S. A. (DBVT). Over 10 years, the gap is even starker: HALO returned +559. 7% versus DBVT's -87. 1%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
04Which is safer — GRFS or DBVT or HALO or REGN?
By beta (market sensitivity over 5 years), Halozyme Therapeutics, Inc.
(HALO) is the lower-risk stock at 0. 51β versus DBV Technologies S. A. 's 1. 26β — meaning DBVT is approximately 146% more volatile than HALO relative to the S&P 500. On balance sheet safety, Regeneron Pharmaceuticals, Inc. (REGN) carries a lower debt/equity ratio of 9% versus 115% for Grifols, S. A. — giving it more financial flexibility in a downturn.
05Which is growing faster — GRFS or DBVT or HALO or REGN?
By revenue growth (latest reported year), Halozyme Therapeutics, Inc.
(HALO) is pulling ahead at 37. 6% versus 0. 2% for Grifols, S. A. (GRFS). On earnings-per-share growth, the picture is similar: Grifols, S. A. grew EPS 147. 8% year-over-year, compared to -347. 5% for DBV Technologies S. A.. Over a 3-year CAGR, HALO leads at 28. 4% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.
06Which has better profit margins — GRFS or DBVT or HALO or REGN?
Regeneron Pharmaceuticals, Inc.
(REGN) is the more profitable company, earning 31. 4% net margin versus 0. 0% for DBV Technologies S. A. — meaning it keeps 31. 4% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: HALO leads at 58. 4% versus 0. 0% for DBVT. At the gross margin level — before operating expenses — REGN leads at 85. 4%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
07Is GRFS or DBVT or HALO or REGN more undervalued right now?
The PEG ratio (forward P/E divided by expected earnings growth rate) is the most precise measure of undervaluation relative to growth potential.
By this metric, Halozyme Therapeutics, Inc. (HALO) is the more undervalued stock at a PEG of 0. 35x versus Regeneron Pharmaceuticals, Inc. 's 2. 43x. A PEG below 1. 0 is traditionally considered the threshold for growth-adjusted undervaluation. On forward earnings alone, Halozyme Therapeutics, Inc. (HALO) trades at 8. 1x forward P/E versus 15. 3x for Regeneron Pharmaceuticals, Inc. — 7. 3x cheaper on a one-year earnings basis. Analyst consensus price targets imply the most upside for DBVT: 131. 8% to $46. 33.
08Which pays a better dividend — GRFS or DBVT or HALO or REGN?
In this comparison, GRFS (2.
6% yield), REGN (0. 5% yield) pay a dividend. DBVT, HALO do not pay a meaningful dividend and should not be held primarily for income.
09Is GRFS or DBVT or HALO or REGN better for a retirement portfolio?
For long-horizon retirement investors, Halozyme Therapeutics, Inc.
(HALO) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0. 51), +559. 7% 10Y return). Both have compounded well over 10 years (HALO: +559. 7%, DBVT: -87. 1%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
10What are the main differences between GRFS and DBVT and HALO and REGN?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both.
In terms of investment character: GRFS is a small-cap deep-value stock; DBVT is a mega-cap quality compounder stock; HALO is a small-cap high-growth stock; REGN is a mid-cap deep-value stock. GRFS pays a dividend while DBVT, HALO, REGN do not, making them suitable for different income and tax situations. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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