Biotechnology
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HCWB vs DBVT vs ALKS vs IMVT vs REGN
Revenue, margins, valuation, and 5-year total return — side by side.
Biotechnology
Biotechnology
Biotechnology
Biotechnology
HCWB vs DBVT vs ALKS vs IMVT vs REGN — Key Financials
Market cap, revenue, margins, and valuation side-by-side.
| Company Snapshot | |||||
|---|---|---|---|---|---|
| Industry | Biotechnology | Biotechnology | Biotechnology | Biotechnology | Biotechnology |
| Market Cap | $668K | $1712.35T | $5.90B | $5.53B | $73.68B |
| Revenue (TTM) | $54K | $0.00 | $1.56B | $0.00 | $14.92B |
| Net Income (TTM) | $-8M | $-168M | $153M | $-464M | $4.42B |
| Gross Margin | -300.7% | — | 65.4% | — | 84.5% |
| Operating Margin | -215.1% | — | 12.3% | — | 24.3% |
| Forward P/E | — | — | 24.8x | — | 15.3x |
| Total Debt | $7M | $22M | $70M | $98K | $2.71B |
| Cash & Equiv. | $2M | $194M | $1.12B | $714M | $3.12B |
HCWB vs DBVT vs ALKS vs IMVT vs REGN — Long-Term Stock Performance
Price return indexed to 100 at period start. Dividends excluded.
| Stock | Jul 21 | May 26 | Return |
|---|---|---|---|
| HCW Biologics Inc. (HCWB) | 100 | 0.2 | -99.8% |
| DBV Technologies S.… (DBVT) | 100 | 38.4 | -61.6% |
| Alkermes plc (ALKS) | 100 | 136.8 | +36.8% |
| Immunovant, Inc. (IMVT) | 100 | 260.2 | +160.2% |
| Regeneron Pharmaceu… (REGN) | 100 | 123.4 | +23.4% |
Price return only. Dividends and distributions are not included.
Quick Verdict: HCWB vs DBVT vs ALKS vs IMVT vs REGN
Each card shows where this stock fits in a portfolio — not just who wins on paper.
HCWB plays a supporting role in this comparison — it may shine differently against other peers.
DBVT is the #2 pick in this set and the best alternative if momentum is your priority.
- +110.4% vs HCWB's -95.4%
ALKS lags the leaders in this set but could rank higher in a more targeted comparison.
IMVT is the clearest fit if your priority is long-term compounding.
- 173.6% 10Y total return vs REGN's 90.0%
REGN carries the broadest edge in this set and is the clearest fit for income & stability and growth exposure.
- Dividend streak 1 yrs, beta 0.81, yield 0.5%
- Rev growth 1.0%, EPS growth 8.2%, 3Y rev CAGR 5.6%
- Lower volatility, beta 0.81, Low D/E 8.7%, current ratio 4.13x
- Beta 0.81, yield 0.5%, current ratio 4.13x
See the full category breakdown
| Category | Winner | Why |
|---|---|---|
| Growth | 1.0% revenue growth vs DBVT's -100.0% | |
| Value | Better valuation composite | |
| Quality / Margins | 29.6% margin vs HCWB's -146.8% | |
| Stability / Safety | Beta 0.81 vs HCWB's 1.54, lower leverage | |
| Dividends | 0.5% yield; 1-year raise streak; the other 4 pay no meaningful dividend | |
| Momentum (1Y) | +110.4% vs HCWB's -95.4% | |
| Efficiency (ROA) | 11.1% ROA vs DBVT's -89.0% |
HCWB vs DBVT vs ALKS vs IMVT vs REGN — Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
Segment breakdown not available.
Segment breakdown not available.
HCWB vs DBVT vs ALKS vs IMVT vs REGN — Financial Metrics
Side-by-side numbers across 5 stocks — who leads on profitability, valuation, growth, and risk.
Who Leads Where
REGN leads in 2 of 6 categories
ALKS leads 2 • IMVT leads 1 • HCWB leads 0 • DBVT leads 0 • 1 tied
Explore the data ↓Income & Cash Flow (Last 12 Months)
REGN leads this category, winning 4 of 6 comparable metrics.
Income & Cash Flow (Last 12 Months)
REGN and IMVT operate at a comparable scale, with $14.9B and $0 in trailing revenue. REGN is the more profitable business, keeping 29.6% of every revenue dollar as net income compared to HCWB's -146.8%. On growth, ALKS holds the edge at +28.2% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | |||||
|---|---|---|---|---|---|
| RevenueTrailing 12 months | $54,231 | $0 | $1.6B | $0 | $14.9B |
| EBITDAEarnings before interest/tax | -$11M | -$112M | $212M | -$487M | $4.2B |
| Net IncomeAfter-tax profit | -$8M | -$168M | $153M | -$464M | $4.4B |
| Free Cash FlowCash after capex | -$13M | -$151M | $392M | -$423M | $4.2B |
| Gross MarginGross profit ÷ Revenue | -3.0% | — | +65.4% | — | +84.5% |
| Operating MarginEBIT ÷ Revenue | -215.1% | — | +12.3% | — | +24.3% |
| Net MarginNet income ÷ Revenue | -146.8% | — | +9.8% | — | +29.6% |
| FCF MarginFCF ÷ Revenue | -246.9% | — | +25.1% | — | +27.9% |
| Rev. Growth (YoY)Latest quarter vs prior year | -93.2% | — | +28.2% | — | +19.0% |
| EPS Growth (YoY)Latest quarter vs prior year | -21.1% | +91.5% | -4.1% | +19.7% | -7.2% |
Valuation Metrics
ALKS leads this category, winning 3 of 5 comparable metrics.
Valuation Metrics
At 17.1x trailing earnings, REGN trades at a 31% valuation discount to ALKS's 24.8x P/E. On an enterprise value basis, ALKS's 17.3x EV/EBITDA is more attractive than REGN's 17.8x.
| Metric | |||||
|---|---|---|---|---|---|
| Market CapShares × price | $668,096 | $1712.35T | $5.9B | $5.5B | $73.7B |
| Enterprise ValueMkt cap + debt − cash | $6M | $1712.35T | $4.9B | $4.8B | $73.3B |
| Trailing P/EPrice ÷ TTM EPS | -0.03x | -0.76x | 24.76x | -9.97x | 17.09x |
| Forward P/EPrice ÷ next-FY EPS est. | — | — | — | — | 15.35x |
| PEG RatioP/E ÷ EPS growth rate | — | — | — | — | 2.70x |
| EV / EBITDAEnterprise value multiple | — | — | 17.25x | — | 17.78x |
| Price / SalesMarket cap ÷ Revenue | 12.32x | — | 4.00x | — | 5.14x |
| Price / BookPrice ÷ Book value/share | 0.24x | 0.66x | 3.28x | 5.83x | 2.46x |
| Price / FCFMarket cap ÷ FCF | — | — | 12.28x | — | 18.06x |
Profitability & Efficiency
ALKS leads this category, winning 4 of 9 comparable metrics.
Profitability & Efficiency
REGN delivers a 14.3% return on equity — every $100 of shareholder capital generates $14 in annual profit, vs $-3 for HCWB. IMVT carries lower financial leverage with a 0.00x debt-to-equity ratio, signaling a more conservative balance sheet compared to HCWB's 2.46x. On the Piotroski fundamental quality scale (0–9), ALKS scores 7/9 vs IMVT's 2/9, reflecting strong financial health.
| Metric | |||||
|---|---|---|---|---|---|
| ROE (TTM)Return on equity | -2.9% | -130.2% | +8.8% | -47.1% | +14.3% |
| ROA (TTM)Return on assets | -30.3% | -89.0% | +5.4% | -44.1% | +11.1% |
| ROICReturn on invested capital | -171.1% | — | +18.9% | — | +8.9% |
| ROCEReturn on capital employed | -5.5% | -145.7% | +14.2% | -66.1% | +10.2% |
| Piotroski ScoreFundamental quality 0–9 | 3 | 4 | 7 | 2 | 5 |
| Debt / EquityFinancial leverage | 2.46x | 0.13x | 0.04x | 0.00x | 0.09x |
| Net DebtTotal debt minus cash | $5M | -$172M | -$1.0B | -$714M | -$412M |
| Cash & Equiv.Liquid assets | $2M | $194M | $1.1B | $714M | $3.1B |
| Total DebtShort + long-term debt | $7M | $22M | $70M | $98,000 | $2.7B |
| Interest CoverageEBIT ÷ Interest expense | -8.05x | -189.82x | 32.30x | — | 108.44x |
Total Returns (Dividends Reinvested)
IMVT leads this category, winning 4 of 6 comparable metrics.
Total Returns (Dividends Reinvested)
A $10,000 investment in IMVT five years ago would be worth $16,241 today (with dividends reinvested), compared to $13 for HCWB. Over the past 12 months, DBVT leads with a +110.4% total return vs HCWB's -95.4%. The 3-year compound annual growth rate (CAGR) favors IMVT at 12.1% vs HCWB's -82.2% — a key indicator of consistent wealth creation.
| Metric | |||||
|---|---|---|---|---|---|
| YTD ReturnYear-to-date | -71.4% | +4.9% | +25.3% | +5.1% | -8.5% |
| 1-Year ReturnPast 12 months | -95.4% | +110.4% | +16.5% | +96.1% | +27.1% |
| 3-Year ReturnCumulative with dividends | -99.4% | +19.7% | +14.5% | +40.9% | -5.1% |
| 5-Year ReturnCumulative with dividends | -99.9% | -69.1% | +60.9% | +62.4% | +43.6% |
| 10-Year ReturnCumulative with dividends | -99.9% | -87.0% | -11.0% | +173.6% | +90.0% |
| CAGR (3Y)Annualised 3-year return | -82.2% | +6.2% | +4.6% | +12.1% | -1.7% |
Risk & Volatility
Evenly matched — ALKS and REGN each lead in 1 of 2 comparable metrics.
Risk & Volatility
REGN is the less volatile stock with a 0.81 beta — it tends to amplify market swings less than HCWB's 1.54 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. ALKS currently trades 96.7% from its 52-week high vs HCWB's 1.8% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | |||||
|---|---|---|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 1.54x | 1.26x | 1.06x | 1.37x | 0.81x |
| 52-Week HighHighest price in past year | $17.80 | $26.18 | $36.60 | $30.09 | $821.11 |
| 52-Week LowLowest price in past year | $0.25 | $7.53 | $25.17 | $13.36 | $476.49 |
| % of 52W HighCurrent price vs 52-week peak | +1.8% | +76.3% | +96.7% | +90.5% | +86.4% |
| RSI (14)Momentum oscillator 0–100 | 41.6 | 48.1 | 60.2 | 60.2 | 44.9 |
| Avg Volume (50D)Average daily shares traded | 10.8M | 252K | 2.3M | 1.4M | 631K |
Analyst Outlook
REGN leads this category, winning 1 of 1 comparable metric.
Analyst Outlook
Analyst consensus: DBVT as "Buy", ALKS as "Buy", IMVT as "Buy", REGN as "Buy". Consensus price targets imply 131.8% upside for DBVT (target: $46) vs 22.1% for REGN (target: $866). REGN is the only dividend payer here at 0.48% yield — a key consideration for income-focused portfolios.
| Metric | |||||
|---|---|---|---|---|---|
| Analyst RatingConsensus buy/hold/sell | — | Buy | Buy | Buy | Buy |
| Price TargetConsensus 12-month target | — | $46.33 | $44.00 | $45.50 | $865.68 |
| # AnalystsCovering analysts | — | 15 | 28 | 23 | 48 |
| Dividend YieldAnnual dividend ÷ price | — | — | — | — | +0.5% |
| Dividend StreakConsecutive years of raises | — | 0 | 0 | — | 1 |
| Dividend / ShareAnnual DPS | — | — | — | — | $3.41 |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | 0.0% | +0.5% | 0.0% | +5.4% |
REGN leads in 2 of 6 categories (Income & Cash Flow, Analyst Outlook). ALKS leads in 2 (Valuation Metrics, Profitability & Efficiency). 1 tied.
HCWB vs DBVT vs ALKS vs IMVT vs REGN: Key Questions Answered
10 questions · data-driven answers · updated daily
01Is HCWB or DBVT or ALKS or IMVT or REGN a better buy right now?
For growth investors, Regeneron Pharmaceuticals, Inc.
(REGN) is the stronger pick with 1. 0% revenue growth year-over-year, versus -97. 9% for HCW Biologics Inc. (HCWB). Regeneron Pharmaceuticals, Inc. (REGN) offers the better valuation at 17. 1x trailing P/E (15. 3x forward), making it the more compelling value choice. Analysts rate DBV Technologies S. A. (DBVT) a "Buy" — based on 15 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which has the better valuation — HCWB or DBVT or ALKS or IMVT or REGN?
On trailing P/E, Regeneron Pharmaceuticals, Inc.
(REGN) is the cheapest at 17. 1x versus Alkermes plc at 24. 8x.
03Which is the better long-term investment — HCWB or DBVT or ALKS or IMVT or REGN?
Over the past 5 years, Immunovant, Inc.
(IMVT) delivered a total return of +62. 4%, compared to -99. 9% for HCW Biologics Inc. (HCWB). Over 10 years, the gap is even starker: IMVT returned +173. 6% versus HCWB's -99. 9%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
04Which is safer — HCWB or DBVT or ALKS or IMVT or REGN?
By beta (market sensitivity over 5 years), Regeneron Pharmaceuticals, Inc.
(REGN) is the lower-risk stock at 0. 81β versus HCW Biologics Inc. 's 1. 54β — meaning HCWB is approximately 91% more volatile than REGN relative to the S&P 500. On balance sheet safety, Immunovant, Inc. (IMVT) carries a lower debt/equity ratio of 0% versus 2% for HCW Biologics Inc. — giving it more financial flexibility in a downturn.
05Which is growing faster — HCWB or DBVT or ALKS or IMVT or REGN?
By revenue growth (latest reported year), Regeneron Pharmaceuticals, Inc.
(REGN) is pulling ahead at 1. 0% versus -97. 9% for HCW Biologics Inc. (HCWB). On earnings-per-share growth, the picture is similar: Regeneron Pharmaceuticals, Inc. grew EPS 8. 2% year-over-year, compared to -1280. 5% for HCW Biologics Inc.. Over a 3-year CAGR, ALKS leads at 9. 9% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.
06Which has better profit margins — HCWB or DBVT or ALKS or IMVT or REGN?
Regeneron Pharmaceuticals, Inc.
(REGN) is the more profitable company, earning 31. 4% net margin versus -146. 8% for HCW Biologics Inc. — meaning it keeps 31. 4% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: REGN leads at 24. 9% versus -207. 6% for HCWB. At the gross margin level — before operating expenses — ALKS leads at 86. 7%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
07Is HCWB or DBVT or ALKS or IMVT or REGN more undervalued right now?
Analyst consensus price targets imply the most upside for DBVT: 131.
8% to $46. 33.
08Which pays a better dividend — HCWB or DBVT or ALKS or IMVT or REGN?
In this comparison, REGN (0.
5% yield) pays a dividend. HCWB, DBVT, ALKS, IMVT do not pay a meaningful dividend and should not be held primarily for income.
09Is HCWB or DBVT or ALKS or IMVT or REGN better for a retirement portfolio?
For long-horizon retirement investors, Regeneron Pharmaceuticals, Inc.
(REGN) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0. 81)). HCW Biologics Inc. (HCWB) carries a higher beta of 1. 54 — meaning larger drawdowns in market downturns, which matters significantly when you cannot wait years for a recovery. Both have compounded well over 10 years (REGN: +90. 0%, HCWB: -99. 9%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
10What are the main differences between HCWB and DBVT and ALKS and IMVT and REGN?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both.
In terms of investment character: HCWB is a small-cap quality compounder stock; DBVT is a mega-cap quality compounder stock; ALKS is a small-cap quality compounder stock; IMVT is a small-cap quality compounder stock; REGN is a mid-cap deep-value stock. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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