Biotechnology
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IBRX vs CRIS vs NKTR vs FATE vs IMVT
Revenue, margins, valuation, and 5-year total return — side by side.
Biotechnology
Biotechnology
Biotechnology
Biotechnology
IBRX vs CRIS vs NKTR vs FATE vs IMVT — Key Financials
Market cap, revenue, margins, and valuation side-by-side.
| Company Snapshot | |||||
|---|---|---|---|---|---|
| Industry | Biotechnology | Biotechnology | Biotechnology | Biotechnology | Biotechnology |
| Market Cap | $7.64B | $76M | $1.69B | $280M | $5.53B |
| Revenue (TTM) | $83M | $9M | $55M | $7M | $0.00 |
| Net Income (TTM) | $-349M | $-8M | $-164M | $-136M | $-464M |
| Gross Margin | 94.8% | 99.5% | 99.6% | — | — |
| Operating Margin | -315.8% | -348.4% | -237.9% | -22.2% | — |
| Total Debt | $504M | $2M | $149M | $78M | $98K |
| Cash & Equiv. | $143M | $5M | $15M | $47M | $714M |
IBRX vs CRIS vs NKTR vs FATE vs IMVT — Long-Term Stock Performance
Price return indexed to 100 at period start. Dividends excluded.
| Stock | May 20 | May 26 | Return |
|---|---|---|---|
| ImmunityBio, Inc. (IBRX) | 100 | 115.1 | +15.1% |
| Curis, Inc. (CRIS) | 100 | 3.5 | -96.5% |
| Nektar Therapeutics (NKTR) | 100 | 25.6 | -74.4% |
| Fate Therapeutics, … (FATE) | 100 | 7.5 | -92.5% |
| Immunovant, Inc. (IMVT) | 100 | 106.1 | +6.1% |
Price return only. Dividends and distributions are not included.
Quick Verdict: IBRX vs CRIS vs NKTR vs FATE vs IMVT
Each card shows where this stock fits in a portfolio — not just who wins on paper.
IBRX is the #2 pick in this set and the best alternative if growth exposure is your priority.
- Rev growth 22.7%, EPS growth 46.1%, 3Y rev CAGR 150.9%
- 22.7% revenue growth vs FATE's -51.2%
CRIS ranks third and is worth considering specifically for efficiency.
- -26.1% ROA vs IBRX's -93.2%
NKTR is the clearest fit if your priority is momentum.
- +8.2% vs CRIS's -72.0%
Among these 5 stocks, FATE doesn't own a clear edge in any measured category.
IMVT carries the broadest edge in this set and is the clearest fit for income & stability and long-term compounding.
- beta 1.37
- 173.6% 10Y total return vs IBRX's -7.5%
- Lower volatility, beta 1.37, Low D/E 0.0%, current ratio 11.16x
- Beta 1.37, current ratio 11.16x
See the full category breakdown
| Category | Winner | Why |
|---|---|---|
| Growth | 22.7% revenue growth vs FATE's -51.2% | |
| Quality / Margins | 3.2% margin vs FATE's -20.5% | |
| Stability / Safety | Beta 1.37 vs IBRX's 2.21 | |
| Dividends | Tie | None of these 5 stocks pay a meaningful dividend |
| Momentum (1Y) | +8.2% vs CRIS's -72.0% | |
| Efficiency (ROA) | -26.1% ROA vs IBRX's -93.2% |
IBRX vs CRIS vs NKTR vs FATE vs IMVT — Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
IBRX vs CRIS vs NKTR vs FATE vs IMVT — Financial Metrics
Side-by-side numbers across 5 stocks — who leads on profitability, valuation, growth, and risk.
Who Leads Where
CRIS leads in 1 of 6 categories
IMVT leads 1 • NKTR leads 1 • IBRX leads 0 • FATE leads 0 • 2 tied
Explore the data ↓Income & Cash Flow (Last 12 Months)
CRIS leads this category, winning 3 of 6 comparable metrics.
Income & Cash Flow (Last 12 Months)
IBRX and IMVT operate at a comparable scale, with $83M and $0 in trailing revenue. Profitability is closely matched — net margins range from -80.3% (CRIS) to -20.5% (FATE). On growth, IBRX holds the edge at +4.3% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | |||||
|---|---|---|---|---|---|
| RevenueTrailing 12 months | $83M | $9M | $55M | $7M | $0 |
| EBITDAEarnings before interest/tax | -$245M | -$33M | -$130M | -$148M | -$487M |
| Net IncomeAfter-tax profit | -$349M | -$8M | -$164M | -$136M | -$464M |
| Free Cash FlowCash after capex | -$324M | -$27M | -$209M | -$88M | -$423M |
| Gross MarginGross profit ÷ Revenue | +94.8% | +99.5% | +99.6% | — | — |
| Operating MarginEBIT ÷ Revenue | -3.2% | -3.5% | -2.4% | -22.2% | — |
| Net MarginNet income ÷ Revenue | -4.2% | -80.3% | -3.0% | -20.5% | — |
| FCF MarginFCF ÷ Revenue | -3.9% | -2.9% | -3.8% | -13.2% | — |
| Rev. Growth (YoY)Latest quarter vs prior year | +4.3% | -66.0% | -25.3% | -26.4% | — |
| EPS Growth (YoY)Latest quarter vs prior year | +40.8% | +198.4% | -4.5% | +38.6% | +19.7% |
Valuation Metrics
Evenly matched — IBRX and CRIS and FATE each lead in 1 of 3 comparable metrics.
Valuation Metrics
| Metric | |||||
|---|---|---|---|---|---|
| Market CapShares × price | $7.6B | $76M | $1.7B | $280M | $5.5B |
| Enterprise ValueMkt cap + debt − cash | $8.0B | $73M | $1.8B | $312M | $4.8B |
| Trailing P/EPrice ÷ TTM EPS | -12.52x | -0.99x | -8.57x | -2.11x | -9.97x |
| Forward P/EPrice ÷ next-FY EPS est. | — | — | — | — | — |
| PEG RatioP/E ÷ EPS growth rate | — | — | — | — | — |
| EV / EBITDAEnterprise value multiple | — | — | — | — | — |
| Price / SalesMarket cap ÷ Revenue | 518.37x | 8.04x | 30.64x | 42.18x | — |
| Price / BookPrice ÷ Book value/share | — | 13.91x | 15.66x | 1.39x | 5.83x |
| Price / FCFMarket cap ÷ FCF | — | — | — | — | — |
Profitability & Efficiency
IMVT leads this category, winning 4 of 9 comparable metrics.
Profitability & Efficiency
IMVT delivers a -47.1% return on equity — every $100 of shareholder capital generates $-47 in annual profit, vs $-4 for NKTR. IMVT carries lower financial leverage with a 0.00x debt-to-equity ratio, signaling a more conservative balance sheet compared to NKTR's 1.66x. On the Piotroski fundamental quality scale (0–9), IBRX scores 4/9 vs IMVT's 2/9, reflecting mixed financial health.
| Metric | |||||
|---|---|---|---|---|---|
| ROE (TTM)Return on equity | — | -138.8% | -4.0% | -65.8% | -47.1% |
| ROA (TTM)Return on assets | -93.2% | -26.1% | -62.8% | -42.7% | -44.1% |
| ROICReturn on invested capital | — | — | -57.2% | -36.5% | — |
| ROCEReturn on capital employed | -88.9% | -2.3% | -55.7% | -43.1% | -66.1% |
| Piotroski ScoreFundamental quality 0–9 | 4 | 3 | 2 | 2 | 2 |
| Debt / EquityFinancial leverage | — | 0.30x | 1.66x | 0.38x | 0.00x |
| Net DebtTotal debt minus cash | $361M | -$3M | $134M | $31M | -$714M |
| Cash & Equiv.Liquid assets | $143M | $5M | $15M | $47M | $714M |
| Total DebtShort + long-term debt | $504M | $2M | $149M | $78M | $98,000 |
| Interest CoverageEBIT ÷ Interest expense | -2.48x | -107.35x | -4.74x | — | — |
Total Returns (Dividends Reinvested)
NKTR leads this category, winning 3 of 6 comparable metrics.
Total Returns (Dividends Reinvested)
A $10,000 investment in IMVT five years ago would be worth $16,241 today (with dividends reinvested), compared to $28 for CRIS. Over the past 12 months, NKTR leads with a +818.2% total return vs CRIS's -72.0%. The 3-year compound annual growth rate (CAGR) favors NKTR at 93.3% vs CRIS's -67.0% — a key indicator of consistent wealth creation.
| Metric | |||||
|---|---|---|---|---|---|
| YTD ReturnYear-to-date | +284.2% | -41.1% | +92.0% | +145.5% | +5.1% |
| 1-Year ReturnPast 12 months | +310.6% | -72.0% | +818.2% | +143.0% | +96.1% |
| 3-Year ReturnCumulative with dividends | +21.1% | -96.4% | +621.8% | -55.4% | +40.9% |
| 5-Year ReturnCumulative with dividends | -53.6% | -99.7% | -72.3% | -96.8% | +62.4% |
| 10-Year ReturnCumulative with dividends | -7.5% | -99.7% | -59.1% | +40.5% | +173.6% |
| CAGR (3Y)Annualised 3-year return | +6.6% | -67.0% | +93.3% | -23.6% | +12.1% |
Risk & Volatility
Evenly matched — FATE and IMVT each lead in 1 of 2 comparable metrics.
Risk & Volatility
IMVT is the less volatile stock with a 1.37 beta — it tends to amplify market swings less than IBRX's 2.21 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. FATE currently trades 98.6% from its 52-week high vs CRIS's 18.4% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | |||||
|---|---|---|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 2.21x | 1.87x | 1.85x | 2.17x | 1.37x |
| 52-Week HighHighest price in past year | $12.43 | $3.13 | $109.00 | $2.46 | $30.09 |
| 52-Week LowLowest price in past year | $1.83 | $0.49 | $7.99 | $0.91 | $13.36 |
| % of 52W HighCurrent price vs 52-week peak | +62.4% | +18.4% | +76.5% | +98.6% | +90.5% |
| RSI (14)Momentum oscillator 0–100 | 59.4 | 48.9 | 53.4 | 81.0 | 60.2 |
| Avg Volume (50D)Average daily shares traded | 20.4M | 444K | 991K | 1.9M | 1.4M |
Analyst Outlook
Insufficient data to determine a leader in this category.
Analyst Outlook
Analyst consensus: IBRX as "Buy", NKTR as "Buy", FATE as "Buy", IMVT as "Buy". Consensus price targets imply 1525.5% upside for FATE (target: $40) vs 59.3% for NKTR (target: $133).
| Metric | |||||
|---|---|---|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Buy | — | Buy | Buy | Buy |
| Price TargetConsensus 12-month target | $13.50 | — | $132.83 | $39.50 | $45.50 |
| # AnalystsCovering analysts | 5 | — | 33 | 31 | 23 |
| Dividend YieldAnnual dividend ÷ price | — | — | — | — | — |
| Dividend StreakConsecutive years of raises | — | — | — | — | — |
| Dividend / ShareAnnual DPS | — | — | — | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% |
CRIS leads in 1 of 6 categories (Income & Cash Flow). IMVT leads in 1 (Profitability & Efficiency). 2 tied.
IBRX vs CRIS vs NKTR vs FATE vs IMVT: Key Questions Answered
8 questions · data-driven answers · updated daily
01Is IBRX or CRIS or NKTR or FATE or IMVT a better buy right now?
For growth investors, ImmunityBio, Inc.
(IBRX) is the stronger pick with 22. 7% revenue growth year-over-year, versus -51. 2% for Fate Therapeutics, Inc. (FATE). Analysts rate ImmunityBio, Inc. (IBRX) a "Buy" — based on 5 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — IBRX or CRIS or NKTR or FATE or IMVT?
Over the past 5 years, Immunovant, Inc.
(IMVT) delivered a total return of +62. 4%, compared to -99. 7% for Curis, Inc. (CRIS). Over 10 years, the gap is even starker: IMVT returned +173. 6% versus CRIS's -99. 7%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — IBRX or CRIS or NKTR or FATE or IMVT?
By beta (market sensitivity over 5 years), Immunovant, Inc.
(IMVT) is the lower-risk stock at 1. 37β versus ImmunityBio, Inc. 's 2. 21β — meaning IBRX is approximately 61% more volatile than IMVT relative to the S&P 500. On balance sheet safety, Immunovant, Inc. (IMVT) carries a lower debt/equity ratio of 0% versus 166% for Nektar Therapeutics — giving it more financial flexibility in a downturn.
04Which is growing faster — IBRX or CRIS or NKTR or FATE or IMVT?
By revenue growth (latest reported year), ImmunityBio, Inc.
(IBRX) is pulling ahead at 22. 7% versus -51. 2% for Fate Therapeutics, Inc. (FATE). On earnings-per-share growth, the picture is similar: Curis, Inc. grew EPS 91. 6% year-over-year, compared to -45. 2% for Immunovant, Inc.. Over a 3-year CAGR, IBRX leads at 150. 9% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.
05Which has better profit margins — IBRX or CRIS or NKTR or FATE or IMVT?
Immunovant, Inc.
(IMVT) is the more profitable company, earning 0. 0% net margin versus -28. 0% for ImmunityBio, Inc. — meaning it keeps 0. 0% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: IMVT leads at 0. 0% versus -23. 3% for IBRX. At the gross margin level — before operating expenses — IBRX leads at 100. 0%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
06Which pays a better dividend — IBRX or CRIS or NKTR or FATE or IMVT?
None of the stocks in this comparison currently pay a material dividend.
All are effectively zero-yield and should be held for capital appreciation rather than income.
07Is IBRX or CRIS or NKTR or FATE or IMVT better for a retirement portfolio?
For long-horizon retirement investors, Immunovant, Inc.
(IMVT) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (+173. 6% 10Y return). ImmunityBio, Inc. (IBRX) carries a higher beta of 2. 21 — meaning larger drawdowns in market downturns, which matters significantly when you cannot wait years for a recovery. Both have compounded well over 10 years (IMVT: +173. 6%, IBRX: -7. 5%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
08What are the main differences between IBRX and CRIS and NKTR and FATE and IMVT?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both.
In terms of investment character: IBRX is a small-cap high-growth stock; CRIS is a small-cap quality compounder stock; NKTR is a small-cap quality compounder stock; FATE is a small-cap quality compounder stock; IMVT is a small-cap quality compounder stock. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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