Biotechnology
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5 / 10Stock Comparison
IMCR vs KYMR vs RCUS vs BEAM vs NTLA
Revenue, margins, valuation, and 5-year total return — side by side.
Biotechnology
Biotechnology
Biotechnology
Biotechnology
IMCR vs KYMR vs RCUS vs BEAM vs NTLA — Key Financials
Market cap, revenue, margins, and valuation side-by-side.
| Company Snapshot | |||||
|---|---|---|---|---|---|
| Industry | Biotechnology | Biotechnology | Biotechnology | Biotechnology | Biotechnology |
| Market Cap | $1.55B | $6.91B | $2.50B | $3.23B | $1.62B |
| Revenue (TTM) | $386M | $51M | $236M | $132M | $68M |
| Net Income (TTM) | $-19M | $-315M | $-369M | $-65M | $-413M |
| Gross Margin | 98.8% | 33.2% | 90.7% | -64.2% | -25.6% |
| Operating Margin | -7.6% | -7.0% | -168.6% | -281.0% | -6.5% |
| Total Debt | $44M | $82M | $99M | $294M | $93M |
| Cash & Equiv. | $468M | $357M | $222M | $295M | $155M |
IMCR vs KYMR vs RCUS vs BEAM vs NTLA — Long-Term Stock Performance
Price return indexed to 100 at period start. Dividends excluded.
| Stock | Feb 21 | May 26 | Return |
|---|---|---|---|
| Immunocore Holdings… (IMCR) | 100 | 63.3 | -36.7% |
| Kymera Therapeutics… (KYMR) | 100 | 176.4 | +76.4% |
| Arcus Biosciences, … (RCUS) | 100 | 70.3 | -29.7% |
| Beam Therapeutics I… (BEAM) | 100 | 35.3 | -64.7% |
| Intellia Therapeuti… (NTLA) | 100 | 22.7 | -77.3% |
Price return only. Dividends and distributions are not included.
Quick Verdict: IMCR vs KYMR vs RCUS vs BEAM vs NTLA
Each card shows where this stock fits in a portfolio — not just who wins on paper.
IMCR carries the broadest edge in this set and is the clearest fit for income & stability.
- beta 0.86
- -4.9% margin vs KYMR's -6.1%
- Beta 0.86 vs NTLA's 2.37, lower leverage
- -1.7% ROA vs NTLA's -45.2%, ROIC -17.2% vs -44.0%
KYMR is the clearest fit if your priority is long-term compounding and sleep-well-at-night.
- 154.4% 10Y total return vs RCUS's 45.9%
- Lower volatility, beta 1.15, Low D/E 5.2%, current ratio 10.47x
- Beta 1.15, current ratio 10.47x
RCUS is the #2 pick in this set and the best alternative if momentum is your priority.
- +209.6% vs IMCR's +2.3%
BEAM ranks third and is worth considering specifically for growth exposure.
- Rev growth 120.0%, EPS growth 82.3%, 3Y rev CAGR 31.9%
- 120.0% revenue growth vs KYMR's -16.7%
Among these 5 stocks, NTLA doesn't own a clear edge in any measured category.
See the full category breakdown
| Category | Winner | Why |
|---|---|---|
| Growth | 120.0% revenue growth vs KYMR's -16.7% | |
| Quality / Margins | -4.9% margin vs KYMR's -6.1% | |
| Stability / Safety | Beta 0.86 vs NTLA's 2.37, lower leverage | |
| Dividends | Tie | None of these 5 stocks pay a meaningful dividend |
| Momentum (1Y) | +209.6% vs IMCR's +2.3% | |
| Efficiency (ROA) | -1.7% ROA vs NTLA's -45.2%, ROIC -17.2% vs -44.0% |
IMCR vs KYMR vs RCUS vs BEAM vs NTLA — Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
Segment breakdown not available.
Segment breakdown not available.
IMCR vs KYMR vs RCUS vs BEAM vs NTLA — Financial Metrics
Side-by-side numbers across 5 stocks — who leads on profitability, valuation, growth, and risk.
Who Leads Where
IMCR leads in 3 of 6 categories
KYMR leads 1 • RCUS leads 0 • BEAM leads 0 • NTLA leads 0 • 1 tied
Explore the data ↓Income & Cash Flow (Last 12 Months)
IMCR leads this category, winning 5 of 6 comparable metrics.
Income & Cash Flow (Last 12 Months)
IMCR is the larger business by revenue, generating $386M annually — 7.5x KYMR's $51M. Profitability is closely matched — net margins range from -4.9% (IMCR) to -6.1% (KYMR). On growth, NTLA holds the edge at +78.8% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | |||||
|---|---|---|---|---|---|
| RevenueTrailing 12 months | $386M | $51M | $236M | $132M | $68M |
| EBITDAEarnings before interest/tax | -$27M | -$352M | -$391M | -$355M | -$431M |
| Net IncomeAfter-tax profit | -$19M | -$315M | -$369M | -$65M | -$413M |
| Free Cash FlowCash after capex | -$31M | -$244M | -$489M | -$384M | -$396M |
| Gross MarginGross profit ÷ Revenue | +98.8% | +33.2% | +90.7% | -64.2% | -25.6% |
| Operating MarginEBIT ÷ Revenue | -7.6% | -7.0% | -168.6% | -2.8% | -6.5% |
| Net MarginNet income ÷ Revenue | -4.9% | -6.1% | -156.4% | -49.2% | -6.1% |
| FCF MarginFCF ÷ Revenue | -8.0% | -4.7% | -2.1% | -2.9% | -5.8% |
| Rev. Growth (YoY)Latest quarter vs prior year | +13.6% | +55.5% | -39.3% | -100.0% | +78.8% |
| EPS Growth (YoY)Latest quarter vs prior year | +157.5% | +13.4% | +10.5% | +26.6% | +34.6% |
Valuation Metrics
IMCR leads this category, winning 2 of 3 comparable metrics.
Valuation Metrics
| Metric | |||||
|---|---|---|---|---|---|
| Market CapShares × price | $1.6B | $6.9B | $2.5B | $3.2B | $1.6B |
| Enterprise ValueMkt cap + debt − cash | $1.1B | $6.6B | $2.4B | $3.2B | $1.6B |
| Trailing P/EPrice ÷ TTM EPS | -57.77x | -22.93x | -7.54x | -38.85x | -3.60x |
| Forward P/EPrice ÷ next-FY EPS est. | — | — | — | — | — |
| PEG RatioP/E ÷ EPS growth rate | — | — | — | — | — |
| EV / EBITDAEnterprise value multiple | — | — | — | — | — |
| Price / SalesMarket cap ÷ Revenue | 5.22x | 176.26x | 10.11x | 23.14x | 23.93x |
| Price / BookPrice ÷ Book value/share | 4.05x | 4.52x | 4.22x | 2.51x | 2.21x |
| Price / FCFMarket cap ÷ FCF | — | — | — | — | — |
Profitability & Efficiency
IMCR leads this category, winning 7 of 9 comparable metrics.
Profitability & Efficiency
IMCR delivers a -4.8% return on equity — every $100 of shareholder capital generates $-5 in annual profit, vs $-69 for RCUS. KYMR carries lower financial leverage with a 0.05x debt-to-equity ratio, signaling a more conservative balance sheet compared to BEAM's 0.24x. On the Piotroski fundamental quality scale (0–9), IMCR scores 5/9 vs RCUS's 0/9, reflecting solid financial health.
| Metric | |||||
|---|---|---|---|---|---|
| ROE (TTM)Return on equity | -4.8% | -25.0% | -69.0% | -5.9% | -56.6% |
| ROA (TTM)Return on assets | -1.7% | -22.3% | -35.3% | -4.6% | -45.2% |
| ROICReturn on invested capital | -17.2% | -24.9% | -64.1% | -31.1% | -44.0% |
| ROCEReturn on capital employed | -4.2% | -27.2% | -42.1% | -33.3% | -48.5% |
| Piotroski ScoreFundamental quality 0–9 | 5 | 4 | 0 | 4 | 4 |
| Debt / EquityFinancial leverage | 0.11x | 0.05x | 0.16x | 0.24x | 0.14x |
| Net DebtTotal debt minus cash | -$424M | -$275M | -$123M | -$1M | -$62M |
| Cash & Equiv.Liquid assets | $468M | $357M | $222M | $295M | $155M |
| Total DebtShort + long-term debt | $44M | $82M | $99M | $294M | $93M |
| Interest CoverageEBIT ÷ Interest expense | -2.04x | -2119.53x | -13.38x | 1.08x | — |
Total Returns (Dividends Reinvested)
KYMR leads this category, winning 4 of 6 comparable metrics.
Total Returns (Dividends Reinvested)
A $10,000 investment in KYMR five years ago would be worth $19,212 today (with dividends reinvested), compared to $2,024 for NTLA. Over the past 12 months, RCUS leads with a +209.6% total return vs IMCR's +2.3%. The 3-year compound annual growth rate (CAGR) favors KYMR at 45.0% vs NTLA's -31.8% — a key indicator of consistent wealth creation.
| Metric | |||||
|---|---|---|---|---|---|
| YTD ReturnYear-to-date | -9.4% | +16.3% | +6.5% | +16.0% | +48.9% |
| 1-Year ReturnPast 12 months | +2.3% | +190.7% | +209.6% | +93.9% | +88.1% |
| 3-Year ReturnCumulative with dividends | -48.9% | +205.1% | +24.9% | -5.6% | -68.3% |
| 5-Year ReturnCumulative with dividends | -24.0% | +92.1% | -18.6% | -55.6% | -79.8% |
| 10-Year ReturnCumulative with dividends | -29.1% | +154.4% | +45.9% | +67.8% | -42.9% |
| CAGR (3Y)Annualised 3-year return | -20.0% | +45.0% | +7.7% | -1.9% | -31.8% |
Risk & Volatility
Evenly matched — IMCR and BEAM each lead in 1 of 2 comparable metrics.
Risk & Volatility
IMCR is the less volatile stock with a 0.86 beta — it tends to amplify market swings less than NTLA's 2.37 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. BEAM currently trades 86.4% from its 52-week high vs NTLA's 48.5% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | |||||
|---|---|---|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 0.86x | 1.15x | 1.95x | 2.14x | 2.37x |
| 52-Week HighHighest price in past year | $40.72 | $103.00 | $28.72 | $36.44 | $28.25 |
| 52-Week LowLowest price in past year | $27.44 | $28.06 | $7.06 | $15.35 | $6.83 |
| % of 52W HighCurrent price vs 52-week peak | +75.2% | +82.2% | +86.3% | +86.4% | +48.5% |
| RSI (14)Momentum oscillator 0–100 | 55.8 | 54.1 | 60.5 | 60.9 | 50.4 |
| Avg Volume (50D)Average daily shares traded | 409K | 602K | 1.2M | 2.0M | 5.3M |
Analyst Outlook
Insufficient data to determine a leader in this category.
Analyst Outlook
Analyst consensus: IMCR as "Buy", KYMR as "Buy", RCUS as "Buy", BEAM as "Buy", NTLA as "Buy". Consensus price targets imply 52.3% upside for NTLA (target: $21) vs 21.0% for RCUS (target: $30).
| Metric | |||||
|---|---|---|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Buy | Buy | Buy | Buy | Buy |
| Price TargetConsensus 12-month target | $43.00 | $117.06 | $30.00 | $40.83 | $20.88 |
| # AnalystsCovering analysts | 14 | 26 | 18 | 27 | 39 |
| Dividend YieldAnnual dividend ÷ price | — | — | — | — | — |
| Dividend StreakConsecutive years of raises | — | — | — | — | — |
| Dividend / ShareAnnual DPS | — | — | — | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% |
IMCR leads in 3 of 6 categories (Income & Cash Flow, Valuation Metrics). KYMR leads in 1 (Total Returns). 1 tied.
IMCR vs KYMR vs RCUS vs BEAM vs NTLA: Key Questions Answered
8 questions · data-driven answers · updated daily
01Is IMCR or KYMR or RCUS or BEAM or NTLA a better buy right now?
For growth investors, Beam Therapeutics Inc.
(BEAM) is the stronger pick with 120. 0% revenue growth year-over-year, versus -16. 7% for Kymera Therapeutics, Inc. (KYMR). Analysts rate Immunocore Holdings plc (IMCR) a "Buy" — based on 14 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — IMCR or KYMR or RCUS or BEAM or NTLA?
Over the past 5 years, Kymera Therapeutics, Inc.
(KYMR) delivered a total return of +92. 1%, compared to -79. 8% for Intellia Therapeutics, Inc. (NTLA). Over 10 years, the gap is even starker: KYMR returned +154. 4% versus NTLA's -42. 9%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — IMCR or KYMR or RCUS or BEAM or NTLA?
By beta (market sensitivity over 5 years), Immunocore Holdings plc (IMCR) is the lower-risk stock at 0.
86β versus Intellia Therapeutics, Inc. 's 2. 37β — meaning NTLA is approximately 175% more volatile than IMCR relative to the S&P 500. On balance sheet safety, Kymera Therapeutics, Inc. (KYMR) carries a lower debt/equity ratio of 5% versus 24% for Beam Therapeutics Inc. — giving it more financial flexibility in a downturn.
04Which is growing faster — IMCR or KYMR or RCUS or BEAM or NTLA?
By revenue growth (latest reported year), Beam Therapeutics Inc.
(BEAM) is pulling ahead at 120. 0% versus -16. 7% for Kymera Therapeutics, Inc. (KYMR). On earnings-per-share growth, the picture is similar: Beam Therapeutics Inc. grew EPS 82. 3% year-over-year, compared to -23. 8% for Kymera Therapeutics, Inc.. Over a 3-year CAGR, BEAM leads at 31. 9% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.
05Which has better profit margins — IMCR or KYMR or RCUS or BEAM or NTLA?
Immunocore Holdings plc (IMCR) is the more profitable company, earning -8.
9% net margin versus -794. 4% for Kymera Therapeutics, Inc. — meaning it keeps -8. 9% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: IMCR leads at -11. 3% versus -891. 3% for KYMR. At the gross margin level — before operating expenses — KYMR leads at 100. 0%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
06Which pays a better dividend — IMCR or KYMR or RCUS or BEAM or NTLA?
None of the stocks in this comparison currently pay a material dividend.
All are effectively zero-yield and should be held for capital appreciation rather than income.
07Is IMCR or KYMR or RCUS or BEAM or NTLA better for a retirement portfolio?
For long-horizon retirement investors, Immunocore Holdings plc (IMCR) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0.
86)). Intellia Therapeutics, Inc. (NTLA) carries a higher beta of 2. 37 — meaning larger drawdowns in market downturns, which matters significantly when you cannot wait years for a recovery. Both have compounded well over 10 years (IMCR: -29. 1%, NTLA: -42. 9%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
08What are the main differences between IMCR and KYMR and RCUS and BEAM and NTLA?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both.
In terms of investment character: IMCR is a small-cap high-growth stock; KYMR is a small-cap quality compounder stock; RCUS is a small-cap quality compounder stock; BEAM is a small-cap high-growth stock; NTLA is a small-cap high-growth stock. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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