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MBRX vs NKTR vs HALO vs IMVT vs RCUS

Revenue, margins, valuation, and 5-year total return — side by side.

Live fundamentals10-year financials5-year price chart
MBRX
Moleculin Biotech, Inc.

Biotechnology

HealthcareNASDAQ • US
Market Cap$29M
5Y Perf.-97.5%
NKTR
Nektar Therapeutics

Biotechnology

HealthcareNASDAQ • US
Market Cap$1.69B
5Y Perf.-74.4%
HALO
Halozyme Therapeutics, Inc.

Biotechnology

HealthcareNASDAQ • US
Market Cap$7.68B
5Y Perf.+168.6%
IMVT
Immunovant, Inc.

Biotechnology

HealthcareNASDAQ • US
Market Cap$5.53B
5Y Perf.+6.1%
RCUS
Arcus Biosciences, Inc.

Biotechnology

HealthcareNYSE • US
Market Cap$2.50B
5Y Perf.-20.9%

MBRX vs NKTR vs HALO vs IMVT vs RCUS — Key Financials

Market cap, revenue, margins, and valuation side-by-side.

Company Snapshot
MBRX logoMBRX
NKTR logoNKTR
HALO logoHALO
IMVT logoIMVT
RCUS logoRCUS
IndustryBiotechnologyBiotechnologyBiotechnologyBiotechnologyBiotechnology
Market Cap$29M$1.69B$7.68B$5.53B$2.50B
Revenue (TTM)$0.00$55M$1.40B$0.00$236M
Net Income (TTM)$-24M$-164M$317M$-464M$-369M
Gross Margin99.6%81.9%90.7%
Operating Margin-237.9%58.4%-168.6%
Forward P/E8.1x
Total Debt$222K$149M$0.00$98K$99M
Cash & Equiv.$9M$15M$134M$714M$222M

MBRX vs NKTR vs HALO vs IMVT vs RCUSLong-Term Stock Performance

Price return indexed to 100 at period start. Dividends excluded.

MBRX
NKTR
HALO
IMVT
RCUS
StockMay 20May 26Return
Moleculin Biotech, … (MBRX)1002.5-97.5%
Nektar Therapeutics (NKTR)10025.6-74.4%
Halozyme Therapeuti… (HALO)100268.6+168.6%
Immunovant, Inc. (IMVT)100106.1+6.1%
Arcus Biosciences, … (RCUS)10079.1-20.9%

Price return only. Dividends and distributions are not included.

Quick Verdict: MBRX vs NKTR vs HALO vs IMVT vs RCUS

Each card shows where this stock fits in a portfolio — not just who wins on paper.

Bottom line: HALO leads in 4 of 6 categories (5-stock set), making it the strongest pick for growth and revenue expansion and profitability and margin quality. Moleculin Biotech, Inc. is the stronger pick specifically for dividend income and shareholder returns. NKTR also leads in specific categories worth noting. As sector peers, any of these can serve as alternatives in the same allocation.
MBRX
Moleculin Biotech, Inc.
The Income Pick

MBRX is the #2 pick in this set and the best alternative if dividends is your priority.

  • 0.4% yield; 1-year raise streak; the other 4 pay no meaningful dividend
Best for: dividends
NKTR
Nektar Therapeutics
The Momentum Pick

NKTR ranks third and is worth considering specifically for momentum.

  • +8.2% vs HALO's -7.1%
Best for: momentum
HALO
Halozyme Therapeutics, Inc.
The Income Pick

HALO carries the broadest edge in this set and is the clearest fit for income & stability and long-term compounding.

  • beta 0.56
  • 5.7% 10Y total return vs IMVT's 173.6%
  • Beta 0.56, current ratio 4.66x
  • 37.6% revenue growth vs NKTR's -43.9%
Best for: income & stability and long-term compounding
IMVT
Immunovant, Inc.
The Defensive Pick

IMVT is the clearest fit if your priority is sleep-well-at-night.

  • Lower volatility, beta 1.37, Low D/E 0.0%, current ratio 11.16x
Best for: sleep-well-at-night
RCUS
Arcus Biosciences, Inc.
The Growth Play

RCUS is the clearest fit if your priority is growth exposure.

  • Rev growth -4.3%, EPS growth -4.8%, 3Y rev CAGR 30.2%
Best for: growth exposure
See the full category breakdown
CategoryWinnerWhy
GrowthHALO logoHALO37.6% revenue growth vs NKTR's -43.9%
Quality / MarginsHALO logoHALO22.7% margin vs NKTR's -297.1%
Stability / SafetyHALO logoHALOBeta 0.56 vs RCUS's 1.95
DividendsMBRX logoMBRX0.4% yield; 1-year raise streak; the other 4 pay no meaningful dividend
Momentum (1Y)NKTR logoNKTR+8.2% vs HALO's -7.1%
Efficiency (ROA)HALO logoHALO12.5% ROA vs MBRX's -112.5%, ROIC 73.4% vs -441.5%

MBRX vs NKTR vs HALO vs IMVT vs RCUS — Revenue Breakdown by Segment

How each company's revenue is distributed across its business units

MBRXMoleculin Biotech, Inc.

Segment breakdown not available.

NKTRNektar Therapeutics
FY 2025
Non Cash Royalty Revenue Related To Sale Of Future Royalties
99.5%$55M
License Collaboration And Other Revenue
0.5%$300,000
HALOHalozyme Therapeutics, Inc.
FY 2025
Royalty
53.6%$868M
Product
23.3%$376M
Collaborative Agreements
9.4%$152M
Bulk rHuPH20
8.2%$133M
Sales-based milestone
4.3%$70M
Upfront Fees
1.1%$18M
IMVTImmunovant, Inc.

Segment breakdown not available.

RCUSArcus Biosciences, Inc.
FY 2025
License And Development Services
87.4%$221M
Development Services
6.7%$17M
R&D Services
3.2%$8M
License
2.8%$7M

MBRX vs NKTR vs HALO vs IMVT vs RCUS — Financial Metrics

Side-by-side numbers across 5 stocks — who leads on profitability, valuation, growth, and risk.

BEST OVERALLHALOLAGGINGRCUS

Income & Cash Flow (Last 12 Months)

HALO leads this category, winning 4 of 6 comparable metrics.

HALO and IMVT operate at a comparable scale, with $1.4B and $0 in trailing revenue. HALO is the more profitable business, keeping 22.7% of every revenue dollar as net income compared to NKTR's -3.0%. On growth, HALO holds the edge at +51.6% YoY revenue growth, suggesting stronger near-term business momentum.

MetricMBRX logoMBRXMoleculin Biotech…NKTR logoNKTRNektar Therapeuti…HALO logoHALOHalozyme Therapeu…IMVT logoIMVTImmunovant, Inc.RCUS logoRCUSArcus Biosciences…
RevenueTrailing 12 months$0$55M$1.4B$0$236M
EBITDAEarnings before interest/tax-$25M-$130M$945M-$487M-$391M
Net IncomeAfter-tax profit-$24M-$164M$317M-$464M-$369M
Free Cash FlowCash after capex-$23M-$209M$645M-$423M-$489M
Gross MarginGross profit ÷ Revenue+99.6%+81.9%+90.7%
Operating MarginEBIT ÷ Revenue-2.4%+58.4%-168.6%
Net MarginNet income ÷ Revenue-3.0%+22.7%-156.4%
FCF MarginFCF ÷ Revenue-3.8%+46.2%-2.1%
Rev. Growth (YoY)Latest quarter vs prior year-25.3%+51.6%-39.3%
EPS Growth (YoY)Latest quarter vs prior year+134.5%-4.5%-2.1%+19.7%+10.5%
HALO leads this category, winning 4 of 6 comparable metrics.

Valuation Metrics

Evenly matched — MBRX and HALO and IMVT each lead in 1 of 3 comparable metrics.
MetricMBRX logoMBRXMoleculin Biotech…NKTR logoNKTRNektar Therapeuti…HALO logoHALOHalozyme Therapeu…IMVT logoIMVTImmunovant, Inc.RCUS logoRCUSArcus Biosciences…
Market CapShares × price$29M$1.7B$7.7B$5.5B$2.5B
Enterprise ValueMkt cap + debt − cash$21M$1.8B$7.5B$4.8B$2.4B
Trailing P/EPrice ÷ TTM EPS-0.09x-8.57x25.46x-9.97x-7.54x
Forward P/EPrice ÷ next-FY EPS est.8.09x
PEG RatioP/E ÷ EPS growth rate1.11x
EV / EBITDAEnterprise value multiple8.34x
Price / SalesMarket cap ÷ Revenue30.64x5.50x10.11x
Price / BookPrice ÷ Book value/share1.97x15.66x165.47x5.83x4.22x
Price / FCFMarket cap ÷ FCF11.91x
Evenly matched — MBRX and HALO and IMVT each lead in 1 of 3 comparable metrics.

Profitability & Efficiency

HALO leads this category, winning 7 of 9 comparable metrics.

HALO delivers a 6.5% return on equity — every $100 of shareholder capital generates $6 in annual profit, vs $-4 for NKTR. IMVT carries lower financial leverage with a 0.00x debt-to-equity ratio, signaling a more conservative balance sheet compared to NKTR's 1.66x. On the Piotroski fundamental quality scale (0–9), HALO scores 5/9 vs RCUS's 0/9, reflecting solid financial health.

MetricMBRX logoMBRXMoleculin Biotech…NKTR logoNKTRNektar Therapeuti…HALO logoHALOHalozyme Therapeu…IMVT logoIMVTImmunovant, Inc.RCUS logoRCUSArcus Biosciences…
ROE (TTM)Return on equity-3.2%-4.0%+6.5%-47.1%-69.0%
ROA (TTM)Return on assets-112.5%-62.8%+12.5%-44.1%-35.3%
ROICReturn on invested capital-4.4%-57.2%+73.4%-64.1%
ROCEReturn on capital employed-187.1%-55.7%+38.2%-66.1%-42.1%
Piotroski ScoreFundamental quality 0–932520
Debt / EquityFinancial leverage0.01x1.66x0.00x0.16x
Net DebtTotal debt minus cash-$9M$134M-$134M-$714M-$123M
Cash & Equiv.Liquid assets$9M$15M$134M$714M$222M
Total DebtShort + long-term debt$222,000$149M$0$98,000$99M
Interest CoverageEBIT ÷ Interest expense-4.74x46.08x-13.38x
HALO leads this category, winning 7 of 9 comparable metrics.

Total Returns (Dividends Reinvested)

NKTR leads this category, winning 4 of 6 comparable metrics.

A $10,000 investment in IMVT five years ago would be worth $16,241 today (with dividends reinvested), compared to $496 for MBRX. Over the past 12 months, NKTR leads with a +818.2% total return vs HALO's -7.1%. The 3-year compound annual growth rate (CAGR) favors NKTR at 93.3% vs MBRX's -40.7% — a key indicator of consistent wealth creation.

MetricMBRX logoMBRXMoleculin Biotech…NKTR logoNKTRNektar Therapeuti…HALO logoHALOHalozyme Therapeu…IMVT logoIMVTImmunovant, Inc.RCUS logoRCUSArcus Biosciences…
YTD ReturnYear-to-date-31.2%+92.0%-7.3%+5.1%+6.5%
1-Year ReturnPast 12 months+149.2%+818.2%-7.1%+96.1%+209.6%
3-Year ReturnCumulative with dividends-79.2%+621.8%+115.3%+40.9%+24.9%
5-Year ReturnCumulative with dividends-95.0%-72.3%+37.0%+62.4%-18.6%
10-Year ReturnCumulative with dividends-99.7%-59.1%+570.7%+173.6%+45.9%
CAGR (3Y)Annualised 3-year return-40.7%+93.3%+29.1%+12.1%+7.7%
NKTR leads this category, winning 4 of 6 comparable metrics.

Risk & Volatility

Evenly matched — HALO and IMVT each lead in 1 of 2 comparable metrics.

HALO is the less volatile stock with a 0.56 beta — it tends to amplify market swings less than RCUS's 1.95 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. IMVT currently trades 90.5% from its 52-week high vs MBRX's 31.2% drawdown — a narrower gap to the peak suggests stronger recent price momentum.

MetricMBRX logoMBRXMoleculin Biotech…NKTR logoNKTRNektar Therapeuti…HALO logoHALOHalozyme Therapeu…IMVT logoIMVTImmunovant, Inc.RCUS logoRCUSArcus Biosciences…
Beta (5Y)Sensitivity to S&P 5001.22x1.85x0.56x1.37x1.95x
52-Week HighHighest price in past year$7.98$109.00$82.22$30.09$28.72
52-Week LowLowest price in past year$0.25$7.99$47.50$13.36$7.06
% of 52W HighCurrent price vs 52-week peak+31.2%+76.5%+79.3%+90.5%+86.3%
RSI (14)Momentum oscillator 0–10048.553.452.460.260.5
Avg Volume (50D)Average daily shares traded110K991K1.4M1.4M1.2M
Evenly matched — HALO and IMVT each lead in 1 of 2 comparable metrics.

Analyst Outlook

Insufficient data to determine a leader in this category.

Analyst consensus: MBRX as "Buy", NKTR as "Buy", HALO as "Buy", IMVT as "Buy", RCUS as "Buy". Consensus price targets imply 67.2% upside for IMVT (target: $46) vs 20.2% for HALO (target: $78). MBRX is the only dividend payer here at 0.35% yield — a key consideration for income-focused portfolios.

MetricMBRX logoMBRXMoleculin Biotech…NKTR logoNKTRNektar Therapeuti…HALO logoHALOHalozyme Therapeu…IMVT logoIMVTImmunovant, Inc.RCUS logoRCUSArcus Biosciences…
Analyst RatingConsensus buy/hold/sellBuyBuyBuyBuyBuy
Price TargetConsensus 12-month target$132.83$78.33$45.50$30.00
# AnalystsCovering analysts433272318
Dividend YieldAnnual dividend ÷ price+0.4%
Dividend StreakConsecutive years of raises1
Dividend / ShareAnnual DPS$0.01
Buyback YieldShare repurchases ÷ mkt cap0.0%0.0%+4.5%0.0%0.0%
Insufficient data to determine a leader in this category.
Key Takeaway

HALO leads in 2 of 6 categories (Income & Cash Flow, Profitability & Efficiency). NKTR leads in 1 (Total Returns). 2 tied.

Best OverallHalozyme Therapeutics, Inc. (HALO)Leads 2 of 6 categories
Loading custom metrics...

MBRX vs NKTR vs HALO vs IMVT vs RCUS: Key Questions Answered

9 questions · data-driven answers · updated daily

01

Is MBRX or NKTR or HALO or IMVT or RCUS a better buy right now?

For growth investors, Halozyme Therapeutics, Inc.

(HALO) is the stronger pick with 37. 6% revenue growth year-over-year, versus -43. 9% for Nektar Therapeutics (NKTR). Halozyme Therapeutics, Inc. (HALO) offers the better valuation at 25. 5x trailing P/E (8. 1x forward), making it the more compelling value choice. Analysts rate Moleculin Biotech, Inc. (MBRX) a "Buy" — based on 4 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.

02

Which is the better long-term investment — MBRX or NKTR or HALO or IMVT or RCUS?

Over the past 5 years, Immunovant, Inc.

(IMVT) delivered a total return of +62. 4%, compared to -95. 0% for Moleculin Biotech, Inc. (MBRX). Over 10 years, the gap is even starker: HALO returned +570. 7% versus MBRX's -99. 7%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.

03

Which is safer — MBRX or NKTR or HALO or IMVT or RCUS?

By beta (market sensitivity over 5 years), Halozyme Therapeutics, Inc.

(HALO) is the lower-risk stock at 0. 56β versus Arcus Biosciences, Inc. 's 1. 95β — meaning RCUS is approximately 250% more volatile than HALO relative to the S&P 500. On balance sheet safety, Immunovant, Inc. (IMVT) carries a lower debt/equity ratio of 0% versus 166% for Nektar Therapeutics — giving it more financial flexibility in a downturn.

04

Which is growing faster — MBRX or NKTR or HALO or IMVT or RCUS?

By revenue growth (latest reported year), Halozyme Therapeutics, Inc.

(HALO) is pulling ahead at 37. 6% versus -43. 9% for Nektar Therapeutics (NKTR). On earnings-per-share growth, the picture is similar: Moleculin Biotech, Inc. grew EPS 82. 0% year-over-year, compared to -45. 2% for Immunovant, Inc.. Over a 3-year CAGR, RCUS leads at 30. 2% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.

05

Which has better profit margins — MBRX or NKTR or HALO or IMVT or RCUS?

Halozyme Therapeutics, Inc.

(HALO) is the more profitable company, earning 22. 7% net margin versus -297. 1% for Nektar Therapeutics — meaning it keeps 22. 7% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: HALO leads at 58. 4% versus -236. 8% for NKTR. At the gross margin level — before operating expenses — NKTR leads at 100. 0%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.

06

Is MBRX or NKTR or HALO or IMVT or RCUS more undervalued right now?

Analyst consensus price targets imply the most upside for IMVT: 67.

2% to $45. 50.

07

Which pays a better dividend — MBRX or NKTR or HALO or IMVT or RCUS?

In this comparison, MBRX (0.

4% yield) pays a dividend. NKTR, HALO, IMVT, RCUS do not pay a meaningful dividend and should not be held primarily for income.

08

Is MBRX or NKTR or HALO or IMVT or RCUS better for a retirement portfolio?

For long-horizon retirement investors, Halozyme Therapeutics, Inc.

(HALO) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0. 56), +570. 7% 10Y return). Arcus Biosciences, Inc. (RCUS) carries a higher beta of 1. 95 — meaning larger drawdowns in market downturns, which matters significantly when you cannot wait years for a recovery. Both have compounded well over 10 years (HALO: +570. 7%, RCUS: +45. 9%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.

09

What are the main differences between MBRX and NKTR and HALO and IMVT and RCUS?

Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both.

In terms of investment character: MBRX is a small-cap quality compounder stock; NKTR is a small-cap quality compounder stock; HALO is a small-cap high-growth stock; IMVT is a small-cap quality compounder stock; RCUS is a small-cap quality compounder stock. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.

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