OCUL
Ocular Therapeutix, Inc.
Biotechnology
Market Cap$2.12B
5Y Perf.+37.5%
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Stock Comparison
OCUL vs KALA
Revenue, margins, valuation, and 5-year total return — side by side.
KALA
KALA BIO, Inc.
Biotechnology
Market Cap$618K
5Y Perf.-100.0%
OCUL vs KALA — Key Financials
Market cap, revenue, margins, and valuation side-by-side.
| Company Snapshot | OCUL | KALA |
|---|---|---|
| Industry | Biotechnology | Biotechnology |
| Market Cap | $2.12B | $618K |
| Revenue (TTM) | $52M | $254K |
| Net Income (TTM) | $-290M | $-36M |
| Gross Margin | 87.2% | -3.1% |
| Operating Margin | -5.8% | -150.6% |
| Total Debt | $80M | $32M |
| Cash & Equiv. | $737M | $51M |
OCUL vs KALA — Long-Term Stock Performance
Price return indexed to 100 at period start. Dividends excluded.
OCUL
KALA
| Stock | May 20 | May 26 | Return |
|---|---|---|---|
| Ocular Therapeutix,… (OCUL) | 100 | 137.5 | +37.5% |
| KALA BIO, Inc. (KALA) | 100 | 0.0 | -100.0% |
Price return only. Dividends and distributions are not included.
Quick Verdict: OCUL vs KALA
Each card shows where this stock fits in a portfolio — not just who wins on paper.
Bottom line: OCUL leads in 4 of 6 categories, making it the strongest pick for profitability and margin quality and capital preservation and lower volatility. KALA BIO, Inc. is the stronger pick specifically for growth and revenue expansion. As sector peers, any of these can serve as alternatives in the same allocation.
OCUL
Ocular Therapeutix, Inc.
The Income Pick
OCUL carries the broadest edge in this set and is the clearest fit for income & stability and long-term compounding.
- beta 1.27
- -10.6% 10Y total return vs KALA's -100.0%
- Lower volatility, beta 1.27, Low D/E 12.2%, current ratio 15.39x
Best for: income & stability and long-term compounding
KALA
KALA BIO, Inc.
The Growth Play
KALA is the clearest fit if your priority is growth exposure.
- Rev growth 262.9%, EPS growth 59.8%
- 262.9% revenue growth vs OCUL's -18.7%
Best for: growth exposure
See the full category breakdown
| Category | Winner | Why |
|---|---|---|
| Growth | KALA | 262.9% revenue growth vs OCUL's -18.7% |
| Quality / Margins | OCUL | -5.6% margin vs KALA's -141.1% |
| Stability / Safety | OCUL | Beta 1.27 vs KALA's 2.09, lower leverage |
| Dividends | Tie | Neither stock pays a meaningful dividend |
| Momentum (1Y) | OCUL | +37.3% vs KALA's -97.6% |
| Efficiency (ROA) | OCUL | -48.4% ROA vs KALA's -143.2% |
OCUL vs KALA — Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
FY 2025
Segment breakdown not available.
OCUL vs KALA — Financial Metrics
Side-by-side numbers across 2 stocks — who leads on profitability, valuation, growth, and risk.
BEST OVERALLOCULLAGGINGKALA
KALAKALA BIO, Inc.
0leads
OCULOcular Therapeutix, I…
4leads
6 Total Categories
CATEGORYLEADERvs KALAMETRICS WON
Income & Cash FlowRevenue, margins, and cash flow strength
OCUL4/5
Valuation MetricsMultiples, price ratios, and targets
Tied
—
Profitability & EfficiencyROE, ROIC, leverage, and quality scores
OCUL6/8
Total Returns1Y, 3Y, 5Y total returns with dividends
OCUL6/6
Risk & VolatilityBeta, volatility, and downside exposure
OCUL2/2
Analyst OutlookRatings, price targets, and dividends
—
—
Income & Cash Flow (Last 12 Months)
OCUL leads this category, winning 4 of 5 comparable metrics.
Income & Cash Flow (Last 12 Months)
OCUL is the larger business by revenue, generating $52M annually — 204.9x KALA's $254,000. OCUL is the more profitable business, keeping -5.6% of every revenue dollar as net income compared to KALA's -141.1%.
| Metric | OCULOcular Therapeuti… | KALAKALA BIO, Inc. |
|---|---|---|
| RevenueTrailing 12 months | $52M | $254,000 |
| EBITDAEarnings before interest/tax | -$295M | -$38M |
| Net IncomeAfter-tax profit | -$290M | -$36M |
| Free Cash FlowCash after capex | -$241M | -$32M |
| Gross MarginGross profit ÷ Revenue | +87.2% | -3.1% |
| Operating MarginEBIT ÷ Revenue | -5.8% | -150.6% |
| Net MarginNet income ÷ Revenue | -5.6% | -141.1% |
| FCF MarginFCF ÷ Revenue | -4.6% | -126.3% |
| Rev. Growth (YoY)Latest quarter vs prior year | +0.8% | — |
| EPS Growth (YoY)Latest quarter vs prior year | -5.3% | +44.6% |
OCUL leads this category, winning 4 of 5 comparable metrics.
Valuation Metrics
Evenly matched — OCUL and KALA each lead in 1 of 2 comparable metrics.
Valuation Metrics
| Metric | OCULOcular Therapeuti… | KALAKALA BIO, Inc. |
|---|---|---|
| Market CapShares × price | $2.1B | $617,676 |
| Enterprise ValueMkt cap + debt − cash | $1.5B | -$18M |
| Trailing P/EPrice ÷ TTM EPS | -6.82x | -0.01x |
| Forward P/EPrice ÷ next-FY EPS est. | — | — |
| PEG RatioP/E ÷ EPS growth rate | — | — |
| EV / EBITDAEnterprise value multiple | — | — |
| Price / SalesMarket cap ÷ Revenue | 40.90x | — |
| Price / BookPrice ÷ Book value/share | 2.77x | 0.04x |
| Price / FCFMarket cap ÷ FCF | — | — |
Evenly matched — OCUL and KALA each lead in 1 of 2 comparable metrics.
Profitability & Efficiency
OCUL leads this category, winning 6 of 8 comparable metrics.
Profitability & Efficiency
OCUL delivers a -64.6% return on equity — every $100 of shareholder capital generates $-65 in annual profit, vs $-4 for KALA. OCUL carries lower financial leverage with a 0.12x debt-to-equity ratio, signaling a more conservative balance sheet compared to KALA's 2.62x. On the Piotroski fundamental quality scale (0–9), OCUL scores 4/9 vs KALA's 2/9, reflecting mixed financial health.
| Metric | OCULOcular Therapeuti… | KALAKALA BIO, Inc. |
|---|---|---|
| ROE (TTM)Return on equity | -64.6% | -3.9% |
| ROA (TTM)Return on assets | -48.4% | -143.2% |
| ROICReturn on invested capital | — | — |
| ROCEReturn on capital employed | -46.0% | -95.2% |
| Piotroski ScoreFundamental quality 0–9 | 4 | 2 |
| Debt / EquityFinancial leverage | 0.12x | 2.62x |
| Net DebtTotal debt minus cash | -$657M | -$19M |
| Cash & Equiv.Liquid assets | $737M | $51M |
| Total DebtShort + long-term debt | $80M | $32M |
| Interest CoverageEBIT ÷ Interest expense | -24.63x | -6.92x |
OCUL leads this category, winning 6 of 8 comparable metrics.
Total Returns (Dividends Reinvested)
OCUL leads this category, winning 6 of 6 comparable metrics.
Total Returns (Dividends Reinvested)
A $10,000 investment in OCUL five years ago would be worth $5,957 today (with dividends reinvested), compared to $3 for KALA. Over the past 12 months, OCUL leads with a +37.3% total return vs KALA's -97.6%. The 3-year compound annual growth rate (CAGR) favors OCUL at 14.8% vs KALA's -82.6% — a key indicator of consistent wealth creation.
| Metric | OCULOcular Therapeuti… | KALAKALA BIO, Inc. |
|---|---|---|
| YTD ReturnYear-to-date | -18.1% | -86.6% |
| 1-Year ReturnPast 12 months | +37.3% | -97.6% |
| 3-Year ReturnCumulative with dividends | +51.2% | -99.5% |
| 5-Year ReturnCumulative with dividends | -40.4% | -100.0% |
| 10-Year ReturnCumulative with dividends | -10.6% | -100.0% |
| CAGR (3Y)Annualised 3-year return | +14.8% | -82.6% |
OCUL leads this category, winning 6 of 6 comparable metrics.
Risk & Volatility
OCUL leads this category, winning 2 of 2 comparable metrics.
Risk & Volatility
OCUL is the less volatile stock with a 1.27 beta — it tends to amplify market swings less than KALA's 2.09 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. OCUL currently trades 58.9% from its 52-week high vs KALA's 0.4% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | OCULOcular Therapeuti… | KALAKALA BIO, Inc. |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 1.27x | 2.09x |
| 52-Week HighHighest price in past year | $16.44 | $20.60 |
| 52-Week LowLowest price in past year | $6.23 | $0.08 |
| % of 52W HighCurrent price vs 52-week peak | +58.9% | +0.4% |
| RSI (14)Momentum oscillator 0–100 | 58.3 | 30.1 |
| Avg Volume (50D)Average daily shares traded | 4.0M | 9.2M |
OCUL leads this category, winning 2 of 2 comparable metrics.
Analyst Outlook
Insufficient data to determine a leader in this category.
Analyst Outlook
Wall Street rates OCUL as "Buy" and KALA as "Buy". Consensus price targets imply 21861.5% upside for KALA (target: $18) vs 163.4% for OCUL (target: $26).
| Metric | OCULOcular Therapeuti… | KALAKALA BIO, Inc. |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Buy | Buy |
| Price TargetConsensus 12-month target | $25.50 | $18.25 |
| # AnalystsCovering analysts | 18 | 9 |
| Dividend YieldAnnual dividend ÷ price | — | — |
| Dividend StreakConsecutive years of raises | — | — |
| Dividend / ShareAnnual DPS | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | 0.0% |
Insufficient data to determine a leader in this category.
Key Takeaway
OCUL leads in 4 of 6 categories — strongest in Income & Cash Flow and Profitability & Efficiency. 1 category is tied.
Best OverallOcular Therapeutix, Inc. (OCUL)Leads 4 of 6 categories
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OCUL vs KALA: Frequently Asked Questions
8 questions · data-driven answers · updated daily
01Is OCUL or KALA a better buy right now?
Analysts rate Ocular Therapeutix, Inc.
(OCUL) a "Buy" — based on 18 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — OCUL or KALA?
Over the past 5 years, Ocular Therapeutix, Inc.
(OCUL) delivered a total return of -40. 4%, compared to -100. 0% for KALA BIO, Inc. (KALA). Over 10 years, the gap is even starker: OCUL returned -10. 6% versus KALA's -100. 0%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — OCUL or KALA?
By beta (market sensitivity over 5 years), Ocular Therapeutix, Inc.
(OCUL) is the lower-risk stock at 1. 27β versus KALA BIO, Inc. 's 2. 09β — meaning KALA is approximately 65% more volatile than OCUL relative to the S&P 500. On balance sheet safety, Ocular Therapeutix, Inc. (OCUL) carries a lower debt/equity ratio of 12% versus 3% for KALA BIO, Inc. — giving it more financial flexibility in a downturn.
04Which is growing faster — OCUL or KALA?
On earnings-per-share growth, the picture is similar: KALA BIO, Inc.
grew EPS 59. 8% year-over-year, compared to -16. 4% for Ocular Therapeutix, Inc.. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.
05Which has better profit margins — OCUL or KALA?
Ocular Therapeutix, Inc.
(OCUL) is the more profitable company, earning -513. 2% net margin versus -141. 1% for KALA BIO, Inc. — meaning it keeps -513. 2% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: OCUL leads at -521. 0% versus -150. 6% for KALA. At the gross margin level — before operating expenses — OCUL leads at 87. 3%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
06Which pays a better dividend — OCUL or KALA?
None of the stocks in this comparison currently pay a material dividend.
All are effectively zero-yield and should be held for capital appreciation rather than income.
07Is OCUL or KALA better for a retirement portfolio?
For long-horizon retirement investors, Ocular Therapeutix, Inc.
(OCUL) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 1. 27)). KALA BIO, Inc. (KALA) carries a higher beta of 2. 09 — meaning larger drawdowns in market downturns, which matters significantly when you cannot wait years for a recovery. Both have compounded well over 10 years (OCUL: -10. 6%, KALA: -100. 0%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
08What are the main differences between OCUL and KALA?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both.
These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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