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Stock Comparison

OFIX vs GMED vs SYK vs NVCR

Revenue, margins, valuation, and 5-year total return — side by side.

Live fundamentals10-year financials5-year price chart
OFIX
Orthofix Medical Inc.

Medical - Devices

HealthcareNASDAQ • US
Market Cap$488M
5Y Perf.-64.6%
GMED
Globus Medical, Inc.

Medical - Devices

HealthcareNYSE • US
Market Cap$11.51B
5Y Perf.+55.7%
SYK
Stryker Corporation

Medical - Devices

HealthcareNYSE • US
Market Cap$112.69B
5Y Perf.+50.3%
NVCR
NovoCure Limited

Medical - Instruments & Supplies

HealthcareNASDAQ • JE
Market Cap$1.92B
5Y Perf.-75.0%

OFIX vs GMED vs SYK vs NVCR — Key Financials

Market cap, revenue, margins, and valuation side-by-side.

Company Snapshot
OFIX logoOFIX
GMED logoGMED
SYK logoSYK
NVCR logoNVCR
IndustryMedical - DevicesMedical - DevicesMedical - DevicesMedical - Instruments & Supplies
Market Cap$488M$11.51B$112.69B$1.92B
Revenue (TTM)$825M$3.10B$25.12B$674M
Net Income (TTM)$-60M$587M$3.25B$-173M
Gross Margin69.0%50.9%63.5%75.2%
Operating Margin-4.0%17.2%22.4%-27.2%
Forward P/E19.0x19.6x
Total Debt$229M$119M$14.86B$290M
Cash & Equiv.$82M$526M$4.01B$103M

OFIX vs GMED vs SYK vs NVCRLong-Term Stock Performance

Price return indexed to 100 at period start. Dividends excluded.

OFIX
GMED
SYK
NVCR
StockMay 20May 26Return
Orthofix Medical In… (OFIX)10035.4-64.6%
Globus Medical, Inc. (GMED)100155.7+55.7%
Stryker Corporation (SYK)100150.3+50.3%
NovoCure Limited (NVCR)10025.0-75.0%

Price return only. Dividends and distributions are not included.

Quick Verdict: OFIX vs GMED vs SYK vs NVCR

Each card shows where this stock fits in a portfolio — not just who wins on paper.

Bottom line: GMED leads in 5 of 7 categories, making it the strongest pick for growth and revenue expansion and valuation and capital efficiency. Stryker Corporation is the stronger pick specifically for capital preservation and lower volatility and dividend income and shareholder returns. As sector peers, any of these can serve as alternatives in the same allocation.
OFIX
Orthofix Medical Inc.
The Specific-Use Pick

OFIX plays a supporting role in this comparison — it may shine differently against other peers.

Best for: healthcare exposure
GMED
Globus Medical, Inc.
The Growth Play

GMED carries the broadest edge in this set and is the clearest fit for growth exposure and long-term compounding.

  • Rev growth 16.7%, EPS growth 422.7%, 3Y rev CAGR 42.2%
  • 264.4% 10Y total return vs SYK's 187.1%
  • Lower volatility, beta 1.29, Low D/E 2.6%, current ratio 4.26x
  • PEG 0.61 vs SYK's 1.32
Best for: growth exposure and long-term compounding
SYK
Stryker Corporation
The Income Pick

SYK is the #2 pick in this set and the best alternative if income & stability is your priority.

  • Dividend streak 34 yrs, beta 0.55, yield 1.1%
  • Beta 0.55 vs NVCR's 2.20, lower leverage
  • 1.1% yield; 34-year raise streak; the other 3 pay no meaningful dividend
Best for: income & stability
NVCR
NovoCure Limited
The Secondary Option

NVCR lags the leaders in this set but could rank higher in a more targeted comparison.

Best for: healthcare exposure
See the full category breakdown
CategoryWinnerWhy
GrowthGMED logoGMED16.7% revenue growth vs OFIX's 2.9%
ValueGMED logoGMEDBetter valuation composite
Quality / MarginsGMED logoGMED18.9% margin vs NVCR's -25.7%
Stability / SafetySYK logoSYKBeta 0.55 vs NVCR's 2.20, lower leverage
DividendsSYK logoSYK1.1% yield; 34-year raise streak; the other 3 pay no meaningful dividend
Momentum (1Y)GMED logoGMED+19.0% vs SYK's -22.5%
Efficiency (ROA)GMED logoGMED11.3% ROA vs NVCR's -16.5%, ROIC 8.9% vs -16.4%

OFIX vs GMED vs SYK vs NVCR — Revenue Breakdown by Segment

How each company's revenue is distributed across its business units

OFIXOrthofix Medical Inc.
FY 2025
Global Spine
100.0%$688M
GMEDGlobus Medical, Inc.
FY 2024
Spine
93.9%$2.4B
Emerging Technology
6.1%$154M
SYKStryker Corporation
FY 2025
MedSurg
62.3%$15.6B
Orthopaedics
37.7%$9.5B
NVCRNovoCure Limited

Segment breakdown not available.

OFIX vs GMED vs SYK vs NVCR — Financial Metrics

Side-by-side numbers across 4 stocks — who leads on profitability, valuation, growth, and risk.

BEST OVERALLGMEDLAGGINGNVCR

Income & Cash Flow (Last 12 Months)

GMED leads this category, winning 4 of 6 comparable metrics.

SYK is the larger business by revenue, generating $25.1B annually — 37.2x NVCR's $674M. GMED is the more profitable business, keeping 18.9% of every revenue dollar as net income compared to NVCR's -25.7%. On growth, GMED holds the edge at +27.0% YoY revenue growth, suggesting stronger near-term business momentum.

MetricOFIX logoOFIXOrthofix Medical …GMED logoGMEDGlobus Medical, I…SYK logoSYKStryker Corporati…NVCR logoNVCRNovoCure Limited
RevenueTrailing 12 months$825M$3.1B$25.1B$674M
EBITDAEarnings before interest/tax$102M$745M$6.3B-$165M
Net IncomeAfter-tax profit-$60M$587M$3.2B-$173M
Free Cash FlowCash after capex-$4M$605M$4.3B-$48M
Gross MarginGross profit ÷ Revenue+69.0%+50.9%+63.5%+75.2%
Operating MarginEBIT ÷ Revenue-4.0%+17.2%+22.4%-27.2%
Net MarginNet income ÷ Revenue-7.3%+18.9%+12.9%-25.7%
FCF MarginFCF ÷ Revenue-0.4%+19.5%+17.1%-7.1%
Rev. Growth (YoY)Latest quarter vs prior year+1.6%+27.0%+11.4%+12.3%
EPS Growth (YoY)Latest quarter vs prior year+61.5%+66.7%+56.0%-100.0%
GMED leads this category, winning 4 of 6 comparable metrics.

Valuation Metrics

GMED leads this category, winning 4 of 7 comparable metrics.

At 21.7x trailing earnings, GMED trades at a 38% valuation discount to SYK's 35.0x P/E. Adjusting for growth (PEG ratio), GMED offers better value at 0.70x vs SYK's 2.36x — a lower PEG means you pay less per unit of expected earnings growth.

MetricOFIX logoOFIXOrthofix Medical …GMED logoGMEDGlobus Medical, I…SYK logoSYKStryker Corporati…NVCR logoNVCRNovoCure Limited
Market CapShares × price$488M$11.5B$112.7B$1.9B
Enterprise ValueMkt cap + debt − cash$635M$11.1B$123.5B$2.1B
Trailing P/EPrice ÷ TTM EPS-5.29x21.70x35.03x-13.80x
Forward P/EPrice ÷ next-FY EPS est.19.03x19.62x
PEG RatioP/E ÷ EPS growth rate0.70x2.36x
EV / EBITDAEnterprise value multiple18.51x20.31x
Price / SalesMarket cap ÷ Revenue0.59x3.92x4.49x2.92x
Price / BookPrice ÷ Book value/share1.07x2.55x5.02x5.51x
Price / FCFMarket cap ÷ FCF19.54x26.31x
GMED leads this category, winning 4 of 7 comparable metrics.

Profitability & Efficiency

GMED leads this category, winning 6 of 9 comparable metrics.

SYK delivers a 15.0% return on equity — every $100 of shareholder capital generates $15 in annual profit, vs $-51 for NVCR. GMED carries lower financial leverage with a 0.03x debt-to-equity ratio, signaling a more conservative balance sheet compared to NVCR's 0.85x. On the Piotroski fundamental quality scale (0–9), GMED scores 9/9 vs OFIX's 4/9, reflecting strong financial health.

MetricOFIX logoOFIXOrthofix Medical …GMED logoGMEDGlobus Medical, I…SYK logoSYKStryker Corporati…NVCR logoNVCRNovoCure Limited
ROE (TTM)Return on equity-13.4%+13.0%+15.0%-50.8%
ROA (TTM)Return on assets-7.0%+11.3%+6.9%-16.5%
ROICReturn on invested capital-8.6%+8.9%+11.4%-16.4%
ROCEReturn on capital employed-9.7%+10.4%+13.0%-28.9%
Piotroski ScoreFundamental quality 0–94965
Debt / EquityFinancial leverage0.51x0.03x0.66x0.85x
Net DebtTotal debt minus cash$147M-$408M$10.8B$187M
Cash & Equiv.Liquid assets$82M$526M$4.0B$103M
Total DebtShort + long-term debt$229M$119M$14.9B$290M
Interest CoverageEBIT ÷ Interest expense-4.97x81.13x6.72x-96.80x
GMED leads this category, winning 6 of 9 comparable metrics.

Total Returns (Dividends Reinvested)

GMED leads this category, winning 4 of 6 comparable metrics.

A $10,000 investment in SYK five years ago would be worth $12,152 today (with dividends reinvested), compared to $875 for NVCR. Over the past 12 months, GMED leads with a +19.0% total return vs SYK's -22.5%. The 3-year compound annual growth rate (CAGR) favors GMED at 13.5% vs NVCR's -37.6% — a key indicator of consistent wealth creation.

MetricOFIX logoOFIXOrthofix Medical …GMED logoGMEDGlobus Medical, I…SYK logoSYKStryker Corporati…NVCR logoNVCRNovoCure Limited
YTD ReturnYear-to-date-18.7%-2.5%-15.2%+28.3%
1-Year ReturnPast 12 months+0.4%+19.0%-22.5%+1.1%
3-Year ReturnCumulative with dividends-35.1%+46.3%+5.5%-75.7%
5-Year ReturnCumulative with dividends-72.7%+16.1%+21.5%-91.3%
10-Year ReturnCumulative with dividends-72.0%+264.4%+187.1%+30.3%
CAGR (3Y)Annualised 3-year return-13.4%+13.5%+1.8%-37.6%
GMED leads this category, winning 4 of 6 comparable metrics.

Risk & Volatility

Evenly matched — GMED and SYK each lead in 1 of 2 comparable metrics.

SYK is the less volatile stock with a 0.55 beta — it tends to amplify market swings less than NVCR's 2.20 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. GMED currently trades 83.9% from its 52-week high vs OFIX's 71.0% drawdown — a narrower gap to the peak suggests stronger recent price momentum.

MetricOFIX logoOFIXOrthofix Medical …GMED logoGMEDGlobus Medical, I…SYK logoSYKStryker Corporati…NVCR logoNVCRNovoCure Limited
Beta (5Y)Sensitivity to S&P 5001.21x1.29x0.55x2.20x
52-Week HighHighest price in past year$16.99$101.40$404.87$20.06
52-Week LowLowest price in past year$10.24$51.79$289.91$9.82
% of 52W HighCurrent price vs 52-week peak+71.0%+83.9%+72.7%+83.9%
RSI (14)Momentum oscillator 0–10050.445.024.369.8
Avg Volume (50D)Average daily shares traded274K998K2.1M1.5M
Evenly matched — GMED and SYK each lead in 1 of 2 comparable metrics.

Analyst Outlook

Insufficient data to determine a leader in this category.

Analyst consensus: OFIX as "Hold", GMED as "Buy", SYK as "Buy", NVCR as "Buy". Consensus price targets imply 99.0% upside for NVCR (target: $34) vs 30.1% for GMED (target: $111). SYK is the only dividend payer here at 1.14% yield — a key consideration for income-focused portfolios.

MetricOFIX logoOFIXOrthofix Medical …GMED logoGMEDGlobus Medical, I…SYK logoSYKStryker Corporati…NVCR logoNVCRNovoCure Limited
Analyst RatingConsensus buy/hold/sellHoldBuyBuyBuy
Price TargetConsensus 12-month target$18.00$110.67$403.69$33.50
# AnalystsCovering analysts17365015
Dividend YieldAnnual dividend ÷ price+1.1%
Dividend StreakConsecutive years of raises34
Dividend / ShareAnnual DPS$3.36
Buyback YieldShare repurchases ÷ mkt cap0.0%+2.6%0.0%0.0%
Insufficient data to determine a leader in this category.
Key Takeaway

GMED leads in 4 of 6 categories — strongest in Income & Cash Flow and Valuation Metrics. 1 category is tied.

Best OverallGlobus Medical, Inc. (GMED)Leads 4 of 6 categories
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OFIX vs GMED vs SYK vs NVCR: Key Questions Answered

10 questions · data-driven answers · updated daily

01

Is OFIX or GMED or SYK or NVCR a better buy right now?

For growth investors, Globus Medical, Inc.

(GMED) is the stronger pick with 16. 7% revenue growth year-over-year, versus 2. 9% for Orthofix Medical Inc. (OFIX). Globus Medical, Inc. (GMED) offers the better valuation at 21. 7x trailing P/E (19. 0x forward), making it the more compelling value choice. Analysts rate Globus Medical, Inc. (GMED) a "Buy" — based on 36 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.

02

Which has the better valuation — OFIX or GMED or SYK or NVCR?

On trailing P/E, Globus Medical, Inc.

(GMED) is the cheapest at 21. 7x versus Stryker Corporation at 35. 0x. On forward P/E, Globus Medical, Inc. is actually cheaper at 19. 0x. The PEG ratio (P/E divided by earnings growth rate) is the most growth-adjusted single valuation metric: Globus Medical, Inc. wins at 0. 61x versus Stryker Corporation's 1. 32x — a PEG below 1. 0 traditionally signals the market is underpricing earnings growth.

03

Which is the better long-term investment — OFIX or GMED or SYK or NVCR?

Over the past 5 years, Stryker Corporation (SYK) delivered a total return of +21.

5%, compared to -91. 3% for NovoCure Limited (NVCR). Over 10 years, the gap is even starker: GMED returned +264. 4% versus OFIX's -72. 0%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.

04

Which is safer — OFIX or GMED or SYK or NVCR?

By beta (market sensitivity over 5 years), Stryker Corporation (SYK) is the lower-risk stock at 0.

55β versus NovoCure Limited's 2. 20β — meaning NVCR is approximately 303% more volatile than SYK relative to the S&P 500. On balance sheet safety, Globus Medical, Inc. (GMED) carries a lower debt/equity ratio of 3% versus 85% for NovoCure Limited — giving it more financial flexibility in a downturn.

05

Which is growing faster — OFIX or GMED or SYK or NVCR?

By revenue growth (latest reported year), Globus Medical, Inc.

(GMED) is pulling ahead at 16. 7% versus 2. 9% for Orthofix Medical Inc. (OFIX). On earnings-per-share growth, the picture is similar: Globus Medical, Inc. grew EPS 422. 7% year-over-year, compared to 8. 2% for Stryker Corporation. Over a 3-year CAGR, GMED leads at 42. 2% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.

06

Which has better profit margins — OFIX or GMED or SYK or NVCR?

Globus Medical, Inc.

(GMED) is the more profitable company, earning 18. 3% net margin versus -20. 8% for NovoCure Limited — meaning it keeps 18. 3% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: SYK leads at 19. 5% versus -23. 5% for NVCR. At the gross margin level — before operating expenses — NVCR leads at 74. 5%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.

07

Is OFIX or GMED or SYK or NVCR more undervalued right now?

The PEG ratio (forward P/E divided by expected earnings growth rate) is the most precise measure of undervaluation relative to growth potential.

By this metric, Globus Medical, Inc. (GMED) is the more undervalued stock at a PEG of 0. 61x versus Stryker Corporation's 1. 32x. A PEG below 1. 0 is traditionally considered the threshold for growth-adjusted undervaluation. On forward earnings alone, Globus Medical, Inc. (GMED) trades at 19. 0x forward P/E versus 19. 6x for Stryker Corporation — 0. 6x cheaper on a one-year earnings basis. Analyst consensus price targets imply the most upside for NVCR: 99. 0% to $33. 50.

08

Which pays a better dividend — OFIX or GMED or SYK or NVCR?

In this comparison, SYK (1.

1% yield) pays a dividend. OFIX, GMED, NVCR do not pay a meaningful dividend and should not be held primarily for income.

09

Is OFIX or GMED or SYK or NVCR better for a retirement portfolio?

For long-horizon retirement investors, Stryker Corporation (SYK) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0.

55), 1. 1% yield, +187. 1% 10Y return). NovoCure Limited (NVCR) carries a higher beta of 2. 20 — meaning larger drawdowns in market downturns, which matters significantly when you cannot wait years for a recovery. Both have compounded well over 10 years (SYK: +187. 1%, NVCR: +30. 3%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.

10

What are the main differences between OFIX and GMED and SYK and NVCR?

Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both.

In terms of investment character: OFIX is a small-cap quality compounder stock; GMED is a mid-cap high-growth stock; SYK is a mid-cap quality compounder stock; NVCR is a small-cap quality compounder stock. SYK pays a dividend while OFIX, GMED, NVCR do not, making them suitable for different income and tax situations. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.

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OFIX

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  • Sector: Healthcare
  • Market Cap > $100B
  • Gross Margin > 41%
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  • Market Cap > $100B
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  • Sector: Healthcare
  • Market Cap > $100B
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NVCR

Quality Business

  • Sector: Healthcare
  • Market Cap > $100B
  • Revenue Growth > 6%
  • Gross Margin > 45%
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Beat Both

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Revenue Growth>
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(OFIX: 1.6% · GMED: 27.0%)

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