OKUR
OnKure Therapeutics, Inc.
Biotechnology
Market Cap$57M
5Y Perf.-97.1%
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Side-by-side financial analysisOKUR
PRAX
ACAD
ARVN
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Stock Comparison
OKUR vs PRAX vs ACAD vs ARVN
Revenue, margins, valuation, and 5-year total return — side by side.
PRAX
Praxis Precision Medicines, Inc.
Biotechnology
Market Cap$7.70B
5Y Perf.-42.0%
ACAD
ACADIA Pharmaceuticals Inc.
Biotechnology
Market Cap$3.61B
5Y Perf.+2.6%
ARVN
Arvinas, Inc.
Biotechnology
Market Cap$489M
5Y Perf.-89.0%
OKUR vs PRAX vs ACAD vs ARVN — Key Financials
Market cap, revenue, margins, and valuation side-by-side.
| Company Snapshot |  OKUR |  PRAX |  ACAD |  ARVN |
|---|---|---|---|---|
| Industry | Biotechnology | Biotechnology | Biotechnology | Biotechnology |
| Market Cap | $57M | $7.70B | $3.61B | $489M |
| Revenue (TTM) | $0.00 | $0.00 | $1.10B | $89M |
| Net Income (TTM) | $-44M | $-327M | $376M | $-221M |
| Gross Margin | — | — | 91.5% | 97.4% |
| Operating Margin | — | — | 7.4% | -279.3% |
| Forward P/E | — | — | 54.2x | — |
| Total Debt | $549K | $110K | $52M | $9M |
| Cash & Equiv. | $59M | $357M | $178M | $143M |
OKUR vs PRAX vs ACAD vs ARVN — Long-Term Stock Performance
Price return indexed to 100 at period start. Dividends excluded.
OKUR
PRAX
ACAD
ARVN
| Stock | Apr 21 | Jun 26 | Return |
|---|---|---|---|
| OnKure Therapeutics… (OKUR) | 100 | 2.9 | -97.1% |
| Praxis Precision Me… (PRAX) | 100 | 58.0 | -42.0% |
| ACADIA Pharmaceutic… (ACAD) | 100 | 102.6 | +2.6% |
| Arvinas, Inc. (ARVN) | 100 | 11.0 | -89.0% |
Price return only. Dividends and distributions are not included.
Quick Verdict: OKUR vs PRAX vs ACAD vs ARVN
Each card shows where this stock fits in a portfolio — not just who wins on paper.
Bottom line: ACAD leads in 3 of 6 categories, making it the strongest pick for profitability and margin quality and capital preservation and lower volatility. OnKure Therapeutics, Inc. is the stronger pick specifically for growth and revenue expansion. PRAX also leads in specific categories worth noting. As sector peers, any of these can serve as alternatives in the same allocation.
🥇ACAD emerged as the overall leader. Track its performance:
OKUR
OnKure Therapeutics, Inc.
The Defensive Pick
OKUR is the #2 pick in this set and the best alternative if sleep-well-at-night and defensive is your priority.
- Lower volatility, beta 1.34, Low D/E 1.0%, current ratio 10.28x
- Beta 1.34, current ratio 10.28x
- 84.4% revenue growth vs PRAX's -100.0%
Best for: sleep-well-at-night and defensive
PRAX
Praxis Precision Medicines, Inc.
The Long-Run Compounder
PRAX is the clearest fit if your priority is long-term compounding.
- -36.1% 10Y total return vs ACAD's -44.6%
- +491.9% vs ACAD's -3.0%
Best for: long-term compounding
ACAD
ACADIA Pharmaceuticals Inc.
The Income Pick
ACAD carries the broadest edge in this set and is the clearest fit for income & stability and growth exposure.
- beta 1.10
- Rev growth 11.9%, EPS growth 68.4%, 3Y rev CAGR 27.5%
- 34.3% margin vs ARVN's -247.5%
- Beta 1.10 vs PRAX's 1.55
Best for: income & stability and growth exposure
ARVN
Arvinas, Inc.
The Secondary Option
ARVN lags the leaders in this set but could rank higher in a more targeted comparison.
Best for: healthcare exposure
See the full category breakdown
| Category | Winner | Why |
|---|---|---|
| Growth |  OKUR | 84.4% revenue growth vs PRAX's -100.0% |
| Quality / Margins |  ACAD | 34.3% margin vs ARVN's -247.5% |
| Stability / Safety | ACAD | Beta 1.10 vs PRAX's 1.55 |
| Dividends | Tie | None of these 4 stocks pay a meaningful dividend |
| Momentum (1Y) |  PRAX | +491.9% vs ACAD's -3.0% |
| Efficiency (ROA) | ACAD | 26.2% ROA vs OKUR's -41.5% |
OKUR vs PRAX vs ACAD vs ARVN — Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
FY 2024
FY 2018
FY 2025
OKUR vs PRAX vs ACAD vs ARVN — Financial Metrics
Side-by-side numbers across 4 stocks — who leads on profitability, valuation, growth, and risk.
BEST OVERALLACADLAGGINGARVN
Who Leads Where
ACAD leads in 2 of 6 categories
PRAX leads 1 • OKUR leads 0 • ARVN leads 0 • 2 tied
Explore the data ↓ARVNArvinas, Inc.
0leads
OKUROnKure Therapeutics, …
0leads
PRAXPraxis Precision Medi…
1leads
ACADACADIA Pharmaceutical…
2leads
6 Total Categories
CATEGORYLEADERvs PRAXvs OKURMETRICS WON
Income & Cash FlowRevenue, margins, and cash flow strength
ACAD4/6
Valuation MetricsMultiples, price ratios, and targets
Tied
—
Profitability & EfficiencyROE, ROIC, leverage, and quality scores
ACAD5/8
Total Returns1Y, 3Y, 5Y total returns with dividends
PRAX5/6
Risk & VolatilityBeta, volatility, and downside exposure
Tied
—
Analyst OutlookRatings, price targets, and dividends
—
—
Income & Cash Flow (Last 12 Months)
ACAD leads this category, winning 4 of 6 comparable metrics.
Income & Cash Flow (Last 12 Months)
ACAD and PRAX operate at a comparable scale, with $1.1B and $0 in trailing revenue. ACAD is the more profitable business, keeping 34.3% of every revenue dollar as net income compared to ARVN's -2.5%. On growth, ACAD holds the edge at +9.7% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | OKUROnKure Therapeuti… | PRAXPraxis Precision … | ACADACADIA Pharmaceut… |  ARVNArvinas, Inc. |
|---|---|---|---|---|
| RevenueTrailing 12 months | $0 | $0 | $1.1B | $89M |
| EBITDAEarnings before interest/tax | -$61M | -$357M | $96M | -$245M |
| Net IncomeAfter-tax profit | -$44M | -$327M | $376M | -$221M |
| Free Cash FlowCash after capex | -$51M | -$283M | $212M | -$257M |
| Gross MarginGross profit ÷ Revenue | — | — | +91.5% | +97.4% |
| Operating MarginEBIT ÷ Revenue | — | — | +7.4% | -2.8% |
| Net MarginNet income ÷ Revenue | — | — | +34.3% | -2.5% |
| FCF MarginFCF ÷ Revenue | — | — | +19.4% | -2.9% |
| Rev. Growth (YoY)Latest quarter vs prior year | — | — | +9.7% | -91.7% |
| EPS Growth (YoY)Latest quarter vs prior year | +6.7% | +2.7% | -81.8% | -178.9% |
ACAD leads this category, winning 4 of 6 comparable metrics.
Valuation Metrics
Evenly matched — OKUR and PRAX and ARVN each lead in 1 of 3 comparable metrics.
Valuation Metrics
| Metric | OKUROnKure Therapeuti… | PRAXPraxis Precision … | ACADACADIA Pharmaceut… | ARVNArvinas, Inc. |
|---|---|---|---|---|
| Market CapShares × price | $57M | $7.7B | $3.6B | $489M |
| Enterprise ValueMkt cap + debt − cash | -$1M | $7.3B | $3.5B | $355M |
| Trailing P/EPrice ÷ TTM EPS | -0.95x | -19.77x | 9.21x | -5.92x |
| Forward P/EPrice ÷ next-FY EPS est. | — | — | 54.20x | — |
| PEG RatioP/E ÷ EPS growth rate | — | — | — | — |
| EV / EBITDAEnterprise value multiple | — | — | 25.09x | — |
| Price / SalesMarket cap ÷ Revenue | — | — | 3.37x | 1.86x |
| Price / BookPrice ÷ Book value/share | 1.01x | 6.83x | 2.94x | 1.13x |
| Price / FCFMarket cap ÷ FCF | — | — | 34.34x | — |
Evenly matched — OKUR and PRAX and ARVN each lead in 1 of 3 comparable metrics.
Profitability & Efficiency
ACAD leads this category, winning 5 of 8 comparable metrics.
Profitability & Efficiency
ACAD delivers a 35.6% return on equity — every $100 of shareholder capital generates $36 in annual profit, vs $-45 for OKUR. PRAX carries lower financial leverage with a 0.00x debt-to-equity ratio, signaling a more conservative balance sheet compared to ACAD's 0.04x. On the Piotroski fundamental quality scale (0–9), ACAD scores 6/9 vs PRAX's 3/9, reflecting solid financial health.
| Metric | OKUROnKure Therapeuti… | PRAXPraxis Precision … | ACADACADIA Pharmaceut… | ARVNArvinas, Inc. |
|---|---|---|---|---|
| ROE (TTM)Return on equity | -45.3% | -43.0% | +35.6% | -44.4% |
| ROA (TTM)Return on assets | -41.5% | -40.2% | +26.2% | -28.4% |
| ROICReturn on invested capital | — | -65.0% | +10.0% | -22.4% |
| ROCEReturn on capital employed | -78.4% | -49.3% | +10.1% | -16.0% |
| Piotroski ScoreFundamental quality 0–9 | 3 | 3 | 6 | 4 |
| Debt / EquityFinancial leverage | 0.01x | 0.00x | 0.04x | 0.02x |
| Net DebtTotal debt minus cash | -$59M | -$357M | -$126M | -$134M |
| Cash & Equiv.Liquid assets | $59M | $357M | $178M | $143M |
| Total DebtShort + long-term debt | $549,000 | $110,000 | $52M | $9M |
| Interest CoverageEBIT ÷ Interest expense | -5448.00x | — | — | — |
ACAD leads this category, winning 5 of 8 comparable metrics.
Total Returns (Dividends Reinvested)
PRAX leads this category, winning 5 of 6 comparable metrics.
Total Returns (Dividends Reinvested)
A $10,000 investment in PRAX five years ago would be worth $8,580 today (with dividends reinvested), compared to $359 for OKUR. Over the past 12 months, PRAX leads with a +491.9% total return vs ACAD's -3.0%. The 3-year compound annual growth rate (CAGR) favors PRAX at 164.8% vs OKUR's -63.7% — a key indicator of consistent wealth creation.
| Metric | OKUROnKure Therapeuti… | PRAXPraxis Precision … | ACADACADIA Pharmaceut… | ARVNArvinas, Inc. |
|---|---|---|---|---|
| YTD ReturnYear-to-date | +41.9% | -6.9% | -19.3% | -33.9% |
| 1-Year ReturnPast 12 months | +47.4% | +491.9% | -3.0% | +0.1% |
| 3-Year ReturnCumulative with dividends | -95.2% | +1757.4% | -14.3% | -73.7% |
| 5-Year ReturnCumulative with dividends | -96.4% | -14.2% | -22.6% | -91.0% |
| 10-Year ReturnCumulative with dividends | -97.2% | -36.1% | -44.6% | -52.8% |
| CAGR (3Y)Annualised 3-year return | -63.7% | +164.8% | -5.0% | -35.9% |
PRAX leads this category, winning 5 of 6 comparable metrics.
Risk & Volatility
Evenly matched — OKUR and ACAD each lead in 1 of 2 comparable metrics.
Risk & Volatility
ACAD is the less volatile stock with a 1.10 beta — it tends to amplify market swings less than PRAX's 1.55 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. OKUR currently trades 78.1% from its 52-week high vs ARVN's 52.2% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | OKUROnKure Therapeuti… | PRAXPraxis Precision … | ACADACADIA Pharmaceut… | ARVNArvinas, Inc. |
|---|---|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 1.34x | 1.55x | 1.10x | 1.14x |
| 52-Week HighHighest price in past year | $5.38 | $366.52 | $27.81 | $14.51 |
| 52-Week LowLowest price in past year | $1.91 | $37.19 | $19.69 | $6.06 |
| % of 52W HighCurrent price vs 52-week peak | +78.1% | +72.7% | +75.8% | +52.2% |
| RSI (14)Momentum oscillator 0–100 | 53.8 | 31.9 | 47.9 | 24.1 |
| Avg Volume (50D)Average daily shares traded | 210K | 396K | 1.4M | 794K |
Evenly matched — OKUR and ACAD each lead in 1 of 2 comparable metrics.
Analyst Outlook
Insufficient data to determine a leader in this category.
Analyst Outlook
Analyst consensus: PRAX as "Buy", ACAD as "Buy", ARVN as "Buy". Consensus price targets imply 127.8% upside for PRAX (target: $607) vs 64.9% for ACAD (target: $35).
| Metric | OKUROnKure Therapeuti… | PRAXPraxis Precision … | ACADACADIA Pharmaceut… | ARVNArvinas, Inc. |
|---|---|---|---|---|
| Analyst RatingConsensus buy/hold/sell | — | Buy | Buy | Buy |
| Price TargetConsensus 12-month target | — | $607.15 | $34.78 | $14.75 |
| # AnalystsCovering analysts | — | 16 | 37 | 26 |
| Dividend YieldAnnual dividend ÷ price | — | — | — | — |
| Dividend StreakConsecutive years of raises | — | — | — | — |
| Dividend / ShareAnnual DPS | — | — | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | 0.0% | 0.0% | +18.8% |
Insufficient data to determine a leader in this category.
Key Takeaway
ACAD leads in 2 of 6 categories (Income & Cash Flow, Profitability & Efficiency). PRAX leads in 1 (Total Returns). 2 tied.
Best OverallACADIA Pharmaceuticals Inc. (ACAD)Leads 2 of 6 categories
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OKUR vs PRAX vs ACAD vs ARVN: Key Questions Answered
9 questions · data-driven answers · updated daily
01Is OKUR or PRAX or ACAD or ARVN a better buy right now?
For growth investors, ACADIA Pharmaceuticals Inc.
(ACAD) is the stronger pick with 11. 9% revenue growth year-over-year, versus -100. 0% for Praxis Precision Medicines, Inc. (PRAX). ACADIA Pharmaceuticals Inc. (ACAD) offers the better valuation at 9. 2x trailing P/E (54. 2x forward), making it the more compelling value choice. Analysts rate Praxis Precision Medicines, Inc. (PRAX) a "Buy" — based on 16 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — OKUR or PRAX or ACAD or ARVN?
Over the past 5 years, Praxis Precision Medicines, Inc.
(PRAX) delivered a total return of -14. 2%, compared to -96. 4% for OnKure Therapeutics, Inc. (OKUR). Over 10 years, the gap is even starker: PRAX returned -36. 1% versus OKUR's -97. 2%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — OKUR or PRAX or ACAD or ARVN?
By beta (market sensitivity over 5 years), ACADIA Pharmaceuticals Inc.
(ACAD) is the lower-risk stock at 1. 10β versus Praxis Precision Medicines, Inc. 's 1. 55β — meaning PRAX is approximately 41% more volatile than ACAD relative to the S&P 500. On balance sheet safety, Praxis Precision Medicines, Inc. (PRAX) carries a lower debt/equity ratio of 0% versus 4% for ACADIA Pharmaceuticals Inc. — giving it more financial flexibility in a downturn.
04Which is growing faster — OKUR or PRAX or ACAD or ARVN?
By revenue growth (latest reported year), ACADIA Pharmaceuticals Inc.
(ACAD) is pulling ahead at 11. 9% versus -100. 0% for Praxis Precision Medicines, Inc. (PRAX). On earnings-per-share growth, the picture is similar: ACADIA Pharmaceuticals Inc. grew EPS 68. 4% year-over-year, compared to -32. 0% for Praxis Precision Medicines, Inc.. Over a 3-year CAGR, ACAD leads at 27. 5% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.
05Which has better profit margins — OKUR or PRAX or ACAD or ARVN?
ACADIA Pharmaceuticals Inc.
(ACAD) is the more profitable company, earning 36. 5% net margin versus -30. 8% for Arvinas, Inc. — meaning it keeps 36. 5% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: ACAD leads at 9. 8% versus -43. 8% for ARVN. At the gross margin level — before operating expenses — ARVN leads at 98. 0%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
06Is OKUR or PRAX or ACAD or ARVN more undervalued right now?
Analyst consensus price targets imply the most upside for PRAX: 127.
8% to $607. 15.
07Which pays a better dividend — OKUR or PRAX or ACAD or ARVN?
None of the stocks in this comparison currently pay a material dividend.
All are effectively zero-yield and should be held for capital appreciation rather than income.
08Is OKUR or PRAX or ACAD or ARVN better for a retirement portfolio?
For long-horizon retirement investors, ACADIA Pharmaceuticals Inc.
(ACAD) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 1. 10)). Praxis Precision Medicines, Inc. (PRAX) carries a higher beta of 1. 55 — meaning larger drawdowns in market downturns, which matters significantly when you cannot wait years for a recovery. Both have compounded well over 10 years (ACAD: -44. 6%, PRAX: -36. 1%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
09What are the main differences between OKUR and PRAX and ACAD and ARVN?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both.
In terms of investment character: OKUR is a small-cap quality compounder stock; PRAX is a small-cap quality compounder stock; ACAD is a small-cap deep-value stock; ARVN is a small-cap quality compounder stock. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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