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PRAX logoPraxis Precision Medicines, Inc.(PRAX)Earnings, Financials & Key Ratios

PRAX•NASDAQ
$333.30
$7.5B mkt cap·Price updated May 6, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryNeuroscience and Psychiatry Therapies
AboutPraxis Precision Medicines, Inc., a clinical-stage biopharmaceutical company, develops therapies for central nervous system disorders characterized by neuronal imbalance. Its lead product candidates include PRAX-114, an extrasynaptic-preferring GABAA receptor positive allosteric modulator that is in Phase IIa clinical trial for the treatment of major depressive disorder and perimenopausal depression; and PRAX-944, a selective small molecule inhibitor of T-type calcium channels, which is in Phase IIa clinical trial for the treatment of essential tremor. The company is also developing PRAX-562, a persistent sodium current blocker that is in Phase I clinical trial to treat severe pediatric epilepsy and adult cephalgia; PRAX-222, an antisense oligonucleotide (ASO) for patients with gain-of-function (GOF) SCN2A epilepsy; and KCNT1 program for the treatment of KCNT1 GOF epilepsy. It has a cooperation and license agreement with RogCon Inc.; a license agreement with Purdue Neuroscience Company; a research collaboration, option, and license agreement with Ionis Pharmaceuticals, Inc.; and collaboration with The Florey Institute to develop three novel ASOs. The company was incorporated in 2015 and is based in Boston, Massachusetts.Show more
  • Revenue$0-100.0%
  • EBITDA-$326M-63.2%
  • Net Income-$303M-65.9%
  • EPS (Diluted)-13.48-32.0%
  • ROE-45.83%+35.4%
  • ROIC-65.03%+51.8%
  • Debt/Equity0.00-95.9%
Technical→

PRAX Key Insights

Praxis Precision Medicines, Inc. (PRAX) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Company is almost debt free
  • ✓Momentum leader: RS Rating 97 (top 3%)

✗Weaknesses

  • ✗Profits declining 37.4% over 5 years
  • ✗Weak Piotroski F-Score: 3/9
  • ✗Shares diluted 25.7% in last year
  • ✗Low asset turnover indicates capital-intensive operations

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

PRAX Price & Volume

Praxis Precision Medicines, Inc. (PRAX) stock price & volume — 10-year historical chart

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PRAX Growth Metrics

Praxis Precision Medicines, Inc. (PRAX) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-
3 Years-
TTM-100%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-65.88%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM-31.06%

Return on Capital

10 Years-100.4%
5 Years-96.38%
3 Years-97.27%
Last Year-49.29%

PRAX Recent Earnings

Praxis Precision Medicines, Inc. (PRAX) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 7/12 qtrs (58%)●Beat Revenue 2/12 qtrs (40%)
Q1 2026Latest
Feb 19, 2026
EPS
$3.50
Est $3.13
-12.0%
Revenue
—
Est $66,667
Q4 2025
Nov 5, 2025
EPS
$3.36
Est $3.45
+2.6%
Revenue
—
Est $256,090
Q3 2025
Aug 4, 2025
EPS
$3.31
Est $3.40
+2.6%
Revenue
—
Est $59,440
Q2 2025
May 2, 2025
EPS
$3.29
Est $3.20
-2.8%
Revenue
—
Est $198,800
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q1 2026LatestFeb 19, 2026
$3.50vs $3.13-12.0%
—vs $66,667
Q4 2025Nov 5, 2025
$3.36vs $3.45+2.6%
—vs $256,090
Q3 2025Aug 4, 2025
$3.31vs $3.40+2.6%
—vs $59,440
Q2 2025May 2, 2025
$3.29vs $3.20-2.8%
—vs $198,800
Based on last 12 quarters of dataView full earnings history →

PRAX Peer Comparison

Praxis Precision Medicines, Inc. (PRAX) competitors in Neuroscience and Psychiatry Therapies — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
ACAD logoACADACADIA Pharmaceuticals Inc.Direct Competitor3.78B22.3516.4331.85%24.94%28.47%4.16%0.07
NRIX logoNRIXNurix Therapeutics, Inc.Direct Competitor1.69B16.60-5.4453.95%-314.9%-49.09%0.10
ARVN logoARVNArvinas, Inc.Direct Competitor678.63M10.61-8.29-0.3%-30.77%-14.25%0.02
LGND logoLGNDLigand Pharmaceuticals IncorporatedDirect Competitor4.57B232.30-1055.9127.28%19.34%5.11%1.7%0.01
OVID logoOVIDOvid Therapeutics Inc.Product Competitor368.42M2.83-11.7911.81%-240.11%-23.98%0.01
PTCT logoPTCTPTC Therapeutics, Inc.Product Competitor5.39B65.048.36114.51%39.44%13.02%
KALA logoKALAKALA BIO, Inc.Product Competitor833.23K0.11-0.02-141.11%-388.29%2.62
ENOV logoENOVEnovis CorporationProduct Competitor1.38B24.12-1.166.66%-52.69%-79.39%1.44%0.06

Compare PRAX vs Peers

Praxis Precision Medicines, Inc. (PRAX) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs ACAD

Most directly comparable listed peer for PRAX.

Scale Benchmark

vs IQV

Larger-name benchmark to compare PRAX against a more recognizable public peer.

Peer Set

Compare Top 5

vs ACAD, NRIX, ARVN, LGND

PRAX Income Statement

Praxis Precision Medicines, Inc. (PRAX) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
Line itemDec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Sales/Revenue000002.45M8.55M0
Revenue Growth %------249.53%-100%
Cost of Goods Sold1K679K00154.44M86.77M152.41M140K
COGS % of Revenue-----3545.81%1781.98%-
Gross Profit
-1K▲ 0%
-679K▼ 67800.0%
0▲ 100.0%
0▲ 0%
-154.44M▲ 0%
-84.32M▲ 45.4%
-143.86M▼ 70.6%
-140K▲ 99.9%
Gross Margin %------3445.81%-1681.98%-
Gross Profit Growth %--67800%100%--45.4%-70.61%99.9%
Operating Expenses22.72M35.79M61.97M167.33M60.55M42.05M56.3M326.06M
OpEx % of Revenue-----1718.59%658.31%-
Selling, General & Admin3.9M6.23M16.99M47.08M59.55M42.05M56.3M59.08M
SG&A % of Revenue-----1718.59%658.31%-
Research & Development18.82M29.56M44.98M120.26M155.04M86.77M152.41M267.12M
R&D % of Revenue-----3545.81%1781.98%-
Other Operating Expenses0000-154.04M-86.77M-152.41M0
Operating Income
-22.72M▲ 0%
-35.79M▼ 57.5%
-61.97M▼ 73.1%
-167.33M▼ 170.0%
-214.99M▼ 28.5%
-126.37M▲ 41.2%
-200.16M▼ 58.4%
-326.2M▼ 63.0%
Operating Margin %------5164.41%-2340.29%-
Operating Income Growth %--57.53%-73.15%-170.03%-28.48%41.22%-58.39%-62.96%
EBITDA-22.72M-35.11M-61.92M-167.15M-214.57M-125.94M-199.81M-326.06M
EBITDA Margin %------5146.75%-2336.1%-
EBITDA Growth %--54.55%-76.35%-169.95%-28.37%41.3%-58.65%-63.19%
D&A (Non-Cash Add-back)1K679K50K182K419K432K358K140K
EBIT-26.27M-35.6M-61.97M-167.33M-213.99M-126.37M-200.16M-303.27M
Net Interest Income-35K193K140K00017.35M22.93M
Interest Income92K193K140K00017.35M22.93M
Interest Expense127K0000000
Other Income/Expense-3.68M193K140K271K957K3.1M17.35M22.93M
Pretax Income
-26.4M▲ 0%
-35.6M▼ 34.8%
-61.83M▼ 73.7%
-167.06M▼ 170.2%
-214.03M▼ 28.1%
-123.28M▲ 42.4%
-182.82M▼ 48.3%
-303.27M▼ 65.9%
Pretax Margin %------5037.88%-2137.48%-
Income Tax133K-84K-8K00000
Effective Tax Rate %-0.5%0.24%0.01%0%0%0%0%0%
Net Income
-26.54M▲ 0%
-35.51M▼ 33.8%
-61.82M▼ 74.1%
-167.06M▼ 170.2%
-214.03M▼ 28.1%
-123.28M▲ 42.4%
-182.82M▼ 48.3%
-303.27M▼ 65.9%
Net Margin %------5037.88%-2137.48%-
Net Income Growth %--33.83%-74.08%-170.24%-28.11%42.4%-48.3%-65.88%
Net Income (Continuing)-26.54M-35.51M-61.82M-167.06M-214.03M-123.28M-182.82M-303.27M
Discontinued Operations00000000
Minority Interest00000000
EPS (Diluted)
-306.73▲ 0%
-348.24▼ 13.5%
-103.61▲ 70.2%
-58.96▲ 43.1%
-69.33▼ 17.6%
-18.69▲ 73.0%
-10.21▲ 45.4%
-13.48▼ 32.0%
EPS Growth %--13.53%70.25%43.09%-17.59%73.04%45.37%-32.03%
EPS (Basic)-306.73-348.24-103.61-58.96-69.33-18.69-10.21-13.48
Diluted Shares Outstanding86.51K101.97K596.68K2.83M3.07M6.59M17.91M22.5M
Basic Shares Outstanding86.51K101.97K596.68K2.83M3.07M6.59M17.91M22.5M
Dividend Payout Ratio--------

PRAX Balance Sheet

Praxis Precision Medicines, Inc. (PRAX) balance sheet — assets, liabilities & shareholders' equity

Line itemDec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Total Current Assets19.13M45.5M302.33M287.41M110.84M84.88M404.37M610.91M
Cash & Short-Term Investments17.95M44.81M296.61M275.91M100.49M81.3M392.57M599.33M
Cash Only17.95M44.81M296.61M138.7M61.62M81.3M215.37M357.33M
Short-Term Investments000137.21M38.87M0177.19M242M
Accounts Receivable00000000
Days Sales Outstanding--------
Inventory00000000
Days Inventory Outstanding--------
Other Current Assets000003.58M11.8M11.58M
Total Non-Current Assets703K2.2M851K5.34M4.29M3.07M78.74M327M
Property, Plant & Equipment103K1.58M836K4.87M3.87M2.65M1.36M239K
Fixed Asset Turnover-----0.92x6.28x-
Goodwill00000000
Intangible Assets00000000
Long-Term Investments600K0000076.96M0
Other Non-Current Assets0620K15K472K416K416K416K326.76M
Total Assets
19.83M▲ 0%
47.69M▲ 140.5%
303.18M▲ 535.7%
292.75M▼ 3.4%
115.13M▼ 60.7%
87.95M▼ 23.6%
483.11M▲ 449.3%
937.91M▲ 94.1%
Asset Turnover-----0.03x0.02x-
Asset Growth %-140.53%535.67%-3.44%-60.67%-23.61%449.31%94.14%
Total Current Liabilities5.14M6.82M15.72M38.43M34.34M15.75M37.55M59.77M
Accounts Payable3.39M2.67M4.09M10.78M14.67M5.82M12.53M24.63M
Days Payables Outstanding1000K1.43K--34.6824.463064.21K
Short-Term Debt0000000110K
Deferred Revenue (Current)00002.82M1.39M00
Other Current Liabilities1.02M007.18M2.8M3.7M9.37M35.03M
Current Ratio3.72x6.67x19.23x7.48x3.23x5.39x10.77x10.22x
Quick Ratio3.72x6.67x19.23x7.48x3.23x5.39x10.77x10.22x
Cash Conversion Cycle--------
Total Non-Current Liabilities2K763K03.5M4.68M2.53M110K0
Long-Term Debt00000000
Capital Lease Obligations0763K03.5M2.5M1.37M110K0
Deferred Tax Liabilities00000000
Other Non-Current Liabilities2K0000000
Total Liabilities5.15M7.58M15.72M41.94M39.02M18.28M37.66M59.77M
Total Debt01.46M763K4.31M3.5M2.5M1.37M110K
Net Debt-17.95M-43.36M-295.85M-134.39M-58.12M-78.81M-214M-357.22M
Debt / Equity-0.04x0.00x0.02x0.05x0.04x0.00x0.00x
Debt / EBITDA--------
Net Debt / EBITDA--------
Interest Coverage-206.89x-------
Total Equity
14.68M▲ 0%
40.11M▲ 173.2%
287.46M▲ 616.6%
250.81M▼ 12.7%
76.11M▼ 69.7%
69.67M▼ 8.5%
445.45M▲ 539.4%
878.14M▲ 97.1%
Equity Growth %-173.21%616.62%-12.75%-69.66%-8.46%539.38%97.13%
Book Value per Share169.72393.36481.7688.6224.7710.5724.8839.02
Total Shareholders' Equity14.68M40.11M287.46M250.81M76.11M69.67M445.45M878.14M
Common Stock1K1K4K5K5K13K14K15K
Retained Earnings-41.37M-81.01M-149.55M-316.62M-530.64M-653.92M-836.74M-1.14B
Treasury Stock00000000
Accumulated OCI-1K00-176K-173K0654K0
Minority Interest00000000

PRAX Cash Flow Statement

Praxis Precision Medicines, Inc. (PRAX) cash flow — operating, investing & free cash flow history

Line itemDec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Cash from Operations-20.72M-32.79M-52.62M-124.55M-185.04M-111.14M-131.76M-249.07M
Operating CF Margin %------4541.72%-1540.48%-
Operating CF Growth %--58.23%-60.5%-136.69%-48.56%39.94%-18.55%-89.04%
Net Income-26.54M-35.51M-61.82M-167.06M-214.03M-123.28M-182.82M-303.27M
Depreciation & Amortization1K679K50K182K419K432K358K-3.45M
Stock-Based Compensation579K05.21M22.69M28.59M24.86M41.36M33.94M
Deferred Taxes3.65M002.09M0000
Other Non-Cash Items127K668K696K1.41M1.75M-121K-1.58M1.03M
Working Capital Changes1.46M1.38M3.24M16.13M-1.78M-13.03M10.92M22.68M
Change in Receivables00000000
Change in Inventory00000000
Change in Payables1.67M-837K960K7.27M3.89M-8.86M6.71M12.1M
Cash from Investing-63K-103K0-140.52M96.89M38.95M-248.49M-311.15M
Capital Expenditures-63K-103K0-1.05M-444K-50K0-56K
CapEx % of Revenue-----2.04%--
Acquisitions000139.47M-97.33M000
Investments--------
Other Investing000-139.47M97.33M000
Cash from Financing37.8M59.76M304.42M107.59M10.46M91.87M514.32M702.17M
Debt Issued (Net)1M-633K0-763K0000
Equity Issued (Net)36.8M60.39M304.42M105.71M9.56M91.59M512M704.26M
Dividends Paid00000000
Share Repurchases00-30M00000
Other Financing0088K2.63M904K279K2.33M-2.09M
Net Change in Cash
17.02M▲ 0%
26.86M▲ 57.8%
251.79M▲ 837.3%
-157.49M▼ 162.5%
-77.69M▲ 50.7%
19.68M▲ 125.3%
134.07M▲ 581.1%
141.96M▲ 5.9%
Free Cash Flow
-20.78M▲ 0%
-32.89M▼ 58.2%
-52.62M▼ 60.0%
-125.6M▼ 138.7%
-185.49M▼ 47.7%
-111.19M▲ 40.1%
-131.76M▼ 18.5%
-249.12M▼ 89.1%
FCF Margin %------4543.77%-1540.48%-
FCF Growth %--58.25%-60%-138.69%-47.68%40.06%-18.5%-89.08%
FCF per Share-240.25-322.53-88.19-44.38-60.36-16.86-7.36-11.07
FCF Conversion (FCF/Net Income)0.78x0.92x0.85x0.75x0.86x0.90x0.72x0.82x
Interest Paid00000000
Taxes Paid00000000

PRAX Key Ratios

Praxis Precision Medicines, Inc. (PRAX) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric20182019202020212022202320242025
Return on Equity (ROE)-180.73%-129.62%-37.74%-62.07%-130.94%-169.13%-70.98%-45.83%
Return on Invested Capital (ROIC)----232.34%-239.92%-2140.71%-135.06%-65.03%
Gross Margin------3445.81%-1681.98%-
Net Margin------5037.88%-2137.48%-
Debt / Equity-0.04x0.00x0.02x0.05x0.04x0.00x0.00x
Interest Coverage-206.89x-------
FCF Conversion0.78x0.92x0.85x0.75x0.86x0.90x0.72x0.82x
Revenue Growth------249.53%-100%

PRAX SEC Filings & Documents

Praxis Precision Medicines, Inc. (PRAX) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Apr 14, 2026·SEC

Material company update

Apr 6, 2026·SEC

Material company update

Feb 19, 2026·SEC

10-K Annual Reports

3
FY 2026

Feb 19, 2026·SEC

FY 2025

Feb 28, 2025·SEC

FY 2024

Mar 5, 2024·SEC

10-Q Quarterly Reports

6
FY 2025

Nov 5, 2025·SEC

FY 2025

Aug 4, 2025·SEC

FY 2025

May 2, 2025·SEC

PRAX Frequently Asked Questions

Praxis Precision Medicines, Inc. (PRAX) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Praxis Precision Medicines, Inc. (PRAX) saw revenue decline by 100.0% over the past year.

Praxis Precision Medicines, Inc. (PRAX) reported a net loss of $303.3M for fiscal year 2025.

Dividend & Returns

Praxis Precision Medicines, Inc. (PRAX) has a return on equity (ROE) of -45.8%. Negative ROE indicates the company is unprofitable.

Praxis Precision Medicines, Inc. (PRAX) had negative free cash flow of $249.5M in fiscal year 2025, likely due to heavy capital investments.

Explore More PRAX

Praxis Precision Medicines, Inc. (PRAX) financial analysis — history, returns, DCA and operating performance tools

Total Return Calculator

Historical returns with dividends reinvested

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DCA Calculator

Dollar cost averaging vs lump sum

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Dividend History

Yield, growth, payout safety & DRIP

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Earnings History

EPS trends, net income & profitability

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Price History

Long-term charts & historical price data

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Revenue History

Sales growth patterns & revenue breakdown

→

Financial Ratios

30 years of market, efficiency and balance-sheet ratios

→

Valuation

DCF intrinsic value, peer multiples & estimates

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