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PRAXPraxis Precision Medicines, Inc.
$282.31$8.2B
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PRAX logoPraxis Precision Medicines, Inc.(PRAX)Earnings, Financials & Key Ratios

PRAX•NASDAQ
Price updated Jun 19, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryNeuroscience and Psychiatry Therapies
AboutPraxis Precision Medicines, Inc., a clinical-stage biopharmaceutical company, develops therapies for central nervous system disorders characterized by neuronal imbalance. Its lead product candidates include PRAX-114, an extrasynaptic-preferring GABAA receptor positive allosteric modulator that is in Phase IIa clinical trial for the treatment of major depressive disorder and perimenopausal depression; and PRAX-944, a selective small molecule inhibitor of T-type calcium channels, which is in Phase IIa clinical trial for the treatment of essential tremor. The company is also developing PRAX-562, a persistent sodium current blocker that is in Phase I clinical trial to treat severe pediatric epilepsy and adult cephalgia; PRAX-222, an antisense oligonucleotide (ASO) for patients with gain-of-function (GOF) SCN2A epilepsy; and KCNT1 program for the treatment of KCNT1 GOF epilepsy. It has a cooperation and license agreement with RogCon Inc.; a license agreement with Purdue Neuroscience Company; a research collaboration, option, and license agreement with Ionis Pharmaceuticals, Inc.; and collaboration with The Florey Institute to develop three novel ASOs. The company was incorporated in 2015 and is based in Boston, Massachusetts.Show more
  • Revenue$0-100.0%
  • EBITDA-$326M-63.2%
  • Net Income-$303M-65.9%
  • EPS (Diluted)-13.48-32.0%
  • ROE-45.83%+35.4%

PRAX Key Insights

Praxis Precision Medicines, Inc. (PRAX) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Company is almost debt free
  • ✓Momentum leader: RS Rating 94 (top 6%)

✗Weaknesses

  • ✗Profits declining 37.4% over 5 years
  • ✗Weak Piotroski F-Score: 3/9
  • ✗Shares diluted 25.7% in last year
  • ✗Low asset turnover indicates capital-intensive operations

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

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PRAX Price & Volume

Praxis Precision Medicines, Inc. (PRAX) stock price & volume — 10-year historical chart

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PRAX Growth Metrics

Praxis Precision Medicines, Inc. (PRAX) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-
3 Years-
TTM-100%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-53.62%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM-24.72%

Return on Capital

10 Years-100.4%
5 Years-96.38%
3 Years-97.27%
Last Year-49.29%

PRAX Recent Earnings

Praxis Precision Medicines, Inc. (PRAX) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 7/12 qtrs (58%)●Beat Revenue 2/12 qtrs (40%)
Q2 2026Latest
May 7, 2026
Metric
Actual
Est
EPS
$3.20+10.6%
$3.58
Rev
—
$100,000
Q1 2026
Feb 19, 2026
Metric
Actual
Est
EPS
$3.50-12.0%
$3.13
Rev
—
$66,667
Q4 2025
Nov 5, 2025
Metric
Actual
Est
EPS
$3.36+2.6%
$3.45
Rev
—
$256,090
Q3 2025
Aug 4, 2025
Metric
Actual
Est
EPS
$3.31+2.6%
$3.40
Rev
—
$59,440
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 7, 2026
$3.20vs $3.58+10.6%
—vs $100,000
Q1 2026Feb 19, 2026
$3.50vs $3.13-12.0%
—vs $66,667
Q4 2025Nov 5, 2025
$3.36vs $3.45+2.6%
—vs $256,090
Q3 2025Aug 4, 2025
$3.31vs $3.40+2.6%
—vs $59,440
Based on last 12 quarters of dataView full earnings history →

PRAX Peer Comparison

Praxis Precision Medicines, Inc. (PRAX) competitors in Neuroscience and Psychiatry Therapies — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
Institutional Holdings
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
ACAD logoACADACADIA Pharmaceuticals Inc.Direct Competitor3.7B21.629.4411.87%34.3%35.65%0.04
NRIX logoNRIXNurix Therapeutics, Inc.Direct Competitor1.79B17.55-5.7553.95%-314.9%-49.09%0.10
ARVN logoARVNArvinas, Inc.Direct Competitor494.88M7.67-5.99-0.3%-247.54%-44.39%0.02
LGND logoLGNDLigand Pharmaceuticals IncorporatedDirect Competitor5.51B274.8844.8460.4%55.95%16.19%0.44
OVID logoOVIDOvid Therapeutics Inc.Product Competitor299.38M2.27-9.4611.81%-339.33%-22.51%0.10
PTCT logoPTCTPTC Therapeutics, Inc.Product Competitor6.55B78.9810.15114.51%-22.58%
KALA logoKALAKALA BIO, Inc.Product Competitor79.17M3.61-1.09-13.36%
ENOV logoENOVEnovis CorporationProduct Competitor1.26B21.97-1.056.66%-49.91%-60.04%0.92

Compare PRAX vs Peers

Praxis Precision Medicines, Inc. (PRAX) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs ACAD

Most directly comparable listed peer for PRAX.

Scale Benchmark

vs NTRA

Larger-name benchmark to compare PRAX against a more recognizable public peer.

Peer Set

Compare Top 5

vs ACAD, NRIX, ARVN, LGND

PRAX Income Statement

Praxis Precision Medicines, Inc. (PRAX) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
MetricDec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Sales/Revenue
000002.45M8.55M00
Revenue Growth %
------249.53%-100%-100%
Cost of Goods Sold
1K679K00154.44M86.77M152.41M140K128.84M
COGS % of Revenue
-----3545.81%1781.98%--
Gross Profit
-1K▲ 0%
-679K▼ 67800.0%
0▲ 100.0%
0▲ 0%
-154.44M▲ 0%
-84.32M▲ 45.4%
-143.86M▼ 70.6%
-140K▲ 99.9%
-128.84M▲ 0%
Gross Margin %
------3445.81%-1681.98%--
Gross Profit Growth %
--67800%100%--45.4%-70.61%99.9%-
Operating Expenses
22.72M35.79M61.97M167.33M60.55M42.05M56.3M326.06M228.53M
OpEx % of Revenue
-----1718.59%658.31%--
Selling, General & Admin
3.9M6.23M16.99M47.08M59.55M42.05M56.3M59.08M73.03M
SG&A % of Revenue
-----1718.59%658.31%--
Research & Development
18.82M29.56M44.98M120.26M155.04M86.77M152.41M267.12M284.3M
R&D % of Revenue
-----3545.81%1781.98%--
Other Operating Expenses
0000-154.04M-86.77M-152.41M0-2M
Operating Income
-22.72M▲ 0%
-35.79M▼ 57.5%
-61.97M▼ 73.1%
-167.33M▼ 170.0%
-214.99M▼ 28.5%
-126.37M▲ 41.2%
-200.16M▼ 58.4%
-326.2M▼ 63.0%
-357.33M▲ 0%
Operating Margin %
------5164.41%-2340.29%--
Operating Income Growth %
--57.53%-73.15%-170.03%-28.48%41.22%-58.39%-62.96%-
EBITDA
-22.72M-35.11M-61.92M-167.15M-214.57M-125.94M-199.81M-326.06M-357.2M
EBITDA Margin %
------5146.75%-2336.1%--
EBITDA Growth %
--54.55%-76.35%-169.95%-28.37%41.3%-58.65%-63.19%-53.49%
D&A (Non-Cash Add-back)
1K679K50K182K419K432K358K140K132K
EBIT
-26.27M-35.6M-61.97M-167.33M-213.99M-126.37M-200.16M-303.27M-352.9M
Net Interest Income
-35K193K140K00017.35M22.93M18.24M
Interest Income
92K193K140K00017.35M22.93M18.24M
Interest Expense
127K00000000
Other Income/Expense
-3.68M193K140K271K957K3.1M17.35M22.93M30.8M
Pretax Income
-26.4M▲ 0%
-35.6M▼ 34.8%
-61.83M▼ 73.7%
-167.06M▼ 170.2%
-214.03M▼ 28.1%
-123.28M▲ 42.4%
-182.82M▼ 48.3%
-303.27M▼ 65.9%
-326.53M▲ 0%
Pretax Margin %
------5037.88%-2137.48%--
Income Tax
133K-84K-8K000000
Effective Tax Rate %
-0.5%0.24%0.01%0%0%0%0%0%0%
Net Income
-26.54M▲ 0%
-35.51M▼ 33.8%
-61.82M▼ 74.1%
-167.06M▼ 170.2%
-214.03M▼ 28.1%
-123.28M▲ 42.4%
-182.82M▼ 48.3%
-303.27M▼ 65.9%
-326.53M▲ 0%
Net Margin %
------5037.88%-2137.48%--
Net Income Growth %
--33.83%-74.08%-170.24%-28.11%42.4%-48.3%-65.88%-53.62%
Net Income (Continuing)
-26.54M-35.51M-61.82M-167.06M-214.03M-123.28M-182.82M-303.27M-326.53M
Discontinued Operations
000000000
Minority Interest
000000000
EPS (Diluted)
-306.73▲ 0%
-348.24▼ 13.5%
-103.61▲ 70.2%
-58.96▲ 43.1%
-69.33▼ 17.6%
-18.69▲ 73.0%
-10.21▲ 45.4%
-13.48▼ 32.0%
-11.31▲ 0%
EPS Growth %
--13.53%70.25%43.09%-17.59%73.04%45.37%-32.03%-24.72%
EPS (Basic)
-306.73-348.24-103.61-58.96-69.33-18.69-10.21-13.48-
Diluted Shares Outstanding
86.51K101.97K596.68K2.83M3.07M6.59M17.91M22.5M28.88M
Basic Shares Outstanding
86.51K101.97K596.68K2.83M3.07M6.59M17.91M22.5M28.88M
Dividend Payout Ratio
---------

PRAX Balance Sheet

Praxis Precision Medicines, Inc. (PRAX) balance sheet — assets, liabilities & shareholders' equity

MetricDec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Total Current Assets
19.13M45.5M302.33M287.41M110.84M84.88M404.37M610.91M797.77M
Cash & Short-Term Investments
17.95M44.81M296.61M275.91M100.49M81.3M392.57M599.33M786.87M
Cash Only
17.95M44.81M296.61M138.7M61.62M81.3M215.37M357.33M536.33M
Short-Term Investments
000137.21M38.87M0177.19M242M250.53M
Accounts Receivable
000000000
Days Sales Outstanding
---------
Inventory
000000000
Days Inventory Outstanding
---------
Other Current Assets
000003.58M11.8M11.58M10.91M
Total Non-Current Assets
703K2.2M851K5.34M4.29M3.07M78.74M327M662.43M
Property, Plant & Equipment
103K1.58M836K4.87M3.87M2.65M1.36M239K1.49M
Fixed Asset Turnover
-----0.92x6.28x-0.00x
Goodwill
000000000
Intangible Assets
000000000
Long-Term Investments
600K0000076.96M0267.38M
Other Non-Current Assets
0620K15K472K416K416K416K326.76M660.94M
Total Assets
19.83M▲ 0%
47.69M▲ 140.5%
303.18M▲ 535.7%
292.75M▼ 3.4%
115.13M▼ 60.7%
87.95M▼ 23.6%
483.11M▲ 449.3%
937.91M▲ 94.1%
1.46B▲ 0%
Asset Turnover
-----0.03x0.02x-0.00x
Asset Growth %
-140.53%535.67%-3.44%-60.67%-23.61%449.31%94.14%297.05%
Total Current Liabilities
5.14M6.82M15.72M38.43M34.34M15.75M37.55M59.77M50.24M
Accounts Payable
3.39M2.67M4.09M10.78M14.67M5.82M12.53M24.63M31.16M
Days Payables Outstanding
1000K1.43K--34.6824.463064.21K81.76
Short-Term Debt
0000000110K1.44M
Deferred Revenue (Current)
00002.82M1.39M000
Other Current Liabilities
1.02M007.18M2.8M3.7M9.37M35.03M17.65M
Current Ratio
3.72x6.67x19.23x7.48x3.23x5.39x10.77x10.22x15.88x
Quick Ratio
3.72x6.67x19.23x7.48x3.23x5.39x10.77x10.22x15.88x
Cash Conversion Cycle
---------
Total Non-Current Liabilities
2K763K03.5M4.68M2.53M110K00
Long-Term Debt
000000000
Capital Lease Obligations
0763K03.5M2.5M1.37M110K00
Deferred Tax Liabilities
000000000
Other Non-Current Liabilities
2K00000000
Total Liabilities
5.15M7.58M15.72M41.94M39.02M18.28M37.66M59.77M50.24M
Total Debt
01.46M763K4.31M3.5M2.5M1.37M110K1.44M
Net Debt
-17.95M-43.36M-295.85M-134.39M-58.12M-78.81M-214M-357.22M-534.9M
Debt / Equity
-0.04x0.00x0.02x0.05x0.04x0.00x0.00x0.00x
Debt / EBITDA
---------0.00x
Net Debt / EBITDA
--------1.50x
Interest Coverage
-206.89x--------
Total Equity
14.68M▲ 0%
40.11M▲ 173.2%
287.46M▲ 616.6%
250.81M▼ 12.7%
76.11M▼ 69.7%
69.67M▼ 8.5%
445.45M▲ 539.4%
878.14M▲ 97.1%
1.41B▲ 0%
Equity Growth %
-173.21%616.62%-12.75%-69.66%-8.46%539.38%97.13%304.37%
Book Value per Share
169.72393.36481.7688.6224.7710.5724.8839.0248.82
Total Shareholders' Equity
14.68M40.11M287.46M250.81M76.11M69.67M445.45M878.14M1.41B
Common Stock
1K1K4K5K5K13K14K15K15K
Retained Earnings
-41.37M-81.01M-149.55M-316.62M-530.64M-653.92M-836.74M-1.14B-1.23B
Treasury Stock
000000000
Accumulated OCI
-1K00-176K-173K0654K0-1.59M
Minority Interest
000000000

PRAX Cash Flow Statement

Praxis Precision Medicines, Inc. (PRAX) cash flow — operating, investing & free cash flow history

MetricDec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Cash from Operations
-20.72M-32.79M-52.62M-124.55M-185.04M-111.14M-131.76M-249.07M-282.72M
Operating CF Margin %
------4541.72%-1540.48%--
Operating CF Growth %
--58.23%-60.5%-136.69%-48.56%39.94%-18.55%-89.04%-336.77%
Net Income
-26.54M-35.51M-61.82M-167.06M-214.03M-123.28M-182.82M-303.27M-326.53M
Depreciation & Amortization
1K679K50K182K419K432K358K-3.45M-855K
Stock-Based Compensation
579K05.21M22.69M28.59M24.86M41.36M33.94M15.22M
Deferred Taxes
3.65M002.09M00000
Other Non-Cash Items
127K668K696K1.41M1.75M-121K-1.58M1.03M26M
Working Capital Changes
1.46M1.38M3.24M16.13M-1.78M-13.03M10.92M22.68M3.45M
Change in Receivables
000000000
Change in Inventory
000000000
Change in Payables
1.67M-837K960K7.27M3.89M-8.86M6.71M12.1M8.25M
Cash from Investing
-63K-103K0-140.52M96.89M38.95M-248.49M-311.15M-604.36M
Capital Expenditures
-63K-103K0-1.05M-444K-50K0-56K-182K
CapEx % of Revenue
-----2.04%---
Acquisitions
000139.47M-97.33M0000
Investments
---------
Other Investing
000-139.47M97.33M00064K
Cash from Financing
37.8M59.76M304.42M107.59M10.46M91.87M514.32M702.17M1.26B
Debt Issued (Net)
1M-633K0-763K0000202K
Equity Issued (Net)
36.8M60.39M304.42M105.71M9.56M91.59M512M704.26M1.27B
Dividends Paid
000000000
Share Repurchases
00-30M000000
Other Financing
0088K2.63M904K279K2.33M-2.09M-13.51M
Net Change in Cash
17.02M▲ 0%
26.86M▲ 57.8%
251.79M▲ 837.3%
-157.49M▼ 162.5%
-77.69M▲ 50.7%
19.68M▲ 125.3%
134.07M▲ 581.1%
141.96M▲ 5.9%
370.77M▲ 0%
Free Cash Flow
-20.78M▲ 0%
-32.89M▼ 58.2%
-52.62M▼ 60.0%
-125.6M▼ 138.7%
-185.49M▼ 47.7%
-111.19M▲ 40.1%
-131.76M▼ 18.5%
-249.12M▼ 89.1%
-282.9M▲ 0%
FCF Margin %
------4543.77%-1540.48%--
FCF Growth %
--58.25%-60%-138.69%-47.68%40.06%-18.5%-89.08%-72.92%
FCF per Share
-240.25-322.53-88.19-44.38-60.36-16.86-7.36-11.07-9.79
FCF Conversion (FCF/Net Income)
0.78x0.92x0.85x0.75x0.86x0.90x0.72x0.82x0.87x
Interest Paid
000000000
Taxes Paid
000000000

PRAX Key Ratios

Praxis Precision Medicines, Inc. (PRAX) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric2019202020212022202320242025TTM
Return on Equity (ROE)
-129.62%-37.74%-62.07%-130.94%-169.13%-70.98%-45.83%-43.02%
Return on Invested Capital (ROIC)
---232.34%-239.92%-2140.71%-135.06%-65.03%-58.33%
Gross Margin
-----3445.81%-1681.98%--
Net Margin
-----5037.88%-2137.48%--
Debt / Equity
0.04x0.00x0.02x0.05x0.04x0.00x0.00x0.00x
FCF Conversion
0.92x0.85x0.75x0.86x0.90x0.72x0.82x0.87x
Revenue Growth
-----249.53%-100%-100%
Related:PRAX Dividend History·PRAX Revenue History·PRAX Price History·PRAX P/E History·PRAX Financial Ratios·PRAX Institutional Holders

PRAX SEC Filings & Documents

Praxis Precision Medicines, Inc. (PRAX) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 13, 2026·SEC

Material company update

Apr 14, 2026·SEC

Material company update

Apr 6, 2026·SEC

10-K Annual Reports

3
FY 2026

Feb 19, 2026·SEC

FY 2025

Feb 28, 2025·SEC

FY 2024

Mar 5, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

May 7, 2026·SEC

FY 2025

Nov 5, 2025·SEC

FY 2025

Aug 4, 2025·SEC

PRAX Frequently Asked Questions

Praxis Precision Medicines, Inc. (PRAX) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Praxis Precision Medicines, Inc. (PRAX) saw revenue decline by 100.0% over the past year.

Praxis Precision Medicines, Inc. (PRAX) reported a net loss of $326.5M for fiscal year 2025.

Dividend & Returns

Praxis Precision Medicines, Inc. (PRAX) has a return on equity (ROE) of -45.8%. Negative ROE indicates the company is unprofitable.

Praxis Precision Medicines, Inc. (PRAX) had negative free cash flow of $282.9M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in PRAX back in 2018?

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