QUAD vs SPIR vs ASTS vs SRPT

For growth investors, AST SpaceMobile, Inc.

(ASTS) is the stronger pick with 1505% revenue growth year-over-year, versus -35. 2% for Spire Global, Inc. (SPIR). Spire Global, Inc. (SPIR) offers the better valuation at 11. 4x trailing P/E, making it the more compelling value choice. Analysts rate Quad/Graphics, Inc. (QUAD) a "Buy" — based on 7 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.

On trailing P/E, Spire Global, Inc.

(SPIR) is the cheapest at 11. 4x versus Quad/Graphics, Inc. at 13. 8x. On forward P/E, Quad/Graphics, Inc. is actually cheaper at 6. 1x — notably different from the trailing picture, reflecting expected earnings growth.

Over the past 5 years, AST SpaceMobile, Inc.

(ASTS) delivered a total return of +808. 5%, compared to -76. 9% for Spire Global, Inc. (SPIR). Over 10 years, the gap is even starker: ASTS returned +623. 4% versus SPIR's -75. 9%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.

By beta (market sensitivity over 5 years), Quad/Graphics, Inc.

(QUAD) is the lower-risk stock at 1. 03β versus Spire Global, Inc. 's 2. 93β — meaning SPIR is approximately 185% more volatile than QUAD relative to the S&P 500. On balance sheet safety, AST SpaceMobile, Inc. (ASTS) carries a lower debt/equity ratio of 1% versus 3% for Quad/Graphics, Inc. — giving it more financial flexibility in a downturn.

By revenue growth (latest reported year), AST SpaceMobile, Inc.

(ASTS) is pulling ahead at 1505% versus -35. 2% for Spire Global, Inc. (SPIR). On earnings-per-share growth, the picture is similar: Quad/Graphics, Inc. grew EPS 150. 5% year-over-year, compared to -404. 7% for Sarepta Therapeutics, Inc.. Over a 3-year CAGR, ASTS leads at 72. 5% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.

Spire Global, Inc.

(SPIR) is the more profitable company, earning 71. 7% net margin versus -482. 2% for AST SpaceMobile, Inc. — meaning it keeps 71. 7% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: QUAD leads at 4. 9% versus -405. 7% for ASTS. At the gross margin level — before operating expenses — SRPT leads at 59. 9%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.

On forward earnings alone, Quad/Graphics, Inc.

(QUAD) trades at 6. 1x forward P/E versus 7. 7x for Sarepta Therapeutics, Inc. — 1. 5x cheaper on a one-year earnings basis. Analyst consensus price targets imply the most upside for ASTS: 46. 6% to $103. 65.

In this comparison, QUAD (3.

9% yield) pays a dividend. SPIR, ASTS, SRPT do not pay a meaningful dividend and should not be held primarily for income.

For long-horizon retirement investors, Quad/Graphics, Inc.

(QUAD) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 1. 03), 3. 9% yield). Spire Global, Inc. (SPIR) carries a higher beta of 2. 93 — meaning larger drawdowns in market downturns, which matters significantly when you cannot wait years for a recovery. Both have compounded well over 10 years (QUAD: -22. 0%, SPIR: -75. 9%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.

These companies operate in different sectors (QUAD (Industrials) and SPIR (Industrials) and ASTS (Technology) and SRPT (Healthcare)), which means they face different economic cycles, regulatory environments, and macro sensitivities — making direct comparison nuanced.

In terms of investment character: QUAD is a small-cap deep-value stock; SPIR is a large-cap deep-value stock; ASTS is a mid-cap high-growth stock; SRPT is a small-cap high-growth stock. QUAD pays a dividend while SPIR, ASTS, SRPT do not, making them suitable for different income and tax situations. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.