Comprehensive Stock Comparison
Compare Synlogic, Inc. (SYBX) vs Apple Inc. (AAPL) Stock
Analyze side-by-side fundamentals, valuation, growth, and profitability to decide which stock is the better buy.
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Quick Verdict
| Category | Winner | Why |
|---|---|---|
| Growth |  AAPL | 6.4% revenue growth vs SYBX's -99.8% |
| Quality / Margins | AAPL | 27.0% net margin vs SYBX's -2.9K% |
| Stability / Safety |  SYBX | Beta 0.97 vs AAPL's 1.28 |
| Dividends | AAPL | 0.4% yield; 14-year raise streak; SYBX pays no meaningful dividend |
| Momentum (1Y) | AAPL | +11.8% vs SYBX's -53.1% |
| Efficiency (ROA) | AAPL | 31.1% ROA vs SYBX's -19.5%, ROIC 64.5% vs -205.7% |
Who Each Stock Is For
Income & stability
SYBXbeta 0.97
Growth exposure
AAPLRev growth 6.4%, EPS growth 22.7%, 3Y rev CAGR 1.8%
Long-term compounding (10Y)
AAPL9.6% 10Y total return vs SYBX's -98.0%
Sleep-well-at-night portfolio
SYBXLower volatility, beta 0.97, current ratio 2.80x
Defensive / Recession hedge
SYBXBeta 0.97, current ratio 2.80x
Business Model
What each company does and how it makes money
Synlogic is a clinical-stage biopharmaceutical company developing synthetic biotic medicines — engineered probiotics — to treat metabolic and immunological diseases. It generates revenue primarily through research collaborations and milestone payments from partners like Roche, with potential future income from drug sales if its pipeline succeeds. The company's key advantage lies in its proprietary platform for engineering bacterial strains to perform therapeutic functions in the gut — a novel approach distinct from traditional small molecules or biologics.
Apple is a technology giant that designs and sells premium consumer electronics — most famously the iPhone — along with related software and services. It generates revenue primarily from hardware sales (roughly 80% of total) and a fast-growing services segment (around 20%) that includes the App Store, subscriptions, and licensing. Its key competitive advantage is a powerful ecosystem that locks users into its hardware, software, and services through seamless integration and high switching costs.
Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
Financial Metrics Comparison
Side-by-side fundamentals across 2 stocks. BestLagging
Financial Scorecard
AAPL 3SYBX 1AAPL3/4 metricsSYBX2/3 metricsAAPL5/7 metricsAAPL6/6 metricsAAPL leads in 3 of 6 categories (Financial Metrics, Profitability & Efficiency). SYBX leads in 1 (Valuation Metrics). 1 tied.
Financial Metrics (TTM)
AAPL and SYBX operate at a comparable scale, with $435.6B and $0 in trailing revenue. AAPL is the more profitable business, keeping 27.0% of every revenue dollar as net income compared to SYBX's -2919.9%.
| Metric | SYBXSynlogic, Inc. | AAPLApple Inc. |
|---|---|---|
| RevenueTrailing 12 months | $0 | $435.6B |
| EBITDAEarnings before interest/tax | -$3M | $152.9B |
| Net IncomeAfter-tax profit | -$3M | $117.8B |
| Free Cash FlowCash after capex | -$4M | $123.3B |
| Gross MarginGross profit ÷ Revenue | +100.0% | +47.3% |
| Operating MarginEBIT ÷ Revenue | -5118.8% | +32.4% |
| Net MarginNet income ÷ Revenue | -2919.9% | +27.0% |
| FCF MarginFCF ÷ Revenue | -3959.0% | +28.3% |
| Rev. Growth (YoY)Latest quarter vs prior year | — | +15.7% |
| EPS Growth (YoY)Latest quarter vs prior year | — | +18.3% |
Valuation Metrics
| Metric | SYBXSynlogic, Inc. | AAPLApple Inc. |
|---|---|---|
| Market CapShares × price | $7M | $3.86T |
| Enterprise ValueMkt cap + debt − cash | -$12M | $3.95T |
| Trailing P/EPrice ÷ TTM EPS | -0.31x | 35.19x |
| Forward P/EPrice ÷ next-FY EPS est. | — | 30.95x |
| PEG RatioP/E ÷ EPS growth rate | — | 1.97x |
| EV / EBITDAEnterprise value multiple | — | 27.29x |
| Price / SalesMarket cap ÷ Revenue | 877.42x | 9.27x |
| Price / BookPrice ÷ Book value/share | 0.57x | 53.42x |
| Price / FCFMarket cap ÷ FCF | — | 39.08x |
Profitability & Efficiency
AAPL delivers a 133.5% return on equity — every $100 of shareholder capital generates $134 in annual profit, vs $-31 for SYBX. On the Piotroski fundamental quality scale (0–9), AAPL scores 7/9 vs SYBX's 2/9, reflecting strong financial health.
| Metric | SYBXSynlogic, Inc. | AAPLApple Inc. |
|---|---|---|
| ROE (TTM)Return on equity | -31.3% | +133.5% |
| ROA (TTM)Return on assets | -19.5% | +31.1% |
| ROICReturn on invested capital | -2.1% | +64.5% |
| ROCEReturn on capital employed | -120.6% | +69.6% |
| Piotroski ScoreFundamental quality 0–9 | 2 | 7 |
| Debt / EquityFinancial leverage | — | 1.67x |
| Net DebtTotal debt minus cash | -$19M | $89.7B |
| Cash & Equiv.Liquid assets | $19M | $33.5B |
| Total DebtShort + long-term debt | $0 | $123.3B |
| Interest CoverageEBIT ÷ Interest expense | — | — |
Total Returns (with DRIP)
A $10,000 investment in AAPL five years ago would be worth $22,020 today (with dividends reinvested), compared to $117 for SYBX. Over the past 12 months, AAPL leads with a +11.8% total return vs SYBX's -53.1%. The 3-year compound annual growth rate (CAGR) favors AAPL at 20.0% vs SYBX's -60.9% — a key indicator of consistent wealth creation.
| Metric | SYBXSynlogic, Inc. | AAPLApple Inc. |
|---|---|---|
| YTD ReturnYear-to-date | -48.7% | -3.0% |
| 1-Year ReturnPast 12 months | -53.1% | +11.8% |
| 3-Year ReturnCumulative with dividends | -94.0% | +72.6% |
| 5-Year ReturnCumulative with dividends | -98.8% | +120.2% |
| 10-Year ReturnCumulative with dividends | -98.0% | +963.0% |
| CAGR (3Y)Annualised 3-year return | -60.9% | +20.0% |
Risk & Volatility
SYBX is the less volatile stock with a 0.97 beta — it tends to amplify market swings less than AAPL's 1.28 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. AAPL currently trades 91.0% from its 52-week high vs SYBX's 30.6% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | SYBXSynlogic, Inc. | AAPLApple Inc. |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 0.97x | 1.28x |
| 52-Week HighHighest price in past year | $1.96 | $288.61 |
| 52-Week LowLowest price in past year | $0.54 | $169.21 |
| % of 52W HighCurrent price vs 52-week peak | +30.6% | +91.0% |
| RSI (14)Momentum oscillator 0–100 | 34.3 | 47.2 |
| Avg Volume (50D)Average daily shares traded | 115K | 46.4M |
Analyst Outlook
AAPL is the only dividend payer here at 0.39% yield — a key consideration for income-focused portfolios.
| Metric | SYBXSynlogic, Inc. | AAPLApple Inc. |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | — | Buy |
| Price TargetConsensus 12-month target | — | $303.11 |
| # AnalystsCovering analysts | — | 109 |
| Dividend YieldAnnual dividend ÷ price | — | +0.4% |
| Dividend StreakConsecutive years of raises | — | 14 |
| Dividend / ShareAnnual DPS | — | $1.03 |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | +2.4% |
Historical Charts
Charts are rendered on first load. Hover for details.
Chart 1Total Return — 5 Years (Rebased to 100)
| Stock | Mar 20 | Mar 26 | Change |
|---|---|---|---|
| Synlogic, Inc. (SYBX) | 100 | 2.01 | -98.0% |
| Apple Inc. (AAPL) | 100 | 361.49 | +261.5% |
Apple Inc. (AAPL) returned +120% over 5 years vs Synlogic, Inc. (SYBX)'s -99%. A $10,000 investment in AAPL 5 years ago would be worth $22,020 today (including dividends reinvested).
Chart 2Revenue Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Synlogic, Inc. (SYBX) | $444000.00 | $8000.00 | -98.2% |
| Apple Inc. (AAPL) | $215.6B | $416.2B | +93.0% |
Apple Inc.'s revenue grew from $215.6B (2016) to $416.2B (2025) — a 7.6% CAGR.
Chart 3Net Margin Trend — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Synlogic, Inc. (SYBX) | -59.2% | -2919.9% | -4835.4% |
| Apple Inc. (AAPL) | 21.2% | 26.9% | +27.0% |
Apple Inc.'s net margin went from 21% (2016) to 27% (2025).
Chart 4P/E Ratio History — 9 Years
| Stock | 2017 | 2025 | Change |
|---|---|---|---|
| Apple Inc. (AAPL) | 18.4 | 36.4 | +97.8% |
Apple Inc. has traded in a 13x–41x P/E range over 9 years; current trailing P/E is ~35x.
Chart 5EPS Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Synlogic, Inc. (SYBX) | -8.83 | -1.92 | +78.3% |
| Apple Inc. (AAPL) | 2.08 | 7.46 | +258.7% |
Apple Inc.'s EPS grew from $2.08 (2016) to $7.46 (2025) — a 15% CAGR.
Chart 6Free Cash Flow — 5 Years
Synlogic, Inc. generated $-32M FCF in 2024 (+40% vs 2021). Apple Inc. generated $99B FCF in 2025 (+6% vs 2021).
SYBX vs AAPL: Frequently Asked Questions
7 questions · data-driven answers · updated daily
01Is SYBX or AAPL a better buy right now?
Apple Inc. (AAPL) offers the better valuation at 35.2x trailing P/E (31.0x forward), making it the more compelling value choice. Analysts rate Apple Inc. (AAPL) a "Buy" — based on 109 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — SYBX or AAPL?
Over the past 5 years, Apple Inc. (AAPL) delivered a total return of +120.2%, compared to -98.8% for Synlogic, Inc. (SYBX). A $10,000 investment in AAPL five years ago would be worth approximately $22K today (assuming dividends reinvested). Over 10 years, the gap is even starker: AAPL returned +963.0% versus SYBX's -98.0%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — SYBX or AAPL?
By beta (market sensitivity over 5 years), Synlogic, Inc. (SYBX) is the lower-risk stock at 0.97β versus Apple Inc.'s 1.28β — meaning AAPL is approximately 32% more volatile than SYBX relative to the S&P 500.
04Which has better profit margins — SYBX or AAPL?
Apple Inc. (AAPL) is the more profitable company, earning 26.9% net margin versus -2919.9% for Synlogic, Inc. — meaning it keeps 26.9% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: AAPL leads at 32.0% versus -5118.8% for SYBX. At the gross margin level — before operating expenses — SYBX leads at 100.0%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
05Which pays a better dividend — SYBX or AAPL?
In this comparison, AAPL (0.4% yield) pays a dividend. SYBX does not pay a meaningful dividend and should not be held primarily for income.
06Is SYBX or AAPL better for a retirement portfolio?
For long-horizon retirement investors, Apple Inc. (AAPL) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 1.28), +963.0% 10Y return). Both have compounded well over 10 years (AAPL: +963.0%, SYBX: -98.0%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
07What are the main differences between SYBX and AAPL?
These companies operate in different sectors (SYBX (Healthcare) and AAPL (Technology)), which means they face different economic cycles, regulatory environments, and macro sensitivities — making direct comparison nuanced. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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