Biotechnology
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5 / 10Stock Comparison
TBPH vs PRGO vs JNJ vs HLN vs MCK
Revenue, margins, valuation, and 5-year total return — side by side.
Drug Manufacturers - Specialty & Generic
Drug Manufacturers - General
Drug Manufacturers - Specialty & Generic
Medical - Distribution
TBPH vs PRGO vs JNJ vs HLN vs MCK — Key Financials
Market cap, revenue, margins, and valuation side-by-side.
| Company Snapshot | |||||
|---|---|---|---|---|---|
| Industry | Biotechnology | Drug Manufacturers - Specialty & Generic | Drug Manufacturers - General | Drug Manufacturers - Specialty & Generic | Medical - Distribution |
| Market Cap | $862M | $1.61B | $536.23B | $41.45B | $92.15B |
| Revenue (TTM) | $80M | $4.18B | $92.15B | $22.01B | $403.43B |
| Net Income (TTM) | $29M | $-1.82B | $25.12B | $3.18B | $4.76B |
| Gross Margin | 62.6% | 34.2% | 68.1% | 63.9% | 3.6% |
| Operating Margin | -40.9% | -4.1% | 26.1% | 21.4% | 1.5% |
| Forward P/E | 6.7x | 5.6x | 19.2x | 22.2x | 19.3x |
| Total Debt | $50M | $3.97B | $36.63B | $8.59B | $7.39B |
| Cash & Equiv. | $38M | $532M | $24.11B | $1.32B | $5.69B |
TBPH vs PRGO vs JNJ vs HLN vs MCK — Long-Term Stock Performance
Price return indexed to 100 at period start. Dividends excluded.
| Stock | Jul 22 | May 26 | Return |
|---|---|---|---|
| Theravance Biopharm… (TBPH) | 100 | 193.6 | +93.6% |
| Perrigo Company plc (PRGO) | 100 | 28.0 | -72.0% |
| Johnson & Johnson (JNJ) | 100 | 127.5 | +27.5% |
| Haleon plc (HLN) | 100 | 132.4 | +32.4% |
| McKesson Corporation (MCK) | 100 | 220.2 | +120.2% |
Price return only. Dividends and distributions are not included.
Quick Verdict: TBPH vs PRGO vs JNJ vs HLN vs MCK
Each card shows where this stock fits in a portfolio — not just who wins on paper.
TBPH has the current edge in this matchup, primarily because of its strength in quality and momentum.
- 36.5% margin vs PRGO's -43.5%
- +70.4% vs PRGO's -51.2%
PRGO is the #2 pick in this set and the best alternative if value and dividends is your priority.
- Lower P/E (5.6x vs 22.2x)
- 9.8% yield, 10-year raise streak, vs JNJ's 2.2%, (1 stock pays no dividend)
JNJ is the clearest fit if your priority is income & stability and sleep-well-at-night.
- Dividend streak 36 yrs, beta 0.06, yield 2.2%
- Lower volatility, beta 0.06, Low D/E 51.2%, current ratio 1.11x
- Beta 0.06, yield 2.2%, current ratio 1.11x
- 13.0% ROA vs PRGO's -19.8%, ROIC 20.7% vs 3.7%
Among these 5 stocks, HLN doesn't own a clear edge in any measured category.
MCK ranks third and is worth considering specifically for growth exposure and long-term compounding.
- Rev growth 16.2%, EPS growth 14.9%, 3Y rev CAGR 10.8%
- 348.1% 10Y total return vs JNJ's 132.3%
- PEG 0.49 vs JNJ's 34.17
- 16.2% revenue growth vs HLN's -4.0%
See the full category breakdown
| Category | Winner | Why |
|---|---|---|
| Growth | 16.2% revenue growth vs HLN's -4.0% | |
| Value | Lower P/E (5.6x vs 22.2x) | |
| Quality / Margins | 36.5% margin vs PRGO's -43.5% | |
| Stability / Safety | Beta 0.04 vs PRGO's 1.18 | |
| Dividends | 9.8% yield, 10-year raise streak, vs JNJ's 2.2%, (1 stock pays no dividend) | |
| Momentum (1Y) | +70.4% vs PRGO's -51.2% | |
| Efficiency (ROA) | 13.0% ROA vs PRGO's -19.8%, ROIC 20.7% vs 3.7% |
TBPH vs PRGO vs JNJ vs HLN vs MCK — Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
TBPH vs PRGO vs JNJ vs HLN vs MCK — Financial Metrics
Side-by-side numbers across 5 stocks — who leads on profitability, valuation, growth, and risk.
Who Leads Where
TBPH leads in 1 of 6 categories
PRGO leads 1 • MCK leads 1 • JNJ leads 0 • HLN leads 0 • 3 tied
Explore the data ↓Income & Cash Flow (Last 12 Months)
TBPH leads this category, winning 4 of 6 comparable metrics.
Income & Cash Flow (Last 12 Months)
MCK is the larger business by revenue, generating $403.4B annually — 5022.3x TBPH's $80M. TBPH is the more profitable business, keeping 36.5% of every revenue dollar as net income compared to PRGO's -43.5%. On growth, TBPH holds the edge at +18.5% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | |||||
|---|---|---|---|---|---|
| RevenueTrailing 12 months | $80M | $4.2B | $92.1B | $22.0B | $403.4B |
| EBITDAEarnings before interest/tax | -$31M | $58M | $31.4B | $5.3B | $6.8B |
| Net IncomeAfter-tax profit | $29M | -$1.8B | $25.1B | $3.2B | $4.8B |
| Free Cash FlowCash after capex | $243M | $108M | $19.1B | $3.1B | $6.0B |
| Gross MarginGross profit ÷ Revenue | +62.6% | +34.2% | +68.1% | +63.9% | +3.6% |
| Operating MarginEBIT ÷ Revenue | -40.9% | -4.1% | +26.1% | +21.4% | +1.5% |
| Net MarginNet income ÷ Revenue | +36.5% | -43.5% | +27.3% | +14.5% | +1.2% |
| FCF MarginFCF ÷ Revenue | +3.0% | +2.6% | +20.7% | +14.2% | +1.5% |
| Rev. Growth (YoY)Latest quarter vs prior year | +18.5% | -7.2% | +6.8% | -0.4% | +6.0% |
| EPS Growth (YoY)Latest quarter vs prior year | +126.9% | -56.4% | +91.0% | +18.8% | +37.0% |
Valuation Metrics
PRGO leads this category, winning 4 of 7 comparable metrics.
Valuation Metrics
At 19.0x trailing earnings, HLN trades at a 51% valuation discount to JNJ's 38.4x P/E. Adjusting for growth (PEG ratio), MCK offers better value at 0.75x vs JNJ's 34.17x — a lower PEG means you pay less per unit of expected earnings growth.
| Metric | |||||
|---|---|---|---|---|---|
| Market CapShares × price | $862M | $1.6B | $536.2B | $41.4B | $92.1B |
| Enterprise ValueMkt cap + debt − cash | $874M | $5.1B | $548.8B | $51.3B | $93.8B |
| Trailing P/EPrice ÷ TTM EPS | -14.80x | -1.14x | 38.43x | 19.01x | 29.25x |
| Forward P/EPrice ÷ next-FY EPS est. | 6.69x | 5.56x | 19.20x | 22.22x | 19.28x |
| PEG RatioP/E ÷ EPS growth rate | — | — | 34.17x | 2.25x | 0.75x |
| EV / EBITDAEnterprise value multiple | — | 7.42x | 18.61x | 13.62x | 18.74x |
| Price / SalesMarket cap ÷ Revenue | 13.40x | 0.38x | 6.04x | 2.83x | 0.26x |
| Price / BookPrice ÷ Book value/share | 4.74x | 0.55x | 7.56x | 1.87x | — |
| Price / FCFMarket cap ÷ FCF | — | 11.12x | 27.02x | 15.47x | 17.63x |
Profitability & Efficiency
Evenly matched — TBPH and MCK each lead in 3 of 9 comparable metrics.
Profitability & Efficiency
MCK delivers a 3.0% return on equity — every $100 of shareholder capital generates $3 in annual profit, vs $-51 for PRGO. TBPH carries lower financial leverage with a 0.28x debt-to-equity ratio, signaling a more conservative balance sheet compared to PRGO's 1.35x. On the Piotroski fundamental quality scale (0–9), HLN scores 8/9 vs PRGO's 4/9, reflecting strong financial health.
| Metric | |||||
|---|---|---|---|---|---|
| ROE (TTM)Return on equity | +14.7% | -50.7% | +31.7% | +19.9% | +3.0% |
| ROA (TTM)Return on assets | +7.6% | -19.8% | +13.0% | +10.0% | +5.7% |
| ROICReturn on invested capital | -17.2% | +3.7% | +20.7% | +7.6% | +5.4% |
| ROCEReturn on capital employed | -13.8% | +4.3% | +17.6% | +8.6% | +30.5% |
| Piotroski ScoreFundamental quality 0–9 | 4 | 4 | 5 | 8 | 6 |
| Debt / EquityFinancial leverage | 0.28x | 1.35x | 0.51x | 0.52x | — |
| Net DebtTotal debt minus cash | $12M | $3.4B | $12.5B | $7.3B | $1.7B |
| Cash & Equiv.Liquid assets | $38M | $532M | $24.1B | $1.3B | $5.7B |
| Total DebtShort + long-term debt | $50M | $4.0B | $36.6B | $8.6B | $7.4B |
| Interest CoverageEBIT ÷ Interest expense | -11.01x | -7.20x | 48.23x | 7.80x | 33.79x |
Total Returns (Dividends Reinvested)
MCK leads this category, winning 4 of 6 comparable metrics.
Total Returns (Dividends Reinvested)
A $10,000 investment in MCK five years ago would be worth $38,689 today (with dividends reinvested), compared to $3,986 for PRGO. Over the past 12 months, TBPH leads with a +70.4% total return vs PRGO's -51.2%. The 3-year compound annual growth rate (CAGR) favors MCK at 27.3% vs PRGO's -25.2% — a key indicator of consistent wealth creation.
| Metric | |||||
|---|---|---|---|---|---|
| YTD ReturnYear-to-date | -6.2% | -13.5% | +7.9% | -5.6% | -8.5% |
| 1-Year ReturnPast 12 months | +70.4% | -51.2% | +44.8% | -11.7% | +4.6% |
| 3-Year ReturnCumulative with dividends | +50.2% | -58.1% | +46.3% | +10.4% | +106.4% |
| 5-Year ReturnCumulative with dividends | -13.8% | -60.1% | +46.1% | +31.7% | +286.9% |
| 10-Year ReturnCumulative with dividends | -8.6% | -77.7% | +132.3% | +31.7% | +348.1% |
| CAGR (3Y)Annualised 3-year return | +14.5% | -25.2% | +13.5% | +3.4% | +27.3% |
Risk & Volatility
Evenly matched — JNJ and MCK each lead in 1 of 2 comparable metrics.
Risk & Volatility
MCK is the less volatile stock with a 0.04 beta — it tends to amplify market swings less than PRGO's 1.18 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. JNJ currently trades 88.4% from its 52-week high vs PRGO's 41.2% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | |||||
|---|---|---|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 0.89x | 1.18x | 0.06x | 0.06x | 0.04x |
| 52-Week HighHighest price in past year | $21.03 | $28.44 | $251.71 | $11.42 | $999.00 |
| 52-Week LowLowest price in past year | $8.33 | $9.23 | $146.12 | $8.71 | $637.00 |
| % of 52W HighCurrent price vs 52-week peak | +80.9% | +41.2% | +88.4% | +81.5% | +75.3% |
| RSI (14)Momentum oscillator 0–100 | 58.4 | 60.9 | 37.1 | 36.0 | 16.2 |
| Avg Volume (50D)Average daily shares traded | 626K | 3.4M | 7.0M | 8.0M | 757K |
Analyst Outlook
Evenly matched — PRGO and JNJ each lead in 1 of 2 comparable metrics.
Analyst Outlook
Analyst consensus: TBPH as "Hold", PRGO as "Hold", JNJ as "Buy", HLN as "Buy", MCK as "Buy". Consensus price targets imply 70.6% upside for PRGO (target: $20) vs 9.6% for HLN (target: $10). For income investors, PRGO offers the higher dividend yield at 9.81% vs MCK's 0.36%.
| Metric | |||||
|---|---|---|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Hold | Hold | Buy | Buy | Buy |
| Price TargetConsensus 12-month target | $27.00 | $20.00 | $249.27 | $10.20 | $1006.50 |
| # AnalystsCovering analysts | 16 | 36 | 40 | 4 | 31 |
| Dividend YieldAnnual dividend ÷ price | — | +9.8% | +2.2% | +1.9% | +0.4% |
| Dividend StreakConsecutive years of raises | — | 10 | 36 | 2 | 17 |
| Dividend / ShareAnnual DPS | — | $1.15 | $4.87 | $0.13 | $2.69 |
| Buyback YieldShare repurchases ÷ mkt cap | +0.4% | 0.0% | +0.5% | +2.1% | +3.4% |
TBPH leads in 1 of 6 categories (Income & Cash Flow). PRGO leads in 1 (Valuation Metrics). 3 tied.
TBPH vs PRGO vs JNJ vs HLN vs MCK: Key Questions Answered
10 questions · data-driven answers · updated daily
01Is TBPH or PRGO or JNJ or HLN or MCK a better buy right now?
For growth investors, McKesson Corporation (MCK) is the stronger pick with 16.
2% revenue growth year-over-year, versus -4. 0% for Haleon plc (HLN). Haleon plc (HLN) offers the better valuation at 19. 0x trailing P/E (22. 2x forward), making it the more compelling value choice. Analysts rate Johnson & Johnson (JNJ) a "Buy" — based on 40 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which has the better valuation — TBPH or PRGO or JNJ or HLN or MCK?
On trailing P/E, Haleon plc (HLN) is the cheapest at 19.
0x versus Johnson & Johnson at 38. 4x. On forward P/E, Perrigo Company plc is actually cheaper at 5. 6x — notably different from the trailing picture, reflecting expected earnings growth. The PEG ratio (P/E divided by earnings growth rate) is the most growth-adjusted single valuation metric: McKesson Corporation wins at 0. 49x versus Johnson & Johnson's 34. 17x — a PEG below 1. 0 traditionally signals the market is underpricing earnings growth.
03Which is the better long-term investment — TBPH or PRGO or JNJ or HLN or MCK?
Over the past 5 years, McKesson Corporation (MCK) delivered a total return of +286.
9%, compared to -60. 1% for Perrigo Company plc (PRGO). Over 10 years, the gap is even starker: MCK returned +348. 1% versus PRGO's -77. 7%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
04Which is safer — TBPH or PRGO or JNJ or HLN or MCK?
By beta (market sensitivity over 5 years), McKesson Corporation (MCK) is the lower-risk stock at 0.
04β versus Perrigo Company plc's 1. 18β — meaning PRGO is approximately 2641% more volatile than MCK relative to the S&P 500. On balance sheet safety, Theravance Biopharma, Inc. (TBPH) carries a lower debt/equity ratio of 28% versus 135% for Perrigo Company plc — giving it more financial flexibility in a downturn.
05Which is growing faster — TBPH or PRGO or JNJ or HLN or MCK?
By revenue growth (latest reported year), McKesson Corporation (MCK) is pulling ahead at 16.
2% versus -4. 0% for Haleon plc (HLN). On earnings-per-share growth, the picture is similar: McKesson Corporation grew EPS 14. 9% year-over-year, compared to -723. 2% for Perrigo Company plc. Over a 3-year CAGR, MCK leads at 10. 8% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.
06Which has better profit margins — TBPH or PRGO or JNJ or HLN or MCK?
Johnson & Johnson (JNJ) is the more profitable company, earning 15.
8% net margin versus -87. 6% for Theravance Biopharma, Inc. — meaning it keeps 15. 8% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: JNJ leads at 24. 9% versus -72. 9% for TBPH. At the gross margin level — before operating expenses — TBPH leads at 100. 0%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
07Is TBPH or PRGO or JNJ or HLN or MCK more undervalued right now?
The PEG ratio (forward P/E divided by expected earnings growth rate) is the most precise measure of undervaluation relative to growth potential.
By this metric, McKesson Corporation (MCK) is the more undervalued stock at a PEG of 0. 49x versus Johnson & Johnson's 34. 17x. A PEG below 1. 0 is traditionally considered the threshold for growth-adjusted undervaluation. On forward earnings alone, Perrigo Company plc (PRGO) trades at 5. 6x forward P/E versus 22. 2x for Haleon plc — 16. 7x cheaper on a one-year earnings basis. Analyst consensus price targets imply the most upside for PRGO: 70. 6% to $20. 00.
08Which pays a better dividend — TBPH or PRGO or JNJ or HLN or MCK?
In this comparison, PRGO (9.
8% yield), JNJ (2. 2% yield), HLN (1. 9% yield), MCK (0. 4% yield) pay a dividend. TBPH does not pay a meaningful dividend and should not be held primarily for income.
09Is TBPH or PRGO or JNJ or HLN or MCK better for a retirement portfolio?
For long-horizon retirement investors, Johnson & Johnson (JNJ) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0.
06), 2. 2% yield, +132. 3% 10Y return). Both have compounded well over 10 years (JNJ: +132. 3%, TBPH: -8. 6%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
10What are the main differences between TBPH and PRGO and JNJ and HLN and MCK?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both.
In terms of investment character: TBPH is a small-cap quality compounder stock; PRGO is a small-cap income-oriented stock; JNJ is a large-cap quality compounder stock; HLN is a mid-cap quality compounder stock; MCK is a mid-cap high-growth stock. PRGO, JNJ, HLN pay a dividend while TBPH, MCK do not, making them suitable for different income and tax situations. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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