TLPH
Talphera, Inc.
Drug Manufacturers - Specialty & Generic
Market Cap$43M
5Y Perf.-96.8%
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Stock Comparison
TLPH vs PRGO
Revenue, margins, valuation, and 5-year total return — side by side.
PRGO
Perrigo Company plc
Drug Manufacturers - Specialty & Generic
Market Cap$1.61B
5Y Perf.-78.6%
TLPH vs PRGO — Key Financials
Market cap, revenue, margins, and valuation side-by-side.
| Company Snapshot | TLPH | PRGO |
|---|---|---|
| Industry | Drug Manufacturers - Specialty & Generic | Drug Manufacturers - Specialty & Generic |
| Market Cap | $43M | $1.61B |
| Revenue (TTM) | $28K | $4.18B |
| Net Income (TTM) | $-14M | $-1.82B |
| Gross Margin | -40.8% | 34.2% |
| Operating Margin | -481.6% | -4.1% |
| Forward P/E | — | 5.6x |
| Total Debt | $0.00 | $3.97B |
| Cash & Equiv. | $6M | $532M |
TLPH vs PRGO — Long-Term Stock Performance
Price return indexed to 100 at period start. Dividends excluded.
TLPH
PRGO
| Stock | May 20 | May 26 | Return |
|---|---|---|---|
| Talphera, Inc. (TLPH) | 100 | 3.2 | -96.8% |
| Perrigo Company plc (PRGO) | 100 | 21.4 | -78.6% |
Price return only. Dividends and distributions are not included.
Quick Verdict: TLPH vs PRGO
Each card shows where this stock fits in a portfolio — not just who wins on paper.
Bottom line: PRGO leads in 4 of 6 categories, making it the strongest pick for growth and revenue expansion and profitability and margin quality. Talphera, Inc. is the stronger pick specifically for capital preservation and lower volatility and recent price momentum and sentiment. As sector peers, any of these can serve as alternatives in the same allocation.
TLPH
Talphera, Inc.
The Income Pick
TLPH is the clearest fit if your priority is income & stability and growth exposure.
- beta 1.10
- EPS growth 32.0%
- Lower volatility, beta 1.10, current ratio 5.49x
Best for: income & stability and growth exposure
PRGO
Perrigo Company plc
The Long-Run Compounder
PRGO carries the broadest edge in this set and is the clearest fit for long-term compounding.
- -77.7% 10Y total return vs TLPH's -98.6%
- -2.8% revenue growth vs TLPH's -18.2%
- -43.5% margin vs TLPH's -510.4%
Best for: long-term compounding
See the full category breakdown
| Category | Winner | Why |
|---|---|---|
| Growth | PRGO | -2.8% revenue growth vs TLPH's -18.2% |
| Quality / Margins | PRGO | -43.5% margin vs TLPH's -510.4% |
| Stability / Safety | TLPH | Beta 1.10 vs PRGO's 1.18 |
| Dividends | PRGO | 9.8% yield; 10-year raise streak; the other pay no meaningful dividend |
| Momentum (1Y) | TLPH | +70.5% vs PRGO's -51.2% |
| Efficiency (ROA) | PRGO | -19.8% ROA vs TLPH's -62.2%, ROIC 3.7% vs -120.3% |
TLPH vs PRGO — Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
FY 2025
TLPH vs PRGO — Financial Metrics
Side-by-side numbers across 2 stocks — who leads on profitability, valuation, growth, and risk.
BEST OVERALLPRGOLAGGINGTLPH
TLPHTalphera, Inc.
1leads
PRGOPerrigo Company plc
3leads
6 Total Categories
CATEGORYLEADERvs TLPHMETRICS WON
Income & Cash FlowRevenue, margins, and cash flow strength
PRGO4/5
Valuation MetricsMultiples, price ratios, and targets
PRGO2/3
Profitability & EfficiencyROE, ROIC, leverage, and quality scores
PRGO4/6
Total Returns1Y, 3Y, 5Y total returns with dividends
Tied
—
Risk & VolatilityBeta, volatility, and downside exposure
TLPH2/2
Analyst OutlookRatings, price targets, and dividends
—
—
Income & Cash Flow (Last 12 Months)
PRGO leads this category, winning 4 of 5 comparable metrics.
Income & Cash Flow (Last 12 Months)
PRGO is the larger business by revenue, generating $4.2B annually — 149228.6x TLPH's $28,000. PRGO is the more profitable business, keeping -43.5% of every revenue dollar as net income compared to TLPH's -510.4%.
| Metric | TLPHTalphera, Inc. | PRGOPerrigo Company p… |
|---|---|---|
| RevenueTrailing 12 months | $28,000 | $4.2B |
| EBITDAEarnings before interest/tax | -$11M | $58M |
| Net IncomeAfter-tax profit | -$14M | -$1.8B |
| Free Cash FlowCash after capex | -$11M | $108M |
| Gross MarginGross profit ÷ Revenue | -40.8% | +34.2% |
| Operating MarginEBIT ÷ Revenue | -481.6% | -4.1% |
| Net MarginNet income ÷ Revenue | -510.4% | -43.5% |
| FCF MarginFCF ÷ Revenue | -405.9% | +2.6% |
| Rev. Growth (YoY)Latest quarter vs prior year | — | -7.2% |
| EPS Growth (YoY)Latest quarter vs prior year | +56.1% | -56.4% |
PRGO leads this category, winning 4 of 5 comparable metrics.
Valuation Metrics
PRGO leads this category, winning 2 of 3 comparable metrics.
Valuation Metrics
| Metric | TLPHTalphera, Inc. | PRGOPerrigo Company p… |
|---|---|---|
| Market CapShares × price | $43M | $1.6B |
| Enterprise ValueMkt cap + debt − cash | $37M | $5.1B |
| Trailing P/EPrice ÷ TTM EPS | -2.58x | -1.14x |
| Forward P/EPrice ÷ next-FY EPS est. | — | 5.56x |
| PEG RatioP/E ÷ EPS growth rate | — | — |
| EV / EBITDAEnterprise value multiple | — | 7.42x |
| Price / SalesMarket cap ÷ Revenue | 1547.32x | 0.38x |
| Price / BookPrice ÷ Book value/share | 2.19x | 0.55x |
| Price / FCFMarket cap ÷ FCF | — | 11.12x |
PRGO leads this category, winning 2 of 3 comparable metrics.
Profitability & Efficiency
PRGO leads this category, winning 4 of 6 comparable metrics.
Profitability & Efficiency
PRGO delivers a -50.7% return on equity — every $100 of shareholder capital generates $-51 in annual profit, vs $-118 for TLPH.
| Metric | TLPHTalphera, Inc. | PRGOPerrigo Company p… |
|---|---|---|
| ROE (TTM)Return on equity | -118.0% | -50.7% |
| ROA (TTM)Return on assets | -62.2% | -19.8% |
| ROICReturn on invested capital | -120.3% | +3.7% |
| ROCEReturn on capital employed | -65.0% | +4.3% |
| Piotroski ScoreFundamental quality 0–9 | 4 | 4 |
| Debt / EquityFinancial leverage | — | 1.35x |
| Net DebtTotal debt minus cash | -$6M | $3.4B |
| Cash & Equiv.Liquid assets | $6M | $532M |
| Total DebtShort + long-term debt | $0 | $4.0B |
| Interest CoverageEBIT ÷ Interest expense | — | -7.20x |
PRGO leads this category, winning 4 of 6 comparable metrics.
Total Returns (Dividends Reinvested)
Evenly matched — TLPH and PRGO each lead in 3 of 6 comparable metrics.
Total Returns (Dividends Reinvested)
A $10,000 investment in PRGO five years ago would be worth $3,986 today (with dividends reinvested), compared to $385 for TLPH. Over the past 12 months, TLPH leads with a +70.5% total return vs PRGO's -51.2%. The 3-year compound annual growth rate (CAGR) favors TLPH at 5.9% vs PRGO's -25.2% — a key indicator of consistent wealth creation.
| Metric | TLPHTalphera, Inc. | PRGOPerrigo Company p… |
|---|---|---|
| YTD ReturnYear-to-date | -24.3% | -13.5% |
| 1-Year ReturnPast 12 months | +70.5% | -51.2% |
| 3-Year ReturnCumulative with dividends | +18.7% | -58.1% |
| 5-Year ReturnCumulative with dividends | -96.1% | -60.1% |
| 10-Year ReturnCumulative with dividends | -98.6% | -77.7% |
| CAGR (3Y)Annualised 3-year return | +5.9% | -25.2% |
Evenly matched — TLPH and PRGO each lead in 3 of 6 comparable metrics.
Risk & Volatility
TLPH leads this category, winning 2 of 2 comparable metrics.
Risk & Volatility
TLPH is the less volatile stock with a 1.10 beta — it tends to amplify market swings less than PRGO's 1.18 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. TLPH currently trades 55.9% from its 52-week high vs PRGO's 41.2% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | TLPHTalphera, Inc. | PRGOPerrigo Company p… |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 1.10x | 1.18x |
| 52-Week HighHighest price in past year | $1.57 | $28.44 |
| 52-Week LowLowest price in past year | $0.38 | $9.23 |
| % of 52W HighCurrent price vs 52-week peak | +55.9% | +41.2% |
| RSI (14)Momentum oscillator 0–100 | 55.7 | 60.9 |
| Avg Volume (50D)Average daily shares traded | 164K | 3.4M |
TLPH leads this category, winning 2 of 2 comparable metrics.
Analyst Outlook
Insufficient data to determine a leader in this category.
Analyst Outlook
PRGO is the only dividend payer here at 9.81% yield — a key consideration for income-focused portfolios.
| Metric | TLPHTalphera, Inc. | PRGOPerrigo Company p… |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | — | Hold |
| Price TargetConsensus 12-month target | — | $20.00 |
| # AnalystsCovering analysts | — | 36 |
| Dividend YieldAnnual dividend ÷ price | — | +9.8% |
| Dividend StreakConsecutive years of raises | — | 10 |
| Dividend / ShareAnnual DPS | — | $1.15 |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | 0.0% |
Insufficient data to determine a leader in this category.
Key Takeaway
PRGO leads in 3 of 6 categories (Income & Cash Flow, Valuation Metrics). TLPH leads in 1 (Risk & Volatility). 1 tied.
Best OverallPerrigo Company plc (PRGO)Leads 3 of 6 categories
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TLPH vs PRGO: Frequently Asked Questions
8 questions · data-driven answers · updated daily
01Is TLPH or PRGO a better buy right now?
Analysts rate Perrigo Company plc (PRGO) a "Hold" — based on 36 analyst ratings — the highest consensus in this comparison.
The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — TLPH or PRGO?
Over the past 5 years, Perrigo Company plc (PRGO) delivered a total return of -60.
1%, compared to -96. 1% for Talphera, Inc. (TLPH). Over 10 years, the gap is even starker: PRGO returned -77. 7% versus TLPH's -98. 6%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — TLPH or PRGO?
By beta (market sensitivity over 5 years), Talphera, Inc.
(TLPH) is the lower-risk stock at 1. 10β versus Perrigo Company plc's 1. 18β — meaning PRGO is approximately 7% more volatile than TLPH relative to the S&P 500.
04Which is growing faster — TLPH or PRGO?
On earnings-per-share growth, the picture is similar: Talphera, Inc.
grew EPS 32. 0% year-over-year, compared to -723. 2% for Perrigo Company plc. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.
05Which has better profit margins — TLPH or PRGO?
Perrigo Company plc (PRGO) is the more profitable company, earning -33.
5% net margin versus -510. 4% for Talphera, Inc. — meaning it keeps -33. 5% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: PRGO leads at 8. 1% versus -481. 6% for TLPH. At the gross margin level — before operating expenses — PRGO leads at 35. 1%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
06Which pays a better dividend — TLPH or PRGO?
In this comparison, PRGO (9.
8% yield) pays a dividend. TLPH does not pay a meaningful dividend and should not be held primarily for income.
07Is TLPH or PRGO better for a retirement portfolio?
For long-horizon retirement investors, Perrigo Company plc (PRGO) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 1.
18), 9. 8% yield). Both have compounded well over 10 years (PRGO: -77. 7%, TLPH: -98. 6%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
08What are the main differences between TLPH and PRGO?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both.
In terms of investment character: TLPH is a small-cap quality compounder stock; PRGO is a small-cap income-oriented stock. PRGO pays a dividend while TLPH does not, making them suitable for different income and tax situations. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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