Biotechnology
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5 / 10Stock Comparison
XTLB vs NRXP vs SIGA vs BFRI vs AEYE
Revenue, margins, valuation, and 5-year total return — side by side.
Biotechnology
Drug Manufacturers - Specialty & Generic
Drug Manufacturers - Specialty & Generic
Software - Application
XTLB vs NRXP vs SIGA vs BFRI vs AEYE — Key Financials
Market cap, revenue, margins, and valuation side-by-side.
| Company Snapshot | |||||
|---|---|---|---|---|---|
| Industry | Biotechnology | Biotechnology | Drug Manufacturers - Specialty & Generic | Drug Manufacturers - Specialty & Generic | Software - Application |
| Market Cap | $294K | $85M | $339M | $13M | $100M |
| Revenue (TTM) | $451K | $242K | $94M | $42M | $40M |
| Net Income (TTM) | $-1M | $-38M | $-4.04T | $-11M | $-3M |
| Gross Margin | 26.4% | 59.5% | 61.8% | 75.8% | 78.3% |
| Operating Margin | -481.6% | -63.0% | 27.7% | -27.2% | -7.9% |
| Forward P/E | — | — | 2.8x | — | — |
| Total Debt | $138K | $631K | $595K | $6M | $721K |
| Cash & Equiv. | $371K | $8M | $155M | $6M | $5M |
XTLB vs NRXP vs SIGA vs BFRI vs AEYE — Long-Term Stock Performance
Price return indexed to 100 at period start. Dividends excluded.
| Stock | Oct 21 | May 26 | Return |
|---|---|---|---|
| XTL Biopharmaceutic… (XTLB) | 100 | 17.5 | -82.5% |
| NRx Pharmaceuticals… (NRXP) | 100 | 3.0 | -97.0% |
| SIGA Technologies, … (SIGA) | 100 | 65.6 | -34.4% |
| Biofrontera Inc. (BFRI) | 100 | 1.3 | -98.7% |
| AudioEye, Inc. (AEYE) | 100 | 81.4 | -18.6% |
Price return only. Dividends and distributions are not included.
Quick Verdict: XTLB vs NRXP vs SIGA vs BFRI vs AEYE
Each card shows where this stock fits in a portfolio — not just who wins on paper.
Among these 5 stocks, XTLB doesn't own a clear edge in any measured category.
NRXP is the #2 pick in this set and the best alternative if growth is your priority.
- 101.1% revenue growth vs XTLB's -173.2%
SIGA carries the broadest edge in this set and is the clearest fit for income & stability and long-term compounding.
- Dividend streak 4 yrs, beta 1.15, yield 12.7%
- 7.6% 10Y total return vs AEYE's 102.2%
- Lower volatility, beta 1.15, Low D/E 0.3%, current ratio 11.83x
- Beta 1.15, yield 12.7%, current ratio 11.83x
BFRI ranks third and is worth considering specifically for growth exposure.
- Rev growth 11.8%, EPS growth 100.0%, 3Y rev CAGR 13.3%
- +62.5% vs XTLB's -50.9%
AEYE is the clearest fit if your priority is quality.
- -7.6% margin vs SIGA's -43K%
See the full category breakdown
| Category | Winner | Why |
|---|---|---|
| Growth | 101.1% revenue growth vs XTLB's -173.2% | |
| Quality / Margins | -7.6% margin vs SIGA's -43K% | |
| Stability / Safety | Beta 1.15 vs AEYE's 2.29, lower leverage | |
| Dividends | 12.7% yield; 4-year raise streak; the other 4 pay no meaningful dividend | |
| Momentum (1Y) | +62.5% vs XTLB's -50.9% | |
| Efficiency (ROA) | -7.4% ROA vs NRXP's -489.9% |
XTLB vs NRXP vs SIGA vs BFRI vs AEYE — Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
XTLB vs NRXP vs SIGA vs BFRI vs AEYE — Financial Metrics
Side-by-side numbers across 5 stocks — who leads on profitability, valuation, growth, and risk.
Who Leads Where
SIGA leads in 3 of 6 categories
XTLB leads 0 • NRXP leads 0 • BFRI leads 0 • AEYE leads 0 • 3 tied
Explore the data ↓Income & Cash Flow (Last 12 Months)
Evenly matched — SIGA and BFRI and AEYE each lead in 2 of 6 comparable metrics.
Income & Cash Flow (Last 12 Months)
SIGA is the larger business by revenue, generating $94M annually — 387.5x NRXP's $242,000. AEYE is the more profitable business, keeping -7.6% of every revenue dollar as net income compared to SIGA's -43117.4%. On growth, BFRI holds the edge at +36.2% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | |||||
|---|---|---|---|---|---|
| RevenueTrailing 12 months | $451,000 | $242,000 | $94M | $42M | $40M |
| EBITDAEarnings before interest/tax | -$1M | -$31M | $26M | -$11M | -$504,000 |
| Net IncomeAfter-tax profit | -$1M | -$38M | -$4.04T | -$11M | -$3M |
| Free Cash FlowCash after capex | $0 | -$12M | $33M | -$13M | $2M |
| Gross MarginGross profit ÷ Revenue | +26.4% | +59.5% | +61.8% | +75.8% | +78.3% |
| Operating MarginEBIT ÷ Revenue | -4.8% | -63.0% | +27.7% | -27.2% | -7.9% |
| Net MarginNet income ÷ Revenue | -2.3% | -157.3% | -43117.4% | -25.3% | -7.6% |
| FCF MarginFCF ÷ Revenue | -3.7% | -49.0% | +35.2% | -32.0% | +5.5% |
| Rev. Growth (YoY)Latest quarter vs prior year | — | — | -11.3% | +36.2% | +7.9% |
| EPS Growth (YoY)Latest quarter vs prior year | +20.0% | -80.0% | — | +100.0% | +29.0% |
Valuation Metrics
Evenly matched — XTLB and BFRI and AEYE each lead in 1 of 3 comparable metrics.
Valuation Metrics
| Metric | |||||
|---|---|---|---|---|---|
| Market CapShares × price | $293,767 | $85M | $339M | $13M | $100M |
| Enterprise ValueMkt cap + debt − cash | $60,767 | $78M | $185M | $13M | $96M |
| Trailing P/EPrice ÷ TTM EPS | -0.28x | -2.28x | 14.33x | — | -32.36x |
| Forward P/EPrice ÷ next-FY EPS est. | — | — | 2.78x | — | — |
| PEG RatioP/E ÷ EPS growth rate | — | — | — | — | — |
| EV / EBITDAEnterprise value multiple | — | — | 7.60x | — | — |
| Price / SalesMarket cap ÷ Revenue | 0.65x | 69.15x | 3.58x | 0.32x | 2.49x |
| Price / BookPrice ÷ Book value/share | 0.05x | — | 1.70x | — | 20.91x |
| Price / FCFMarket cap ÷ FCF | — | — | 6.96x | — | — |
Profitability & Efficiency
SIGA leads this category, winning 7 of 9 comparable metrics.
Profitability & Efficiency
SIGA delivers a -10.7% return on equity — every $100 of shareholder capital generates $-11 in annual profit, vs $-11 for BFRI. SIGA carries lower financial leverage with a 0.00x debt-to-equity ratio, signaling a more conservative balance sheet compared to BFRI's 0.59x. On the Piotroski fundamental quality scale (0–9), NRXP scores 5/9 vs XTLB's 3/9, reflecting solid financial health.
| Metric | |||||
|---|---|---|---|---|---|
| ROE (TTM)Return on equity | -25.5% | — | -10.7% | -11.4% | -47.8% |
| ROA (TTM)Return on assets | -17.7% | -4.9% | -7.4% | -52.2% | -9.5% |
| ROICReturn on invested capital | -54.1% | — | +33.7% | -124.3% | -42.4% |
| ROCEReturn on capital employed | -50.7% | — | +11.3% | -84.8% | -17.7% |
| Piotroski ScoreFundamental quality 0–9 | 3 | 5 | 5 | 4 | 4 |
| Debt / EquityFinancial leverage | 0.03x | — | 0.00x | 0.59x | 0.15x |
| Net DebtTotal debt minus cash | -$233,000 | -$7M | -$154M | -$231,000 | -$5M |
| Cash & Equiv.Liquid assets | $371,000 | $8M | $155M | $6M | $5M |
| Total DebtShort + long-term debt | $138,000 | $631,000 | $595,169 | $6M | $721,000 |
| Interest CoverageEBIT ÷ Interest expense | -13.31x | -24.18x | — | -69.93x | -2.79x |
Total Returns (Dividends Reinvested)
SIGA leads this category, winning 4 of 6 comparable metrics.
Total Returns (Dividends Reinvested)
A $10,000 investment in SIGA five years ago would be worth $10,136 today (with dividends reinvested), compared to $92 for NRXP. Over the past 12 months, BFRI leads with a +62.5% total return vs XTLB's -50.9%. The 3-year compound annual growth rate (CAGR) favors SIGA at 6.9% vs BFRI's -54.4% — a key indicator of consistent wealth creation.
| Metric | |||||
|---|---|---|---|---|---|
| YTD ReturnYear-to-date | +11.3% | +16.8% | -15.0% | +57.2% | -18.7% |
| 1-Year ReturnPast 12 months | -50.9% | +55.3% | +1.5% | +62.5% | -27.9% |
| 3-Year ReturnCumulative with dividends | -45.7% | -50.6% | +22.2% | -90.5% | +20.6% |
| 5-Year ReturnCumulative with dividends | -80.4% | -99.1% | +1.4% | -98.7% | -60.2% |
| 10-Year ReturnCumulative with dividends | -87.3% | -96.8% | +764.0% | -98.7% | +102.2% |
| CAGR (3Y)Annualised 3-year return | -18.4% | -21.0% | +6.9% | -54.4% | +6.4% |
Risk & Volatility
Evenly matched — SIGA and BFRI each lead in 1 of 2 comparable metrics.
Risk & Volatility
SIGA is the less volatile stock with a 1.15 beta — it tends to amplify market swings less than AEYE's 2.29 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. BFRI currently trades 95.8% from its 52-week high vs XTLB's 26.0% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | |||||
|---|---|---|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 1.71x | 1.91x | 1.15x | 1.67x | 2.29x |
| 52-Week HighHighest price in past year | $10.28 | $3.84 | $9.62 | $1.19 | $16.39 |
| 52-Week LowLowest price in past year | $1.05 | $1.62 | $4.29 | $0.54 | $5.31 |
| % of 52W HighCurrent price vs 52-week peak | +26.0% | +79.7% | +49.2% | +95.8% | +49.4% |
| RSI (14)Momentum oscillator 0–100 | 57.0 | 64.7 | 47.0 | 63.6 | 61.3 |
| Avg Volume (50D)Average daily shares traded | 2.4M | 913K | 688K | 122K | 194K |
Analyst Outlook
SIGA leads this category, winning 1 of 1 comparable metric.
Analyst Outlook
SIGA is the only dividend payer here at 12.73% yield — a key consideration for income-focused portfolios.
| Metric | |||||
|---|---|---|---|---|---|
| Analyst RatingConsensus buy/hold/sell | — | — | Buy | — | — |
| Price TargetConsensus 12-month target | — | — | — | — | — |
| # AnalystsCovering analysts | — | — | 1 | — | — |
| Dividend YieldAnnual dividend ÷ price | — | — | +12.7% | — | — |
| Dividend StreakConsecutive years of raises | — | — | 4 | — | 1 |
| Dividend / ShareAnnual DPS | — | — | $0.60 | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% |
SIGA leads in 3 of 6 categories — strongest in Profitability & Efficiency and Total Returns. 3 categories are tied.
XTLB vs NRXP vs SIGA vs BFRI vs AEYE: Key Questions Answered
8 questions · data-driven answers · updated daily
01Is XTLB or NRXP or SIGA or BFRI or AEYE a better buy right now?
For growth investors, AudioEye, Inc.
(AEYE) is the stronger pick with 14. 5% revenue growth year-over-year, versus -31. 8% for SIGA Technologies, Inc. (SIGA). SIGA Technologies, Inc. (SIGA) offers the better valuation at 14. 3x trailing P/E (2. 8x forward), making it the more compelling value choice. Analysts rate SIGA Technologies, Inc. (SIGA) a "Buy" — based on 1 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — XTLB or NRXP or SIGA or BFRI or AEYE?
Over the past 5 years, SIGA Technologies, Inc.
(SIGA) delivered a total return of +1. 4%, compared to -99. 1% for NRx Pharmaceuticals, Inc. (NRXP). Over 10 years, the gap is even starker: SIGA returned +764. 0% versus BFRI's -98. 7%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — XTLB or NRXP or SIGA or BFRI or AEYE?
By beta (market sensitivity over 5 years), SIGA Technologies, Inc.
(SIGA) is the lower-risk stock at 1. 15β versus AudioEye, Inc. 's 2. 29β — meaning AEYE is approximately 99% more volatile than SIGA relative to the S&P 500. On balance sheet safety, SIGA Technologies, Inc. (SIGA) carries a lower debt/equity ratio of 0% versus 59% for Biofrontera Inc. — giving it more financial flexibility in a downturn.
04Which is growing faster — XTLB or NRXP or SIGA or BFRI or AEYE?
By revenue growth (latest reported year), AudioEye, Inc.
(AEYE) is pulling ahead at 14. 5% versus -31. 8% for SIGA Technologies, Inc. (SIGA). On earnings-per-share growth, the picture is similar: Biofrontera Inc. grew EPS 100. 0% year-over-year, compared to -60. 2% for SIGA Technologies, Inc.. Over a 3-year CAGR, BFRI leads at 13. 3% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.
05Which has better profit margins — XTLB or NRXP or SIGA or BFRI or AEYE?
SIGA Technologies, Inc.
(SIGA) is the more profitable company, earning 24. 6% net margin versus -23. 4% for NRx Pharmaceuticals, Inc. — meaning it keeps 24. 6% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: SIGA leads at 25. 1% versus -1324. 4% for NRXP. At the gross margin level — before operating expenses — AEYE leads at 78. 3%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
06Which pays a better dividend — XTLB or NRXP or SIGA or BFRI or AEYE?
In this comparison, SIGA (12.
7% yield) pays a dividend. XTLB, NRXP, BFRI, AEYE do not pay a meaningful dividend and should not be held primarily for income.
07Is XTLB or NRXP or SIGA or BFRI or AEYE better for a retirement portfolio?
For long-horizon retirement investors, SIGA Technologies, Inc.
(SIGA) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 1. 15), 12. 7% yield, +764. 0% 10Y return). NRx Pharmaceuticals, Inc. (NRXP) carries a higher beta of 1. 91 — meaning larger drawdowns in market downturns, which matters significantly when you cannot wait years for a recovery. Both have compounded well over 10 years (SIGA: +764. 0%, NRXP: -96. 8%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
08What are the main differences between XTLB and NRXP and SIGA and BFRI and AEYE?
These companies operate in different sectors (XTLB (Healthcare) and NRXP (Healthcare) and SIGA (Healthcare) and BFRI (Healthcare) and AEYE (Technology)), which means they face different economic cycles, regulatory environments, and macro sensitivities — making direct comparison nuanced.
In terms of investment character: XTLB is a small-cap quality compounder stock; NRXP is a small-cap quality compounder stock; SIGA is a small-cap deep-value stock; BFRI is a small-cap quality compounder stock; AEYE is a small-cap quality compounder stock. SIGA pays a dividend while XTLB, NRXP, BFRI, AEYE do not, making them suitable for different income and tax situations. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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