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SNDX logoSyndax Pharmaceuticals, Inc.(SNDX)Earnings, Financials & Key Ratios

SNDX•NASDAQ
$20.65
$1.82B mkt cap·Price updated May 6, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryOncology Therapeutics Developers
AboutSyndax Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company, develops therapies for the treatment of cancer. Its lead product candidates are SNDX-5613, which is in phase 1/2 clinical trial targeting the binding interaction of Menin with the mixed lineage leukemia 1 protein for the treatment of MLL-rearranged (MLLr) and nucleophosmin 1 mutant acute myeloid leukemia (NPM1c AML); and SNDX-6352 or axatilimab, a monoclonal antibody that blocks the colony stimulating factor 1, or CSF-1 receptor for the treatment of patients with chronic graft versus host disease (cGVHD). The company is also developing Entinostat. It also has collaborative research and development agreement with National Cancer Institute; a clinical trial agreement with Eastern Cooperative Oncology Group; and a license agreement with Kyowa Hakko Kirin Co., Ltd. Syndax Pharmaceuticals, Inc. was incorporated in 2005 and is headquartered in Waltham, Massachusetts.Massachusetts.Show more
  • Revenue$172M+627.8%
  • EBITDA-$273M+19.6%
  • Net Income-$285M+10.5%
  • EPS (Diluted)-3.29+11.8%
  • Gross Margin95.96%-0.6%
  • EBITDA Margin-158.44%+89.0%
  • Operating Margin-158.45%+89.0%
  • Net Margin-165.6%+87.7%
  • ROE-161.82%-113.8%
  • ROIC-54.19%+21.3%
  • Debt/Equity5.36+346.8%
  • Interest Coverage-7.45+88.3%
Technical→

SNDX Key Insights

Syndax Pharmaceuticals, Inc. (SNDX) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Strong 5Y sales CAGR of 157.7%

✗Weaknesses

  • ✗High debt to equity ratio of 5.4x
  • ✗Profits declining 31.3% over 5 years
  • ✗Weak Piotroski F-Score: 2/9
  • ✗Negative free cash flow
  • ✗Expensive at 27.7x book value

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

SNDX Price & Volume

Syndax Pharmaceuticals, Inc. (SNDX) stock price & volume — 10-year historical chart

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SNDX Growth Metrics

Syndax Pharmaceuticals, Inc. (SNDX) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years75.35%
5 Years157.68%
3 Years-
TTM396.72%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM26.56%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM40.31%

Return on Capital

10 Years-51.19%
5 Years-36.43%
3 Years-51.9%
Last Year-52.98%

SNDX Recent Earnings

Syndax Pharmaceuticals, Inc. (SNDX) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 9/12 qtrs (75%)●Beat Revenue 2/12 qtrs (29%)
Q2 2026Latest
Apr 30, 2026
EPS
$0.48
Est $0.59
+18.6%
Revenue
$65M
Est $70M
-7.0%
Q1 2026
Feb 26, 2026
EPS
$0.78
Est $0.58
-33.6%
Revenue
$69M
Est $64M
+6.9%
Q4 2025
Nov 3, 2025
EPS
$0.70
Est $0.74
+5.4%
Revenue
$46M
Est $63M
-27.6%
Q3 2025
Aug 4, 2025
EPS
$0.83
Est $1.00
+17.0%
Revenue
$38M
Est $46M
-16.9%
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestApr 30, 2026
$0.48vs $0.59+18.6%
$65Mvs $70M-7.0%
Q1 2026Feb 26, 2026
$0.78vs $0.58-33.6%
$69Mvs $64M+6.9%
Q4 2025Nov 3, 2025
$0.70vs $0.74+5.4%
$46Mvs $63M-27.6%
Q3 2025Aug 4, 2025
$0.83vs $1.00+17.0%
$38Mvs $46M-16.9%
Based on last 12 quarters of dataView full earnings history →

SNDX Peer Comparison

Syndax Pharmaceuticals, Inc. (SNDX) competitors in Oncology Therapeutics Developers — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
KYMR logoKYMRKymera Therapeutics, Inc.Direct Competitor7.04B86.26-23.38-16.72%-6.12%-25.02%0.05
IMVT logoIMVTImmunovant, Inc.Direct Competitor5.83B28.67-10.50-47.07%0.00
RVMD logoRVMDRevolution Medicines, Inc.Direct Competitor32.12B151.07-25.39-83.22%0.10
TGTX logoTGTXTG Therapeutics, Inc.Direct Competitor6.7B41.9715.1587.32%65.95%87.36%0.40
PRAX logoPRAXPraxis Precision Medicines, Inc.Direct Competitor7.61B337.95-25.07-100%-58.74%0.00
VERA logoVERAVera Therapeutics, Inc.Direct Competitor2.62B36.60-7.85-59.72%0.13
IOVA logoIOVAIovance Biotherapeutics, Inc.Product Competitor1.68B4.09-3.7560.6%-148.38%-55.97%0.07
FATE logoFATEFate Therapeutics, Inc.Product Competitor264.17M2.29-1.99-51.24%-20.51%-65.79%0.38

Compare SNDX vs Peers

Syndax Pharmaceuticals, Inc. (SNDX) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs KYMR

Most directly comparable listed peer for SNDX.

Scale Benchmark

vs ABBV

Larger-name benchmark to compare SNDX against a more recognizable public peer.

Peer Set

Compare Top 5

vs KYMR, IMVT, RVMD, TGTX

SNDX Income Statement

Syndax Pharmaceuticals, Inc. (SNDX) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Sales/Revenue2.11M1.52M1.52M1.52M139.71M0023.68M172.35M217.17M
Revenue Growth %72.79%-28.04%0%0%9109.56%-100%--627.84%396.72%
Cost of Goods Sold0000000826K6.97M4.44M
COGS % of Revenue-------3.49%4.04%-
Gross Profit
2.11M▲ 0%
1.52M▼ 28.0%
1.52M▲ 0.0%
1.52M▲ 0.0%
139.71M▲ 9109.6%
0▼ 100.0%
0▲ 0%
22.85M▲ 0%
165.38M▲ 623.6%
212.73M▲ 0%
Gross Margin %100%100%100%100%100%--96.51%95.96%97.96%
Gross Profit Growth %72.79%-28.04%0%0%9109.56%-100%--623.65%-
Operating Expenses64.06M77.39M59.06M72.94M113.49M151.76M229.95M362.53M438.47M436.26M
OpEx % of Revenue3038.99%5101.71%3892.95%4808.17%81.23%--1530.94%254.4%-
Selling, General & Admin15.86M17.29M16.06M22.5M25.24M33.26M66.92M120.88M179.68M176.24M
SG&A % of Revenue752.42%1139.55%1058.8%1483.52%18.07%--510.47%104.25%-
Research & Development48.2M60.11M42.99M50.44M88.25M118.5M163.03M241.65M258.78M255.99M
R&D % of Revenue2286.57%3962.16%2834.15%3324.65%63.17%--1020.47%150.15%-
Other Operating Expenses0000000001000K
Operating Income
-61.95M▲ 0%
-75.88M▼ 22.5%
-57.54M▲ 24.2%
-71.42M▼ 24.1%
26.22M▲ 136.7%
-151.76M▼ 678.8%
-229.95M▼ 51.5%
-339.67M▼ 47.7%
-273.08M▲ 19.6%
-223.53M▲ 0%
Operating Margin %-2938.99%-5001.71%-3792.95%-4708.17%18.77%---1434.43%-158.45%-102.93%
Operating Income Growth %-41.56%-22.47%24.17%-24.13%136.71%-678.78%-51.53%-47.71%19.6%-
EBITDA-61.88M-75.8M-57.09M-70.91M26.26M-151.72M-229.94M-339.66M-273.08M-218.16M
EBITDA Margin %-2935.39%-4996.57%-3763.22%-4674.23%18.8%---1434.39%-158.44%-100.45%
EBITDA Growth %-41.67%-22.5%24.68%-24.21%137.04%-677.71%-51.55%-47.72%19.6%33.44%
D&A (Non-Cash Add-back)76K78K451K515K43K33K12K8K6K6K
EBIT-61.95M-73.96M-56.05M-70.8M26.82M-146.2M-209.15M-313.83M-251.64M-131.73M
Net Interest Income1.42M1.94M1.57M-1.52M-1.5M2.73M20.95M21.16M-11.05M-48.03M
Interest Income001.57M841K403K5.87M21.16M26.09M22.73M24.38M
Interest Expense1.42M1.94M02.36M1.9M3.14M208K4.93M33.78M57M
Other Income/Expense1.15M1.92M1.49M-1.74M-1.29M2.42M20.59M20.91M-12.34M-19.72M
Pretax Income
-60.8M▲ 0%
-73.96M▼ 21.6%
-56.05M▲ 24.2%
-73.16M▼ 30.5%
24.93M▲ 134.1%
-149.34M▼ 699.1%
-209.36M▼ 40.2%
-318.76M▼ 52.3%
-285.42M▲ 10.5%
-243.25M▲ 0%
Pretax Margin %-2884.35%-4875.48%-3694.59%-4822.54%17.84%---1346.11%-165.6%-112.01%
Income Tax-76K000000000
Effective Tax Rate %0.12%0%0%0%0%0%0%0%0%0%
Net Income
-60.8M▲ 0%
-73.96M▼ 21.6%
-55.95M▲ 24.3%
-73.07M▼ 30.6%
24.93M▲ 134.1%
-149.34M▼ 699.1%
-209.36M▼ 40.2%
-318.76M▼ 52.3%
-285.42M▲ 10.5%
-243.25M▲ 0%
Net Margin %-2884.35%-4875.48%-3688.53%-4816.68%17.84%---1346.11%-165.6%-112.01%
Net Income Growth %-36.72%-21.64%24.35%-30.59%134.11%-699.13%-40.19%-52.25%10.46%26.56%
Net Income (Continuing)-60.8M-73.96M-56.05M-73.16M24.93M-149.34M-209.36M-318.76M-285.42M-243.25M
Discontinued Operations0000000000
Minority Interest0000000000
EPS (Diluted)
-2.90▲ 0%
-2.92▼ 0.7%
-1.84▲ 37.0%
-1.77▲ 3.8%
0.48▲ 127.1%
-2.46▼ 612.5%
-2.98▼ 21.1%
-3.73▼ 25.2%
-3.29▲ 11.8%
-▲ 0%
EPS Growth %4.61%-0.69%36.99%3.8%127.12%-612.5%-21.14%-25.17%11.8%40.31%
EPS (Basic)-2.90-2.92-1.84-1.770.48-2.46-2.98-3.73-3.29-
Diluted Shares Outstanding21M25.37M30.49M41.31M52.06M60.76M70.37M85.62M86.63M0
Basic Shares Outstanding21M25.37M30.49M41.31M52.06M60.76M70.37M85.62M86.63M0
Dividend Payout Ratio----------

SNDX Balance Sheet

Syndax Pharmaceuticals, Inc. (SNDX) balance sheet — assets, liabilities & shareholders' equity

Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Total Current Assets133.44M83.35M62.33M298.86M448.4M489.79M580.88M603.06M528.08M471.18M
Cash & Short-Term Investments133.22M80.91M59.77M293.06M446.83M484.4M577.58M582.91M394.07M352.06M
Cash Only35.17M33.77M24.61M115.24M221.97M74.36M295.39M154.08M134.93M130.89M
Short-Term Investments94.81M47.14M35.17M177.82M224.87M410.04M282.19M428.83M259.14M221.17M
Accounts Receivable377K253K116K175K429K4.06M1.23M13.87M38M38.12M
Days Sales Outstanding65.2860.8727.9142.111.12--213.8180.4758.38
Inventory-1.44M1.05M00000366K32.75M34.95M
Days Inventory Outstanding-------161.731.72K2.32K
Other Current Assets1.29M1.79M2.06M456K265K117K63K-2.02M63.26M46.05M
Total Non-Current Assets3.74M592K1.19M1.75M1.26M7.45M32M121.76M1.63M1.49M
Property, Plant & Equipment267K373K997K482K1.26M1.06M1.5M2.02M1.52M1.39M
Fixed Asset Turnover7.90x4.07x1.52x3.15x110.79x--11.71x113.17x141.48x
Goodwill0000000000
Intangible Assets0000000000
Long-Term Investments3.25M0115K005.47M29.83M119.52M082.88M
Other Non-Current Assets231K219K82K1.27M0922K680K217K102K536K
Total Assets
137.19M▲ 0%
83.94M▼ 38.8%
63.52M▼ 24.3%
300.61M▲ 373.2%
449.66M▲ 49.6%
497.24M▲ 10.6%
612.88M▲ 23.3%
724.82M▲ 18.3%
529.71M▼ 26.9%
472.67M▲ 0%
Asset Turnover0.02x0.02x0.02x0.01x0.31x--0.03x0.33x0.40x
Asset Growth %25.84%-38.81%-24.32%373.22%49.58%10.58%23.26%18.26%-26.92%1.43%
Total Current Liabilities15.8M16.11M18.37M18.87M20.68M29.07M58.1M103.55M120.12M86.17M
Accounts Payable2.23M1.44M6.18M3.51M5.67M4.35M9.96M11.63M16.58M10.84M
Days Payables Outstanding-------5.14K868.251.2K
Short-Term Debt0002.29M00012.12M472K0
Deferred Revenue (Current)1.57M1.52M1.52M1.52M000000
Other Current Liabilities9.6M10.35M7.39M3.74M6.23M6.55M35.92M79.33M103.06M75.33M
Current Ratio8.45x5.18x3.39x15.84x21.68x16.85x10.00x5.82x4.40x4.40x
Quick Ratio8.54x5.11x3.39x15.84x21.68x16.85x10.00x5.82x4.12x4.12x
Cash Conversion Cycle--------4.76K927.451.17K
Total Non-Current Liabilities17.07M14.79M13.56M29.55M20.61M722K588K333.14M344.96M258.7M
Long-Term Debt00017.83M19.89M00331.56M344.96M0
Capital Lease Obligations00419K101K711K722K588K1.58M1.05M3.57M
Deferred Tax Liabilities0000000000
Other Non-Current Liabilities310K136K5K1K0000-1.05M582.06M
Total Liabilities32.87M30.89M31.93M48.42M41.29M29.79M58.68M436.69M465.08M344.87M
Total Debt00897K20.54M20.97M1.16M1.64M345.74M346.48M0
Net Debt-35.17M-33.77M-23.71M-94.71M-201M-73.19M-293.76M191.66M211.55M-130.89M
Debt / Equity--0.03x0.08x0.05x0.00x0.00x1.20x5.36x5.36x
Debt / EBITDA----0.80x-----0.00x
Net Debt / EBITDA-----7.65x----0.60x
Interest Coverage-43.60x-38.08x--30.04x14.13x-46.61x-1005.54x-63.67x-7.45x-2.31x
Total Equity
104.32M▲ 0%
53.05M▼ 49.1%
31.6M▼ 40.4%
252.19M▲ 698.1%
408.37M▲ 61.9%
467.45M▲ 14.5%
554.2M▲ 18.6%
288.12M▼ 48.0%
64.63M▼ 77.6%
41.62M▲ 0%
Equity Growth %23.98%-49.15%-40.43%698.06%61.93%14.47%18.56%-48.01%-77.57%-290.47%
Book Value per Share4.972.091.046.117.847.697.883.370.750.47
Total Shareholders' Equity104.32M53.05M31.6M252.19M408.37M467.45M554.2M288.12M64.63M41.62M
Common Stock2K2K3K5K6K7K8K9K9K9K
Retained Earnings-366.11M-439.42M-495.47M-568.63M-543.7M-693.04M-902.4M-1.22B-1.51B-1.55B
Treasury Stock0000000000
Accumulated OCI-143K-25K0-4K45K-806K218K163K452K0
Minority Interest0000000000

SNDX Cash Flow Statement

Syndax Pharmaceuticals, Inc. (SNDX) cash flow — operating, investing & free cash flow history

Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Cash from Operations-47.37M-68.53M-50.61M-71.26M29.13M-133.68M-160.6M-274.9M-322.98M-322.98M
Operating CF Margin %-2247.2%-4517.53%-3336.32%-4697.43%20.85%---1160.91%-187.4%-
Operating CF Growth %-34.74%-44.67%26.15%-40.8%140.88%-558.88%-20.14%-71.17%-17.49%-9.71%
Net Income-60.8M-73.96M-56.05M-73.16M24.93M-149.34M-209.36M-318.76M-285.42M-243.25M
Depreciation & Amortization76K78K92K89K43K33K12K8K6K-102K
Stock-Based Compensation5.45M6.2M6M9.06M13.32M16.02M30.95M43.03M47.5M49.18M
Deferred Taxes223K-558K-780K0255K00000
Other Non-Cash Items8K11K359K686K187K-2.04M-14.06M-12.45M-5.75M-22.1M
Working Capital Changes7.67M-302K-241K-7.93M-9.6M1.66M31.86M13.27M-79.32M-61.89M
Change in Receivables00000-3.47M0-11.24M-36.83M-28.88M
Change in Inventory000003.47M0-366K-32.09M-29.96M
Change in Payables-194K-792K4.74M-2.67M2.16M-1.32M5.61M1.67M4.95M796K
Cash from Investing-17.03M51.4M12.78M-142.53M-40.87M-186.19M117.61M-219.78M290.04M234.28M
Capital Expenditures-84K-187K00-129K-225K00-187K-187K
CapEx % of Revenue3.98%12.33%--0.09%---0.11%-
Acquisitions000040.74K225K0000
Investments----------
Other Investing45K51.59K12.78K0-40.74K225K0000
Cash from Financing75.72M15.73M28.57M304.42M118.46M172.25M264.13M353.37M13.68M20.66M
Debt Issued (Net)00019.73M0-21M0000
Equity Issued (Net)75.35M15.5M28.21M278.06M86.34M181.39M258.09M9.71M13.68M12.75M
Dividends Paid0000000000
Share Repurchases0000000000
Other Financing374K232K360K6.63M32.13M11.86M6.04M343.65M07.92M
Net Change in Cash
11.32M▲ 0%
-1.4M▼ 112.4%
-9.26M▼ 559.6%
90.63M▲ 1078.7%
106.72M▲ 17.8%
-147.61M▼ 238.3%
221.14M▲ 249.8%
-141.31M▼ 163.9%
-19.27M▲ 86.4%
-23.21M▲ 0%
Free Cash Flow
-47.45M▲ 0%
-68.72M▼ 44.8%
-50.61M▲ 26.3%
-71.26M▼ 40.8%
29M▲ 140.7%
-133.9M▼ 561.7%
-160.6M▼ 19.9%
-274.9M▼ 71.2%
-323.17M▼ 17.6%
-278.35M▲ 0%
FCF Margin %-2251.19%-4529.86%-3336.32%-4697.43%20.76%---1160.91%-187.5%-128.17%
FCF Growth %-33.99%-44.81%26.35%-40.8%140.7%-561.69%-19.94%-71.17%-17.56%2.85%
FCF per Share-2.26-2.71-1.66-1.730.56-2.20-2.28-3.21-3.73-3.73
FCF Conversion (FCF/Net Income)0.78x0.93x0.90x0.98x1.17x0.90x0.77x0.86x1.13x1.14x
Interest Paid0000000000
Taxes Paid0000000000

SNDX Key Ratios

Syndax Pharmaceuticals, Inc. (SNDX) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric201720182019202020212022202320242025TTM
Return on Equity (ROE)-64.53%-94%-132.21%-51.5%7.55%-34.1%-40.98%-75.69%-161.82%-256.66%
Return on Invested Capital (ROIC)-71.79%-128.71%-317.71%-64.79%10.78%-37.84%-52.69%-68.83%-54.19%-54.19%
Gross Margin100%100%100%100%100%--96.51%95.96%97.96%
Net Margin-2884.35%-4875.48%-3688.53%-4816.68%17.84%---1346.11%-165.6%-112.01%
Debt / Equity--0.03x0.08x0.05x0.00x0.00x1.20x5.36x5.36x
Interest Coverage-43.60x-38.08x--30.04x14.13x-46.61x-1005.54x-63.67x-7.45x-2.31x
FCF Conversion0.78x0.93x0.90x0.98x1.17x0.90x0.77x0.86x1.13x1.14x
Revenue Growth72.79%-28.04%0%0%9109.56%-100%--627.84%396.72%

SNDX SEC Filings & Documents

Syndax Pharmaceuticals, Inc. (SNDX) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Apr 30, 2026·SEC

Material company update

Feb 26, 2026·SEC

Material company update

Jan 12, 2026·SEC

10-K Annual Reports

4
FY 2026

Feb 26, 2026·SEC

FY 2025

Mar 3, 2025·SEC

FY 2024

Feb 27, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

Apr 30, 2026·SEC

FY 2025

Nov 3, 2025·SEC

FY 2025

Aug 4, 2025·SEC

SNDX Frequently Asked Questions

Syndax Pharmaceuticals, Inc. (SNDX) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Syndax Pharmaceuticals, Inc. (SNDX) reported $217.2M in revenue for fiscal year 2025.

Syndax Pharmaceuticals, Inc. (SNDX) grew revenue by 627.8% over the past year. This is strong growth.

Syndax Pharmaceuticals, Inc. (SNDX) reported a net loss of $243.2M for fiscal year 2025.

Dividend & Returns

Syndax Pharmaceuticals, Inc. (SNDX) has a return on equity (ROE) of -161.8%. Negative ROE indicates the company is unprofitable.

Syndax Pharmaceuticals, Inc. (SNDX) had negative free cash flow of $278.4M in fiscal year 2025, likely due to heavy capital investments.

Explore More SNDX

Syndax Pharmaceuticals, Inc. (SNDX) financial analysis — history, returns, DCA and operating performance tools

Total Return Calculator

Historical returns with dividends reinvested

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Dividend History

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