Last 48 quarters of trend data · Healthcare · Biotechnology
Quarterly valuation ratios — annualised for comparability. YoY Δ shows same-quarter-prior-year change.
| Metric | TTM | Q1 '26 | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P/E Ratio → | -1.40 | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| P/S Ratio | 45.56 | 134.36 | 5.52 | — | — | — | — | — | — | — | 379923.66 | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| P/B Ratio | 0.92 | 3.04 | 1.18 | 1.69 | 0.45 | 121.32 | 91.38 | 95.79 | 90.51 | 668.86 | 395.61 | 207.37 | 204.09 |
| — | -97.5% | -98.7% | -98.2% | -99.5% | -81.9% | -76.9% | -53.8% | -55.7% | +446.9% | +5.8% | +246.1% | +261.7% | |
| P/FCF | — | — | 2.70 | — | — | — | — | 14.03 | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| EV / EBITDA | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| EV / EBIT | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — |
Quarterly margins and returns. Watch for margin compression across consecutive quarters.
Crescent Biopharma, Inc.'s operating margin was -2380.1% in Q1 2026, down 1536.4 pp QoQ. The trailing four-quarter average of -1611.9% exceeds the current quarter, suggesting the latest result may reflect seasonal weakness or a one-off headwind.
| Metric | TTM | Q1 '26 | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gross Margin | 100.0% | 100.0% | 100.0% | — | — | — | — | — | — | — | 100.0% | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| Operating Margin | -1407.5% | -2380.1% | -843.7% | — | — | — | — | — | — | — | -95908.3% | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| Net Margin | -1419.6% | -2240.9% | -852.1% | — | — | — | — | — | — | — | -90786.4% | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — |
| Metric | TTM | Q1 '26 | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ROE | -164.2% | -12.0% | -57.8% | -19.2% | -30.6% | -348.7% | -214.1% | -62.5% | -41.2% | -31.9% | -21.4% | -18.2% | -14.1% |
| — | +96.5% | +73.0% | +69.2% | +25.9% | -993.2% | -901.9% | -244.1% | -192.0% | -61.8% | +5.0% | -10.6% | +34.1% | |
| ROA | -111.6% | -10.6% | -48.8% | -16.6% | -26.7% | -177.3% | -133.4% | -49.0% | -34.4% | -27.0% | -18.4% | -16.0% | -12.6% |
| — | +94.0% | +63.4% | +66.0% | +22.6% | -556.7% | -623.7% | -206.1% | -172.6% | -57.4% | +3.1% | -13.6% | +30.2% | |
| ROIC | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — |
Quarterly solvency trend — watch for debt spikes or covenant pressure.
The current ratio has improved 501.8% YoY to 13.78x, strengthening the short-term liquidity position.
| Metric | TTM | Q1 '26 | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Debt / Equity | 0.01 | 0.01 | 0.01 | 0.03 | 0.02 | — | 0.01 | 0.02 | 0.02 | 0.02 | 0.02 | 0.02 | 0.02 |
| — | — | -35.6% | +14.0% | -1.2% | — | -40.2% | +6.0% | -3.4% | +108.2% | -1.6% | -11.4% | -10.1% | |
| Debt / EBITDA | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| Current Ratio | 6.56 | 13.78 | 6.56 | 6.63 | 9.21 | 2.29 | 1.92 | 3.62 | 5.48 | 6.28 | 6.41 | 8.14 | 9.19 |
| — | +501.8% | +241.8% | +83.1% | +68.2% | -63.6% | -70.0% | -55.5% | -40.4% | -37.8% | +12.2% | +17.1% | +34.0% | |
| Quick Ratio | 6.56 | 13.78 | 6.56 | 6.63 | 9.21 | 2.29 | 1.92 | 3.62 | 5.48 | 6.28 | 6.41 | 8.14 | 9.19 |
| — | +501.8% | +241.8% | +83.1% | +68.2% | -63.6% | -70.0% | -55.5% | -40.4% | -37.8% | +12.2% | +17.1% | +34.0% | |
| Interest Coverage | -68.54 | — | — | — | -19.31 | -12.62 | -19.97 | — | — | — | — | — | — |
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Includes 30+ ratios · 48 years · Updated daily
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Crescent Biopharma, Inc.'s current P/E is -1.4x. Quarterly P/E ratios can vary due to seasonal revenue patterns and one-time charges.
Crescent Biopharma, Inc.'s current operating margin is -1407.5%. Margins have been compressing over recent quarters. Quarterly margins are particularly useful for identifying trend inflections that annual data smooths over.
Quarterly financial ratios reveal short-term trend shifts — margin compression, debt spikes, or valuation re-ratings — that annual figures smooth over. They're essential for active investors tracking Crescent Biopharma, Inc.'s business trajectory between earnings reports.