55% buyers of institutions opening or closing positions this quarter
3 more new buyers than exits, ownership rose 31.63 percentage points vs the prior quarter, and 2 well-known fund managers in the top 25.
55% buyers of institutions opening or closing positions this quarter
81.0% institutional ownership
FCPM III SERVICES portfolio allocation
Institutional ownership vs Biotechnology peers
No Form 4 insider transactions on file
Latest positioning in CBIO across 13F flow, ownership shift, marquee holders, and holder-count growth.
Ranked by reported Q1 2026 13F market value
Share of total reported institutional value in CBIO held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4.1M | $75.9M | 0.0% | 14.992% | 0.00% |
| 2 | BVF INC/IL | 2.7M | $50.5M | 0.0% | 9.969% | 1.61% |
| 3 | Fairmount Funds Management LLC | 2.7M | $50.5M | 0.0% | 9.966% | 3.65% |
| 4 | VR Adviser, LLC | 2.1M | $39.2M | 0.0% | 7.738% | 1.46% |
| 5 | FCPM III SERVICES B.V. | 1.7M | $30.8M | 0.0% | 6.085% | 4.27% |
| 6 | BALYASNY ASSET MANAGEMENT LLC | 1.5M | $27.7M | +1251.7% | 5.477% | 0.04% |
| 7 | Vestal Point Capital, LP | 1.5M | $27.6M | 0.0% | 5.440% | 0.77% |
| 8 | Opaleye Management Inc. | 1.3M | $24.1M | +11.4% | 4.761% | 3.18% |
| 9 | TANG CAPITAL MANAGEMENT LLC | 1.2M | $21.3M | +33.0% | 4.207% | 1.08% |
| 10 | VANGUARD CAPITAL MANAGEMENT LLC | 801K | $14.7M | — | 2.907% | 0.00% |
| 11 | Logos Global Management LP | 483K | $8.9M | -19.6% | 1.750% | 0.44% |
| 12 | Deep Track Capital, LP | 454K | $8.3M | 0.0% | 1.646% | 0.14% |
| 13 | RTW INVESTMENTS, LP | 373K | $6.8M | 0.0% | 1.352% | 0.07% |
| 14 | NEXTBio Capital Management LP | 373K | $6.8M | 0.0% | 1.352% | 3.18% |
| 15 | MILLENNIUM MANAGEMENT LLC | 324K | $5.9M | +422.9% | 1.173% | 0.00% |
| 16 | Point72 Asset Management, L.P. | 300K | $5.5M | 0.0% | 1.088% | 0.01% |
| 17 | Alyeska Investment Group, L.P. | 264K | $4.8M | 0.0% | 0.958% | 0.01% |
| 18 | GOLDMAN SACHS GROUP INC | 228K | $4.2M | +805.0% | 0.829% | 0.00% |
| 19 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 214K | $3.9M | +274.5% | 0.775% | 0.00% |
| 20 | PERCEPTIVE ADVISORS LLC | 207K | $3.8M | -54.4% | 0.751% | 0.07% |
| 21 | MARSHALL WACE, LLP | 201K | $3.7M | +819.9% | 0.728% | 0.00% |
| 22 | Exome Asset Management LLC | 153K | $2.8M | — | 0.556% | 1.46% |
| 23 | JENNISON ASSOCIATES LLC | 153K | $2.8M | — | 0.555% | 0.00% |
| 24 | SILVERARC CAPITAL MANAGEMENT, LLC | 131K | $2.4M | — | 0.473% | 0.24% |
| 25 | TWO SIGMA INVESTMENTS, LP | 116K | $2.1M | -7.5% | 0.420% | 0.00% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). “% of Fund” shows how much of that investor’s total 13F portfolio is invested in CBIO — a direct measure of their conviction.
Filings activity in CBIO during Q1 2026, grouped by how each filer changed its position.
Institutions that opened a new CBIO position in Q1 2026
Institutions that fully closed their CBIO position in Q1 2026
8 quarters of 13F filings · Δ columns show change vs prior quarter
| Quarter | Inst. Holders | Δ Holders | Ownership % | Δ Ownership | Total 13F Value | Δ Value |
|---|---|---|---|---|---|---|
| Q1 2026 | 59 | +5.4% | 81.05% | +31.63 pp | $455M | +64% |
| Q4 2025 | 56 | +37% | 49.42% | +26.25 pp | $277M | +113% |
| Q3 2025 | 41 | +32% | 23.17% | 7.76 pp | $130M | 25% |
| Q2 2025 | 31 | +3000% | 30.93% | +30.93 pp | $174M | +102075471% |
| Q1 2025 | 1 | +0.0% | 0.00% | +0.00 pp | $0M | 6.6% |
| Q4 2024 | 1 | 99% | 0.00% | 15.67 pp | $0M | 100% |
| Q2 2021 | 67 | 25% | 15.67% | 24.59 pp | $88M | 61% |
| Q1 2021 | 89 | — | 40.26% | — | $226M | — |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Δ columns compare to the immediately prior filed quarter.
No recent Form 4 insider transactions on file for CBIO.
Quick answers to the most common questions about buying CBIO stock.
Based on Q1 2026 13F filings, institutional ownership of Crescent Biopharma, Inc. stands at 81.0%, held across 59 reporting institutions.
FMR LLC is the largest reported institutional holder of CBIO, with approximately 4,133,514 shares worth $0.08B as of Q1 2026.
Yes — 2 widely-followed marquee investors appear among the top 25 institutional holders of CBIO, including Point72 Asset Management, L.P., TWO SIGMA INVESTMENTS, LP.
Our composite Smart Money Score for CBIO is 64 out of 100 (Bullish). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
17 institutions opened new positions in CBIO during Q1 2026, while 14 fully exited. 38 added to existing positions and 3 trimmed.
CBIO institutional ownership rose by 31.63 percentage points quarter-over-quarter, with a net change of — holders.
The top 10 institutions account for 79.7% of all reported 13F value in CBIO, and the top 25 account for 95.7%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.