| Name | Market Cap | Current Price | P/E Ratio | Revenue Growth 1Y | Net Margin | ROE | FCF Yield | Debt/Equity |
|---|---|---|---|---|---|---|---|---|
| CORTCorcept Therapeutics Incorporated | 3.78B | 35.70 | 43.54 | 12.79% | 13.01% | 15.3% | 3.75% | 0.01 |
| BMRNBioMarin Pharmaceutical Inc. | 11.86B | 61.73 | 34.29 | 10.83% | 5.73% | 6.11% | 0.10 | |
| VRTXVertex Pharmaceuticals Incorporated | 126.19B | 496.83 | 32.43 | 8.9% | 31.35% | 21.22% | 2.53% | 0.20 |
| CPRXCatalyst Pharmaceuticals, Inc. | 2.83B | 23.08 | 13.74 | 19.78% | 36.39% | 22.46% | 7.38% | 0.00 |
| HRMYHarmony Biosciences Holdings, Inc. | 1.65B | 28.54 | 10.53 | 21.51% | 18.27% | 18.24% | 21.12% | 0.02 |
| PTCTPTC Therapeutics, Inc. | 5.45B | 68.19 | 8.76 | 114.51% | 42.25% | |||
| BCRXBioCryst Pharmaceuticals, Inc. | 1.86B | 8.75 | 7.23 | 94.1% | 30.16% | 18.63% | ||
| RAREUltragenyx Pharmaceutical Inc. | 2.26B | 23.39 | -3.72 | 29.01% | -91.95% | -35.88% | 0.15 |
Analyze head-to-head performance against top industry competitors across valuation, growth, and profitability metrics.
| Dec 2016 | Dec 2017 | Dec 2018 | Dec 2019 | Dec 2020 | Dec 2021 | Dec 2022 | Dec 2023 | Dec 2024 | Dec 2025 | |
|---|---|---|---|---|---|---|---|---|---|---|
| Sales/Revenue | 6.36M | 8.36M | 9.73M | 22.5M | 7.87M | 0 | 0 | 0 | 0 | 0 |
| Revenue Growth % | 112.83% | 31.55% | 16.44% | 131.14% | -65.02% | -100% | - | - | - | - |
| Cost of Goods Sold | 0 | 0 | 0 | 43.71K | 25.74M | 0 | 0 | 0 | 0 | 4.62M |
| COGS % of Revenue | - | - | - | 0.19% | 327% | - | - | - | - | - |
| Gross Profit | 6.36M | 8.36M | 9.73M | 22.46M | -17.87M | 0 | 0 | 0 | 0 | -4.62M |
| Gross Margin % | 100% | 100% | 100% | 99.81% | -227% | - | - | - | - | - |
| Gross Profit Growth % | 112.83% | 31.55% | 16.44% | 130.69% | -179.57% | 100% | - | - | - | - |
| Operating Expenses | 25.43M | 34.51M | 45.74M | 54.68M | 64.33M | 75.55M | 147.84M | 208.13M | 275.94M | 328.74M |
| OpEx % of Revenue | 400.08% | 412.82% | 469.89% | 243.02% | 817.33% | - | - | - | - | - |
| Selling, General & Admin | 3.43M | 4.68M | 7.45M | 10.97M | 17.42M | 19.64M | 26.21M | 34.38M | 43.28M | 63.58M |
| SG&A % of Revenue | 54.02% | 55.98% | 76.58% | 48.75% | 221.34% | - | - | - | - | - |
| Research & Development | 21.99M | 29.83M | 38.28M | 43.71M | 72.65M | 55.91M | 121.63M | 173.75M | 232.66M | 269.78M |
| R&D % of Revenue | 346.06% | 356.84% | 393.31% | 194.27% | 922.98% | - | - | - | - | - |
| Other Operating Expenses | 0 | 274K | 320K | 78K | -25.74M | 0 | 0 | 0 | 0 | -4.62M |
| Operating Income | -19.07M | -26.15M | -36.01M | -32.18M | -82.2M | -75.55M | -147.84M | -208.13M | -275.94M | -333.36M |
| Operating Margin % | -300.08% | -312.82% | -369.89% | -143.02% | -1044.33% | - | - | - | - | - |
| Operating Income Growth % | -189.29% | -37.14% | -37.68% | 10.63% | -155.45% | 8.09% | -95.68% | -40.78% | -32.58% | -20.81% |
| EBITDA | -18.24M | -24.98M | -34.68M | -30.89M | -81.48M | -73.56M | -141.96M | -204.54M | -271.59M | -328.74M |
| EBITDA Margin % | -287.02% | -298.82% | -356.32% | -137.27% | -1035.18% | - | - | - | - | - |
| EBITDA Growth % | -184.42% | -36.96% | -38.84% | 10.95% | -163.81% | 9.72% | -92.99% | -44.08% | -32.78% | -21.05% |
| D&A (Non-Cash Add-back) | 830K | 1.17M | 1.32M | 1.29M | 720K | 1.99M | 5.88M | 3.59M | 4.35M | 4.62M |
| EBIT | -19.07M | -26.15M | -36.01M | -32.18M | -35.29M | -75.55M | -147.84M | -208.13M | -275.94M | -333.36M |
| Net Interest Income | 265K | 386K | 1.15M | 267K | 144K | 467K | 0 | 13.08M | 18.09M | 11.63M |
| Interest Income | 265K | 386K | 1.15M | 267K | 144K | 467K | 3.99M | 13.08M | 18.09M | 14.69M |
| Interest Expense | 0 | 0 | 0 | 0 | 0 | 0 | 3.99M | 0 | 0 | 3.06M |
| Other Income/Expense | 946K | 660K | 1.47M | 345K | 7.39M | 3.28M | 7.6M | 15.72M | 20.08M | 4.43M |
| Pretax Income | -18.12M | -25.49M | -34.53M | -31.83M | -74.81M | -72.27M | -140.24M | -192.41M | -255.86M | -328.94M |
| Pretax Margin % | -285.19% | -304.93% | -354.76% | -141.49% | -950.43% | - | - | - | - | - |
| Income Tax | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Effective Tax Rate % | 100% | 100% | 100% | 95.1% | 100% | 100% | 100% | 100% | 100% | 100% |
| Net Income | -18.12M | -25.49M | -34.53M | -30.27M | -74.81M | -72.27M | -140.24M | -192.41M | -255.86M | -328.94M |
| Net Margin % | -285.19% | -304.93% | -354.76% | -134.55% | -950.43% | - | - | - | - | - |
| Net Income Growth % | -174.94% | -40.65% | -35.46% | 12.33% | -147.11% | 3.39% | -94.04% | -37.2% | -32.98% | -28.56% |
| Net Income (Continuing) | -18.12M | -25.49M | -34.53M | -31.83M | -74.81M | -72.27M | -140.24M | -192.41M | -255.86M | -328.94M |
| Discontinued Operations | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Minority Interest | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| EPS (Diluted) | -2.45 | -3.45 | -5.55 | -3.97 | -6.00 | -1.85 | -2.26 | -2.42 | -2.46 | -2.55 |
| EPS Growth % | -175.28% | -40.82% | -60.87% | 28.47% | -51.13% | 69.17% | -22.16% | -7.08% | -1.65% | -3.66% |
| EPS (Basic) | -3.10 | -3.45 | -5.55 | -3.97 | -6.00 | -1.85 | -2.26 | -2.42 | -2.46 | -2.55 |
| Diluted Shares Outstanding | 7.4M | 7.4M | 6.22M | 7.62M | 11.08M | 38.73M | 58.74M | 79.66M | 103.86M | 67.6M |
| Basic Shares Outstanding | 5.86M | 7.4M | 6.22M | 7.62M | 11.08M | 38.73M | 58.74M | 79.66M | 103.86M | 67.6M |
| Dividend Payout Ratio | - | - | - | - | - | - | - | - | - | - |
| Dec 2016 | Dec 2017 | Dec 2018 | Dec 2019 | Dec 2020 | Dec 2021 | Dec 2022 | Dec 2023 | Dec 2024 | Dec 2025 | |
|---|---|---|---|---|---|---|---|---|---|---|
| Total Current Assets | 69.73M | 42.38M | 81M | 40.59M | 244.91M | 222.63M | 264.97M | 270.77M | 296.47M | 910.36M |
| Cash & Short-Term Investments | 68.51M | 40.96M | 78.59M | 37.42M | 242.19M | 219.68M | 259.28M | 265.71M | 287.08M | 900.76M |
| Cash Only | 41.32M | 28.27M | 55.67M | 37.42M | 242.19M | 219.68M | 139.89M | 53.23M | 98.17M | 312.01M |
| Short-Term Investments | 27.19M | 12.69M | 22.92M | 0 | 0 | 0 | 119.39M | 212.48M | 188.91M | 588.75M |
| Accounts Receivable | 928K | 830K | 1.67M | 2M | 0 | 0 | 0 | 0 | 0 | 0 |
| Days Sales Outstanding | 53.3 | 36.24 | 62.55 | 32.45 | - | - | - | - | - | - |
| Inventory | 0 | 75K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Days Inventory Outstanding | - | - | - | - | - | - | - | - | - | - |
| Other Current Assets | 0 | 75K | 740K | 0 | 0 | 0 | 1.25M | 5.06M | 9.39M | 9.59M |
| Total Non-Current Assets | 5.82M | 6.74M | 4.92M | 8.83M | 6M | 9.46M | 35.84M | 42.67M | 31.43M | 27.25M |
| Property, Plant & Equipment | 4.56M | 4.11M | 3.25M | 7.15M | 4.75M | 4.48M | 31.1M | 30.34M | 26.56M | 23.54M |
| Fixed Asset Turnover | 1.39x | 2.04x | 2.99x | 3.15x | 1.66x | - | - | - | - | - |
| Goodwill | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Intangible Assets | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Long-Term Investments | 1.25M | 1.25M | 1.25M | 0 | 0 | 0 | 0 | 7.46M | 0 | 0 |
| Other Non-Current Assets | 0 | 1.37M | 419K | 1.68M | 1.25M | 4.98M | 4.75M | 4.86M | 4.86M | 3.72M |
| Total Assets | 75.55M | 49.12M | 85.93M | 49.42M | 250.92M | 232.09M | 300.81M | 313.44M | 327.9M | 937.61M |
| Asset Turnover | 0.08x | 0.17x | 0.11x | 0.46x | 0.03x | - | - | - | - | - |
| Asset Growth % | -20.28% | -34.99% | 74.95% | -42.48% | 407.69% | -7.5% | 29.61% | 4.2% | 4.61% | 185.94% |
| Total Current Liabilities | 8.74M | 11.19M | 24.95M | 13.25M | 13.09M | 17.08M | 26.85M | 38.17M | 55.71M | 63.95M |
| Accounts Payable | 1.45M | 1.35M | 1.52M | 3.18M | 732K | 3.48M | 5.84M | 10.65M | 12.01M | 9.5M |
| Days Payables Outstanding | - | - | - | 26.58K | 10.38 | - | - | - | - | 751.02 |
| Short-Term Debt | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.55M |
| Deferred Revenue (Current) | 5.96M | 6.89M | 17.95M | 1.31M | 0 | 3.06M | 1.7M | 0 | 0 | 0 |
| Other Current Liabilities | 118K | 1.64M | 3.88M | 3.39M | 7.28M | 3.62M | 6.47M | 10.31M | 12.63M | 52.9M |
| Current Ratio | 7.98x | 3.79x | 3.25x | 3.06x | 18.70x | 13.04x | 9.87x | 7.09x | 5.32x | 14.23x |
| Quick Ratio | 7.98x | 3.78x | 3.25x | 3.06x | 18.70x | 13.04x | 9.87x | 7.09x | 5.32x | 14.23x |
| Cash Conversion Cycle | - | - | - | - | - | - | - | - | - | - |
| Total Non-Current Liabilities | 14.43M | 9.62M | 748K | 4.41M | 3.15M | 831K | 18.23M | 17.47M | 15.9M | 237.28M |
| Long-Term Debt | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 237.25M |
| Capital Lease Obligations | 0 | 0 | 0 | 4.41M | 3.15M | 831K | 18.23M | 17.47M | 15.9M | 14.36M |
| Deferred Tax Liabilities | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Non-Current Liabilities | 908K | 906K | 748K | 0 | 0 | 0 | 0 | 0 | 0 | -14.32M |
| Total Liabilities | 23.16M | 20.81M | 25.69M | 17.66M | 16.25M | 17.91M | 45.08M | 55.63M | 71.61M | 301.24M |
| Total Debt | 0 | 0 | 0 | 6.03M | 5.21M | 3.15M | 19.65M | 18.85M | 17.47M | 253.15M |
| Net Debt | -41.32M | -28.27M | -55.67M | -31.39M | -236.98M | -216.53M | -120.24M | -34.38M | -80.7M | -58.86M |
| Debt / Equity | - | - | - | 0.19x | 0.02x | 0.01x | 0.08x | 0.07x | 0.07x | 0.40x |
| Debt / EBITDA | - | - | - | - | - | - | - | - | - | - |
| Net Debt / EBITDA | - | - | - | - | - | - | - | - | - | - |
| Interest Coverage | - | - | - | - | - | - | -37.06x | - | - | -108.87x |
| Total Equity | 52.39M | 28.3M | 60.23M | 31.76M | 234.67M | 214.18M | 255.74M | 257.8M | 256.29M | 636.37M |
| Equity Growth % | -24.64% | -45.97% | 112.8% | -47.27% | 638.83% | -8.73% | 19.4% | 0.81% | -0.59% | 148.31% |
| Book Value per Share | 7.08 | 3.83 | 9.68 | 4.17 | 21.18 | 5.53 | 4.35 | 3.24 | 2.47 | 9.41 |
| Total Shareholders' Equity | 52.39M | 28.3M | 60.23M | 31.76M | 234.67M | 214.18M | 255.74M | 257.8M | 256.29M | 636.37M |
| Common Stock | 10K | 10K | 30K | 8K | 32K | 44K | 70K | 86K | 110K | 161K |
| Retained Earnings | -25.85M | -51.34M | -92.06M | -123.89M | -198.7M | -270.97M | -411.21M | -603.62M | -859.48M | -1.19B |
| Treasury Stock | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Accumulated OCI | -24K | -16K | -12K | 0 | 0 | 0 | -104K | 246K | 447K | 355K |
| Minority Interest | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Dec 2016 | Dec 2017 | Dec 2018 | Dec 2019 | Dec 2020 | Dec 2021 | Dec 2022 | Dec 2023 | Dec 2024 | Dec 2025 | |
|---|---|---|---|---|---|---|---|---|---|---|
| Cash from Operations | -18.64M | -25.84M | -32.49M | -41.51M | -35.85M | -58.76M | -118.64M | -153.62M | -207.79M | -264.44M |
| Operating CF Margin % | -293.31% | -309.03% | -333.77% | -184.51% | -455.47% | - | - | - | - | - |
| Operating CF Growth % | -205.22% | -38.6% | -25.76% | -27.78% | 13.64% | -63.91% | -101.89% | -29.49% | -35.26% | -27.26% |
| Net Income | -18.12M | -25.49M | -34.53M | -31.83M | -74.81M | -72.27M | -140.24M | -192.41M | -255.86M | -328.94M |
| Depreciation & Amortization | 830K | 1.17M | 1.32M | 1.29M | 720K | 147K | 5.88M | 3.59M | 4.35M | 4.58M |
| Stock-Based Compensation | 1.02M | 1.34M | 3.09M | 3.24M | 6.02M | 11.69M | 18.37M | 30.62M | 39.74M | 46.08M |
| Deferred Taxes | 17K | 17K | -236K | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Non-Cash Items | -56K | 7K | 23K | -131K | 37.54M | -343K | -3.39M | -6.87M | -7.62M | 5.82M |
| Working Capital Changes | -2.32M | -2.88M | -2.15M | -14.08M | -5.32M | 2.02M | 751K | 11.44M | 11.6M | 8.01M |
| Change in Receivables | -634K | 98K | -838K | -332K | 2M | 0 | 0 | 0 | 0 | 0 |
| Change in Inventory | 784K | 931K | 2.21M | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Change in Payables | 389K | -31K | 367K | 1.66M | -2.45M | 2.75M | 2.36M | 4.81M | 1.36M | -2.51M |
| Cash from Investing | -30.43M | 13.51M | -10.53M | 23.16M | 8.42M | -1.72M | -124.72M | -97.82M | 38.28M | -399.53M |
| Capital Expenditures | -3.31M | -912K | -549K | -33K | 0 | -1.72M | -6.86M | -2.8M | -573K | -1.55M |
| CapEx % of Revenue | 52.04% | 10.91% | 5.64% | 0.15% | - | - | - | - | - | - |
| Acquisitions | 0 | 0 | 0 | 204K | 0 | 0 | 117.86K | 0 | 0 | 0 |
| Investments | - | - | - | - | - | - | - | - | - | - |
| Other Investing | 50K | -75K | 0 | 0 | 8.42M | 0 | -117.86K | 0 | 0 | 0 |
| Cash from Financing | -40K | -729K | 70.35M | 108K | 232.2M | 37.98M | 163.56M | 163.54M | 214.45M | 878.23M |
| Debt Issued (Net) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 215.13M |
| Equity Issued (Net) | 0 | 60K | 1000K | 108K | 1000K | 1000K | 1000K | 1000K | 1000K | 1000K |
| Dividends Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Share Repurchases | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Financing | -40K | -789K | -1.45M | 0 | 560K | -30K | 1.61M | 0 | 1.11M | -48.9M |
| Net Change in Cash | -49.11M | -13.05M | 27.33M | -18.25M | 204.77M | -22.51M | -79.8M | -87.91M | 44.94M | 214.26M |
| Free Cash Flow | -21.95M | -26.75M | -33.04M | -41.55M | -35.85M | -60.48M | -125.5M | -156.42M | -208.36M | -266M |
| FCF Margin % | -345.35% | -319.94% | -339.41% | -184.66% | -455.47% | - | - | - | - | - |
| FCF Growth % | -239.59% | -21.87% | -23.52% | -25.76% | 13.71% | -68.71% | -107.5% | -24.64% | -33.21% | -27.66% |
| FCF per Share | -2.97 | -3.62 | -5.31 | -5.45 | -3.24 | -1.56 | -2.14 | -1.96 | -2.01 | -3.93 |
| FCF Conversion (FCF/Net Income) | 1.03x | 1.01x | 0.94x | 1.37x | 0.48x | 0.81x | 0.85x | 0.80x | 0.81x | 0.80x |
| Interest Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Taxes Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Metric | 2016 | 2017 | 2018 | 2019 | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 |
|---|---|---|---|---|---|---|---|---|---|---|
| Return on Equity (ROE) | -29.73% | -63.18% | -78% | -65.81% | -56.16% | -32.2% | -59.69% | -74.94% | -99.54% | -73.7% |
| Return on Invested Capital (ROIC) | - | -353.34% | -1174.59% | -978.45% | - | - | -166.54% | -86.98% | -103.73% | -66.4% |
| Gross Margin | 100% | 100% | 100% | 99.81% | -227% | - | - | - | - | - |
| Net Margin | -285.19% | -304.93% | -354.76% | -134.55% | -950.43% | - | - | - | - | - |
| Debt / Equity | - | - | - | 0.19x | 0.02x | 0.01x | 0.08x | 0.07x | 0.07x | 0.40x |
| Interest Coverage | - | - | - | - | - | - | -37.06x | - | - | -108.87x |
| FCF Conversion | 1.03x | 1.01x | 0.94x | 1.37x | 0.48x | 0.81x | 0.85x | 0.80x | 0.81x | 0.80x |
| Revenue Growth | 112.83% | 31.55% | 16.44% | 131.14% | -65.02% | -100% | - | - | - | - |
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