No significant weaknesses identified
| Name | Market Cap | Current Price | P/E Ratio | Revenue Growth 1Y | Net Margin | ROE | FCF Yield | Debt/Equity |
|---|---|---|---|---|---|---|---|---|
| CORTCorcept Therapeutics Incorporated | 3.78B | 35.70 | 43.54 | 12.79% | 13.01% | 15.3% | 3.75% | 0.01 |
| BMRNBioMarin Pharmaceutical Inc. | 11.86B | 61.73 | 34.29 | 10.83% | 5.73% | 6.11% | 0.10 | |
| VRTXVertex Pharmaceuticals Incorporated | 126.19B | 496.83 | 32.43 | 8.9% | 31.35% | 21.22% | 2.53% | 0.20 |
| CPRXCatalyst Pharmaceuticals, Inc. | 2.83B | 23.08 | 13.74 | 19.78% | 36.39% | 22.46% | 7.38% | 0.00 |
| HRMYHarmony Biosciences Holdings, Inc. | 1.65B | 28.54 | 10.53 | 21.51% | 18.27% | 18.24% | 21.12% | 0.02 |
| PTCTPTC Therapeutics, Inc. | 5.45B | 68.19 | 8.76 | 114.51% | 42.25% | |||
| BCRXBioCryst Pharmaceuticals, Inc. | 1.86B | 8.75 | 7.23 | 94.1% | 30.16% | 18.63% | ||
| RAREUltragenyx Pharmaceutical Inc. | 2.26B | 23.39 | -3.72 | 29.01% | -91.95% | -35.88% | 0.15 |
Analyze head-to-head performance against top industry competitors across valuation, growth, and profitability metrics.
| Dec 2016 | Dec 2017 | Dec 2018 | Dec 2019 | Dec 2020 | Dec 2021 | Dec 2022 | Dec 2023 | Dec 2024 | Dec 2025 | |
|---|---|---|---|---|---|---|---|---|---|---|
| Sales/Revenue | 26.35M | 25.19M | 20.65M | 48.84M | 17.81M | 157.17M | 270.83M | 331.41M | 450.71M | 874.84M |
| Revenue Growth % | -45.39% | -4.43% | -18% | 136.45% | -63.53% | 782.38% | 72.31% | 22.37% | 36% | 94.1% |
| Cost of Goods Sold | 2.7M | 1.7M | 471K | 4.1M | 1.68M | 7.26M | 6.59M | 4.66M | 12.48M | 19.07M |
| COGS % of Revenue | 10.24% | 6.76% | 2.28% | 8.4% | 9.41% | 4.62% | 2.43% | 1.41% | 2.77% | 2.18% |
| Gross Profit | 23.65M | 23.48M | 20.18M | 44.73M | 16.14M | 149.91M | 264.23M | 326.75M | 438.23M | 855.76M |
| Gross Margin % | 89.76% | 93.24% | 97.72% | 91.6% | 90.59% | 95.38% | 97.57% | 98.59% | 97.23% | 97.82% |
| Gross Profit Growth % | -48.98% | -0.72% | -14.06% | 121.65% | -63.93% | 829.02% | 76.27% | 23.66% | 34.12% | 95.28% |
| Operating Expenses | 72.26M | 80.89M | 114.4M | 144.19M | 190.89M | 327.63M | 412.67M | 430.46M | 440.77M | 514.77M |
| OpEx % of Revenue | 274.2% | 321.19% | 553.92% | 295.26% | 1071.71% | 208.45% | 152.37% | 129.89% | 97.79% | 58.84% |
| Selling, General & Admin | 11.25M | 13.93M | 29.51M | 37.12M | 67.93M | 118.82M | 159.37M | 213.89M | 266.13M | 348.65M |
| SG&A % of Revenue | 42.7% | 55.32% | 142.9% | 76.01% | 381.37% | 75.6% | 58.85% | 64.54% | 59.05% | 39.85% |
| Research & Development | 61.01M | 66.96M | 84.89M | 107.07M | 122.96M | 208.81M | 253.3M | 216.57M | 174.64M | 166.13M |
| R&D % of Revenue | 231.5% | 265.87% | 411.02% | 219.24% | 690.34% | 132.85% | 93.53% | 65.35% | 38.75% | 18.99% |
| Other Operating Expenses | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Operating Income | -48.61M | -57.41M | -94.22M | -99.45M | -174.76M | -177.72M | -148.44M | -103.71M | -2.54M | 340.99M |
| Operating Margin % | -184.45% | -227.95% | -456.2% | -203.66% | -981.12% | -113.07% | -54.81% | -31.29% | -0.56% | 38.98% |
| Operating Income Growth % | -23.23% | -18.11% | -64.11% | -5.56% | -75.71% | -1.7% | 16.48% | 30.13% | 97.55% | 13508.93% |
| EBITDA | -48.12M | -56.71M | -93.45M | -98.73M | -174.01M | -176.94M | -147M | -102.05M | -1.3M | 340.99M |
| EBITDA Margin % | -182.61% | -225.15% | -452.48% | -202.17% | -976.92% | -112.58% | -54.28% | -30.79% | -0.29% | 38.98% |
| EBITDA Growth % | -22.57% | -17.84% | -64.79% | -5.65% | -76.25% | -1.69% | 16.92% | 30.57% | 98.73% | 26390.59% |
| D&A (Non-Cash Add-back) | 483K | 704K | 770K | 724K | 748K | 777K | 1.44M | 1.66M | 1.25M | 0 |
| EBIT | -48.66M | -57.22M | -92.08M | -97M | -168.31M | -122.52M | -145.29M | -117.99M | 11.56M | 0 |
| Net Interest Income | -5.69M | -7.55M | -6.92M | -9.96M | -5.08M | -59.23M | -93.97M | -92.46M | -83.77M | 0 |
| Interest Income | 793K | 1.01M | 2.25M | 1.93M | 9.42M | 62K | 5.13M | 15.78M | 14.75M | 10.67M |
| Interest Expense | 6.49M | 8.56M | 9.18M | 11.89M | 14.5M | 59.29M | 99.09M | 108.24M | 98.52M | -78.87M |
| Other Income/Expense | -6.54M | -8.37M | -7.03M | -9.44M | -8.06M | -4.09M | -95.95M | -122.52M | -84.41M | -73.6M |
| Pretax Income | -55.14M | -65.78M | -101.25M | -108.9M | -182.81M | -181.81M | -244.38M | -226.23M | -86.95M | 267.39M |
| Pretax Margin % | -209.25% | -261.18% | -490.25% | -222.99% | -1026.35% | -115.68% | -90.24% | -68.26% | -19.29% | 30.56% |
| Income Tax | 0 | 0 | 0 | 0 | 0 | 2.25M | 2.73M | 310K | 1.93M | 3.53M |
| Effective Tax Rate % | 100% | 100% | 100% | 100% | 100% | 101.24% | 101.12% | 100.14% | 102.22% | 98.68% |
| Net Income | -55.14M | -65.78M | -101.25M | -108.9M | -182.81M | -184.06M | -247.12M | -226.54M | -88.88M | 263.86M |
| Net Margin % | -209.25% | -261.18% | -490.25% | -222.99% | -1026.35% | -117.11% | -91.25% | -68.36% | -19.72% | 30.16% |
| Net Income Growth % | -28.19% | -19.29% | -53.92% | -7.55% | -67.88% | -0.68% | -34.26% | 8.33% | 60.77% | 396.87% |
| Net Income (Continuing) | -55.14M | -65.78M | -101.25M | -108.9M | -182.81M | -184.06M | -247.12M | -226.54M | -88.88M | 263.86M |
| Discontinued Operations | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Minority Interest | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| EPS (Diluted) | -0.75 | -0.78 | -0.98 | -0.94 | -1.09 | -1.03 | -1.33 | -1.18 | -0.43 | 1.21 |
| EPS Growth % | -27.12% | -4% | -25.64% | 4.08% | -15.96% | 5.5% | -29.13% | 11.28% | 63.56% | 381.4% |
| EPS (Basic) | -0.75 | -0.78 | -0.98 | -0.94 | -1.09 | -1.03 | -1.33 | -1.18 | -0.43 | 1.26 |
| Diluted Shares Outstanding | 73.7M | 84.45M | 103.19M | 115.6M | 167.27M | 179.12M | 185.91M | 192.2M | 206.7M | 218.58M |
| Basic Shares Outstanding | 73.7M | 84.45M | 103.19M | 115.6M | 167.27M | 179.12M | 185.91M | 192.2M | 206.7M | 209.89M |
| Dividend Payout Ratio | - | - | - | - | - | - | - | - | - | - |
| Dec 2016 | Dec 2017 | Dec 2018 | Dec 2019 | Dec 2020 | Dec 2021 | Dec 2022 | Dec 2023 | Dec 2024 | Dec 2025 | |
|---|---|---|---|---|---|---|---|---|---|---|
| Total Current Assets | 66.99M | 125.39M | 114.35M | 164.34M | 323.8M | 566.14M | 516.5M | 495.97M | 421.97M | 404.35M |
| Cash & Short-Term Investments | 63.58M | 155.69M | 126.84M | 136.23M | 300.37M | 507.6M | 424.31M | 388.99M | 321.06M | 274.75M |
| Cash Only | 22.1M | 50.28M | 26.73M | 114.17M | 272.13M | 504.39M | 304.77M | 110.64M | 104.92M | 89.74M |
| Short-Term Investments | 32.55M | 64.11M | 77.74M | 22.05M | 28.24M | 3.21M | 119.54M | 278.34M | 216.14M | 185.01M |
| Accounts Receivable | 8.77M | 6.12M | 4.29M | 22.15M | 8.65M | 29.41M | 50.6M | 56.95M | 79.07M | 0 |
| Days Sales Outstanding | 121.44 | 88.65 | 75.87 | 165.52 | 177.17 | 68.31 | 68.19 | 62.72 | 64.03 | - |
| Inventory | 500K | -37.8M | 1.65M | 0 | 7.04M | 15.79M | 27.53M | 28.68M | 8.09M | 5.4M |
| Days Inventory Outstanding | 67.62 | - | 1.28K | - | 1.53K | 793.46 | 1.52K | 2.25K | 236.42 | 103.29 |
| Other Current Assets | 1.63M | 3.5M | 1.54M | 1.55M | 2.22M | 3.35M | 14.06M | 21.35M | 13.75M | 124.2M |
| Total Non-Current Assets | 22.86M | 52.87M | 32.49M | 10.94M | 10.91M | 22.02M | 33.5M | 20.99M | 68.45M | 109.81M |
| Property, Plant & Equipment | 9.92M | 9.55M | 9.13M | 7.35M | 7.11M | 15.19M | 8.62M | 20.91M | 19.79M | 18.99M |
| Fixed Asset Turnover | 2.66x | 2.64x | 2.26x | 6.65x | 2.50x | 10.35x | 31.43x | 15.85x | 22.78x | 46.08x |
| Goodwill | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Intangible Assets | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Long-Term Investments | 8.93M | 41.3M | 22.38M | 0 | 0 | 6.83M | 18.08M | 0 | 21.72M | 61.16M |
| Other Non-Current Assets | 4.01M | 2.03M | 978K | 3.59M | 3.8M | 0 | 6.81M | 80K | 26.94M | 29.66M |
| Total Assets | 89.85M | 178.26M | 146.84M | 175.28M | 334.71M | 588.15M | 550M | 516.96M | 490.42M | 514.16M |
| Asset Turnover | 0.29x | 0.14x | 0.14x | 0.28x | 0.05x | 0.27x | 0.49x | 0.64x | 0.92x | 1.70x |
| Asset Growth % | -27.87% | 98.4% | -17.62% | 19.37% | 90.96% | 75.72% | -6.49% | -6.01% | -5.13% | 4.84% |
| Total Current Liabilities | 54.36M | 74.84M | 69.48M | 92.33M | 105.65M | 103.72M | 105.51M | 149.99M | 160.38M | 196.07M |
| Accounts Payable | 4.27M | 6.34M | 7.77M | 13.99M | 18.71M | 27.81M | 14.36M | 20.89M | 11.64M | 15.83M |
| Days Payables Outstanding | 577.32 | 1.36K | 6.02K | 1.24K | 4.08K | 1.4K | 794.65 | 1.64K | 340.41 | 302.83 |
| Short-Term Debt | 28.24M | 35.15M | 33.7M | 38.58M | 30M | 0 | 0 | 0 | 35.45M | 1.63M |
| Deferred Revenue (Current) | 2.02M | 8.48M | 221K | 2.12M | 150K | 1.42M | 1.22M | 0 | 0 | 0 |
| Other Current Liabilities | 19.4M | 21.89M | 23.08M | 6.19M | 44.58M | 52M | 36.46M | 86.59M | 64.66M | 194.44M |
| Current Ratio | 1.23x | 1.68x | 1.65x | 1.78x | 3.06x | 5.46x | 4.90x | 3.31x | 2.63x | 2.06x |
| Quick Ratio | 1.22x | 2.18x | 1.62x | 1.78x | 3.00x | 5.31x | 4.63x | 3.12x | 2.58x | 2.03x |
| Cash Conversion Cycle | -388.26 | - | -4.67K | - | -2.37K | -535.52 | 797.58 | 672.75 | -39.96 | - |
| Total Non-Current Liabilities | 33.91M | 19.66M | 28.13M | 44.7M | 248.32M | 591.42M | 739.08M | 822.5M | 805.97M | 437.25M |
| Long-Term Debt | 22.78M | 16.75M | 25.37M | 41.29M | 244.45M | 585.46M | 733.28M | 811.26M | 795.92M | 10.01M |
| Capital Lease Obligations | 2.7M | 2.75M | 2.7M | 3.41M | 3.87M | 5.96M | 5.8M | 11.23M | 10.05M | 0 |
| Deferred Tax Liabilities | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Non-Current Liabilities | 244K | 155K | 54K | 0 | 0 | 0 | 0 | 0 | 0 | 427.23M |
| Total Liabilities | 88.27M | 94.49M | 97.61M | 137.03M | 353.98M | 695.14M | 844.6M | 972.49M | 966.35M | 633.31M |
| Total Debt | 53.72M | 54.72M | 61.82M | 84.65M | 279.5M | 593.24M | 741.45M | 825.15M | 841.42M | 11.64M |
| Net Debt | 31.62M | 4.44M | 35.09M | -29.52M | 7.38M | 88.85M | 436.69M | 714.5M | 736.5M | -78.09M |
| Debt / Equity | - | - | - | 2.21x | - | - | - | - | - | - |
| Debt / EBITDA | - | - | - | - | - | - | - | - | - | 0.03x |
| Net Debt / EBITDA | - | - | - | - | - | - | - | - | - | -0.23x |
| Interest Coverage | -7.49x | -6.70x | -10.27x | -8.36x | -12.05x | -3.00x | -1.50x | -0.96x | -0.03x | - |
| Total Equity | -566.06M | -631.84M | -731.97M | 38.25M | -19.26M | -106.99M | -294.6M | -455.53M | -475.93M | -119.15M |
| Equity Growth % | -10.79% | -11.62% | -15.85% | 105.23% | -150.36% | -455.43% | -175.36% | -54.63% | -4.48% | 74.96% |
| Book Value per Share | -7.68 | -7.48 | -7.09 | 0.33 | -0.12 | -0.60 | -1.58 | -2.37 | -2.30 | -0.55 |
| Total Shareholders' Equity | -566.06M | -631.84M | -731.97M | 38.25M | -19.26M | -106.99M | -294.6M | -455.53M | -475.93M | -119.15M |
| Common Stock | 738K | 984K | 1.1M | 1.54M | 1.77M | 1.84M | 1.88M | 2.06M | 2.08M | 2.13M |
| Retained Earnings | -566.06M | -631.84M | -731.97M | -840.63M | -1.02B | -1.21B | -1.45B | -1.68B | -1.77B | -1.51B |
| Treasury Stock | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Accumulated OCI | -12K | -243K | -297K | 39K | 3K | 177K | 26K | 1.34M | 921K | 38K |
| Minority Interest | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Dec 2016 | Dec 2017 | Dec 2018 | Dec 2019 | Dec 2020 | Dec 2021 | Dec 2022 | Dec 2023 | Dec 2024 | Dec 2025 | |
|---|---|---|---|---|---|---|---|---|---|---|
| Cash from Operations | -53.44M | -41.14M | -92.56M | -89.58M | -137.22M | -142.16M | -161.85M | -95.14M | -52.02M | 347.37M |
| Operating CF Margin % | -202.78% | -163.36% | -448.19% | -183.44% | -770.36% | -90.45% | -59.76% | -28.71% | -11.54% | 39.71% |
| Operating CF Growth % | -307.43% | 23.01% | -124.98% | 3.22% | -53.17% | -3.6% | -13.85% | 41.22% | 45.32% | 767.76% |
| Net Income | -55.14M | -65.78M | -101.25M | -108.9M | -182.81M | -184.06M | -247.12M | -226.54M | -88.88M | 263.86M |
| Depreciation & Amortization | 483K | 704K | 770K | 724K | 748K | 777K | 1.44M | 1.66M | 1.25M | 1.39M |
| Stock-Based Compensation | 8.49M | 12.62M | 9.4M | 17.72M | 0 | 34.64M | 44.7M | 55.62M | 65.41M | 85.07M |
| Deferred Taxes | -271K | 1.11M | 1.17M | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Non-Cash Items | 558K | 876K | 885K | 1.74M | 17.98M | -1.64M | 98.07M | 106.53M | 57.48M | -2.95M |
| Working Capital Changes | -7.55M | 9.33M | -3.53M | -872K | 26.88M | 8.12M | -58.95M | -32.4M | -87.28M | 0 |
| Change in Receivables | -2.52M | 2.65M | 568K | -17.85M | 13.9M | -20.82M | -21.47M | -6.09M | -22.7M | 0 |
| Change in Inventory | 1.11M | 500K | -1.65M | 1.65M | -7.04M | -8.77M | -12.42M | -1.45M | -4.16M | 985K |
| Change in Payables | -10.52M | 3.84M | 4.49M | 11.74M | 17.36M | 39.41M | -22.36M | -16.81M | -62.38M | 57.8M |
| Cash from Investing | 23.34M | -66.38M | 4.77M | 77.93M | -6.86M | 15.8M | -128.24M | -131.5M | 52.59M | -13.69M |
| Capital Expenditures | -5.28M | -328K | -366K | -343K | -514K | -2.38M | -1.35M | -2.17M | -1.12M | 0 |
| CapEx % of Revenue | 20.02% | 1.3% | 1.77% | 0.7% | 2.89% | 1.52% | 0.5% | 0.65% | 0.25% | - |
| Acquisitions | 4K | 12K | 366K | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Investments | - | - | - | - | - | - | - | - | - | - |
| Other Investing | 66K | -1.74M | -366K | 0 | 1K | 0 | 0 | 0 | 0 | -8.1M |
| Cash from Financing | 23.3M | 135.7M | 62.5M | 99.1M | 302.7M | 359.67M | 88.03M | 32.48M | -5.76M | -349.93M |
| Debt Issued (Net) | 22.99M | 122K | 6.25M | 19.48M | 67.45M | 293.87M | 73.07M | 58.38M | -1.7M | 0 |
| Equity Issued (Net) | 0 | 1000K | 1000K | 1000K | 1000K | 1000K | 190K | 342K | 34K | 0 |
| Dividends Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Share Repurchases | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Financing | 317K | 1.58M | 2.85M | 0 | 124.71M | 15.73M | 14.77M | -26.24M | -4.09M | -349.93M |
| Net Change in Cash | -6.79M | 28.18M | -25.29M | 87.45M | 158.63M | 233.39M | -201.5M | -193.79M | -6.12M | -14.99M |
| Free Cash Flow | -58.72M | -41.47M | -92.93M | -89.93M | -137.73M | -144.54M | -163.2M | -97.31M | -53.14M | 347.37M |
| FCF Margin % | -222.8% | -164.66% | -449.96% | -184.14% | -773.24% | -91.97% | -60.26% | -29.36% | -11.79% | 39.71% |
| FCF Growth % | -221.94% | 29.37% | -124.09% | 3.23% | -53.16% | -4.95% | -12.91% | 40.37% | 45.39% | 753.64% |
| FCF per Share | -0.80 | -0.49 | -0.90 | -0.78 | -0.82 | -0.81 | -0.88 | -0.51 | -0.26 | 1.59 |
| FCF Conversion (FCF/Net Income) | 0.97x | 0.63x | 0.91x | 0.82x | 0.75x | 0.77x | 0.65x | 0.42x | 0.59x | 1.32x |
| Interest Paid | 0 | 0 | 0 | 0 | 0 | 900K | 0 | 22.14M | 30.38M | 0 |
| Taxes Paid | 0 | 0 | 0 | 0 | 0 | 118K | 3.54M | 1.43M | 1.6M | 0 |
| Metric | 2016 | 2017 | 2018 | 2019 | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 |
|---|---|---|---|---|---|---|---|---|---|---|
| Return on Equity (ROE) | - | - | - | -284.68% | -1925.37% | - | - | - | - | - |
| Return on Invested Capital (ROIC) | - | - | - | - | - | - | -179.63% | -38.79% | -0.73% | 807.86% |
| Gross Margin | 89.76% | 93.24% | 97.72% | 91.6% | 90.59% | 95.38% | 97.57% | 98.59% | 97.23% | 97.82% |
| Net Margin | -209.25% | -261.18% | -490.25% | -222.99% | -1026.35% | -117.11% | -91.25% | -68.36% | -19.72% | 30.16% |
| Debt / Equity | - | - | - | 2.21x | - | - | - | - | - | - |
| Interest Coverage | -7.49x | -6.70x | -10.27x | -8.36x | -12.05x | -3.00x | -1.50x | -0.96x | -0.03x | - |
| FCF Conversion | 0.97x | 0.63x | 0.91x | 0.82x | 0.75x | 0.77x | 0.65x | 0.42x | 0.59x | 1.32x |
| Revenue Growth | -45.39% | -4.43% | -18% | 136.45% | -63.53% | 782.38% | 72.31% | 22.37% | 36% | 94.1% |
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