Liquidity is under significant pressure, evidenced by a $9.1 million free cash flow deficit in 2026Q1 and a rapid decline in cash reserves from $15.6 million in 2025Q4 to $4.9 million.
| Metric | TTM | Dec'25 | Dec'24 | Dec'23 | Dec'22 | Dec'21 | Dec'20 | Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 | Dec'08 | Dec'07 | Dec'06 | Dec'05 | Dec'04 |
|---|
| Cash from Operations | -31.05M | -29.06M | -22.08M | -18.73M | -11.51M | -12.25M | -9.19M | -9.1M | -5.7M | -3.9M | -3.02M | -1.37M | -3.76M | -5.5M | -5.48M | -3.44M | -2.38M | -2.15M | -1.47M | -1.21M | -801.16K | -831.17K | -99.35K |
| Operating CF Margin % | - | - | - | - | - | - | - | - | -1139.2% | - | - | - | - | - | - | - | - | - | - | -755.4% | -3112.87% | -3236.75% | -293.24% |
| Operating CF Growth % | -163.62% | -31.65% | -17.88% | -62.7% | 6.05% | -33.39% | -0.91% | -59.8% | -46.05% | -29% | -121.33% | 63.63% | 31.75% | -0.34% | -59.6% | -44.57% | -10.72% | -46.4% | -20.85% | -51.45% | 3.61% | -736.57% | - |
| Net Income | -35.1M | -32.77M | -24.44M | -19.38M | -13.68M | -13.59M | -12.29M | -10.65M | -5.73M | -4.26M | -2.22M | -1.44M | -4.82M | -7.41M | -10.05M | -6.61M | -4.27M | -2.44M | -1.85M | -2.33M | -778.02K | -210.6K | -640.02K |
| Depreciation & Amortization | 52K | -899K | 39K | 30K | 25K | 24K | 21K | 21K | 15K | 4K | 2.2K | 4.11K | 2.47K | 1.11M | 2.37M | 2.3M | 1.67M | 30.2K | 26.74K | 18.35K | 3.32K | 28.15K | 6.41K |
| Stock-Based Compensation | 1.96M | 3.85M | 2.08M | 1.68M | 1.5M | 1.56M | 1.84M | 1.16M | 620K | 409K | 263.31K | 125.49K | 343.3K | 704.57K | 1.03M | 0 | 294.49K | 252.4K | 155.33K | 0 | 0 | 0 | 0 |
| Deferred Taxes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 84.6K | -169.95K | 21.54K | -343.3K | -704.57K | -1.03M | 0 | -218.25K | -252.4K | -155.33K | 0 | 0 | 0 | 0 |
| Other Non-Cash Items | 966.11K | 82K | -1.27M | -1.15M | 53K | 219K | 48K | -25K | 39K | -93.6K | 22.86K | -21.54K | 621.61K | 734.35K | 1.03M | 832.58K | 294.49K | 294.09K | 318.76K | 958.9K | 0 | 6.44K | 33.95K |
| Working Capital Changes | 1.07M | 675K | 1.51M | 93K | 585K | -461K | 1.2M | 387K | -636K | -44K | -918.45K | -52.97K | 437.98K | 66.58K | 1.17M | 36.23K | -148.89K | -35.59K | 41.67K | 142.9K | -26.46K | -655.16K | 500.3K |
| Change in Receivables | -49.73K | -22K | 133K | -287K | 48K | 210K | 483K | -43K | -700K | -27K | -42.36K | -2.78K | 4.76K | 5 | 31 | 0 | -170.84K | -11.71K | 46.62K | 0 | 0 | 0 | 0 |
| Change in Inventory | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -372K | -756K | -32.3K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Change in Payables | 1.8M | 535K | 14K | 192K | 225K | -590K | 917K | -301K | 372K | 248K | -599.07K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Cash from Investing | -11.37M | -2.19M | 8.56M | -18.3M | 11.54M | -20.54M | -16.13M | -3.91M | -50K | -22K | -6.89K | -5.39K | -31.33K | -134.27K | -63.37K | -79.31K | -57.62K | -92.09K | -85.26K | -296.17K | -108.89K | -76.99K | -103.46K |
| Capital Expenditures | -36.19K | -40K | -25K | -24K | -81K | -22K | -47K | -2K | -50K | -22K | -6.89K | -5.39K | -31.33K | -134.27K | -63.37K | -79.31K | -57.76K | -92.09K | -85.26K | -296.17K | -108.89K | -76.99K | -103.46K |
| CapEx % of Revenue | - | - | - | - | - | - | - | - | 10% | - | - | - | - | - | - | - | - | - | - | 184.39% | 423.11% | 299.8% | 305.37% |
| Acquisitions | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.5K | 0 | 0 | 0 | 0 | 0 | 149 | 0 | 0 | 0 | 0 | 0 | 0 |
| Investments | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Other Investing | 0 | 0 | 0 | 0 | 0 | 2K | 16K | 13K | 0 | 0 | 1 | 0 | -31 | -117 | -59 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Cash from Financing | 44.68M | 43.88M | 11.99M | 36.84M | -6K | 30.09M | 28.84M | 70K | 21.22M | 3.54M | 4.59M | 1.37M | 1.68M | 5.97M | 5.17M | 3.39M | 4.61M | 0 | 1.17M | 4.69M | 905.88K | 1.18M | 159.51K |
| Debt Issued (Net) | -10.03K | -10K | -9K | -6K | -6K | -6K | -5K | -5K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -174.08K | 134.91K |
| Equity Issued (Net) | 44.53M | 44.29M | 11.75M | 36.85M | 0 | 29.85M | 28.8M | 0 | 20.57M | 2.92M | 4.12M | 1.5M | 1.61M | 5.89M | 0 | 3.18M | 1.79M | 0 | 1.17M | 4.69M | 905.88K | 1.35M | 24.6K |
| Dividends Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Share Repurchases | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Financing | 158.25K | -400K | 256K | 0 | 0 | 244K | 45K | 75K | 650K | 622K | 470.63K | -22.56K | 152.49K | 95.44K | 5.16M | 211.56K | 2.82M | 0 | 0 | 0 | 0 | 0 | 0 |
| Net Change in Cash | 2.28M | 12.62M | -1.52M | -185K | 21K | -2.7M | 3.53M | -12.94M | 15.47M | -383K | 1.57M | -4.78K | -2.11M | 335.14K | -381.99K | -126.9K | 2.18M | -2.24M | -381.43K | 3.18M | -4.17K | 266.86K | -43.31K |
| Free Cash Flow | -31.09M | -29.1M | -22.1M | -18.75M | -11.59M | -12.27M | -9.23M | -9.1M | -5.75M | -3.92M | -3.03M | -1.37M | -3.79M | -5.64M | -5.55M | -3.52M | -2.43M | -2.24M | -1.55M | -1.51M | -910.05K | -908.15K | -202.82K |
| FCF Margin % | - | - | - | - | - | - | - | - | -1149.2% | - | - | - | - | - | - | - | - | - | - | -939.79% | -3535.98% | -3536.56% | -598.61% |
| FCF Growth % | -37.55% | -31.68% | -17.86% | -61.77% | 5.56% | -32.95% | -1.41% | -58.44% | -46.51% | -29.44% | -120.96% | 63.79% | 32.82% | -1.62% | -57.8% | -44.39% | -8.74% | -44.29% | -2.79% | -65.87% | -0.21% | -347.77% | - |
| FCF per Share | -0.58 | -0.62 | -0.55 | -0.58 | -0.44 | -0.59 | -0.59 | -0.76 | -0.74 | -0.66 | -0.64 | -0.38 | -1.22 | -2.06 | -2.27 | -1.56 | -1.70 | -2.33 | -1.71 | -1.88 | -1.04 | -1.04 | -0.01 |
| FCF Conversion (FCF/Net Income) | 0.89x | 0.89x | 0.90x | 0.97x | 0.84x | 0.90x | 0.75x | 0.85x | 0.99x | 0.92x | 1.36x | 0.95x | 0.78x | 0.74x | 0.55x | 0.52x | 0.56x | 0.88x | 0.79x | 0.52x | 1.03x | 3.95x | 0.16x |
| Interest Paid | 0 | 0 | 0 | 0 | 0 | 0 | 2K | 2K | 11K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Taxes Paid | 16K | 28K | 26K | 33K | 27K | 28K | 36K | 26K | 80K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Clinical trial funding shortfall
As reported in financial statements, DMAC's operating cash flow consistently tracks closely with net losses, with an OCF/NI ratio of 0.90 in 2026Q1, indicating that the company's reported losses are almost entirely representative of actual cash outflows required to sustain its clinical development pipeline.
The high correlation between net income and operating cash flow suggests that non-cash adjustments, such as stock-based compensation, provide only a marginal buffer against the company's core operational burn. Investors should monitor this tight conversion ratio, as it implies that any increase in clinical trial intensity will translate directly into accelerated cash depletion.
Based on the company's reported figures, free cash flow has remained deeply negative throughout the last ten quarters, reaching a deficit of $9.1 million in 2026Q1, which underscores the firm's total reliance on external financing to fund its ongoing REMEDY2 clinical trial activities.
The trajectory of free cash flow shows no signs of stabilization, reflecting the high-cost nature of late-stage biopharmaceutical development. This persistent cash burn warrants further investigation into the company's ability to maintain its current trial velocity without resorting to dilutive equity raises in the near term.
According to recent SEC filings, working capital changes have fluctuated significantly, ranging from a $1.6 million inflow in 2024Q3 to a $513,000 outflow in 2025Q2, suggesting that the timing of vendor payments and clinical site milestones creates meaningful, albeit temporary, noise in the company's quarterly cash position.
These swings in working capital appear to be driven by the irregular timing of payments to contract research organizations rather than fundamental shifts in operational efficiency. Analysts should interpret these variances as timing differences that do not alter the underlying reality of the company's structural cash burn.
As indicated by the provided data, DMAC maintains minimal capital expenditure, with quarterly outlays consistently below $20,000, confirming that the company's cash requirements are almost exclusively driven by R&D and clinical trial operations rather than investments in physical infrastructure or manufacturing capacity.
The lack of significant capital investment suggests that the company is operating as a lean, research-focused entity that outsources its manufacturing and clinical execution. While this preserves cash in the short term, it may indicate a lack of control over the long-term scalability of the DM199 production process.
Quick answers to the most common questions about buying DMAC stock.
DiaMedica Therapeutics Inc. (DMAC) generated $-29.1M in net cash from operating activities in 2025. This reflects the cash generated directly from core business operations.
DiaMedica Therapeutics Inc. (DMAC) reported negative free cash flow of $29.1M in 2025, indicating capital requirements exceeded cash from operations.
DiaMedica Therapeutics Inc. (DMAC) spent $0.0M on capital expenditures in 2025. CapEx represents the cash invested in physical assets like property, plant, and equipment to maintain or grow the business.