Free cash flow remains deeply negative with a $4.0 million outflow in 2025Q4, highlighting a persistent disconnect between accounting losses and the cash required to sustain clinical operations.
| Cash from Operations | -5.7M | -9.22M | -12.38M | -22.34M | -32.29M | -11.22M | -14.03K | -10.87M | -7.18M | -4.53M | -4.17K | -1.01K | 57 |
| Operating CF Margin % | -15731.49% | - | - | - | - | - | - | - | - | - | - | - | - |
| Operating CF Growth % | 38.13% | 25.53% | 44.6% | 30.8% | -187.73% | -79862.49% | 99.87% | -51.29% | -58.43% | -108642.99% | -311.92% | -1890.13% | - |
| Net Income | -6.55M | -18.06M | -15.79M | -14.63M | -58.54M | -32.67M | -15.18K | -13.53M | -11.1M | -14.59M | -5.93K | -2.95K | -1.01K |
| Depreciation & Amortization | 574.71K | 48.95K | 29.27K | 29.27K | 542.25K | 565.35K | 635 | 798.45K | 754K | 734.5K | 734 | 434 | 12 |
| Stock-Based Compensation | 733.95K | 631.55K | 1.04M | 769.12K | 1.37M | 549.42K | 1.39K | 2.84K | 2.02K | 604 | 0 | 0 | 0 |
| Deferred Taxes | -418.63K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Non-Cash Items | -39.27K | 5.63M | 157.02K | 277.43K | 3.46M | 5.4M | 397 | 6.62M | 5.16M | 9.95M | 1.68K | 653 | -17 |
| Working Capital Changes | 0 | 2.53M | 2.19M | -10.5M | 17.1M | 14.15M | -1.28K | -1.71M | -268.2K | 704.87K | -653 | 853 | 1.08K |
| Change in Receivables | 7.29K | 0 | 93.01K | -93 | 551 | 2.08K | -750 | -2.19M | 3.44K | 132.04K | -638 | 356 | 38 |
| Change in Inventory | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Change in Payables | 464.2K | 1.64M | -165.76K | -1.99M | 1.42M | -750.03K | -420.79K | 741.62K | -233.78K | 0 | 0 | 0 | 0 |
| Cash from Investing | 323.48K | 88.17K | -500K | 0 | -10.32M | 87.35K | -24 | -305.47K | -32.17K | -12.36K | -24 | -752 | 0 |
| Capital Expenditures | 0 | 0 | -500K | 0 | -10.32M | -4.17K | -24.1K | -305.47K | -32.17K | -12.36K | -24 | -191 | 0 |
| CapEx % of Revenue | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Acquisitions | -8.72M | 88.17K | 0 | 0 | 0 | 91.52K | 0 | 0 | 0 | 0 | 0 | -561 | 0 |
| Investments | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Other Investing | 9.04M | 0 | 0 | 0 | -10.25K | 92 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Cash from Financing | 5.89M | 5.58M | 15.23M | 15.74M | 44.76M | 17.05M | 13.14K | 11.71M | 6.01M | 5.75M | 4.68K | 1.85K | -10 |
| Debt Issued (Net) | 0 | -644.58K | -603.49K | -641.24K | 88.83K | 2.86M | 3.61M | -190.68K | 1M | 1.89M | 5.02M | 991K | 0 |
| Equity Issued (Net) | 0 | 6.23M | 15.83M | 23.25M | 39.77M | 14.19M | 9.48M | 11.9M | 5.01M | 5.28M | 0 | 859.49K | 0 |
| Dividends Paid | -337.24K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Share Repurchases | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Financing | 6.23M | 45 | 657 | -6.87M | 4.91M | 0 | 61.59K | 0 | 0 | -1.42M | -340.52K | 0 | -10 |
| Net Change in Cash | 714.79K | -3.55M | 2.35M | -6.86M | 2.19M | 5.89M | -939 | 540.87K | -1.2M | 1.77M | 448 | 86 | 48 |
| Free Cash Flow | -5.7M | -9.22M | -12.88M | -22.34M | -42.61M | -11.23M | -38.13K | -11.17M | -7.22M | -4.55M | -4.2K | -1.2K | 57 |
| FCF Margin % | -15731.49% | - | - | - | - | - | - | - | - | - | - | - | - |
| FCF Growth % | 38.13% | 28.42% | 42.37% | 47.56% | -279.55% | -29339.45% | 99.66% | -54.84% | -58.71% | -108305.5% | -248.57% | -2227.87% | - |
| FCF per Share | -3.53 | -2.68 | -38.29 | -622.19 | -20049.05 | -16580.21 | -71.42 | -30399.11 | -28517.32 | -29360.37 | -18.02 | -5.17 | 0.24 |
| FCF Conversion (FCF/Net Income) | 0.87x | 0.51x | 0.78x | 1.53x | 0.55x | 0.34x | 0.00x | 0.80x | 0.65x | 0.31x | 0.00x | 0.00x | -0.06x |
| Interest Paid | 0 | 36.16K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Taxes Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Imminent liquidity and dilution
According to recent financial statements, ENTO's operating cash flow consistently trails net income, with the 2025Q4 period showing a $4.0 million cash outflow despite a $3.1 million net loss, highlighting the persistent gap between accounting losses and the actual cash required to sustain clinical operations.
The divergence between net income and operating cash flow suggests that non-cash items and working capital adjustments are insufficient to bridge the company's fundamental funding gap. Investors should interpret this persistent negative cash flow as a signal that the company's clinical development costs are not being offset by any meaningful operational efficiency.
As reported in quarterly filings, ENTO's free cash flow remains deeply negative, reaching a $4.0 million outflow in 2025Q4, which underscores the company's reliance on external capital markets to fund its ongoing research and development activities rather than generating internal cash from its clinical pipeline.
The lack of positive free cash flow is a structural reality for a pre-commercial entity, yet the magnitude of these outflows relative to the company's limited cash reserves warrants extreme caution. This trajectory suggests that without a significant change in funding strategy or clinical milestones, the company will continue to face severe liquidity pressure.
Based on historical data, ENTO's working capital changes have been erratic, with a $604,200 inflow in 2025Q2 followed by a $0 change in 2025Q4, indicating that management's ability to optimize cash cycles is secondary to the overwhelming pressure of funding clinical trial expenditures.
The inconsistency in working capital movements appears to reflect the timing of vendor payments and clinical trial milestones rather than operational improvements. Analysts should monitor these fluctuations as they may indicate the company's struggle to manage payables while maintaining critical research operations.
As indicated in recent SEC filings, ENTO utilized $8.7 million for acquisitions in 2025Q4, a move that significantly depleted available liquidity and shifted the company's strategic focus toward the latiglutenase program at the expense of its already strained cash position.
This aggressive deployment of capital into intangible assets suggests a high-stakes pivot intended to secure a viable clinical future. However, the timing of such expenditures, given the company's limited cash runway, implies a high degree of risk regarding the company's ability to sustain operations through the next phase of development.
Quick answers to the most common questions about buying ENTO stock.
Entero Therapeutics, Inc. (ENTO) generated $-5.7M in net cash from operating activities in 2025. This reflects the cash generated directly from core business operations.
Entero Therapeutics, Inc. (ENTO) reported negative free cash flow of $5.7M in 2025, indicating capital requirements exceeded cash from operations.
Entero Therapeutics, Inc. (ENTO) spent $0.0M on capital expenditures in 2025. CapEx represents the cash invested in physical assets like property, plant, and equipment to maintain or grow the business.
In 2025, Entero Therapeutics, Inc. (ENTO) returned $0.3M to shareholders via cash dividends. This shows the company's commitment to returning capital to its equity investors.