Last 9 quarters of trend data · Healthcare · Biotechnology
Quarterly valuation ratios — annualised for comparability. YoY Δ shows same-quarter-prior-year change.
| Metric | TTM | Q1 '26 | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q4 '23 |
|---|---|---|---|---|---|---|---|---|---|---|
| P/E Ratio → | -7.89 | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | |
| P/S Ratio | — | 20.11 | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | |
| P/B Ratio | 2.91 | 4.71 | 5.02 | 3.13 | 2.05 | 1.65 | — | — | — | — |
| — | +185.2% | — | — | — | — | — | — | — | — | |
| P/FCF | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | |
| EV / EBITDA | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | |
| EV / EBIT | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — |
Quarterly margins and returns. Watch for margin compression across consecutive quarters.
Maze Therapeutics, Inc.'s operating margin was -132.8% in Q1 2026.
| Metric | TTM | Q1 '26 | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q4 '23 |
|---|---|---|---|---|---|---|---|---|---|---|
| Gross Margin | — | 97.8% | — | — | — | — | — | 100.0% | 100.0% | — |
| — | — | — | — | — | — | — | — | — | — | |
| Operating Margin | — | -132.8% | — | — | — | — | — | -969.2% | 84.6% | — |
| — | — | — | — | — | — | — | — | — | — | |
| Net Margin | — | -121.0% | — | — | — | — | — | -990.1% | 84.3% | — |
| — | — | — | — | — | — | — | — | — | — |
| Metric | TTM | Q1 '26 | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q4 '23 |
|---|---|---|---|---|---|---|---|---|---|---|
| ROE | -47.5% | -6.9% | -9.4% | -9.4% | -12.2% | -13.4% | -20.0% | -24.9% | — | -264.3% |
| — | +48.2% | +52.9% | +62.4% | — | +94.9% | — | — | — | — | |
| ROA | -41.1% | -5.9% | -8.4% | -8.3% | -10.6% | -11.4% | -13.7% | -12.1% | 96.8% | -37.2% |
| — | +48.2% | +38.2% | +31.6% | -110.9% | +69.2% | — | — | — | — | |
| ROIC | -99.4% | -10.1% | -20.7% | -45.1% | -118.4% | -105.7% | -80.1% | -62.8% | — | — |
| — | +90.4% | +74.2% | +28.2% | — | — | — | — | — | — |
Quarterly solvency trend — watch for debt spikes or covenant pressure.
The current ratio has improved 11.1% YoY to 17.88x, strengthening the short-term liquidity position. Debt/Equity has risen for 3 consecutive quarters, indicating increasing financial leverage that investors should watch closely.
| Metric | TTM | Q1 '26 | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q4 '23 |
|---|---|---|---|---|---|---|---|---|---|---|
| Debt / Equity | 0.07 | 0.18 | 0.07 | 0.06 | 0.10 | 0.09 | 0.14 | 0.80 | — | 4.94 |
| — | +102.7% | -51.4% | -92.0% | — | -98.2% | — | — | — | — | |
| Debt / EBITDA | — | — | — | — | — | — | — | — | 0.55 | — |
| — | — | — | — | — | — | — | — | — | — | |
| Current Ratio | 15.50 | 17.88 | 15.50 | 17.70 | 13.63 | 16.10 | 9.76 | 8.77 | 8.30 | 2.09 |
| — | +11.1% | +58.9% | +101.8% | +64.1% | +670.1% | — | — | — | — | |
| Quick Ratio | 15.50 | 17.88 | 15.50 | 17.70 | 13.63 | 16.10 | 9.76 | 8.77 | 8.30 | 2.09 |
| — | +11.1% | +58.9% | +101.8% | +64.1% | +670.1% | — | — | — | — | |
| Interest Coverage | — | -30.66 | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — |
Includes 30+ ratios · 9 years · Updated daily
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Maze Therapeutics, Inc.'s current P/E is -7.9x. Quarterly P/E ratios can vary due to seasonal revenue patterns and one-time charges.
Quarterly financial ratios reveal short-term trend shifts — margin compression, debt spikes, or valuation re-ratings — that annual figures smooth over. They're essential for active investors tracking Maze Therapeutics, Inc.'s business trajectory between earnings reports.