Persistent negative free cash flow remains a critical concern, with quarterly outflows reaching as high as $5.5 million in 2025Q1, necessitating constant reliance on external capital markets.
| Metric | TTM | Dec'25 | Dec'24 | Dec'23 | Dec'22 | Dec'21 | Dec'20 | Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 | Dec'08 | Dec'07 | Dec'06 | Dec'05 | Dec'04 | Dec'03 | Dec'02 | Dec'01 | Dec'00 | Dec'99 |
|---|
| Cash from Operations | -7.92M | -12.01T | -10.91M | -16.44M | -26.97M | -27.28M | -20.03M | -18.28M | -14.48M | -8.44M | -6.51M | -4.34M | -2.19M | -694.58K | -1.57M | -1.31M | -925.04K | -1.12M | -714.42K | -1.23M | -1.19M | -1.16M | -1.21M | -2.59M | -1.41M | 2.38K | -879.74K | -815.18K |
| Operating CF Margin % | - | - | -165.53% | -496.51% | -767.66% | -2196.95% | -4292.06% | -8576.36% | -7029.29% | -4610.1% | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -2765.52% | -675.29% |
| Operating CF Growth % | -147.05% | -99999900% | 33.64% | 39.05% | 1.13% | -36.16% | -9.57% | -26.27% | -71.57% | -29.64% | -49.88% | -98.59% | -214.89% | 55.62% | -19.49% | -41.6% | 17.53% | -57.01% | 41.71% | -3.36% | -1.82% | 4.14% | 53.12% | -84.22% | -59281.28% | 100.27% | -7.92% | - |
| Net Income | -10.9M | -12.16T | -10.73M | -14.05M | -19.78M | -41.88M | -28.71M | -21.43M | -147.96M | -10.98M | -2.46M | -34.07M | -30.88M | -5.53M | -5.86M | -2.03M | -5.09M | -4.46M | -2.2M | -3.89M | -1.3M | -985.6K | -2.68M | -5.78M | -2.28M | -379.86K | -1.29M | -1.13M |
| Depreciation & Amortization | 0 | 0 | 0 | 0 | 0 | 3.16M | 1.08M | 286.58K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.74K | 7.48K | 5.97K | 6.37K | 71.51K | 37.45K | 42.37K | 40.89K | 0 | 20.64K | 17.7K |
| Stock-Based Compensation | 158.4K | 537.54B | 245.86K | 858.27K | 0 | 5.96M | 5.23M | 5.36M | 16.35M | 2.74M | 1.56M | 1.71M | 1.39M | 132.09K | 2.44M | 1.26M | 2.29M | 2.53M | 234.17K | 964.22K | 0 | 0 | 2.73M | 0 | 0 | 0 | 0 | 0 |
| Deferred Taxes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -955.66K | 0 | -964.22K | 0 | 0 | -2.73M | 0 | 0 | 0 | 0 | 0 |
| Other Non-Cash Items | 178.42K | -388B | 0 | -6.1M | -2.43M | 0 | -31K | -18K | 116.08M | -497.87K | -5.87M | 27.91M | 27.52M | 2.12M | -372.76K | -597.68K | 1.15M | 1.07M | 754.54K | 2.3M | 370.21K | -90.73K | 148.9K | 2.74M | 630.27K | 243.26K | 843.11K | 284.27K |
| Working Capital Changes | 2.64M | -388K | -424.87K | 2.85M | -4.76M | 5.47M | 2.4M | -2.48M | 1.04M | 302.37K | 256.24K | 109.72K | -212.7K | 2.58M | 2.23M | 54.77K | 729.06K | 693.2K | 485.32K | 361.36K | -258.06K | -159.87K | 1.28M | 402.11K | 206.81K | 138.98K | -451.65K | 10.17K |
| Change in Receivables | 1.08M | 977.3K | -1.32M | 1.37M | -2.4M | 1M | 55.63K | 51.99K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Change in Inventory | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 27.8K |
| Change in Payables | -176.38K | -454.57K | 8.76K | 611.26K | -1.32M | 0 | 0 | -963.97K | 1.24M | 283.37K | 257.58K | 96.02K | -145.2K | 2.48M | 2.03M | -66.12K | 0 | 0 | 389.32K | 373.87K | 3.02K | 3.02K | 106.16K | 0 | 0 | 0 | 0 | 0 |
| Cash from Investing | 0 | 0 | 0 | 18.66M | -4.95M | -3.13M | -9.25M | -374.98K | -147.67K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -22.43K | -1.97K | -1.97K | -2.25K | -2.25K | 417.55K | 0 | -2.86K | -36.76K |
| Capital Expenditures | 0 | 0 | 0 | 0 | 0 | -3.13M | -9.25M | -374.98K | -147.67K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -22.43K | 0 | -1.97K | 0 | -2.25K | -5.82K | 0 | -2.86K | -54.03K |
| CapEx % of Revenue | 0% | - | - | - | 0% | 252.16% | 1982.26% | 175.89% | 71.69% | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 8.99% | 44.76% |
| Acquisitions | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Investments | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Other Investing | 0 | 0 | 0 | 18.66M | -4.95M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -22.43K | -1.97K | -1.97K | -2.25K | 0 | 423.37K | 0 | 0 | 17.27K |
| Cash from Financing | 9.86M | 9.86T | 14.99M | 1.11M | 202.13K | 52.56M | 6.74M | 816.48K | 71.25M | 5.72M | 7.78M | 10.78M | 2.28M | 709.33K | 1.37M | 1.54M | 807.13K | 1.26M | 547.87K | 1.32M | 1.22M | 1.21M | 1.22M | 2.01M | 1.63M | -2.38K | 807.79K | 888.21K |
| Debt Issued (Net) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -48K | 0 | 403K | 740.2K | 761.25K | 724.53K | 563.92K | 485K | 122K | 583.23K | 376.14K | 60K | 500K | 0 | 68.55K | 0 | 184.79K | -83.49K |
| Equity Issued (Net) | 9.86M | 9.86M | 14.93M | 1.01M | 202.13K | 52.55M | 6.19M | 816.48K | 66.87M | 5.1M | 2.33M | 2.46M | 1.88M | 0 | 555K | 683.45K | 0 | 700K | 60K | 457.5K | 1.09M | 1.36M | 550K | 1.96M | 1.57M | 0 | 623K | 971.7K |
| Dividends Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Share Repurchases | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -71.71K | -310.49K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Financing | 0 | 9.86T | 62.16K | 90.48K | 0 | 3.09K | 550K | 0 | 4.37M | 619.62K | 5.5M | 8.31M | 0 | -30.87K | 55.95K | 128.6K | 243.21K | 77.17K | 365.87K | 277.61K | 0 | -206.65K | 174.04K | 44.21K | -12.69K | -2.38K | 0 | 0 |
| Net Change in Cash | 1.95M | -2.15T | 4.08M | 3.33M | -31.72M | 22.14M | -22.55M | -17.84M | 56.62M | -2.72M | 1.27M | 6.43M | 93.36K | 14.75K | -199.56K | 226.72K | -117.92K | 140.44K | -166.55K | 47.1K | 64.19K | 44.6K | -7.8K | -623.14K | 631.03K | 0 | -43.58K | 5.83K |
| Free Cash Flow | -7.92M | -12.01T | -10.91M | -16.44M | -26.97M | -30.41M | -29.29M | -18.66M | -14.63M | -8.44M | -6.51M | -4.34M | -2.19M | -694.58K | -1.57M | -1.31M | -925.04K | -1.12M | -714.42K | -1.25M | -1.19M | -1.17M | -1.21M | -2.59M | -1.41M | 2.38K | -882.6K | -869.21K |
| FCF Margin % | -378.13% | - | -165.53% | -496.51% | -767.66% | -2449.11% | -6274.32% | -8752.25% | -7100.98% | -4610.1% | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -2774.51% | -720.05% |
| FCF Growth % | 37.02% | -99999900% | 33.64% | 39.05% | 11.31% | -3.84% | -56.96% | -27.56% | -73.32% | -29.64% | -49.88% | -98.59% | -214.89% | 55.62% | -19.49% | -41.6% | 17.53% | -57.01% | 42.76% | -5.25% | -1.65% | 3.98% | 53.16% | -83.62% | -59526.13% | 100.27% | -1.54% | - |
| FCF per Share | -0.41 | -784721.16 | -1.21 | -1.87 | -3.23 | -3.97 | -6.23 | -4.09 | -7.66 | -8.93 | -0.88 | -11.86 | -16.97 | -73.37 | -286.65 | -341.82 | -278.96 | -683.15 | -365.81 | -7195.15 | -12195.14 | -12399.00 | -0.06 | - | - | - | - | - |
| FCF Conversion (FCF/Net Income) | 0.73x | 987706.04x | 1.02x | 2.00x | 0.90x | 0.65x | 0.70x | 0.85x | 0.10x | 0.77x | 2.65x | 0.13x | 0.07x | 0.13x | 0.27x | 0.65x | 0.18x | 0.25x | 0.33x | 0.31x | 0.91x | 1.18x | 0.45x | 0.45x | 0.62x | -0.01x | 0.68x | 0.72x |
| Interest Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Taxes Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Clinical Trial Funding Dependency
According to quarterly financial data, Marker Therapeutics exhibits a persistent disconnect between net losses and operating cash flow, with OCF/NI ratios frequently exceeding 1.0, suggesting that non-cash items and working capital fluctuations are significantly distorting the company's underlying cash burn profile during its clinical development phase.
The frequent divergence between net income and operating cash flow indicates that the company's reported losses do not fully capture the immediate liquidity impact of its R&D-heavy operations. Investors should monitor these fluctuations as they suggest that the timing of clinical trial expenditures and grant-related inflows creates significant noise in the cash flow statement.
As reported in recent financial statements, Marker Therapeutics has consistently generated negative free cash flow, with quarterly outflows reaching as high as $5.5 million in 2025Q1, reflecting the company's total reliance on external financing to sustain its ongoing clinical trial programs and laboratory infrastructure.
The lack of a positive FCF trajectory underscores the company's status as a pre-revenue entity where cash burn is the primary operational metric. The absence of any meaningful FCF margin improvement suggests that the company remains entirely dependent on capital markets to bridge the gap until potential commercialization.
Based on reported figures, working capital changes have been highly erratic, swinging from a $3.5 million inflow in 2024Q3 to a $1.4 million outflow in 2025Q1, which highlights the company's struggle to manage cash cycles while navigating the complex logistics of cell therapy clinical trials.
These swings in working capital appear to be driven by the timing of clinical site payments and potential milestone-based grant receipts rather than operational efficiency. This volatility complicates cash forecasting and suggests that the company's liquidity position is highly sensitive to the timing of specific trial-related obligations.
As indicated by historical cash flow statements, stock-based compensation remains a recurring non-cash expense, which effectively masks the true economic cost of retaining specialized scientific talent required for the company's non-engineered T cell platform development in a highly competitive biotechnology labor market.
While SBC is a non-cash item, it represents a real dilution risk to shareholders that is not fully captured in the cash burn metrics. Analysts should adjust for these expenses to understand the true cost of operations and the potential for future equity-based financing requirements.
Quick answers to the most common questions about buying MRKR stock.
Marker Therapeutics, Inc. (MRKR) generated $-12014081.0M in net cash from operating activities in 2025. This reflects the cash generated directly from core business operations.
Marker Therapeutics, Inc. (MRKR) reported negative free cash flow of $12.01T in 2025, indicating capital requirements exceeded cash from operations.
Marker Therapeutics, Inc. (MRKR) spent $0.0M on capital expenditures in 2025. CapEx represents the cash invested in physical assets like property, plant, and equipment to maintain or grow the business.