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PHIO
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PHIOPhio Pharmaceuticals Corp.
$1.00$12M
Overview & Tools
OverviewChart Terminal ↗Visualize
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Analyst TargetsPrice History
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PHIO logo

Phio Pharmaceuticals Corp.

PHIO
NASDAQ · Biotechnology
$1.00
At close - Sep 22, 4:00 PM EDT - USD
Market Cap$12M
P/E-0.7x
52W High$4.19
Volume204.07K
OverviewTerminalAnalysisFinancialsValuationEarningsBreakoutsOwnership
VCP Research Verdict2026Q1

Persistent Clinical Burn Outpaces Capital Reserves

Phio Pharmaceuticals remains a pre-commercial biotechnology entity characterized by a total absence of revenue and an escalating R&D burn rate that reached $2.8 million in 2026Q1. The company's reliance on external capital to fund its clinical-stage programs p...

GrowthContracting
ProfitabilityNegative
ValuationReview
TechnicalsWeak
Explore valuation models
MARKET ACTION

PHIO price & volume

Price trend, volume and key moving averages

Launch Terminal
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Decision Checklist4 Core Signals

What matters now

The signals most likely to change the investment case.

01

Earnings momentum

No Data

No recent earnings data

02

Valuation risk

-102% Peers

P/E is 102% below peer median

03

Market leadership

RS 41 · Lag

Laggard (Underperforming 59% of market)

04

Weak Trend

Below 200DMA

Price < 200DMA

Next CatalystConfirmed earnings · Nov 12

Market performance

Price History →

Trailing total returns as of 9/23/2026, which may include dividends or other distributions. Benchmark is S&P 500 (^GSPC).

YTD Return
PHIO-8.26%
S&P 500 (^GSPC)+13.20%
1-Year Return
PHIO-55.36%
S&P 500 (^GSPC)+15.98%
3-Year Return
PHIO-92.01%
S&P 500 (^GSPC)+79.50%
5-Year Return
PHIO-99.58%
S&P 500 (^GSPC)+74.14%

Growth & profitability

Annual revenue & EPS trend
Revenue
-
Net income
-$9M-21.7% YoY
Free cash flow
-$8M-12.3% YoY
Operating margin
-
ROIC (TTM)-
Avg ROIC 5Y-
ROE (TTM)-69.9%
Piotroski Score3 / 9
Financial Statements →
03

Monitor what changed

Recent results and news deserve attention only when they alter the forward view.

MARKET COVERAGE

Latest News

5 Stories
Newsfile Corp·Sep 14, 2026
Phio Announces Key Development Milestone for PH-762 with FDA Submission Supporting Next Stage of Clinical Development in Cutaneous Squamous Cell Carcinoma

King of Prussia, Pennsylvania--(Newsfile Corp. - September 14, 2026) - Phio Pharmaceuticals Corp. (NASDAQ: PHIO) is a clinical-stage siRNA biopharmaceutical

Newsfile Corp·Sep 11, 2026
Phio Pharmaceuticals to Participate in the H.C. Wainwright 28th Annual Global Investment Conference

Management to Meet with Investors and Highlight Progress and Future Development Plans for PH-762 King of Prussia, Pennsylvania--(Newsfile Corp. - September 11, 2026) - Phio Pharmaceuticals Corp. (NASDAQ: PHIO), a clinical-stage biotechnology company developing therapeutics based on its proprietary INTASYL® siRNA gene-silencing technology designed to eliminate cancer, today announced that members of its management team will be available for one-on-one investor meetings at the H.C. Wainwright 28th Annual Global Investment Conference, taking place September 14-16, 2026, at the Lotte New York Palace Hotel in New York City.

Newsfile Corp·Aug 11, 2026
Phio Pharmaceuticals Secures U.S. Notice of Allowance for INTASYL Composition Selectively Targeting BRD4 Protein with Compound PH-894

King of Prussia, Pennsylvania--(Newsfile Corp. - August 11, 2026) - Phio Pharmaceuticals Corp. (NASDAQ: PHIO), a clinical-stage biotechnology company developing

Newsfile Corp·Aug 6, 2026
Phio Pharmaceuticals Reports Second Quarter 2026 Financial Results and Business Update

Strategic milestone advancements for lead clinical candidate PH-762 Initiation of commercial scale API, long term non-clinical toxicology, completion of Phase 1b pharmacology, and new IP announcements King of Prussia, Pennsylvania--(Newsfile Corp. - August 6, 2026) - Phio Pharmaceuticals Corp. (NASDAQ: PHIO) is a clinical-stage siRNA biopharmaceutical company developing therapeutics using its proprietary INTASYL® gene silencing technology to eliminate cancer. Phio today reported its financial results for the quarter ended June 30, 2026, and provided a business update.

Filtered for Phio Pharmaceuticals Corp.More Headlines
04

Compare before deciding

Benchmark PHIO against direct peers instead of judging its metrics in isolation.

Peers Comparison

Key metrics vs top competitors for Phio Pharmaceuticals Corp. (PHIO)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
PHIO logoPHIOPhio Pharmaceuticals Corp.Current
$1.00$11.62M-0.69——-69.95%—
SRPT logoSRPTSarepta Therapeutics, Inc.
$20.81$2.2B-2.9215.58%-6.93%-9.96%—
ARWR logoARWRArrowhead Pharmaceuticals, Inc.
$71.86$10.12B-5890.1623258.15%-47.79%-60.05%—
ALNY logoALNYAlnylam Pharmaceuticals, Inc.
$251.65$33.6B108.0065.19%16.82%93.61%—
NTLA logoNTLAIntellia Therapeutics, Inc.
$12.69$1.42B-3.3316.92%-672.16%-57.79%—
BEAM logoBEAMBeam Therapeutics Inc.
$25.93$2.67B-32.01120.01%-54.75%-7.7%—

Compare PHIO vs Peers

Phio Pharmaceuticals Corp. (PHIO) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs SRPT

Most directly comparable listed peer for PHIO.

Scale Benchmark

vs TMO

Larger-name benchmark to compare PHIO against a more recognizable public peer.

Peer Set

Compare Top 5

vs SRPT, ARWR, ALNY, NTLA

05

Keep researching

Verify the primary filings, follow material updates, and answer the remaining questions.

PHIO SEC Filings & Documents

Phio Pharmaceuticals Corp. (PHIO) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Aug 6, 2026·SEC

Material company update

Jul 21, 2026·SEC

Material company update

May 7, 2026·SEC

10-K Annual Reports

2
FY 2026

Mar 5, 2026·SEC

FY 2025

Mar 31, 2025·SEC

10-Q Quarterly Reports

6
FY 2026

Aug 6, 2026·SEC

FY 2026

May 7, 2026·SEC

FY 2025

Nov 13, 2025·SEC

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PHIO Frequently Asked Questions

Phio Pharmaceuticals Corp. (PHIO) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
Is PHIO profitable?

Phio Pharmaceuticals Corp. (PHIO) reported a net loss of $12.9M for fiscal year 2025.

Dividend & Returns
What is PHIO's return on equity?

Phio Pharmaceuticals Corp. (PHIO) has a return on equity (ROE) of -69.9%. Negative ROE indicates the company is unprofitable.

What is Phio Pharmaceuticals Corp.'s free cash flow?

Phio Pharmaceuticals Corp. (PHIO) had negative free cash flow of $16.2M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in PHIO back in 2011?

Total return calculator · dividends reinvested · 15+ years of data

See returns →