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PHIOPhio Pharmaceuticals Corp.
$1.03$12M
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PHIO logoPhio Pharmaceuticals Corp.(PHIO)Earnings, Financials & Key Ratios

PHIO•NASDAQ
Price updated Jun 19, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryRNA and Genome Editing Developers
AboutPhio Pharmaceuticals Corp. develops immuno-oncology therapeutics in the United States. It offers INTASYL therapeutic platform focuses on targeting tumor and immune cells by regulating genes of the immune system. The company develops PH-762 that activates immune cells to recognize and kill cancer cells by reducing the expression of the checkpoint protein PD-1 for immunotherapy in adoptive cell transfer (ACT); PH-894 that silences the epigenetic protein BRD4, which is an intracellular regulator of gene expression for use in ACT; and PH-804 that targets the suppressive immune receptor TIGIT, which is a checkpoint protein present on T cells and natural killer cells for use in ACT. It has collaborations with AgonOx Inc. on clinical development of novel T cell-based cancer immunotherapies. The company was formerly known as RXi Pharmaceuticals Corporation and changed its name to Phio Pharmaceuticals Corp. in November 2018. Phio Pharmaceuticals Corp. was incorporated in 2011 and is headquartered in Marlborough, Massachusetts.Show more
  • Revenue$0
  • EBITDA-$9M-24.8%
  • Net Income-$9M-21.7%
  • EPS (Diluted)-1.45-59.3%
  • ROE-69.95%+39.1%

PHIO Key Insights

Phio Pharmaceuticals Corp. (PHIO) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Trading at only 0.3x book value

✗Weaknesses

  • ✗Weak Piotroski F-Score: 3/9
  • ✗Weak momentum: RS Rating 18 (bottom 18%)
  • ✗Shares diluted 100.0% in last year
  • ✗Trading more than 30% below 52-week high
  • ✗Low asset turnover indicates capital-intensive operations

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

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PHIO Price & Volume

Phio Pharmaceuticals Corp. (PHIO) stock price & volume — 10-year historical chart

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PHIO Growth Metrics

Phio Pharmaceuticals Corp. (PHIO) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-
3 Years-
TTM-

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-61.6%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM100%

Return on Capital

10 Years-104.07%
5 Years-90.37%
3 Years-102.18%
Last Year-71.54%

PHIO Peer Comparison

Phio Pharmaceuticals Corp. (PHIO) competitors in RNA and Genome Editing Developers — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
Institutional Holdings
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
SRPT logoSRPTSarepta Therapeutics, Inc.Direct Competitor1.85B17.53-2.4615.58%2.98%4.89%0.91
ARWR logoARWRArrowhead Pharmaceuticals, Inc.Direct Competitor11.52B81.82-6706.56232.58%-48.38%-55.09%0.73
ALNY logoALNYAlnylam Pharmaceuticals, Inc.Product Competitor37.1B278.09119.3565.19%13.46%98.29%1.62
NTLA logoNTLAIntellia Therapeutics, Inc.Product Competitor1.76B15.67-4.1116.92%-5.97%-57.27%0.14
BEAM logoBEAMBeam Therapeutics Inc.Product Competitor3.51B34.14-42.15120.01%-49.17%-5.89%0.24
EDIT logoEDITEditas Medicine, Inc.Product Competitor263.37M2.69-1.4925.39%-281.59%-6.77%2.81
CRSP logoCRSPCRISPR Therapeutics AGProduct Competitor5.22B54.09-8.36-89.97%-138.57%-30.88%0.21
IOVA logoIOVAIovance Biotherapeutics, Inc.Product Competitor1.4B3.91-3.5960.6%-123.9%-50.17%0.07

Compare PHIO vs Peers

Phio Pharmaceuticals Corp. (PHIO) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs SRPT

Most directly comparable listed peer for PHIO.

Scale Benchmark

vs TMO

Larger-name benchmark to compare PHIO against a more recognizable public peer.

Peer Set

Compare Top 5

vs SRPT, ARWR, ALNY, NTLA

PHIO Income Statement

Phio Pharmaceuticals Corp. (PHIO) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Sales/Revenue
15K138K21K0000000
Revenue Growth %
-21.05%820%-84.78%-100%------
Cost of Goods Sold
5.37M4.33M03.72M8.89M7.01M6.33M3.64M01.07M
COGS % of Revenue
35800%3134.78%--------
Gross Profit
-5.36M▲ 0%
-4.19M▲ 21.8%
21K▲ 100.5%
-3.72M▼ 17795.2%
-8.89M▼ 139.1%
-7.01M▲ 21.1%
-6.33M▲ 9.7%
-3.64M▲ 42.5%
0▲ 100.0%
-1.07M▲ 0%
Gross Margin %
-35700%-3034.78%100%-------
Gross Profit Growth %
0.76%21.79%100.5%-17795.24%-139.13%21.09%9.7%42.47%100%-
Operating Expenses
9.38M7.5M9.01M5.08M4.63M4.45M4.49M3.74M9.22M10.44M
OpEx % of Revenue
62540%5436.23%42895.24%-------
Selling, General & Admin
4.01M3.18M4.71M5.08M4.63M4.45M4.29M3.74M4.6M4.99M
SG&A % of Revenue
26740%2301.45%22419.05%-------
Research & Development
5.37M4.33M4.3M3.72M8.89M7.01M6.33M3.64M4.62M6.53M
R&D % of Revenue
35800%3134.78%20476.19%-------
Other Operating Expenses
4.7M4K0-3.72M-8.89M-7.01M-6.13M-3.64M0-1000K
Operating Income
-14.06M▲ 0%
-7.36M▲ 47.6%
-8.99M▼ 22.0%
-8.79M▲ 2.2%
-13.51M▼ 53.7%
-11.46M▲ 15.2%
-10.82M▲ 5.6%
-7.39M▲ 31.8%
-9.22M▼ 24.8%
-11.52M▲ 0%
Operating Margin %
-93746.67%-5336.23%-42795.24%-------
Operating Income Growth %
-55.98%47.63%-22.04%2.16%-53.66%15.17%5.57%31.75%-24.81%-
EBITDA
-13.99M-7.28M-8.92M-8.72M-13.44M-11.39M-10.64M-7.38M-9.22M-11.51M
EBITDA Margin %
-93280%-5277.54%-42476.19%-------
EBITDA Growth %
-56.13%47.95%-22.48%2.23%-54.06%15.22%6.59%30.59%-24.81%-66.87%
D&A (Non-Cash Add-back)
70K81K67K72K75K71K184K2K3K4.5K
EBIT
-14.07M-7.36M-8.99M-8.79M-13.51M-11.46M-10.83M-7.39M-9.22M-11.52M
Net Interest Income
-1K000000231K0280K
Interest Income
0000000231K0280K
Interest Expense
1K000000000
Other Income/Expense
-11K4K79K-1K224K-18K-2K237K522K583K
Pretax Income
-14.07M▲ 0%
-7.36M▲ 47.7%
-8.91M▼ 21.0%
-8.79M▲ 1.3%
-13.29M▼ 51.1%
-11.48M▲ 13.6%
-10.83M▲ 5.7%
-7.15M▲ 34.0%
-8.7M▼ 21.7%
-10.93M▲ 0%
Pretax Margin %
-93820%-5333.33%-42419.05%-------
Income Tax
-1.62M4K00000000
Effective Tax Rate %
11.52%-0.05%0%0%0%0%0%0%0%0%
Net Income
-12.45M▲ 0%
-7.36M▲ 40.9%
-8.91M▼ 21.0%
-8.79M▲ 1.3%
-13.29M▼ 51.1%
-11.48M▲ 13.6%
-10.83M▲ 5.7%
-7.15M▲ 34.0%
-8.7M▼ 21.7%
-10.93M▲ 0%
Net Margin %
-83013.33%-5333.33%-42419.05%-------
Net Income Growth %
-38.45%40.89%-21.03%1.28%-51.09%13.6%5.7%33.96%-21.65%-61.6%
Net Income (Continuing)
-12.45M-7.36M-8.91M-8.79M-13.29M-11.48M-10.83M-7.15M-8.7M-10.93M
Discontinued Operations
0000000000
Minority Interest
0000000000
EPS (Diluted)
-32801.22▲ 0%
-6218.35▲ 81.0%
-2074.18▲ 66.6%
-207.25▲ 90.0%
-111.32▲ 46.3%
-89.61▲ 19.5%
-46.76▲ 47.8%
-0.91▲ 98.1%
-1.45▼ 59.3%
-0.94▲ 0%
EPS Growth %
58.63%81.04%66.64%90.01%46.29%19.5%47.82%98.05%-59.34%100%
EPS (Basic)
-32801.22-6218.35-2074.18-207.25-111.32-89.61-46.87-0.91-1.45-
Diluted Shares Outstanding
3801.18K4.26K42.43K118.68K126.16K231.51K787.47K5.98M11.62M
Basic Shares Outstanding
3801.18K4.26K42.43K118.68K126.16K231K787.47K5.98M11.62M
Dividend Payout Ratio
----------

PHIO Balance Sheet

Phio Pharmaceuticals Corp. (PHIO) balance sheet — assets, liabilities & shareholders' equity

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Total Current Assets
3.83M15.15M7.3M15.16M24.73M12.45M9.32M5.74M21.48M17.4M
Cash & Short-Term Investments
3.58M14.88M6.93M14.24M24.06M11.78M8.49M5.38M21.03M17.03M
Cash Only
3.58M14.88M6.93M14.24M24.06M11.78M8.49M5.38M21.03M17.03M
Short-Term Investments
0000000000
Accounts Receivable
0000000000
Days Sales Outstanding
----------
Inventory
0000000000
Days Inventory Outstanding
----------
Other Current Assets
50K50K50K50K50K50K832K354K445K371K
Total Non-Current Assets
266K172K739K575K443K368K42K2K11K10K
Property, Plant & Equipment
248K172K721K557K416K344K39K2K11K10K
Fixed Asset Turnover
0.06x0.80x0.03x------0.00x
Goodwill
0000000000
Intangible Assets
0000000000
Long-Term Investments
0000000000
Other Non-Current Assets
18K018K18K27K24K3K000
Total Assets
4.1M▲ 0%
15.32M▲ 273.9%
8.04M▼ 47.5%
15.74M▲ 95.8%
25.17M▲ 59.9%
12.81M▼ 49.1%
9.36M▼ 26.9%
5.74M▼ 38.7%
21.49M▲ 274.5%
17.41M▲ 0%
Asset Turnover
0.00x0.01x0.00x------0.00x
Asset Growth %
-69.41%273.89%-47.53%95.78%59.92%-49.09%-26.92%-38.72%274.47%513.57%
Total Current Liabilities
2.27M1.74M1.88M2.2M3.07M1.94M1.63M1.01M435K260K
Accounts Payable
511K550K809K728K283K779K657K253K435K260K
Days Payables Outstanding
34.7346.41-71.5111.6240.5537.8725.35-122.74
Short-Term Debt
0000000000
Deferred Revenue (Current)
0000000000
Other Current Liabilities
00551K722K019K720K731K-360K0
Current Ratio
1.69x8.69x3.88x6.91x8.06x6.42x5.71x5.65x49.37x66.93x
Quick Ratio
1.69x8.69x3.88x6.91x8.06x6.42x5.71x5.65x49.37x66.93x
Cash Conversion Cycle
----------
Total Non-Current Liabilities
00411K526K170K35K00905K690K
Long-Term Debt
000231K000000
Capital Lease Obligations
00411K295K170K35K0000
Deferred Tax Liabilities
0000000000
Other Non-Current Liabilities
00000000905K690K
Total Liabilities
2.27M1.74M2.29M2.72M3.24M1.97M1.63M1.01M1.34M950K
Total Debt
00518K642K295K170K35K000
Net Debt
-3.58M-14.88M-6.42M-13.6M-23.76M-11.61M-8.46M-5.38M-21.03M-17.03M
Debt / Equity
--0.09x0.05x0.01x0.02x0.00x--0.00x
Debt / EBITDA
----------0.00x
Net Debt / EBITDA
---------1.48x
Interest Coverage
-14073.00x---------
Total Equity
1.83M▲ 0%
13.58M▲ 640.8%
5.75M▼ 57.7%
13.02M▲ 126.5%
21.93M▲ 68.5%
10.84M▼ 50.6%
7.73M▼ 28.7%
4.72M▼ 38.9%
20.15M▲ 326.6%
16.46M▲ 0%
Equity Growth %
-83.11%640.75%-57.67%126.46%68.49%-50.57%-28.69%-38.9%326.57%628.33%
Book Value per Share
4828.5111471.851348.54306.77184.7985.9233.396.003.371.42
Total Shareholders' Equity
1.83M13.58M5.75M13.02M21.93M10.84M7.73M4.72M20.15M16.46M
Common Stock
02K1K1K00001K1K
Retained Earnings
-78.55M-85.91M-94.82M-103.61M-116.9M-128.38M-139.21M-146.36M-155.05M-159.06M
Treasury Stock
0000000000
Accumulated OCI
-900K-981K00000000
Minority Interest
0000000000

PHIO Cash Flow Statement

Phio Pharmaceuticals Corp. (PHIO) cash flow — operating, investing & free cash flow history

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Cash from Operations
-9.51M-7.52M-8.64M-8.8M-11.86M-12.13M-10.75M-7.11M-7.98M-10.71M
Operating CF Margin %
-63426.67%-5449.28%-41166.67%-------
Operating CF Growth %
-22.6%20.96%-14.96%-1.82%-34.72%-2.29%11.38%33.84%-12.19%-315.3%
Net Income
-12.45M-7.36M-8.91M-8.79M-13.29M-11.48M-10.83M-7.15M-8.7M-10.93M
Depreciation & Amortization
70K81K67K72K75K193K184K35K3K4K
Stock-Based Compensation
314K282K300K136K480K414K303K147K481K164K
Deferred Taxes
-1.62M000-233K00000
Other Non-Cash Items
4.71M405K109K111K117K0126K-6K0589K
Working Capital Changes
-530K-523K-213K-327K990K-1.26M-536K-138K235K-532K
Change in Receivables
0000000000
Change in Inventory
0000000000
Change in Payables
-608K39K259K-81K-445K496K-122K-404K183K-166K
Cash from Investing
-103K-5K-72K-19K-51K-121K-5K8K-12K-7K
Capital Expenditures
-203K-5K-72K-19K-51K-121K-5K-1K-12K-10K
CapEx % of Revenue
1353.33%3.62%342.86%-------
Acquisitions
100K000000003K
Investments
----------
Other Investing
100K0000009K00
Cash from Financing
292K18.82M772K16.13M21.72M-26K7.41M4M23.64M14.47M
Debt Issued (Net)
00-6K204K000000
Equity Issued (Net)
292K18.82M709K12.07M19.58M2K7.44M4M23.67M14.5M
Dividends Paid
0000000000
Share Repurchases
000-15K00-11K-1K00
Other Financing
0069K3.85M2.15M-28K-26K-5K-30K-30K
Net Change in Cash
-9.32M▲ 0%
11.3M▲ 221.2%
-7.95M▼ 170.3%
7.31M▲ 192.0%
9.81M▲ 34.2%
-12.28M▼ 225.1%
-3.34M▲ 72.8%
-3.11M▲ 7.0%
15.65M▲ 603.5%
3.75M▲ 0%
Free Cash Flow
-9.72M▲ 0%
-7.53M▲ 22.6%
-8.72M▼ 15.8%
-8.82M▼ 1.2%
-11.91M▼ 35.0%
-12.25M▼ 2.9%
-10.75M▲ 12.2%
-7.11M▲ 33.9%
-7.99M▼ 12.3%
-10.72M▲ 0%
FCF Margin %
-64780%-5452.9%-41509.52%-------
FCF Growth %
-25.15%22.56%-15.84%-1.19%-35.01%-2.86%12.21%33.86%-12.34%-68%
FCF per Share
-25596.65-6357.76-2045.09-207.89-100.34-97.10-46.45-9.03-1.34-0.92
FCF Conversion (FCF/Net Income)
0.76x1.02x0.97x1.00x0.89x1.06x0.99x0.99x0.92x0.98x
Interest Paid
00000011K000
Taxes Paid
0000000000

PHIO Key Ratios

Phio Pharmaceuticals Corp. (PHIO) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric201720182019202020212022202320242025TTM
Return on Equity (ROE)
-196.28%-95.52%-92.19%-93.73%-76.04%-70.06%-116.6%-114.83%-69.95%-77.34%
Return on Invested Capital (ROIC)
---------1151.88%
Gross Margin
-35700%-3034.78%100%-------
Net Margin
-83013.33%-5333.33%-42419.05%-------
Debt / Equity
--0.09x0.05x0.01x0.02x0.00x--0.00x
Interest Coverage
-14073.00x---------
FCF Conversion
0.76x1.02x0.97x1.00x0.89x1.06x0.99x0.99x0.92x0.98x
Revenue Growth
-21.05%820%-84.78%-100%------
Related:PHIO Dividend History·PHIO Revenue History·PHIO Price History·PHIO P/E History·PHIO Financial Ratios·PHIO Institutional Holders

PHIO SEC Filings & Documents

Phio Pharmaceuticals Corp. (PHIO) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 7, 2026·SEC

Material company update

Apr 8, 2026·SEC

Material company update

Mar 30, 2026·SEC

10-K Annual Reports

2
FY 2026

Mar 5, 2026·SEC

FY 2025

Mar 31, 2025·SEC

10-Q Quarterly Reports

6
FY 2026

May 7, 2026·SEC

FY 2025

Nov 13, 2025·SEC

FY 2025

Aug 14, 2025·SEC

PHIO Frequently Asked Questions

Phio Pharmaceuticals Corp. (PHIO) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Phio Pharmaceuticals Corp. (PHIO) grew revenue by 0.0% over the past year. Growth has been modest.

Phio Pharmaceuticals Corp. (PHIO) reported a net loss of $10.9M for fiscal year 2025.

Dividend & Returns

Phio Pharmaceuticals Corp. (PHIO) has a return on equity (ROE) of -69.9%. Negative ROE indicates the company is unprofitable.

Phio Pharmaceuticals Corp. (PHIO) had negative free cash flow of $10.7M in fiscal year 2025, likely due to heavy capital investments.

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