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PHIO logoPhio Pharmaceuticals Corp.(PHIO)Earnings, Financials & Key Ratios

PHIO•NASDAQ
$1.15
$7M mkt cap·Price updated May 6, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryRNA and Genome Editing Developers
AboutPhio Pharmaceuticals Corp. develops immuno-oncology therapeutics in the United States. It offers INTASYL therapeutic platform focuses on targeting tumor and immune cells by regulating genes of the immune system. The company develops PH-762 that activates immune cells to recognize and kill cancer cells by reducing the expression of the checkpoint protein PD-1 for immunotherapy in adoptive cell transfer (ACT); PH-894 that silences the epigenetic protein BRD4, which is an intracellular regulator of gene expression for use in ACT; and PH-804 that targets the suppressive immune receptor TIGIT, which is a checkpoint protein present on T cells and natural killer cells for use in ACT. It has collaborations with AgonOx Inc. on clinical development of novel T cell-based cancer immunotherapies. The company was formerly known as RXi Pharmaceuticals Corporation and changed its name to Phio Pharmaceuticals Corp. in November 2018. Phio Pharmaceuticals Corp. was incorporated in 2011 and is headquartered in Marlborough, Massachusetts.Show more
  • Revenue$0
  • EBITDA$0+100.0%
  • Net Income-$9M-21.7%
  • EPS (Diluted)-1.45-59.3%
  • ROE-69.95%+39.1%
Technical→

PHIO Key Insights

Phio Pharmaceuticals Corp. (PHIO) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Trading at only 0.3x book value

✗Weaknesses

  • ✗Weak Piotroski F-Score: 2/9
  • ✗Shares diluted 100.0% in last year
  • ✗Trading more than 30% below 52-week high
  • ✗Low asset turnover indicates capital-intensive operations

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

PHIO Price & Volume

Phio Pharmaceuticals Corp. (PHIO) stock price & volume — 10-year historical chart

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PHIO Growth Metrics

Phio Pharmaceuticals Corp. (PHIO) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-
3 Years-
TTM-

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-7.2%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM-294107.81%

Return on Capital

10 Years-107.69%
5 Years-95.08%
3 Years-117.5%
Last Year-

PHIO Peer Comparison

Phio Pharmaceuticals Corp. (PHIO) competitors in RNA and Genome Editing Developers — business model, growth, and fundamentals comparison

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Stock Universe
Valuation
Growth
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Price Performance
Technical
Fundamentals ($)
Sector-Specific
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
SRPT logoSRPTSarepta Therapeutics, Inc.Direct Competitor2.42B23.03-3.2315.58%2.98%4.89%0.91
ARWR logoARWRArrowhead Pharmaceuticals, Inc.Direct Competitor11.08B79.14-6486.89232.58%18.54%35.64%0.73
ALNY logoALNYAlnylam Pharmaceuticals, Inc.Product Competitor40.43B303.00130.0465.19%13.46%98.29%1.62
NTLA logoNTLAIntellia Therapeutics, Inc.Product Competitor1.61B13.85-3.64-100%-61.47%0.14
BEAM logoBEAMBeam Therapeutics Inc.Product Competitor3.32B32.33-39.92120.01%-57.24%-7.31%0.24
EDIT logoEDITEditas Medicine, Inc.Product Competitor310.73M3.18-1.76-100%-5.23%0.66
CRSP logoCRSPCRISPR Therapeutics AGProduct Competitor5.31B55.08-8.51-89.97%-138.57%-30.88%0.21
IOVA logoIOVAIovance Biotherapeutics, Inc.Product Competitor1.68B4.09-3.7560.6%-148.38%-55.97%0.07

Compare PHIO vs Peers

Phio Pharmaceuticals Corp. (PHIO) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs SRPT

Most directly comparable listed peer for PHIO.

Scale Benchmark

vs TMO

Larger-name benchmark to compare PHIO against a more recognizable public peer.

Peer Set

Compare Top 5

vs SRPT, ARWR, ALNY, NTLA

PHIO Income Statement

Phio Pharmaceuticals Corp. (PHIO) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Sales/Revenue15K138K21K0000000
Revenue Growth %-21.05%820%-84.78%-100%------
Cost of Goods Sold5.37M4.33M03.72M8.89M7.01M6.33M3.64M01.08M
COGS % of Revenue35800%3134.78%--------
Gross Profit
-5.36M▲ 0%
-4.19M▲ 21.8%
21K▲ 100.5%
-3.72M▼ 17795.2%
-8.89M▼ 139.1%
-7.01M▲ 21.1%
-6.33M▲ 9.7%
-3.64M▲ 42.5%
0▲ 100.0%
-1.08M▲ 0%
Gross Margin %-35700%-3034.78%100%-------
Gross Profit Growth %0.76%21.79%100.5%-17795.24%-139.13%21.09%9.7%42.47%100%-
Operating Expenses9.38M7.5M9.01M5.08M4.63M4.45M4.49M3.74M9.22M7.28M
OpEx % of Revenue62540%5436.23%42895.24%-------
Selling, General & Admin4.01M3.18M4.71M5.08M4.63M4.45M4.29M3.74M4.6M4.23M
SG&A % of Revenue26740%2301.45%22419.05%-------
Research & Development5.37M4.33M4.3M3.72M8.89M7.01M6.33M3.64M4.62M4.13M
R&D % of Revenue35800%3134.78%20476.19%-------
Other Operating Expenses4.7M4K0-3.72M-8.89M-7.01M-6.13M-3.64M0-1000K
Operating Income
-14.06M▲ 0%
-7.36M▲ 47.6%
-8.99M▼ 22.0%
-8.79M▲ 2.2%
-13.51M▼ 53.7%
-11.46M▲ 15.2%
-10.82M▲ 5.6%
-7.39M▲ 31.8%
0▲ 100.0%
-8.36M▲ 0%
Operating Margin %-93746.67%-5336.23%-42795.24%-------
Operating Income Growth %-55.98%47.63%-22.04%2.16%-53.66%15.17%5.57%31.75%100%-
EBITDA-13.99M-7.28M-8.92M-8.72M-13.44M-11.39M-10.64M-7.38M0-8.21M
EBITDA Margin %-93280%-5277.54%-42476.19%-------
EBITDA Growth %-56.13%47.95%-22.48%2.23%-54.06%15.22%6.59%30.59%100%-10.78%
D&A (Non-Cash Add-back)70K81K67K72K75K71K184K2K02.5K
EBIT-14.07M-7.36M-8.99M-8.79M-13.51M-11.46M-10.83M-7.39M0-8.1M
Net Interest Income-1K000000231K0588K
Interest Income0000000231K0588K
Interest Expense1K000000000
Other Income/Expense-11K4K79K-1K224K-18K-2K237K0407K
Pretax Income
-14.07M▲ 0%
-7.36M▲ 47.7%
-8.91M▼ 21.0%
-8.79M▲ 1.3%
-13.29M▼ 51.1%
-11.48M▲ 13.6%
-10.83M▲ 5.7%
-7.15M▲ 34.0%
-8.7M▼ 21.7%
-7.95M▲ 0%
Pretax Margin %-93820%-5333.33%-42419.05%-------
Income Tax-1.62M4K00000000
Effective Tax Rate %11.52%-0.05%0%0%0%0%0%0%0%0%
Net Income
-12.45M▲ 0%
-7.36M▲ 40.9%
-8.91M▼ 21.0%
-8.79M▲ 1.3%
-13.29M▼ 51.1%
-11.48M▲ 13.6%
-10.83M▲ 5.7%
-7.15M▲ 34.0%
-8.7M▼ 21.7%
-7.95M▲ 0%
Net Margin %-83013.33%-5333.33%-42419.05%-------
Net Income Growth %-38.45%40.89%-21.03%1.28%-51.09%13.6%5.7%33.96%-21.65%-7.2%
Net Income (Continuing)-12.45M-7.36M-8.91M-8.79M-13.29M-11.48M-10.83M-7.15M-8.7M-7.95M
Discontinued Operations0000000000
Minority Interest0000000000
EPS (Diluted)
-32801.22▲ 0%
-6218.35▲ 81.0%
-2074.18▲ 66.6%
-207.25▲ 90.0%
-111.32▲ 46.3%
-89.61▲ 19.5%
-46.76▲ 47.8%
-0.91▲ 98.1%
-1.45▼ 59.3%
-1.45▲ 0%
EPS Growth %58.63%81.04%66.64%90.01%46.29%19.5%47.82%98.05%-59.34%-294107.81%
EPS (Basic)-32801.22-6218.35-2074.18-207.25-111.32-89.61-46.87-0.91-1.45-
Diluted Shares Outstanding3801.18K4.26K42.43K118.68K126.16K231.51K787.47K5.98M5.47M
Basic Shares Outstanding3801.18K4.26K42.43K118.68K126.16K231K787.47K5.98M5.47M
Dividend Payout Ratio----------

PHIO Balance Sheet

Phio Pharmaceuticals Corp. (PHIO) balance sheet — assets, liabilities & shareholders' equity

Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Total Current Assets3.83M15.15M7.3M15.16M24.73M12.45M9.32M5.74M21.48M11.49M
Cash & Short-Term Investments3.58M14.88M6.93M14.24M24.06M11.78M8.49M5.38M21.03M10.71M
Cash Only3.58M14.88M6.93M14.24M24.06M11.78M8.49M5.38M21.03M10.71M
Short-Term Investments0000000000
Accounts Receivable0000000000
Days Sales Outstanding----------
Inventory0000000000
Days Inventory Outstanding----------
Other Current Assets50K50K50K50K50K50K832K354K445K788K
Total Non-Current Assets266K172K739K575K443K368K42K2K11K12K
Property, Plant & Equipment248K172K721K557K416K344K39K2K11K12K
Fixed Asset Turnover0.06x0.80x0.03x------0.00x
Goodwill0000000000
Intangible Assets0000000000
Long-Term Investments0000000000
Other Non-Current Assets18K018K18K27K24K3K000
Total Assets
4.1M▲ 0%
15.32M▲ 273.9%
8.04M▼ 47.5%
15.74M▲ 95.8%
25.17M▲ 59.9%
12.81M▼ 49.1%
9.36M▼ 26.9%
5.74M▼ 38.7%
21.49M▲ 274.5%
11.51M▲ 0%
Asset Turnover0.00x0.01x0.00x------0.00x
Asset Growth %-69.41%273.89%-47.53%95.78%59.92%-49.09%-26.92%-38.72%274.47%266.95%
Total Current Liabilities2.27M1.74M1.88M2.2M3.07M1.94M1.63M1.01M435K516K
Accounts Payable511K550K809K728K283K779K657K253K435K516K
Days Payables Outstanding34.7346.41-71.5111.6240.5537.8725.35-121.36
Short-Term Debt0000000000
Deferred Revenue (Current)0000000000
Other Current Liabilities00551K722K019K720K731K435K-732K
Current Ratio1.69x8.69x3.88x6.91x8.06x6.42x5.71x5.65x49.37x49.37x
Quick Ratio1.69x8.69x3.88x6.91x8.06x6.42x5.71x5.65x49.37x49.37x
Cash Conversion Cycle----------
Total Non-Current Liabilities00411K526K170K35K00905K1.15M
Long-Term Debt000231K000000
Capital Lease Obligations00411K295K170K35K0000
Deferred Tax Liabilities0000000000
Other Non-Current Liabilities00000000905K1.15M
Total Liabilities2.27M1.74M2.29M2.72M3.24M1.97M1.63M1.01M1.34M1.67M
Total Debt00518K642K295K170K35K000
Net Debt-3.58M-14.88M-6.42M-13.6M-23.76M-11.61M-8.46M-5.38M-21.03M-10.71M
Debt / Equity--0.09x0.05x0.01x0.02x0.00x--0.00x
Debt / EBITDA----------0.00x
Net Debt / EBITDA---------1.30x
Interest Coverage-14062.00x---------
Total Equity
1.83M▲ 0%
13.58M▲ 640.8%
5.75M▼ 57.7%
13.02M▲ 126.5%
21.93M▲ 68.5%
10.84M▼ 50.6%
7.73M▼ 28.7%
4.72M▼ 38.9%
20.15M▲ 326.6%
9.84M▲ 0%
Equity Growth %-83.11%640.75%-57.67%126.46%68.49%-50.57%-28.69%-38.9%326.57%344.75%
Book Value per Share4828.5111471.851348.54306.77184.7985.9233.396.003.371.80
Total Shareholders' Equity1.83M13.58M5.75M13.02M21.93M10.84M7.73M4.72M20.15M9.84M
Common Stock02K1K1K00001K1K
Retained Earnings-78.55M-85.91M-94.82M-103.61M-116.9M-128.38M-139.21M-146.36M-155.05M-152.68M
Treasury Stock0000000000
Accumulated OCI-900K-981K00000000
Minority Interest0000000000

PHIO Cash Flow Statement

Phio Pharmaceuticals Corp. (PHIO) cash flow — operating, investing & free cash flow history

Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Cash from Operations-9.51M-7.52M-8.64M-8.8M-11.86M-12.13M-10.75M-7.11M-8.7M-8.7M
Operating CF Margin %-63426.67%-5449.28%-41166.67%-------
Operating CF Growth %-22.6%20.96%-14.96%-1.82%-34.72%-2.29%11.38%33.84%-22.3%29.05%
Net Income-12.45M-7.36M-8.91M-8.79M-13.29M-11.48M-10.83M-7.15M0-7.95M
Depreciation & Amortization70K81K67K72K75K193K184K35K3K44K
Stock-Based Compensation314K282K300K136K480K414K303K147K481K255K
Deferred Taxes-1.62M000-233K00000
Other Non-Cash Items4.71M405K109K111K117K0126K-6K-9.18M-51K
Working Capital Changes-530K-523K-213K-327K990K-1.26M-536K-138K0434K
Change in Receivables0000000000
Change in Inventory0000000000
Change in Payables-608K39K259K-81K-445K496K-122K-404K183K332K
Cash from Investing-103K-5K-72K-19K-51K-121K-5K8K-12K-4K
Capital Expenditures-203K-5K-72K-19K-51K-121K-5K-1K-12K-13K
CapEx % of Revenue1353.33%3.62%342.86%-------
Acquisitions100K000000000
Investments----------
Other Investing100K0000009K09K
Cash from Financing292K18.82M772K16.13M21.72M-26K7.41M4M23.64M12.59M
Debt Issued (Net)00-6K204K000000
Equity Issued (Net)292K1000K709K1000K1000K2K1000K1000K03.04M
Dividends Paid0000000000
Share Repurchases000-15K00-11K-1K00
Other Financing0069K3.85M2.15M-28K-26K-5K23.64M-31K
Net Change in Cash
-9.32M▲ 0%
11.3M▲ 221.2%
-7.95M▼ 170.3%
7.31M▲ 192.0%
9.81M▲ 34.2%
-12.28M▼ 225.1%
-3.34M▲ 72.8%
-3.11M▲ 7.0%
15.65M▲ 603.5%
5.32M▲ 0%
Free Cash Flow
-9.72M▲ 0%
-7.53M▲ 22.6%
-8.72M▼ 15.8%
-8.82M▼ 1.2%
-11.91M▼ 35.0%
-12.25M▼ 2.9%
-10.75M▲ 12.2%
-7.11M▲ 33.9%
-8.71M▼ 22.5%
-7.28M▲ 0%
FCF Margin %-64780%-5452.9%-41509.52%-------
FCF Growth %-25.15%22.56%-15.84%-1.19%-35.01%-2.86%12.21%33.86%-22.45%10.2%
FCF per Share-25596.65-6357.76-2045.09-207.89-100.34-97.10-46.45-9.03-1.46-1.46
FCF Conversion (FCF/Net Income)0.76x1.02x0.97x1.00x0.89x1.06x0.99x0.99x1.00x0.92x
Interest Paid00000011K000
Taxes Paid0000000000

PHIO Key Ratios

Phio Pharmaceuticals Corp. (PHIO) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric201720182019202020212022202320242025TTM
Return on Equity (ROE)-196.28%-95.52%-92.19%-93.73%-76.04%-70.06%-116.6%-114.83%-69.95%-86.38%
Return on Invested Capital (ROIC)---------757.02%
Gross Margin-35700%-3034.78%100%-------
Net Margin-83013.33%-5333.33%-42419.05%-------
Debt / Equity--0.09x0.05x0.01x0.02x0.00x--0.00x
Interest Coverage-14062.00x---------
FCF Conversion0.76x1.02x0.97x1.00x0.89x1.06x0.99x0.99x1.00x0.92x
Revenue Growth-21.05%820%-84.78%-100%------

PHIO Frequently Asked Questions

Phio Pharmaceuticals Corp. (PHIO) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Phio Pharmaceuticals Corp. (PHIO) grew revenue by 0.0% over the past year. Growth has been modest.

Phio Pharmaceuticals Corp. (PHIO) reported a net loss of $8.0M for fiscal year 2025.

Dividend & Returns

Phio Pharmaceuticals Corp. (PHIO) has a return on equity (ROE) of -69.9%. Negative ROE indicates the company is unprofitable.

Phio Pharmaceuticals Corp. (PHIO) had negative free cash flow of $7.3M in fiscal year 2025, likely due to heavy capital investments.

Explore More PHIO

Phio Pharmaceuticals Corp. (PHIO) financial analysis — history, returns, DCA and operating performance tools

Total Return Calculator

Historical returns with dividends reinvested

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Dividend History

Yield, growth, payout safety & DRIP

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Earnings History

EPS trends, net income & profitability

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Price History

Long-term charts & historical price data

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Revenue History

Sales growth patterns & revenue breakdown

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Financial Ratios

30 years of market, efficiency and balance-sheet ratios

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Valuation

DCF intrinsic value, peer multiples & estimates

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