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PTIXProtagenic Therapeutics, Inc.
$0.36$696556
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HomeStocksPTIXFinancials

Protagenic Therapeutics, Inc. (PTIX) Financials

29Y historyFree accessUpdated daily

The company remains a pre-revenue entity with persistent operating losses, evidenced by a $925.1K operating loss in 2025Q4 despite reported non-operating net income anomalies.

PTIX Income Statement

Income StatementBalance SheetCash FlowRatios
AnnualQuarterly
MetricDec'25Dec'24Dec'23Dec'22Dec'21Dec'20Dec'19Dec'18Dec'17Dec'16Jun'15Jun'14Jun'13Dec'10Dec'09Dec'08Dec'07Dec'06Jul'05Jul'04Jul'03Jul'02Jul'01Jul'00Jul'99Jul'98Jul'97Jul'96Jul'95
Sales/Revenue00000000000085K40.03M69.09M113.88M36.98M18.72M00018.57M21.63M21.39M18.76M15.62M12.57M9.9M6.9M
Revenue Growth %------------100%-99.79%-42.07%-39.33%207.94%97.54%----100%-14.12%1.11%13.99%20.16%24.19%27%43.48%-
Cost of Goods Sold37.72K50.29K28.22K30028633934714853400042.71M53.87M84.29M5.01M597K00010.55M12.27M11.78M10.96M7.8M6.74M5.1M3.4M
COGS % of Revenue-------------106.7%77.97%74.01%13.56%3.19%---56.79%56.73%55.1%58.4%49.96%53.59%51.52%49.28%
Gross Profit-37.72K-50.29K-28.22K-300-286-339-347-148-5340085K-2.68M15.22M29.59M31.97M18.12M0008.03M9.36M9.6M7.8M7.81M5.83M4.8M3.5M
Gross Margin %------------100%-6.7%22.03%25.99%86.44%96.81%---43.21%43.27%44.9%41.6%50.04%46.41%48.48%50.72%
Gross Profit Growth %25%-78.21%-93960%-100%15.63%2.31%-134.46%72.28%---100%103.17%-117.61%-48.58%-7.43%76.38%----100%-14.24%-2.56%23.05%-0.1%33.9%21.56%37.14%-
Operating Expenses5.81M5.7M4.5M3.56M4.14M2.55M2.09M2.31M2.37M1.83M491K975K758K14.77M44.08M146.68M37.47M16.65M94.47K-2.23M-7.9M8.55M8.61M7.77M8.08M6.95M6.5M5.1M4.1M
OpEx % of Revenue------------891.76%36.89%63.8%128.8%101.31%88.94%---46.05%39.82%36.32%43.06%44.49%51.67%51.52%59.42%
Selling, General & Admin1.7M1.76M1.18M1.97M3M1.85M1.28M1.43M1.65M1.3M491K933K758K13.12M23.09M35.78M37.47M16.65M94.47K008.55M8.61M7.77M8.08M6.95M6.5M5.1M4.1M
SG&A % of Revenue------------891.76%32.78%33.42%31.42%101.31%88.94%---46.05%39.82%36.32%43.06%44.49%51.67%51.52%59.42%
Research & Development1.7M3.85M3.32M1.59M1.14M699.8K807.95K881.19K717.45K417.87K464269.44K00000000000000000
R&D % of Revenue-----------------------------
Other Operating Expenses2.41M97K00-1K2035300404.17K0-84.23K01.64M3.7M5.87M000-2.23M-7.9M00000000
Operating Income-5.83M-5.7M-4.53M-3.56M-4.14M-2.55M-2.09M-2.31M-2.37M-2.23M-491K-975K-673K-22.3M-28.86M-117.09M-5.5M1.47M-94.47K-2.23M-7.9M-528K747K1.83M-275K866K-661K-700K-1M
Operating Margin %-------------791.76%-55.7%-41.78%-102.82%-14.87%7.87%----2.84%3.45%8.58%-1.47%5.55%-5.26%-7.07%-14.49%
Operating Income Growth %-2.29%-25.93%-27.23%14.06%-62.23%-22.34%9.85%2.16%-5.86%-354.99%49.64%-44.87%96.98%22.75%75.35%-2029.3%-473.07%1660.28%95.77%71.72%-1396.21%-170.68%-59.29%767.27%-131.76%231.01%5.57%30%-
EBITDA-5.79M-5.65M-4.5M-3.56M-4.14M-2.55M-2.09M-2.31M-2.36M-2.23M-490.86K-347K-806K-20.65M-25.16M-111.22M-4.15M1.5M675K-1.33M-5.41M1.57M2.77M3.73M1.64M2.41M462K350K100K
EBITDA Margin %-------------948.24%-51.59%-36.42%-97.66%-11.22%8.01%---8.43%12.83%17.42%8.72%15.46%3.67%3.54%1.45%
EBITDA Growth %-2.53%-25.61%-26.44%14.05%-62.23%-22.35%9.85%2.17%-5.88%-355.01%-41.46%56.95%96.1%17.93%77.38%-2580.07%-376.85%122.07%150.87%75.47%-445.47%-43.55%-25.53%127.55%-32.19%422.51%32%250%-
D&A (Non-Cash Add-back)37.72K50.29K28.22K30286286339347148534143001.64M3.7M5.87M1.35M25K002.49M2.09M2.03M1.89M1.91M1.55M1.12M1.05M1.1M
EBIT-7.14M-5.53M-4.53M-3.42M-4.14M-2.55M-2.09M-2.31M-2.37M-2.27M-1.02M-347K-806K-20.59M-28.79M-116.5M-5.5M1.47M666K-1.33M-7.9M-528K747K1.83M-275K866K-600K-700K-1M
Net Interest Income-196.29K43.46K156.79K48.33K-464K-246K-13.07K00-6.25K000-6K-4K601K442K-14K000-306K-440K-496K00-197K00
Interest Income8.1K43.47K264.48K185.79K33.21K5022.81K2.79K13.89K90700010K72K748K464K000000000000
Interest Expense296.89K0107.68K137.46K496.91K246.18K15.89K2.79K13.89K7.16K18K3K016K76K147K22K14K000306K440K496K00197K-200K-200K
Other Income/Expense675.23K175.61K-474K2.28K-383K2.88K335.22K-243K105.69K-42.33K1.62K-57.9K25.84M1.68M1K448K430K-89K-36K907K0-306K-440K-496K-399K0-136K200K200K
Pretax Income-5.16M-5.53M-5M-3.56M-4.52M-2.55M-1.75M-2.56M-2.26M-2.28M-1.02M-302K-806K-20.61M-28.86M-116.64M-5.07M1.39M657K-1.33M0-834K307K1.34M-674K00-500K-800K
Pretax Margin %-------------948.24%-51.49%-41.77%-102.42%-13.71%7.4%----4.49%1.42%6.26%-3.59%---5.05%-11.59%
Income Tax00000015.89K000-33K101K354K-1.07M640K-852K-1.2M708K94.47K00-106K163K203K0218K197K-200K-200K
Effective Tax Rate %0%0%0%0%0%0%-0.91%0%0%0%3.23%-33.44%-43.92%5.18%-2.22%0.73%23.73%51.12%14.38%0%-12.71%53.09%15.16%0%--40%25%
Net Income-5.16M-5.53M-5M-3.56M-4.52M-2.55M-1.75M-2.56M-2.26M-2.28M-476K-1.08M-1.03M-19.73M-29.47M-115.77M-4.15M677K-94.47K-2.23M-7.9M-728K144K1.14M-674K648K-900K-300K-600K
Net Margin %-------------1208.24%-49.29%-42.66%-101.65%-11.22%3.62%----3.92%0.67%5.31%-3.59%4.15%-7.16%-3.03%-8.7%
Net Income Growth %6.67%-10.5%-40.61%21.38%-77.46%-45.56%31.55%-13.19%0.7%-378.15%55.89%-5.06%94.79%33.06%74.54%-2690.21%-712.85%816.63%95.77%71.72%-985.16%-605.56%-87.32%268.55%-204.01%172%-200%50%-
Net Income (Continuing)-5.16M-5.53M-5M-3.56M-4.52M-2.55M0-2.56M-2.26M-2.28M-1.02M-350K-806K-19.54M-29.5M-115.79M-4.15M677K387K-1.33M-7.9M-728K144K1.14M-674K648K-900K-300K-600K
Discontinued Operations00000000000000000000000000000
Minority Interest0000000000-74K-49K000260K283K000000000000
EPS (Diluted)-3.45-1.13-1.15-0.82-1.24-1.00-0.69-1.00-0.88-1.72-73.23-166.00-632.00-193401.96-350833.33-999999.00-84673.47677000.00-94470.00-0.53-1.86-728000.00144000.00999999.00-674000.00648000.00-858000.00-0.07-0.14
EPS Growth %-205.31%1.74%-40.24%33.87%-24%-44.93%31%-13.64%48.84%97.65%55.89%73.73%99.67%44.87%73.94%-1489.77%-112.51%816.63%-17824428.3%71.51%100%-605.56%-87.32%268.55%-204.01%175.52%-99999900%49.43%-
EPS (Basic)-3.45-1.13-1.15-0.82-1.24-1.00-0.69-1.00-0.88-1.72-73.23-166.86-632.00-193401.96-350833.33-999999.00-84673.47677000.00-94470.00-0.53-1.86-728000.00144000.00999999.00-674000.00648000.00-858000.00-0.07-0.14
Diluted Shares Outstanding1.93M4.9M4.34M4.32M3.69M2.58M2.56M2.56M2.56M1.33M118.09K6.5K1.7B102848649004.24M4.24M0000004.24M4.24M
Basic Shares Outstanding1.93M4.9M4.34M4.32M3.69M2.58M2.56M2.56M2.56M1.33M118K6.47K1.7B102848649004.24M4.24M0000004.24M4.24M
Dividend Payout Ratio-----------------------------

Key Metrics

Growth RegimeMixed
ProfitabilityNegative
Balance SheetVulnerable
Cash FlowBurning
Top Statement Risk

Binary clinical trial failure

Verified Source

Metrics are mathematically derived from official filings.

SEC 10-K (2025Q4)

Revenue Generation Remains Non-Existent

As indicated by the company's historical financial statements, PTIX remains a pre-revenue entity with no commercial product sales, leaving its financial trajectory entirely dependent on external capital infusions rather than organic growth, which warrants caution regarding the firm's long-term viability without a strategic partnership or milestone achievement.

The absence of recurring revenue streams underscores the binary nature of the company's business model, where value is tied exclusively to clinical trial outcomes. Investors should monitor the lack of top-line growth as a primary indicator that the firm has yet to transition from a research-focused entity to a commercial enterprise.

R&D Intensity Drives Capital Depletion

Based on reported figures, the company's cost structure is dominated by R&D expenditures, which reached a peak of $1.5 million in 2024Q1, reflecting the high fixed-cost burden inherent in clinical-stage biotechnology development and the ongoing necessity for significant investment to advance the PT00114 program.

The volatility in R&D spending appears to correlate with the timing of clinical trial cohorts, suggesting that management lacks control over the timing of these cash outflows. This high-intensity cost structure necessitates constant capital raises, which may continue to dilute existing shareholders until a clear path to commercialization is established.

Non-Operating Items Distort Net Results

According to recent SEC filings, the reported net income of $2.2 million in 2025Q4 appears to be an anomaly likely driven by non-operating items or warrant revaluations rather than operational success, which obscures the underlying reality of the company's persistent and deep operating losses.

Analysts should exercise caution when interpreting the positive net income figure, as it does not reflect a fundamental improvement in the core business. The disconnect between operating losses and net income suggests that non-cash accounting adjustments are significantly impacting the bottom line, potentially misleading investors about the firm's true financial health.

Operating Leverage Remains Severely Constrained

As reported in financial statements, the company's operating losses have remained consistently deep, with quarterly operating losses frequently exceeding $1 million, indicating that the firm has yet to achieve any meaningful operating leverage or efficiency in its clinical development and administrative overhead management.

The inability to scale operating expenses relative to clinical progress suggests that the company's current administrative and research infrastructure is not yet optimized for cost-effective drug development. This lack of leverage implies that any future expansion in clinical activity will likely lead to a proportional or greater increase in cash burn.

Liquidity Risks Threaten Operational Continuity

Based on the reported cash balance of approximately $2.2 million, the company faces a significant liquidity risk that may necessitate immediate dilutive financing, as the current burn rate suggests a very limited runway for continued operations without a major capital injection or strategic partnership.

Short-sellers would likely focus on the precarious cash position, which leaves little room for error in clinical trial execution or unexpected regulatory delays. The reliance on external funding in a high-interest-rate environment poses a structural threat to the company's ability to reach its next critical data inflection point.

PTIX — Frequently Asked Questions

Quick answers to the most common questions about buying PTIX stock.

What was Protagenic Therapeutics, Inc.'s (PTIX) revenue in 2025?

For fiscal year 2025, Protagenic Therapeutics, Inc. (PTIX) reported total revenue of $0.0M. This represents a 100.0% decline compared to $6.9M in 1995.

Is Protagenic Therapeutics, Inc. (PTIX) profitable?

Protagenic Therapeutics, Inc. (PTIX) reported a net loss of $5.2M for the fiscal year ending 2025.