The company remains a pre-revenue entity with persistent operating losses, evidenced by a $925.1K operating loss in 2025Q4 despite reported non-operating net income anomalies.
| Metric | Dec'25 | Dec'24 | Dec'23 | Dec'22 | Dec'21 | Dec'20 | Dec'19 | Dec'18 | Dec'17 | Dec'16 | Jun'15 | Jun'14 | Jun'13 | Dec'10 | Dec'09 | Dec'08 | Dec'07 | Dec'06 | Jul'05 | Jul'04 | Jul'03 | Jul'02 | Jul'01 | Jul'00 | Jul'99 | Jul'98 | Jul'97 | Jul'96 | Jul'95 |
|---|
| Sales/Revenue | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 85K | 40.03M | 69.09M | 113.88M | 36.98M | 18.72M | 0 | 0 | 0 | 18.57M | 21.63M | 21.39M | 18.76M | 15.62M | 12.57M | 9.9M | 6.9M |
| Revenue Growth % | - | - | - | - | - | - | - | - | - | - | - | -100% | -99.79% | -42.07% | -39.33% | 207.94% | 97.54% | - | - | - | -100% | -14.12% | 1.11% | 13.99% | 20.16% | 24.19% | 27% | 43.48% | - |
| Cost of Goods Sold | 37.72K | 50.29K | 28.22K | 30 | 0 | 286 | 339 | 347 | 148 | 534 | 0 | 0 | 0 | 42.71M | 53.87M | 84.29M | 5.01M | 597K | 0 | 0 | 0 | 10.55M | 12.27M | 11.78M | 10.96M | 7.8M | 6.74M | 5.1M | 3.4M |
| COGS % of Revenue | - | - | - | - | - | - | - | - | - | - | - | - | - | 106.7% | 77.97% | 74.01% | 13.56% | 3.19% | - | - | - | 56.79% | 56.73% | 55.1% | 58.4% | 49.96% | 53.59% | 51.52% | 49.28% |
| Gross Profit | -37.72K | -50.29K | -28.22K | -30 | 0 | -286 | -339 | -347 | -148 | -534 | 0 | 0 | 85K | -2.68M | 15.22M | 29.59M | 31.97M | 18.12M | 0 | 0 | 0 | 8.03M | 9.36M | 9.6M | 7.8M | 7.81M | 5.83M | 4.8M | 3.5M |
| Gross Margin % | - | - | - | - | - | - | - | - | - | - | - | - | 100% | -6.7% | 22.03% | 25.99% | 86.44% | 96.81% | - | - | - | 43.21% | 43.27% | 44.9% | 41.6% | 50.04% | 46.41% | 48.48% | 50.72% |
| Gross Profit Growth % | 25% | -78.21% | -93960% | - | 100% | 15.63% | 2.31% | -134.46% | 72.28% | - | - | -100% | 103.17% | -117.61% | -48.58% | -7.43% | 76.38% | - | - | - | -100% | -14.24% | -2.56% | 23.05% | -0.1% | 33.9% | 21.56% | 37.14% | - |
| Operating Expenses | 5.81M | 5.7M | 4.5M | 3.56M | 4.14M | 2.55M | 2.09M | 2.31M | 2.37M | 1.83M | 491K | 975K | 758K | 14.77M | 44.08M | 146.68M | 37.47M | 16.65M | 94.47K | -2.23M | -7.9M | 8.55M | 8.61M | 7.77M | 8.08M | 6.95M | 6.5M | 5.1M | 4.1M |
| OpEx % of Revenue | - | - | - | - | - | - | - | - | - | - | - | - | 891.76% | 36.89% | 63.8% | 128.8% | 101.31% | 88.94% | - | - | - | 46.05% | 39.82% | 36.32% | 43.06% | 44.49% | 51.67% | 51.52% | 59.42% |
| Selling, General & Admin | 1.7M | 1.76M | 1.18M | 1.97M | 3M | 1.85M | 1.28M | 1.43M | 1.65M | 1.3M | 491K | 933K | 758K | 13.12M | 23.09M | 35.78M | 37.47M | 16.65M | 94.47K | 0 | 0 | 8.55M | 8.61M | 7.77M | 8.08M | 6.95M | 6.5M | 5.1M | 4.1M |
| SG&A % of Revenue | - | - | - | - | - | - | - | - | - | - | - | - | 891.76% | 32.78% | 33.42% | 31.42% | 101.31% | 88.94% | - | - | - | 46.05% | 39.82% | 36.32% | 43.06% | 44.49% | 51.67% | 51.52% | 59.42% |
| Research & Development | 1.7M | 3.85M | 3.32M | 1.59M | 1.14M | 699.8K | 807.95K | 881.19K | 717.45K | 417.87K | 464 | 269.44K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| R&D % of Revenue | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Other Operating Expenses | 2.41M | 97K | 0 | 0 | -1K | 203 | 53 | 0 | 0 | 404.17K | 0 | -84.23K | 0 | 1.64M | 3.7M | 5.87M | 0 | 0 | 0 | -2.23M | -7.9M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Operating Income | -5.83M | -5.7M | -4.53M | -3.56M | -4.14M | -2.55M | -2.09M | -2.31M | -2.37M | -2.23M | -491K | -975K | -673K | -22.3M | -28.86M | -117.09M | -5.5M | 1.47M | -94.47K | -2.23M | -7.9M | -528K | 747K | 1.83M | -275K | 866K | -661K | -700K | -1M |
| Operating Margin % | - | - | - | - | - | - | - | - | - | - | - | - | -791.76% | -55.7% | -41.78% | -102.82% | -14.87% | 7.87% | - | - | - | -2.84% | 3.45% | 8.58% | -1.47% | 5.55% | -5.26% | -7.07% | -14.49% |
| Operating Income Growth % | -2.29% | -25.93% | -27.23% | 14.06% | -62.23% | -22.34% | 9.85% | 2.16% | -5.86% | -354.99% | 49.64% | -44.87% | 96.98% | 22.75% | 75.35% | -2029.3% | -473.07% | 1660.28% | 95.77% | 71.72% | -1396.21% | -170.68% | -59.29% | 767.27% | -131.76% | 231.01% | 5.57% | 30% | - |
| EBITDA | -5.79M | -5.65M | -4.5M | -3.56M | -4.14M | -2.55M | -2.09M | -2.31M | -2.36M | -2.23M | -490.86K | -347K | -806K | -20.65M | -25.16M | -111.22M | -4.15M | 1.5M | 675K | -1.33M | -5.41M | 1.57M | 2.77M | 3.73M | 1.64M | 2.41M | 462K | 350K | 100K |
| EBITDA Margin % | - | - | - | - | - | - | - | - | - | - | - | - | -948.24% | -51.59% | -36.42% | -97.66% | -11.22% | 8.01% | - | - | - | 8.43% | 12.83% | 17.42% | 8.72% | 15.46% | 3.67% | 3.54% | 1.45% |
| EBITDA Growth % | -2.53% | -25.61% | -26.44% | 14.05% | -62.23% | -22.35% | 9.85% | 2.17% | -5.88% | -355.01% | -41.46% | 56.95% | 96.1% | 17.93% | 77.38% | -2580.07% | -376.85% | 122.07% | 150.87% | 75.47% | -445.47% | -43.55% | -25.53% | 127.55% | -32.19% | 422.51% | 32% | 250% | - |
| D&A (Non-Cash Add-back) | 37.72K | 50.29K | 28.22K | 30 | 286 | 286 | 339 | 347 | 148 | 534 | 143 | 0 | 0 | 1.64M | 3.7M | 5.87M | 1.35M | 25K | 0 | 0 | 2.49M | 2.09M | 2.03M | 1.89M | 1.91M | 1.55M | 1.12M | 1.05M | 1.1M |
| EBIT | -7.14M | -5.53M | -4.53M | -3.42M | -4.14M | -2.55M | -2.09M | -2.31M | -2.37M | -2.27M | -1.02M | -347K | -806K | -20.59M | -28.79M | -116.5M | -5.5M | 1.47M | 666K | -1.33M | -7.9M | -528K | 747K | 1.83M | -275K | 866K | -600K | -700K | -1M |
| Net Interest Income | -196.29K | 43.46K | 156.79K | 48.33K | -464K | -246K | -13.07K | 0 | 0 | -6.25K | 0 | 0 | 0 | -6K | -4K | 601K | 442K | -14K | 0 | 0 | 0 | -306K | -440K | -496K | 0 | 0 | -197K | 0 | 0 |
| Interest Income | 8.1K | 43.47K | 264.48K | 185.79K | 33.21K | 502 | 2.81K | 2.79K | 13.89K | 907 | 0 | 0 | 0 | 10K | 72K | 748K | 464K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Interest Expense | 296.89K | 0 | 107.68K | 137.46K | 496.91K | 246.18K | 15.89K | 2.79K | 13.89K | 7.16K | 18K | 3K | 0 | 16K | 76K | 147K | 22K | 14K | 0 | 0 | 0 | 306K | 440K | 496K | 0 | 0 | 197K | -200K | -200K |
| Other Income/Expense | 675.23K | 175.61K | -474K | 2.28K | -383K | 2.88K | 335.22K | -243K | 105.69K | -42.33K | 1.62K | -57.9K | 25.84M | 1.68M | 1K | 448K | 430K | -89K | -36K | 907K | 0 | -306K | -440K | -496K | -399K | 0 | -136K | 200K | 200K |
| Pretax Income | -5.16M | -5.53M | -5M | -3.56M | -4.52M | -2.55M | -1.75M | -2.56M | -2.26M | -2.28M | -1.02M | -302K | -806K | -20.61M | -28.86M | -116.64M | -5.07M | 1.39M | 657K | -1.33M | 0 | -834K | 307K | 1.34M | -674K | 0 | 0 | -500K | -800K |
| Pretax Margin % | - | - | - | - | - | - | - | - | - | - | - | - | -948.24% | -51.49% | -41.77% | -102.42% | -13.71% | 7.4% | - | - | - | -4.49% | 1.42% | 6.26% | -3.59% | - | - | -5.05% | -11.59% |
| Income Tax | 0 | 0 | 0 | 0 | 0 | 0 | 15.89K | 0 | 0 | 0 | -33K | 101K | 354K | -1.07M | 640K | -852K | -1.2M | 708K | 94.47K | 0 | 0 | -106K | 163K | 203K | 0 | 218K | 197K | -200K | -200K |
| Effective Tax Rate % | 0% | 0% | 0% | 0% | 0% | 0% | -0.91% | 0% | 0% | 0% | 3.23% | -33.44% | -43.92% | 5.18% | -2.22% | 0.73% | 23.73% | 51.12% | 14.38% | 0% | - | 12.71% | 53.09% | 15.16% | 0% | - | - | 40% | 25% |
| Net Income | -5.16M | -5.53M | -5M | -3.56M | -4.52M | -2.55M | -1.75M | -2.56M | -2.26M | -2.28M | -476K | -1.08M | -1.03M | -19.73M | -29.47M | -115.77M | -4.15M | 677K | -94.47K | -2.23M | -7.9M | -728K | 144K | 1.14M | -674K | 648K | -900K | -300K | -600K |
| Net Margin % | - | - | - | - | - | - | - | - | - | - | - | - | -1208.24% | -49.29% | -42.66% | -101.65% | -11.22% | 3.62% | - | - | - | -3.92% | 0.67% | 5.31% | -3.59% | 4.15% | -7.16% | -3.03% | -8.7% |
| Net Income Growth % | 6.67% | -10.5% | -40.61% | 21.38% | -77.46% | -45.56% | 31.55% | -13.19% | 0.7% | -378.15% | 55.89% | -5.06% | 94.79% | 33.06% | 74.54% | -2690.21% | -712.85% | 816.63% | 95.77% | 71.72% | -985.16% | -605.56% | -87.32% | 268.55% | -204.01% | 172% | -200% | 50% | - |
| Net Income (Continuing) | -5.16M | -5.53M | -5M | -3.56M | -4.52M | -2.55M | 0 | -2.56M | -2.26M | -2.28M | -1.02M | -350K | -806K | -19.54M | -29.5M | -115.79M | -4.15M | 677K | 387K | -1.33M | -7.9M | -728K | 144K | 1.14M | -674K | 648K | -900K | -300K | -600K |
| Discontinued Operations | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Minority Interest | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -74K | -49K | 0 | 0 | 0 | 260K | 283K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| EPS (Diluted) | -3.45 | -1.13 | -1.15 | -0.82 | -1.24 | -1.00 | -0.69 | -1.00 | -0.88 | -1.72 | -73.23 | -166.00 | -632.00 | -193401.96 | -350833.33 | -999999.00 | -84673.47 | 677000.00 | -94470.00 | -0.53 | -1.86 | -728000.00 | 144000.00 | 999999.00 | -674000.00 | 648000.00 | -858000.00 | -0.07 | -0.14 |
| EPS Growth % | -205.31% | 1.74% | -40.24% | 33.87% | -24% | -44.93% | 31% | -13.64% | 48.84% | 97.65% | 55.89% | 73.73% | 99.67% | 44.87% | 73.94% | -1489.77% | -112.51% | 816.63% | -17824428.3% | 71.51% | 100% | -605.56% | -87.32% | 268.55% | -204.01% | 175.52% | -99999900% | 49.43% | - |
| EPS (Basic) | -3.45 | -1.13 | -1.15 | -0.82 | -1.24 | -1.00 | -0.69 | -1.00 | -0.88 | -1.72 | -73.23 | -166.86 | -632.00 | -193401.96 | -350833.33 | -999999.00 | -84673.47 | 677000.00 | -94470.00 | -0.53 | -1.86 | -728000.00 | 144000.00 | 999999.00 | -674000.00 | 648000.00 | -858000.00 | -0.07 | -0.14 |
| Diluted Shares Outstanding | 1.93M | 4.9M | 4.34M | 4.32M | 3.69M | 2.58M | 2.56M | 2.56M | 2.56M | 1.33M | 118.09K | 6.5K | 1.7B | 102 | 84 | 86 | 49 | 0 | 0 | 4.24M | 4.24M | 0 | 0 | 0 | 0 | 0 | 0 | 4.24M | 4.24M |
| Basic Shares Outstanding | 1.93M | 4.9M | 4.34M | 4.32M | 3.69M | 2.58M | 2.56M | 2.56M | 2.56M | 1.33M | 118K | 6.47K | 1.7B | 102 | 84 | 86 | 49 | 0 | 0 | 4.24M | 4.24M | 0 | 0 | 0 | 0 | 0 | 0 | 4.24M | 4.24M |
| Dividend Payout Ratio | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Binary clinical trial failure
As indicated by the company's historical financial statements, PTIX remains a pre-revenue entity with no commercial product sales, leaving its financial trajectory entirely dependent on external capital infusions rather than organic growth, which warrants caution regarding the firm's long-term viability without a strategic partnership or milestone achievement.
The absence of recurring revenue streams underscores the binary nature of the company's business model, where value is tied exclusively to clinical trial outcomes. Investors should monitor the lack of top-line growth as a primary indicator that the firm has yet to transition from a research-focused entity to a commercial enterprise.
Based on reported figures, the company's cost structure is dominated by R&D expenditures, which reached a peak of $1.5 million in 2024Q1, reflecting the high fixed-cost burden inherent in clinical-stage biotechnology development and the ongoing necessity for significant investment to advance the PT00114 program.
The volatility in R&D spending appears to correlate with the timing of clinical trial cohorts, suggesting that management lacks control over the timing of these cash outflows. This high-intensity cost structure necessitates constant capital raises, which may continue to dilute existing shareholders until a clear path to commercialization is established.
According to recent SEC filings, the reported net income of $2.2 million in 2025Q4 appears to be an anomaly likely driven by non-operating items or warrant revaluations rather than operational success, which obscures the underlying reality of the company's persistent and deep operating losses.
Analysts should exercise caution when interpreting the positive net income figure, as it does not reflect a fundamental improvement in the core business. The disconnect between operating losses and net income suggests that non-cash accounting adjustments are significantly impacting the bottom line, potentially misleading investors about the firm's true financial health.
As reported in financial statements, the company's operating losses have remained consistently deep, with quarterly operating losses frequently exceeding $1 million, indicating that the firm has yet to achieve any meaningful operating leverage or efficiency in its clinical development and administrative overhead management.
The inability to scale operating expenses relative to clinical progress suggests that the company's current administrative and research infrastructure is not yet optimized for cost-effective drug development. This lack of leverage implies that any future expansion in clinical activity will likely lead to a proportional or greater increase in cash burn.
Based on the reported cash balance of approximately $2.2 million, the company faces a significant liquidity risk that may necessitate immediate dilutive financing, as the current burn rate suggests a very limited runway for continued operations without a major capital injection or strategic partnership.
Short-sellers would likely focus on the precarious cash position, which leaves little room for error in clinical trial execution or unexpected regulatory delays. The reliance on external funding in a high-interest-rate environment poses a structural threat to the company's ability to reach its next critical data inflection point.
Quick answers to the most common questions about buying PTIX stock.
For fiscal year 2025, Protagenic Therapeutics, Inc. (PTIX) reported total revenue of $0.0M. This represents a 100.0% decline compared to $6.9M in 1995.
Protagenic Therapeutics, Inc. (PTIX) reported a net loss of $5.2M for the fiscal year ending 2025.