Schrödinger, Inc. (SDGR) Financial Ratios
9 years of historical data (2017–2025) · Healthcare · Medical - Healthcare Information Services
EV/EBITDA
N/A
—
5yr avg: N/A
P/FCF
79.66
↓-24% vs avg
5yr avg: 105.42
30Y Low105.4·High105.4
P/B Ratio
↓
2.68
↓-30% vs avg
5yr avg: 3.84
30Y Low3.0·High7.6
ROE
↓
-26.3%
↑-27% vs avg
5yr avg: -20.7%
30Y Low-39%·High8%
Debt/EBITDA
N/A
—
5yr avg: N/A
Percentile shows where the current value sits in 30-year historical distribution. Sparklines show 5-year trend.
SDGR Valuation Multiples
Price-based multiples — how expensive the stock is relative to earnings, sales, book value, and cash flow
Schrödinger, Inc. currently has a negative P/E ratio, indicating the company is operating at a loss on a trailing-twelve-month basis. On a free-cash-flow basis, the stock trades at 79.7x P/FCF, 24% below the 5-year average of 105.4x.
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 |
|---|---|---|---|---|---|---|---|---|---|---|
| Market Cap | $992M | $1.3B | $1.4B | $2.7B | $1.3B | $2.5B | $4.8B | — | — | — |
| Enterprise Value | $871M | $1.2B | $1.4B | $2.7B | $1.4B | $2.4B | $4.6B | — | — | — |
| P/E Ratio → | -9.42 | — | — | 66.30 | — | — | — | — | — | — |
| P/S Ratio | 3.88 | 5.13 | 6.75 | 12.39 | 7.35 | 17.83 | 43.97 | — | — | — |
| P/B Ratio | 2.68 | 3.61 | 3.33 | 4.89 | 2.97 | 4.41 | 7.62 | — | — | — |
| P/FCF | 79.66 | 105.42 | — | — | — | — | 334.25 | — | — | — |
| P/OCF | 71.39 | 94.48 | — | — | — | — | 283.63 | — | — | — |
P/E links to full P/E history page with 30-year chart
SDGR EV Ratios
Enterprise-value multiples — capital-structure-neutral measures of total business value
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 |
|---|---|---|---|---|---|---|---|---|---|---|
| EV / Revenue | — | 4.66 | 6.61 | 12.26 | 7.49 | 17.53 | 42.21 | — | — | — |
| EV / EBITDA | — | — | — | — | — | — | — | — | — | — |
| EV / EBIT | — | — | — | — | — | — | — | — | — | — |
| EV / FCF | — | 95.68 | — | — | — | — | 320.85 | — | — | — |
SDGR Profitability
Margins and return-on-capital ratios measuring operating efficiency
Schrödinger, Inc. earns an operating margin of -65.2%. Operating margins have expanded from -81.9% to -65.2% over the past 3 years, signaling improving operational efficiency. A negative ROE of -26.3% indicates the company is currently destroying shareholder equity.
Margins
Full margin charts and quarterly trend are on the Earnings History page
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 |
|---|---|---|---|---|---|---|---|---|---|---|
| Gross Margin | 55.7% | 55.7% | 63.6% | 64.9% | 55.8% | 47.6% | 58.7% | 57.4% | 64.4% | 71.5% |
| Operating Margin | -65.2% | -65.2% | -100.8% | -81.9% | -81.1% | -80.8% | -56.4% | -45.3% | -42.0% | -34.2% |
| Net Profit Margin | -40.4% | -40.4% | -90.2% | 18.8% | -82.4% | -72.8% | -22.6% | -28.7% | -42.7% | -31.2% |
Return on Capital
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 |
|---|---|---|---|---|---|---|---|---|---|---|
| ROE | -26.3% | -26.3% | -38.6% | 8.2% | -29.7% | -17.0% | -9.2% | — | — | — |
| ROA | -13.3% | -13.3% | -23.0% | 5.5% | -20.6% | -13.4% | -5.4% | -17.8% | -31.8% | -30.0% |
| ROIC | -39.4% | -39.4% | -34.4% | -26.7% | -22.2% | -17.6% | -27.8% | — | — | — |
| ROCE | -28.6% | -28.6% | -32.2% | -28.4% | -23.6% | -16.7% | -15.6% | -38.0% | -41.8% | -47.3% |
SDGR Leverage & Debt
Solvency and debt-coverage ratios — lower is generally safer
The company holds a net cash position — cash of $231M exceeds total debt of $109M, providing substantial financial flexibility for buybacks, acquisitions, or weathering downturns.
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 |
|---|---|---|---|---|---|---|---|---|---|---|
| Debt / Equity | 0.30 | 0.30 | 0.28 | 0.23 | 0.26 | 0.14 | 0.02 | — | — | — |
| Debt / EBITDA | — | — | — | — | — | — | — | — | — | — |
| Net Debt / Equity | — | -0.33 | -0.07 | -0.05 | 0.06 | -0.07 | -0.31 | — | — | — |
| Net Debt / EBITDA | — | — | — | — | — | — | — | — | — | — |
| Debt / FCF | — | -9.74 | — | — | — | — | -13.40 | — | — | — |
| Interest Coverage | — | — | — | — | -48939.00 | — | — | — | — | — |
Net cash position: cash ($231M) exceeds total debt ($109M)
SDGR Liquidity & Efficiency
Short-term solvency ratios and asset-utilisation metrics
Schrödinger, Inc.'s current ratio of 2.75x is well above the 1.0 safety threshold, indicating strong short-term liquidity with ample room to cover current liabilities. The current ratio has declined from 4.25x to 2.75x over the past 3 years.
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 |
|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 2.75 | 2.75 | 3.31 | 4.25 | 4.91 | 6.85 | 9.33 | 2.63 | 3.88 | 2.70 |
| Quick Ratio | 2.75 | 2.75 | 3.31 | 4.25 | 4.91 | 6.85 | 9.33 | 2.63 | 3.88 | 2.70 |
| Cash Ratio | 2.09 | 2.09 | 1.84 | 3.46 | 4.15 | 6.32 | 8.78 | 1.91 | 3.11 | 2.04 |
| Asset Turnover | — | 0.35 | 0.25 | 0.27 | 0.26 | 0.18 | 0.14 | 0.55 | 0.55 | 0.96 |
| Inventory Turnover | — | — | — | — | — | — | — | — | — | — |
| Days Sales Outstanding | — | 118.46 | 449.06 | 150.13 | 139.36 | 107.31 | 119.46 | 109.82 | 98.71 | 63.96 |
SDGR Shareholder Yields
Earnings, FCF, buyback, and dividend yields — total returns to shareholders
Schrödinger, Inc. does not currently pay a dividend and has no material buyback yield, reinvesting earnings back into the business.
Dividends
Full dividend history and growth charts are on the Dividend History page
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 |
|---|---|---|---|---|---|---|---|---|---|---|
| Dividend Yield | — | — | — | — | — | — | — | — | — | — |
| Payout Ratio | — | — | — | — | — | — | — | — | — | — |
Total Shareholder Return Metrics
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 |
|---|---|---|---|---|---|---|---|---|---|---|
| Earnings Yield | — | — | — | 1.5% | — | — | — | — | — | — |
| FCF Yield | 1.3% | 0.9% | — | — | — | — | 0.3% | — | — | — |
| Buyback Yield | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | — | — | — |
| Total Shareholder Yield | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | — | — | — |
| Shares Outstanding | — | $73M | $73M | $75M | $71M | $71M | $60M | $63M | $48M | $6M |
Peer Comparison
Compare SDGR with 10 similar companies in its peer group
| Company | Market Cap | P/E | EV/EBITDA | P/FCF | Gross Margin | Op Margin | ROE | ROIC | Debt/EBITDA |
|---|---|---|---|---|---|---|---|---|---|
 SDGRYou | $992M | -9.4 | — | 79.7 | 55.7% | -65.2% | -26.3% | -39.4% | — |
 RXRX | $1B | -2.3 | — | — | -62.0% | -867.9% | -59.5% | -95.8% | — |
 ABSI | $894M | -6.8 | — | — | -319.4% | -4454.2% | -62.5% | -58.0% | — |
 RLAY | $2B | -7.8 | — | — | 76.8% | -1971.6% | -41.1% | -37.3% | — |
 CDNS | $99B | 87.9 | 52.0 | 62.1 | 86.4% | 31.1% | 21.9% | 25.9% | 1.3 |
 CERT | $1B | -631.0 | 11.0 | 10.9 | 61.5% | 5.0% | -0.2% | 1.5% | 0.1 |
 SLP | $324M | -5.0 | — | 18.6 | 58.4% | -89.3% | -42.1% | -39.6% | — |
 VEEV | $27B | 30.9 | 28.4 | 19.3 | 75.5% | 28.7% | 13.9% | 12.9% | 0.1 |
 NVDA | $5.1T | 43.2 | 38.6 | 53.2 | 71.1% | 60.4% | 101.5% | 81.8% | 0.1 |
 TMO | $176B | 26.8 | 19.0 | 28.0 | 37.7% | 18.2% | 13.1% | 7.5% | 3.8 |
 ILMN | $21B | 25.5 | 19.6 | 22.6 | 66.7% | 19.9% | 33.4% | 16.8% | 2.3 |
| Healthcare Median | — | 22.3 | 14.4 | 18.5 | 63.9% | -5.2% | -33.7% | -11.2% | 3.3 |
Peer selection based on competitive and market overlap. Compare multiple stocks →
Download Financial Ratios Data
Includes 30+ ratios · 9 years · Updated daily
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Start ComparisonSDGR — Frequently Asked Questions
Quick answers to the most common questions about buying SDGR stock.
What is Schrödinger, Inc.'s P/E ratio?
Schrödinger, Inc.'s current P/E ratio is -9.4x. The historical average is 66.3x.
What is Schrödinger, Inc.'s ROE?
Schrödinger, Inc.'s return on equity (ROE) is -26.3%. The historical average is -18.8%.
Is SDGR stock overvalued?
Based on historical data, Schrödinger, Inc. is trading at a P/E of -9.4x. Compare with industry peers and growth rates for a complete picture.
What are Schrödinger, Inc.'s profit margins?
Schrödinger, Inc. has 55.7% gross margin and -65.2% operating margin.