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Mersana Therapeutics, Inc. (MRSN) Total Return Calculator with Dividends Reinvested

Mersana Therapeutics, Inc.

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The total return for Mersana Therapeutics, Inc. (MRSN) stock is +266.71% over the past 12 months. So far it's up 0.14% this year. The 5-year total return is -92.20%, meaning $10,000 invested in MRSN stock 5 years ago would be worth $780 today. Total return includes price appreciation plus reinvesting any dividends paid out.

If you invested $10,000 in MRSN 1 year ago, it would be worth $35,769 today — you'd have gained $25,769.

With Dividends Reinvested$35,769+257.69%

Price Only (No DRIP)$35,769+257.69%

Period2025-05-07 → 2026-01-06

Price

Total Return (DRIP)

S&P 500

If You Invested $10,000 in MRSN

1Y$36,671+$26,671 (+266.7%)266.7% CAGR

3Y$1,568-$8,432 (-84.3%)-46.1% CAGR

5Y$780-$9,220 (-92.2%)-40.0% CAGR

10Y$831-$9,169 (-91.7%)-22.0% CAGR

15Y$831-$9,169 (-91.7%)-15.3% CAGR

20Y$831-$9,169 (-91.7%)-11.7% CAGR

30Y$831-$9,169 (-91.7%)-8.0% CAGR

Mersana Therapeutics, Inc. did not pay dividends during this period. Total return = price return.

Loading MRSN total return...

As of 2026-05-06

Returns at a Glance

Period	Total Return	CAGR	Price Only	Div. Contrib.	$10K →
YTD	+0.14%	—	+0.14%	—	$10,014
1Y	+266.71%	266.71%	+266.71%	—	$36,671
3Y	-84.32%	-46.08%	-84.32%	—	$1,568
5Y	-92.20%	-39.96%	-92.20%	—	$780
10Y	-91.69%	-22.03%	-91.69%	—	$831
15Y	-91.69%	-15.28%	-91.69%	—	$831
20Y	-91.69%	-11.70%	-91.69%	—	$831
30Y	-91.69%	-7.96%	-91.69%	—	$831

Risk & Highlights

Best Year+396.46%2020

Worst Year-76.55%2021

Max Drawdown-41.36%2025-06-10 → 2025-08-11 · Recovered 2025-10-14

Annual Returns

Year	Total Return	Price Return	Div.	S&P 500	vs S&P
2026YTD	+0.14%	+0.14%	—	+0.41%	-0.3pp
2025	-17.34%	-17.34%	—	+16.64%	-34.0pp
2024	-37.00%	-37.00%	—	+24.00%	-61.0pp
2023	-59.51%	-59.51%	—	+24.81%	-84.3pp
2022	-9.01%	-9.01%	—	-19.95%	+10.9pp

MRSN outperformed the S&P 500 by 235.39pp over the past year (+266.71% vs +31.32%).

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MRSN Peers' Total Return

Accurate peer set · 10 comparable names

Name	Mkt Cap	30D Rtn	YTD Total Rtn	1Y Total Rtn	Div Contrib	3Y Total Rtn	5Y Total Rtn	10Y Total Rtn
MRSNMersana Therapeutics, Inc.	$145M	—	+0.1%	+266.7%	—	-84.3%	-92.2%	-91.7%
RCUSArcus Biosciences, Inc.	$2.6B	+16.9%	+11.6%	+220.2%	—	+31.0%	-13.7%	+52.9%
SNDXSyndax Pharmaceuticals, Inc.	$1.8B	-15.0%	-3.1%	+94.1%	—	+1.8%	+35.1%	+42.5%
AGENAgenus Inc.	$137M	+3.2%	+20.4%	+31.0%	—	-87.8%	-93.1%	-93.5%
TGTXTG Therapeutics, Inc.	$6.7B	+24.6%	+43.3%	+20.4%	—	+26.8%	+5.3%	+425.9%
NKTRNektar Therapeutics	$1.7B	+13.9%	+96.0%	+783.6%	—	+636.7%	-69.4%	-57.6%
ARVNArvinas, Inc.	$656M	-8.6%	-10.5%	+47.6%	—	-58.4%	-83.8%	-36.1%
BCABBioAtla, Inc.	$5M	-20.4%	-83.2%	-81.1%	—	-97.2%	-99.8%	-99.7%
BYSIBeyondSpring Inc.	$66M	-4.7%	+1.2%	-23.5%	—	+66.3%	-83.6%	-90.3%
PBYIPuma Biotechnology, Inc.	$379M	+8.1%	+29.1%	+150.0%	—	+132.8%	-23.0%	-68.3%
PFEPfizer Inc.	$150.8B	-4.8%	+7.0%	+23.4%	+7.5pp	-18.4%	-11.3%	+30.7%

Compare:MRSN vs RCUS MRSN vs SNDX MRSN vs AGEN MRSN vs RCUS vs SNDX

About MRSN Dividend Returns

Mersana Therapeutics, Inc. (MRSN) does not currently pay dividends. Many growth-focused companies reinvest profits back into the business rather than distributing them as dividends.

How We Calculate Total Return

Our total return calculator simulates dividend reinvestment (DRIP) by assuming each dividend payment is used to purchase additional shares at the closing price on the ex-dividend date. This methodology provides an accurate representation of how a dividend reinvestment plan would perform.

Frequently Asked Questions

Q1What is the total return of MRSN over the past year?

Mersana Therapeutics, Inc. (MRSN) delivered a return of 266.71% over the past year. Since MRSN does not currently pay dividends, the total return equals the price-only return.

Q2How much would $10,000 invested in MRSN be worth today?

A $10,000 investment in Mersana Therapeutics, Inc. one year ago would be worth $36,671 today, representing a gain of $26,671.

Q3Does MRSN pay dividends?

Mersana Therapeutics, Inc. (MRSN) does not currently pay dividends. Many growth-focused companies reinvest profits back into the business rather than distributing them as dividends. For MRSN, the total return equals the price-only return.

Q4Did MRSN beat the S&P 500?

Yes, Mersana Therapeutics, Inc. (MRSN) outperformed the S&P 500 by 235.39 percentage points over the past year. MRSN delivered a total return of 266.71%, compared to the S&P 500's 31.32%. This 235.39pp alpha means investors in MRSN earned more than a passive S&P 500 index fund.

Q5What is MRSN's worst drawdown?

Mersana Therapeutics, Inc. (MRSN) experienced a maximum drawdown of -41.36% over the past year, declining from its peak on 2025-06-10 to its trough on 2025-08-11. The stock recovered to its prior peak by 2025-10-14. Maximum drawdown measures the worst peak-to-trough decline and is an important risk metric for investors.

Q6What is MRSN's long-term total return over 10, 20, or 30 years?

Here are Mersana Therapeutics, Inc. (MRSN)'s long-term returns with dividends reinvested. Over 10 years, the total return is -91.7% (-22.0% CAGR) — $10,000 would have grown to $831. Over 20 years: -91.7% total return (-11.7% CAGR) — $10,000 → $831. Over 30 years: -91.7% total return (-8.0% CAGR) — $10,000 → $831. Long-term investors benefit from compounding: dividends buy additional shares, which generate their own dividends, creating an exponential growth effect.

Q7What was MRSN's best and worst year?

Mersana Therapeutics, Inc.'s best calendar year was 2020 with a total return of 396.5%. Its worst year was 2021 with a total return of -76.5%. This range shows the volatility investors should expect — the difference between the best and worst year is 473.0 percentage points.