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Stock Comparison

PRE vs EXAS vs NTRA

Revenue, margins, valuation, and 5-year total return — side by side.

Live fundamentals10-year financials5-year price chart
PRE
Prenetics Global Limited

Medical - Diagnostics & Research

HealthcareNASDAQ • HK
Market Cap$242M
5Y Perf.-85.9%
EXAS
Exact Sciences Corporation

Medical - Diagnostics & Research

HealthcareNASDAQ • US
Market Cap$20.02B
5Y Perf.-4.1%
NTRA
Natera, Inc.

Medical - Diagnostics & Research

HealthcareNASDAQ • US
Market Cap$31.16B
5Y Perf.+91.9%

PRE vs EXAS vs NTRA — Key Financials

Market cap, revenue, margins, and valuation side-by-side.

Company Snapshot
PRE logoPRE
EXAS logoEXAS
NTRA logoNTRA
IndustryMedical - Diagnostics & ResearchMedical - Diagnostics & ResearchMedical - Diagnostics & Research
Market Cap$242M$20.02B$31.16B
Revenue (TTM)$69M$3.25B$2.31B
Net Income (TTM)$-47M$-208M$-208M
Gross Margin47.2%69.7%64.8%
Operating Margin-62.9%-6.4%-13.4%
Forward P/E582.8x
Total Debt$2M$2.52B$214M
Cash & Equiv.$32M$956M$1.08B

PRE vs EXAS vs NTRALong-Term Stock Performance

Price return indexed to 100 at period start. Dividends excluded.

PRE
EXAS
NTRA
StockJul 21May 26Return
Prenetics Global Li… (PRE)10014.1-85.9%
Exact Sciences Corp… (EXAS)10095.9-4.1%
Natera, Inc. (NTRA)100191.9+91.9%

Price return only. Dividends and distributions are not included.

Quick Verdict: PRE vs EXAS vs NTRA

Each card shows where this stock fits in a portfolio — not just who wins on paper.

Bottom line: EXAS leads in 4 of 7 categories, making it the strongest pick for valuation and capital efficiency and profitability and margin quality. Prenetics Global Limited is the stronger pick specifically for growth and revenue expansion and recent price momentum and sentiment. As sector peers, any of these can serve as alternatives in the same allocation.
PRE
Prenetics Global Limited
The Growth Play

PRE is the clearest fit if your priority is growth exposure and sleep-well-at-night.

  • Rev growth 201.7%, EPS growth -14.0%, 3Y rev CAGR 91.5%
  • Lower volatility, beta 0.27, Low D/E 1.3%, current ratio 3.01x
  • 201.7% revenue growth vs EXAS's 17.7%
Best for: growth exposure and sleep-well-at-night
EXAS
Exact Sciences Corporation
The Income Pick

EXAS carries the broadest edge in this set and is the clearest fit for income & stability and defensive.

  • beta 0.12
  • Beta 0.12, current ratio 2.43x
  • Better valuation composite
Best for: income & stability and defensive
NTRA
Natera, Inc.
The Long-Run Compounder

NTRA is the clearest fit if your priority is long-term compounding.

  • 20.9% 10Y total return vs EXAS's 16.7%
Best for: long-term compounding
See the full category breakdown
CategoryWinnerWhy
GrowthPRE logoPRE201.7% revenue growth vs EXAS's 17.7%
ValueEXAS logoEXASBetter valuation composite
Quality / MarginsEXAS logoEXAS-6.4% margin vs PRE's -67.4%
Stability / SafetyEXAS logoEXASBeta 0.12 vs NTRA's 1.26
DividendsTieNone of these 3 stocks pay a meaningful dividend
Momentum (1Y)PRE logoPRE+205.2% vs NTRA's +37.3%
Efficiency (ROA)EXAS logoEXAS-3.5% ROA vs PRE's -23.7%, ROIC -3.6% vs -20.8%

PRE vs EXAS vs NTRA — Revenue Breakdown by Segment

How each company's revenue is distributed across its business units

PREPrenetics Global Limited

Segment breakdown not available.

EXASExact Sciences Corporation
FY 2025
Screening
77.9%$2.5B
Precision Oncology
22.1%$717M
NTRANatera, Inc.
FY 2025
Product
99.6%$2.3B
Licensing and other
0.4%$10M

PRE vs EXAS vs NTRA — Financial Metrics

Side-by-side numbers across 3 stocks — who leads on profitability, valuation, growth, and risk.

BEST OVERALLEXASLAGGINGNTRA

Income & Cash Flow (Last 12 Months)

EXAS leads this category, winning 4 of 6 comparable metrics.

EXAS is the larger business by revenue, generating $3.2B annually — 47.0x PRE's $69M. EXAS is the more profitable business, keeping -6.4% of every revenue dollar as net income compared to PRE's -67.4%. On growth, PRE holds the edge at +2.0% YoY revenue growth, suggesting stronger near-term business momentum.

MetricPRE logoPREPrenetics Global …EXAS logoEXASExact Sciences Co…NTRA logoNTRANatera, Inc.
RevenueTrailing 12 months$69M$3.2B$2.3B
EBITDAEarnings before interest/tax-$54M-$41M-$310M
Net IncomeAfter-tax profit-$47M-$208M-$208M
Free Cash FlowCash after capex$0$357M$97M
Gross MarginGross profit ÷ Revenue+47.2%+69.7%+64.8%
Operating MarginEBIT ÷ Revenue-62.9%-6.4%-13.4%
Net MarginNet income ÷ Revenue-67.4%-6.4%-9.0%
FCF MarginFCF ÷ Revenue-23.8%+11.0%+4.2%
Rev. Growth (YoY)Latest quarter vs prior year+2.0%+23.1%+39.8%
EPS Growth (YoY)Latest quarter vs prior year+36.9%+90.4%+185.4%
EXAS leads this category, winning 4 of 6 comparable metrics.

Valuation Metrics

PRE leads this category, winning 2 of 4 comparable metrics.
MetricPRE logoPREPrenetics Global …EXAS logoEXASExact Sciences Co…NTRA logoNTRANatera, Inc.
Market CapShares × price$242M$20.0B$31.2B
Enterprise ValueMkt cap + debt − cash$212M$21.6B$30.3B
Trailing P/EPrice ÷ TTM EPS-3.82x-95.37x-144.62x
Forward P/EPrice ÷ next-FY EPS est.582.83x
PEG RatioP/E ÷ EPS growth rate
EV / EBITDAEnterprise value multiple
Price / SalesMarket cap ÷ Revenue2.62x6.16x13.51x
Price / BookPrice ÷ Book value/share1.28x8.24x17.55x
Price / FCFMarket cap ÷ FCF56.10x285.53x
PRE leads this category, winning 2 of 4 comparable metrics.

Profitability & Efficiency

EXAS leads this category, winning 6 of 9 comparable metrics.

EXAS delivers a -8.7% return on equity — every $100 of shareholder capital generates $-9 in annual profit, vs $-29 for PRE. PRE carries lower financial leverage with a 0.01x debt-to-equity ratio, signaling a more conservative balance sheet compared to EXAS's 1.05x. On the Piotroski fundamental quality scale (0–9), EXAS scores 7/9 vs NTRA's 5/9, reflecting strong financial health.

MetricPRE logoPREPrenetics Global …EXAS logoEXASExact Sciences Co…NTRA logoNTRANatera, Inc.
ROE (TTM)Return on equity-28.9%-8.7%-15.3%
ROA (TTM)Return on assets-23.7%-3.5%-10.6%
ROICReturn on invested capital-20.8%-3.6%-36.1%
ROCEReturn on capital employed-21.2%-4.0%-18.3%
Piotroski ScoreFundamental quality 0–9575
Debt / EquityFinancial leverage0.01x1.05x0.13x
Net DebtTotal debt minus cash-$30M$1.6B-$862M
Cash & Equiv.Liquid assets$32M$956M$1.1B
Total DebtShort + long-term debt$2M$2.5B$214M
Interest CoverageEBIT ÷ Interest expense-199.93x-5.47x-25.21x
EXAS leads this category, winning 6 of 9 comparable metrics.

Total Returns (Dividends Reinvested)

NTRA leads this category, winning 4 of 6 comparable metrics.

A $10,000 investment in NTRA five years ago would be worth $21,587 today (with dividends reinvested), compared to $1,393 for PRE. Over the past 12 months, PRE leads with a +205.2% total return vs NTRA's +37.3%. The 3-year compound annual growth rate (CAGR) favors NTRA at 60.6% vs PRE's 7.6% — a key indicator of consistent wealth creation.

MetricPRE logoPREPrenetics Global …EXAS logoEXASExact Sciences Co…NTRA logoNTRANatera, Inc.
YTD ReturnYear-to-date+0.6%+3.1%-3.9%
1-Year ReturnPast 12 months+205.2%+96.9%+37.3%
3-Year ReturnCumulative with dividends+24.5%+53.0%+314.0%
5-Year ReturnCumulative with dividends-86.1%+0.4%+115.9%
10-Year ReturnCumulative with dividends-86.1%+1669.1%+2089.4%
CAGR (3Y)Annualised 3-year return+7.6%+15.2%+60.6%
NTRA leads this category, winning 4 of 6 comparable metrics.

Risk & Volatility

EXAS leads this category, winning 2 of 2 comparable metrics.

EXAS is the less volatile stock with a 0.12 beta — it tends to amplify market swings less than NTRA's 1.26 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. EXAS currently trades 99.9% from its 52-week high vs PRE's 67.2% drawdown — a narrower gap to the peak suggests stronger recent price momentum.

MetricPRE logoPREPrenetics Global …EXAS logoEXASExact Sciences Co…NTRA logoNTRANatera, Inc.
Beta (5Y)Sensitivity to S&P 5000.27x0.12x1.26x
52-Week HighHighest price in past year$23.63$104.98$256.36
52-Week LowLowest price in past year$5.07$38.81$131.81
% of 52W HighCurrent price vs 52-week peak+67.2%+99.9%+85.7%
RSI (14)Momentum oscillator 0–10037.176.457.1
Avg Volume (50D)Average daily shares traded186K4.2M1.3M
EXAS leads this category, winning 2 of 2 comparable metrics.

Analyst Outlook

Insufficient data to determine a leader in this category.

Analyst consensus: PRE as "Buy", EXAS as "Buy", NTRA as "Buy". Consensus price targets imply 126.8% upside for PRE (target: $36) vs -1.6% for EXAS (target: $103).

MetricPRE logoPREPrenetics Global …EXAS logoEXASExact Sciences Co…NTRA logoNTRANatera, Inc.
Analyst RatingConsensus buy/hold/sellBuyBuyBuy
Price TargetConsensus 12-month target$36.00$103.18$262.50
# AnalystsCovering analysts14127
Dividend YieldAnnual dividend ÷ price
Dividend StreakConsecutive years of raises
Dividend / ShareAnnual DPS
Buyback YieldShare repurchases ÷ mkt cap0.0%+0.1%0.0%
Insufficient data to determine a leader in this category.
Key Takeaway

EXAS leads in 3 of 6 categories (Income & Cash Flow, Profitability & Efficiency). PRE leads in 1 (Valuation Metrics).

Best OverallExact Sciences Corporation (EXAS)Leads 3 of 6 categories
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PRE vs EXAS vs NTRA: Key Questions Answered

9 questions · data-driven answers · updated daily

01

Is PRE or EXAS or NTRA a better buy right now?

For growth investors, Prenetics Global Limited (PRE) is the stronger pick with 201.

7% revenue growth year-over-year, versus 17. 7% for Exact Sciences Corporation (EXAS). Analysts rate Prenetics Global Limited (PRE) a "Buy" — based on 1 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.

02

Which is the better long-term investment — PRE or EXAS or NTRA?

Over the past 5 years, Natera, Inc.

(NTRA) delivered a total return of +115. 9%, compared to -86. 1% for Prenetics Global Limited (PRE). Over 10 years, the gap is even starker: NTRA returned +20. 9% versus PRE's -86. 1%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.

03

Which is safer — PRE or EXAS or NTRA?

By beta (market sensitivity over 5 years), Exact Sciences Corporation (EXAS) is the lower-risk stock at 0.

12β versus Natera, Inc. 's 1. 26β — meaning NTRA is approximately 943% more volatile than EXAS relative to the S&P 500. On balance sheet safety, Prenetics Global Limited (PRE) carries a lower debt/equity ratio of 1% versus 105% for Exact Sciences Corporation — giving it more financial flexibility in a downturn.

04

Which is growing faster — PRE or EXAS or NTRA?

By revenue growth (latest reported year), Prenetics Global Limited (PRE) is pulling ahead at 201.

7% versus 17. 7% for Exact Sciences Corporation (EXAS). On earnings-per-share growth, the picture is similar: Exact Sciences Corporation grew EPS 80. 3% year-over-year, compared to -14. 0% for Prenetics Global Limited. Over a 3-year CAGR, PRE leads at 91. 5% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.

05

Which has better profit margins — PRE or EXAS or NTRA?

Exact Sciences Corporation (EXAS) is the more profitable company, earning -6.

4% net margin versus -63. 1% for Prenetics Global Limited — meaning it keeps -6. 4% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: EXAS leads at -6. 4% versus -40. 5% for PRE. At the gross margin level — before operating expenses — EXAS leads at 69. 7%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.

06

Is PRE or EXAS or NTRA more undervalued right now?

Analyst consensus price targets imply the most upside for PRE: 126.

8% to $36. 00.

07

Which pays a better dividend — PRE or EXAS or NTRA?

None of the stocks in this comparison currently pay a material dividend.

All are effectively zero-yield and should be held for capital appreciation rather than income.

08

Is PRE or EXAS or NTRA better for a retirement portfolio?

For long-horizon retirement investors, Exact Sciences Corporation (EXAS) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0.

12), +1669% 10Y return). Both have compounded well over 10 years (EXAS: +1669%, NTRA: +20. 9%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.

09

What are the main differences between PRE and EXAS and NTRA?

Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both.

These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.

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