ANNX vs BEAM

Analysts rate Annexon, Inc.

(ANNX) a "Buy" — based on 10 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.

Over the past 5 years, Beam Therapeutics Inc.

(BEAM) delivered a total return of -53. 9%, compared to -71. 2% for Annexon, Inc. (ANNX). Over 10 years, the gap is even starker: BEAM returned +72. 4% versus ANNX's -67. 9%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.

By beta (market sensitivity over 5 years), Beam Therapeutics Inc.

(BEAM) is the lower-risk stock at 2. 14β versus Annexon, Inc. 's 2. 25β — meaning ANNX is approximately 5% more volatile than BEAM relative to the S&P 500. On balance sheet safety, Annexon, Inc. (ANNX) carries a lower debt/equity ratio of 10% versus 24% for Beam Therapeutics Inc. — giving it more financial flexibility in a downturn.

On earnings-per-share growth, the picture is similar: Beam Therapeutics Inc.

grew EPS 82. 3% year-over-year, compared to 42. 9% for Annexon, Inc.. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.

Annexon, Inc.

(ANNX) is the more profitable company, earning 0. 0% net margin versus -57. 2% for Beam Therapeutics Inc. — meaning it keeps 0. 0% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: ANNX leads at 0. 0% versus -274. 6% for BEAM. At the gross margin level — before operating expenses — BEAM leads at 84. 0%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.

None of the stocks in this comparison currently pay a material dividend.

All are effectively zero-yield and should be held for capital appreciation rather than income.

For long-horizon retirement investors, Beam Therapeutics Inc.

(BEAM) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding. Annexon, Inc. (ANNX) carries a higher beta of 2. 25 — meaning larger drawdowns in market downturns, which matters significantly when you cannot wait years for a recovery. Both have compounded well over 10 years (BEAM: +72. 4%, ANNX: -67. 9%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.

Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both.

In terms of investment character: ANNX is a small-cap quality compounder stock; BEAM is a small-cap high-growth stock. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.