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CTMX vs IMVT vs RCUS vs ALXO vs KYMR

Revenue, margins, valuation, and 5-year total return — side by side.

Live fundamentals10-year financials5-year price chart
CTMX
CytomX Therapeutics, Inc.

Biotechnology

HealthcareNASDAQ • US
Market Cap$681M
5Y Perf.-45.2%
IMVT
Immunovant, Inc.

Biotechnology

HealthcareNASDAQ • US
Market Cap$5.53B
5Y Perf.-19.8%
RCUS
Arcus Biosciences, Inc.

Biotechnology

HealthcareNYSE • US
Market Cap$2.50B
5Y Perf.+4.2%
ALXO
ALX Oncology Holdings Inc.

Biotechnology

HealthcareNASDAQ • US
Market Cap$100M
5Y Perf.-95.4%
KYMR
Kymera Therapeutics, Inc.

Biotechnology

HealthcareNASDAQ • US
Market Cap$6.91B
5Y Perf.+165.3%

CTMX vs IMVT vs RCUS vs ALXO vs KYMR — Key Financials

Market cap, revenue, margins, and valuation side-by-side.

Company Snapshot
CTMX logoCTMX
IMVT logoIMVT
RCUS logoRCUS
ALXO logoALXO
KYMR logoKYMR
IndustryBiotechnologyBiotechnologyBiotechnologyBiotechnologyBiotechnology
Market Cap$681M$5.53B$2.50B$100M$6.91B
Revenue (TTM)$36M$0.00$236M$0.00$51M
Net Income (TTM)$-59M$-464M$-369M$-108M$-315M
Gross Margin69.7%90.7%33.2%
Operating Margin-181.9%-168.6%-7.0%
Total Debt$4M$98K$99M$17M$82M
Cash & Equiv.$13M$714M$222M$18M$357M

CTMX vs IMVT vs RCUS vs ALXO vs KYMRLong-Term Stock Performance

Price return indexed to 100 at period start. Dividends excluded.

CTMX
IMVT
RCUS
ALXO
KYMR
StockAug 20May 26Return
CytomX Therapeutics… (CTMX)10054.8-45.2%
Immunovant, Inc. (IMVT)10080.2-19.8%
Arcus Biosciences, … (RCUS)100104.2+4.2%
ALX Oncology Holdin… (ALXO)1004.6-95.4%
Kymera Therapeutics… (KYMR)100265.3+165.3%

Price return only. Dividends and distributions are not included.

Quick Verdict: CTMX vs IMVT vs RCUS vs ALXO vs KYMR

Each card shows where this stock fits in a portfolio — not just who wins on paper.

Bottom line: CTMX and ALXO are tied at the top with 2 categories each (5-stock set) — the right choice depends on your priorities. ALX Oncology Holdings Inc. is the stronger pick specifically for growth and revenue expansion and profitability and margin quality. KYMR also leads in specific categories worth noting. As sector peers, any of these can serve as alternatives in the same allocation.
CTMX
CytomX Therapeutics, Inc.
The Income Pick

CTMX carries the broadest edge in this set and is the clearest fit for dividends and momentum.

  • 0.5% yield; the other 4 pay no meaningful dividend
  • +316.4% vs IMVT's +96.1%
Best for: dividends and momentum
IMVT
Immunovant, Inc.
The Long-Run Compounder

IMVT is the clearest fit if your priority is long-term compounding and sleep-well-at-night.

  • 173.6% 10Y total return vs KYMR's 154.4%
  • Lower volatility, beta 1.37, Low D/E 0.0%, current ratio 11.16x
Best for: long-term compounding and sleep-well-at-night
RCUS
Arcus Biosciences, Inc.
The Growth Play

RCUS is the clearest fit if your priority is growth exposure.

  • Rev growth -4.3%, EPS growth -4.8%, 3Y rev CAGR 30.2%
Best for: growth exposure
ALXO
ALX Oncology Holdings Inc.
The Growth Leader

ALXO is the #2 pick in this set and the best alternative if growth and quality is your priority.

  • 28.6% revenue growth vs CTMX's -44.8%
  • 5.2% margin vs KYMR's -6.1%
Best for: growth and quality
KYMR
Kymera Therapeutics, Inc.
The Income Pick

KYMR ranks third and is worth considering specifically for income & stability and defensive.

  • beta 1.15
  • Beta 1.15, current ratio 10.47x
  • Beta 1.15 vs RCUS's 1.95, lower leverage
  • -22.3% ROA vs ALXO's -130.6%, ROIC -24.9% vs -71.8%
Best for: income & stability and defensive
See the full category breakdown
CategoryWinnerWhy
GrowthALXO logoALXO28.6% revenue growth vs CTMX's -44.8%
Quality / MarginsALXO logoALXO5.2% margin vs KYMR's -6.1%
Stability / SafetyKYMR logoKYMRBeta 1.15 vs RCUS's 1.95, lower leverage
DividendsCTMX logoCTMX0.5% yield; the other 4 pay no meaningful dividend
Momentum (1Y)CTMX logoCTMX+316.4% vs IMVT's +96.1%
Efficiency (ROA)KYMR logoKYMR-22.3% ROA vs ALXO's -130.6%, ROIC -24.9% vs -71.8%

CTMX vs IMVT vs RCUS vs ALXO vs KYMR — Revenue Breakdown by Segment

How each company's revenue is distributed across its business units

CTMXCytomX Therapeutics, Inc.

Segment breakdown not available.

IMVTImmunovant, Inc.

Segment breakdown not available.

RCUSArcus Biosciences, Inc.
FY 2025
License And Development Services
87.4%$221M
Development Services
6.7%$17M
R&D Services
3.2%$8M
License
2.8%$7M
ALXOALX Oncology Holdings Inc.

Segment breakdown not available.

KYMRKymera Therapeutics, Inc.

Segment breakdown not available.

CTMX vs IMVT vs RCUS vs ALXO vs KYMR — Financial Metrics

Side-by-side numbers across 5 stocks — who leads on profitability, valuation, growth, and risk.

BEST OVERALLKYMRLAGGINGALXO

Income & Cash Flow (Last 12 Months)

RCUS leads this category, winning 4 of 6 comparable metrics.

RCUS and ALXO operate at a comparable scale, with $236M and $0 in trailing revenue. Profitability is closely matched — net margins range from -156.4% (RCUS) to -6.1% (KYMR). On growth, KYMR holds the edge at +55.5% YoY revenue growth, suggesting stronger near-term business momentum.

MetricCTMX logoCTMXCytomX Therapeuti…IMVT logoIMVTImmunovant, Inc.RCUS logoRCUSArcus Biosciences…ALXO logoALXOALX Oncology Hold…KYMR logoKYMRKymera Therapeuti…
RevenueTrailing 12 months$36M$0$236M$0$51M
EBITDAEarnings before interest/tax-$64M-$487M-$391M-$111M-$352M
Net IncomeAfter-tax profit-$59M-$464M-$369M-$108M-$315M
Free Cash FlowCash after capex-$80M-$423M-$489M-$97M-$244M
Gross MarginGross profit ÷ Revenue+69.7%+90.7%+33.2%
Operating MarginEBIT ÷ Revenue-181.9%-168.6%-7.0%
Net MarginNet income ÷ Revenue-166.4%-156.4%-6.1%
FCF MarginFCF ÷ Revenue-2.3%-2.1%-4.7%
Rev. Growth (YoY)Latest quarter vs prior year-79.9%-39.3%+55.5%
EPS Growth (YoY)Latest quarter vs prior year-137.0%+19.7%+10.5%+29.3%+13.4%
RCUS leads this category, winning 4 of 6 comparable metrics.

Valuation Metrics

CTMX leads this category, winning 2 of 3 comparable metrics.
MetricCTMX logoCTMXCytomX Therapeuti…IMVT logoIMVTImmunovant, Inc.RCUS logoRCUSArcus Biosciences…ALXO logoALXOALX Oncology Hold…KYMR logoKYMRKymera Therapeuti…
Market CapShares × price$681M$5.5B$2.5B$100M$6.9B
Enterprise ValueMkt cap + debt − cash$673M$4.8B$2.4B$100M$6.6B
Trailing P/EPrice ÷ TTM EPS-26.67x-9.97x-7.54x-0.72x-22.93x
Forward P/EPrice ÷ next-FY EPS est.
PEG RatioP/E ÷ EPS growth rate
EV / EBITDAEnterprise value multiple
Price / SalesMarket cap ÷ Revenue8.94x10.11x176.26x
Price / BookPrice ÷ Book value/share5.57x5.83x4.22x0.86x4.52x
Price / FCFMarket cap ÷ FCF
CTMX leads this category, winning 2 of 3 comparable metrics.

Profitability & Efficiency

KYMR leads this category, winning 5 of 9 comparable metrics.

KYMR delivers a -25.0% return on equity — every $100 of shareholder capital generates $-25 in annual profit, vs $-2 for ALXO. IMVT carries lower financial leverage with a 0.00x debt-to-equity ratio, signaling a more conservative balance sheet compared to RCUS's 0.16x. On the Piotroski fundamental quality scale (0–9), KYMR scores 4/9 vs RCUS's 0/9, reflecting mixed financial health.

MetricCTMX logoCTMXCytomX Therapeuti…IMVT logoIMVTImmunovant, Inc.RCUS logoRCUSArcus Biosciences…ALXO logoALXOALX Oncology Hold…KYMR logoKYMRKymera Therapeuti…
ROE (TTM)Return on equity-36.6%-47.1%-69.0%-2.4%-25.0%
ROA (TTM)Return on assets-28.0%-44.1%-35.3%-130.6%-22.3%
ROICReturn on invested capital-47.7%-64.1%-71.8%-24.9%
ROCEReturn on capital employed-28.0%-66.1%-42.1%-84.8%-27.2%
Piotroski ScoreFundamental quality 0–922024
Debt / EquityFinancial leverage0.04x0.00x0.16x0.15x0.05x
Net DebtTotal debt minus cash-$8M-$714M-$123M-$589,000-$275M
Cash & Equiv.Liquid assets$13M$714M$222M$18M$357M
Total DebtShort + long-term debt$4M$98,000$99M$17M$82M
Interest CoverageEBIT ÷ Interest expense-13.38x-64.62x-2119.53x
KYMR leads this category, winning 5 of 9 comparable metrics.

Total Returns (Dividends Reinvested)

KYMR leads this category, winning 3 of 6 comparable metrics.

A $10,000 investment in KYMR five years ago would be worth $19,212 today (with dividends reinvested), compared to $288 for ALXO. Over the past 12 months, CTMX leads with a +316.4% total return vs IMVT's +96.1%. The 3-year compound annual growth rate (CAGR) favors KYMR at 45.0% vs ALXO's -32.7% — a key indicator of consistent wealth creation.

MetricCTMX logoCTMXCytomX Therapeuti…IMVT logoIMVTImmunovant, Inc.RCUS logoRCUSArcus Biosciences…ALXO logoALXOALX Oncology Hold…KYMR logoKYMRKymera Therapeuti…
YTD ReturnYear-to-date-5.9%+5.1%+6.5%+62.6%+16.3%
1-Year ReturnPast 12 months+316.4%+96.1%+209.6%+286.3%+190.7%
3-Year ReturnCumulative with dividends+138.1%+40.9%+24.9%-69.5%+205.1%
5-Year ReturnCumulative with dividends-53.2%+62.4%-18.6%-97.1%+92.1%
10-Year ReturnCumulative with dividends-66.9%+173.6%+45.9%-93.8%+154.4%
CAGR (3Y)Annualised 3-year return+33.5%+12.1%+7.7%-32.7%+45.0%
KYMR leads this category, winning 3 of 6 comparable metrics.

Risk & Volatility

Evenly matched — IMVT and KYMR each lead in 1 of 2 comparable metrics.

KYMR is the less volatile stock with a 1.15 beta — it tends to amplify market swings less than RCUS's 1.95 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. IMVT currently trades 90.5% from its 52-week high vs CTMX's 48.8% drawdown — a narrower gap to the peak suggests stronger recent price momentum.

MetricCTMX logoCTMXCytomX Therapeuti…IMVT logoIMVTImmunovant, Inc.RCUS logoRCUSArcus Biosciences…ALXO logoALXOALX Oncology Hold…KYMR logoKYMRKymera Therapeuti…
Beta (5Y)Sensitivity to S&P 5001.48x1.37x1.95x1.44x1.15x
52-Week HighHighest price in past year$8.20$30.09$28.72$2.66$103.00
52-Week LowLowest price in past year$0.91$13.36$7.06$0.40$28.06
% of 52W HighCurrent price vs 52-week peak+48.8%+90.5%+86.3%+70.3%+82.2%
RSI (14)Momentum oscillator 0–10041.360.260.564.054.1
Avg Volume (50D)Average daily shares traded7.2M1.4M1.2M927K602K
Evenly matched — IMVT and KYMR each lead in 1 of 2 comparable metrics.

Analyst Outlook

Insufficient data to determine a leader in this category.

Analyst consensus: CTMX as "Buy", IMVT as "Buy", RCUS as "Buy", ALXO as "Buy", KYMR as "Buy". Consensus price targets imply 190.0% upside for CTMX (target: $12) vs 21.0% for RCUS (target: $30). CTMX is the only dividend payer here at 0.54% yield — a key consideration for income-focused portfolios.

MetricCTMX logoCTMXCytomX Therapeuti…IMVT logoIMVTImmunovant, Inc.RCUS logoRCUSArcus Biosciences…ALXO logoALXOALX Oncology Hold…KYMR logoKYMRKymera Therapeuti…
Analyst RatingConsensus buy/hold/sellBuyBuyBuyBuyBuy
Price TargetConsensus 12-month target$11.60$45.50$30.00$4.00$117.06
# AnalystsCovering analysts212318726
Dividend YieldAnnual dividend ÷ price+0.5%
Dividend StreakConsecutive years of raises0
Dividend / ShareAnnual DPS$0.02
Buyback YieldShare repurchases ÷ mkt cap0.0%0.0%0.0%0.0%0.0%
Insufficient data to determine a leader in this category.
Key Takeaway

KYMR leads in 2 of 6 categories (Profitability & Efficiency, Total Returns). RCUS leads in 1 (Income & Cash Flow). 1 tied.

Best OverallKymera Therapeutics, Inc. (KYMR)Leads 2 of 6 categories
Loading custom metrics...

CTMX vs IMVT vs RCUS vs ALXO vs KYMR: Key Questions Answered

8 questions · data-driven answers · updated daily

01

Is CTMX or IMVT or RCUS or ALXO or KYMR a better buy right now?

For growth investors, Arcus Biosciences, Inc.

(RCUS) is the stronger pick with -4. 3% revenue growth year-over-year, versus -44. 8% for CytomX Therapeutics, Inc. (CTMX). Analysts rate CytomX Therapeutics, Inc. (CTMX) a "Buy" — based on 21 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.

02

Which is the better long-term investment — CTMX or IMVT or RCUS or ALXO or KYMR?

Over the past 5 years, Kymera Therapeutics, Inc.

(KYMR) delivered a total return of +92. 1%, compared to -97. 1% for ALX Oncology Holdings Inc. (ALXO). Over 10 years, the gap is even starker: IMVT returned +173. 6% versus ALXO's -93. 8%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.

03

Which is safer — CTMX or IMVT or RCUS or ALXO or KYMR?

By beta (market sensitivity over 5 years), Kymera Therapeutics, Inc.

(KYMR) is the lower-risk stock at 1. 15β versus Arcus Biosciences, Inc. 's 1. 95β — meaning RCUS is approximately 70% more volatile than KYMR relative to the S&P 500. On balance sheet safety, Immunovant, Inc. (IMVT) carries a lower debt/equity ratio of 0% versus 16% for Arcus Biosciences, Inc. — giving it more financial flexibility in a downturn.

04

Which is growing faster — CTMX or IMVT or RCUS or ALXO or KYMR?

By revenue growth (latest reported year), Arcus Biosciences, Inc.

(RCUS) is pulling ahead at -4. 3% versus -44. 8% for CytomX Therapeutics, Inc. (CTMX). On earnings-per-share growth, the picture is similar: ALX Oncology Holdings Inc. grew EPS 31. 0% year-over-year, compared to -139. 5% for CytomX Therapeutics, Inc.. Over a 3-year CAGR, RCUS leads at 30. 2% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.

05

Which has better profit margins — CTMX or IMVT or RCUS or ALXO or KYMR?

Immunovant, Inc.

(IMVT) is the more profitable company, earning 0. 0% net margin versus -794. 4% for Kymera Therapeutics, Inc. — meaning it keeps 0. 0% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: IMVT leads at 0. 0% versus -891. 3% for KYMR. At the gross margin level — before operating expenses — CTMX leads at 100. 0%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.

06

Which pays a better dividend — CTMX or IMVT or RCUS or ALXO or KYMR?

In this comparison, CTMX (0.

5% yield) pays a dividend. IMVT, RCUS, ALXO, KYMR do not pay a meaningful dividend and should not be held primarily for income.

07

Is CTMX or IMVT or RCUS or ALXO or KYMR better for a retirement portfolio?

For long-horizon retirement investors, CytomX Therapeutics, Inc.

(CTMX) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (0. 5% yield). Arcus Biosciences, Inc. (RCUS) carries a higher beta of 1. 95 — meaning larger drawdowns in market downturns, which matters significantly when you cannot wait years for a recovery. Both have compounded well over 10 years (CTMX: -66. 9%, RCUS: +45. 9%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.

08

What are the main differences between CTMX and IMVT and RCUS and ALXO and KYMR?

Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both.

CTMX pays a dividend while IMVT, RCUS, ALXO, KYMR do not, making them suitable for different income and tax situations. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.

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