FOLD
Amicus Therapeutics, Inc.
Biotechnology
Market Cap$4.47B
5Y Perf.+16.2%
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Stock Comparison
FOLD vs IQV
Revenue, margins, valuation, and 5-year total return — side by side.
IQV
IQVIA Holdings Inc.
Medical - Diagnostics & Research
Market Cap$29.95B
5Y Perf.+14.1%
FOLD vs IQV — Key Financials
Market cap, revenue, margins, and valuation side-by-side.
| Company Snapshot | FOLD | IQV |
|---|---|---|
| Industry | Biotechnology | Medical - Diagnostics & Research |
| Market Cap | $4.47B | $29.95B |
| Revenue (TTM) | $599M | $16.63B |
| Net Income (TTM) | $-14M | $1.39B |
| Gross Margin | 89.5% | 26.1% |
| Operating Margin | 5.5% | 13.9% |
| Forward P/E | 40.6x | 13.9x |
| Total Debt | $444M | $16.17B |
| Cash & Equiv. | $214M | $1.98B |
FOLD vs IQV — Long-Term Stock Performance
Price return indexed to 100 at period start. Dividends excluded.
FOLD
IQV
| Stock | May 20 | Apr 26 | Return |
|---|---|---|---|
| Amicus Therapeutics… (FOLD) | 100 | 116.2 | +16.2% |
| IQVIA Holdings Inc. (IQV) | 100 | 114.1 | +14.1% |
Price return only. Dividends and distributions are not included.
Quick Verdict: FOLD vs IQV
Each card shows where this stock fits in a portfolio — not just who wins on paper.
Bottom line: FOLD and IQV are tied at the top with 3 categories each — the right choice depends on your priorities. IQVIA Holdings Inc. is the stronger pick specifically for valuation and capital efficiency and profitability and margin quality. As sector peers, any of these can serve as alternatives in the same allocation.
FOLD
Amicus Therapeutics, Inc.
The Income Pick
FOLD has the current edge in this matchup, primarily because of its strength in income & stability and growth exposure.
- beta 0.63
- Rev growth 32.3%, EPS growth 64.7%, 3Y rev CAGR 20.0%
- Lower volatility, beta 0.63, current ratio 3.39x
Best for: income & stability and growth exposure
IQV
IQVIA Holdings Inc.
The Long-Run Compounder
IQV is the clearest fit if your priority is long-term compounding.
- 167.5% 10Y total return vs FOLD's 125.0%
- Lower P/E (13.9x vs 40.6x)
- 8.3% margin vs FOLD's -2.3%
Best for: long-term compounding
See the full category breakdown
| Category | Winner | Why |
|---|---|---|
| Growth | FOLD | 32.3% revenue growth vs IQV's 5.9% |
| Value | IQV | Lower P/E (13.9x vs 40.6x) |
| Quality / Margins | IQV | 8.3% margin vs FOLD's -2.3% |
| Stability / Safety | FOLD | Beta 0.63 vs IQV's 1.33, lower leverage |
| Dividends | Tie | Neither stock pays a meaningful dividend |
| Momentum (1Y) | FOLD | +134.1% vs IQV's +20.7% |
| Efficiency (ROA) | IQV | 4.7% ROA vs FOLD's -1.6%, ROIC 8.7% vs 4.8% |
FOLD vs IQV — Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
FY 2025
FOLD vs IQV — Financial Metrics
Side-by-side numbers across 2 stocks — who leads on profitability, valuation, growth, and risk.
BEST OVERALLFOLDLAGGINGIQV
IQVIQVIA Holdings Inc.
2leads
FOLDAmicus Therapeutics, …
2leads
6 Total Categories
CATEGORYLEADERvs IQVMETRICS WON
Income & Cash FlowRevenue, margins, and cash flow strength
Tied
—
Valuation MetricsMultiples, price ratios, and targets
IQV4/5
Profitability & EfficiencyROE, ROIC, leverage, and quality scores
IQV5/9
Total Returns1Y, 3Y, 5Y total returns with dividends
FOLD5/6
Risk & VolatilityBeta, volatility, and downside exposure
FOLD2/2
Analyst OutlookRatings, price targets, and dividends
—
—
Income & Cash Flow (Last 12 Months)
Evenly matched — FOLD and IQV each lead in 3 of 6 comparable metrics.
Income & Cash Flow (Last 12 Months)
IQV is the larger business by revenue, generating $16.6B annually — 27.8x FOLD's $599M. IQV is the more profitable business, keeping 8.3% of every revenue dollar as net income compared to FOLD's -2.3%. On growth, FOLD holds the edge at +19.5% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | FOLDAmicus Therapeuti… | IQVIQVIA Holdings In… |
|---|---|---|
| RevenueTrailing 12 months | $599M | $16.6B |
| EBITDAEarnings before interest/tax | $40M | $3.5B |
| Net IncomeAfter-tax profit | -$14M | $1.4B |
| Free Cash FlowCash after capex | $10M | $2.7B |
| Gross MarginGross profit ÷ Revenue | +89.5% | +26.1% |
| Operating MarginEBIT ÷ Revenue | +5.5% | +13.9% |
| Net MarginNet income ÷ Revenue | -2.3% | +8.3% |
| FCF MarginFCF ÷ Revenue | +1.6% | +16.1% |
| Rev. Growth (YoY)Latest quarter vs prior year | +19.5% | +8.4% |
| EPS Growth (YoY)Latest quarter vs prior year | +3.8% | +15.0% |
Evenly matched — FOLD and IQV each lead in 3 of 6 comparable metrics.
Valuation Metrics
IQV leads this category, winning 4 of 5 comparable metrics.
Valuation Metrics
On an enterprise value basis, IQV's 12.9x EV/EBITDA is more attractive than FOLD's 140.6x.
| Metric | FOLDAmicus Therapeuti… | IQVIQVIA Holdings In… |
|---|---|---|
| Market CapShares × price | $4.5B | $29.9B |
| Enterprise ValueMkt cap + debt − cash | $4.7B | $44.1B |
| Trailing P/EPrice ÷ TTM EPS | -80.50x | 22.51x |
| Forward P/EPrice ÷ next-FY EPS est. | 40.62x | 13.89x |
| PEG RatioP/E ÷ EPS growth rate | — | 0.56x |
| EV / EBITDAEnterprise value multiple | 140.62x | 12.87x |
| Price / SalesMarket cap ÷ Revenue | 8.46x | 1.84x |
| Price / BookPrice ÷ Book value/share | 22.73x | 4.62x |
| Price / FCFMarket cap ÷ FCF | — | 14.60x |
IQV leads this category, winning 4 of 5 comparable metrics.
Profitability & Efficiency
IQV leads this category, winning 5 of 9 comparable metrics.
Profitability & Efficiency
IQV delivers a 22.1% return on equity — every $100 of shareholder capital generates $22 in annual profit, vs $-6 for FOLD. FOLD carries lower financial leverage with a 2.29x debt-to-equity ratio, signaling a more conservative balance sheet compared to IQV's 2.44x. On the Piotroski fundamental quality scale (0–9), FOLD scores 5/9 vs IQV's 4/9, reflecting solid financial health.
| Metric | FOLDAmicus Therapeuti… | IQVIQVIA Holdings In… |
|---|---|---|
| ROE (TTM)Return on equity | -6.1% | +22.1% |
| ROA (TTM)Return on assets | -1.6% | +4.7% |
| ROICReturn on invested capital | +4.8% | +8.7% |
| ROCEReturn on capital employed | +4.0% | +11.0% |
| Piotroski ScoreFundamental quality 0–9 | 5 | 4 |
| Debt / EquityFinancial leverage | 2.29x | 2.44x |
| Net DebtTotal debt minus cash | $230M | $14.2B |
| Cash & Equiv.Liquid assets | $214M | $2.0B |
| Total DebtShort + long-term debt | $444M | $16.2B |
| Interest CoverageEBIT ÷ Interest expense | 1.11x | 3.10x |
IQV leads this category, winning 5 of 9 comparable metrics.
Total Returns (Dividends Reinvested)
FOLD leads this category, winning 5 of 6 comparable metrics.
Total Returns (Dividends Reinvested)
A $10,000 investment in FOLD five years ago would be worth $15,094 today (with dividends reinvested), compared to $7,632 for IQV. Over the past 12 months, FOLD leads with a +134.1% total return vs IQV's +20.7%. The 3-year compound annual growth rate (CAGR) favors FOLD at 6.0% vs IQV's -2.4% — a key indicator of consistent wealth creation.
| Metric | FOLDAmicus Therapeuti… | IQVIQVIA Holdings In… |
|---|---|---|
| YTD ReturnYear-to-date | +1.5% | -21.7% |
| 1-Year ReturnPast 12 months | +134.1% | +20.7% |
| 3-Year ReturnCumulative with dividends | +19.0% | -7.0% |
| 5-Year ReturnCumulative with dividends | +50.9% | -23.7% |
| 10-Year ReturnCumulative with dividends | +125.0% | +167.5% |
| CAGR (3Y)Annualised 3-year return | +6.0% | -2.4% |
FOLD leads this category, winning 5 of 6 comparable metrics.
Risk & Volatility
FOLD leads this category, winning 2 of 2 comparable metrics.
Risk & Volatility
FOLD is the less volatile stock with a 0.63 beta — it tends to amplify market swings less than IQV's 1.33 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. FOLD currently trades 99.9% from its 52-week high vs IQV's 71.4% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | FOLDAmicus Therapeuti… | IQVIQVIA Holdings In… |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 0.63x | 1.33x |
| 52-Week HighHighest price in past year | $14.50 | $247.05 |
| 52-Week LowLowest price in past year | $5.51 | $134.65 |
| % of 52W HighCurrent price vs 52-week peak | +99.9% | +71.4% |
| RSI (14)Momentum oscillator 0–100 | 72.2 | 58.4 |
| Avg Volume (50D)Average daily shares traded | 3.0M | 1.6M |
FOLD leads this category, winning 2 of 2 comparable metrics.
Analyst Outlook
Insufficient data to determine a leader in this category.
Analyst Outlook
Wall Street rates FOLD as "Buy" and IQV as "Buy". Consensus price targets imply 27.9% upside for IQV (target: $226) vs 0.1% for FOLD (target: $15).
| Metric | FOLDAmicus Therapeuti… | IQVIQVIA Holdings In… |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Buy | Buy |
| Price TargetConsensus 12-month target | $14.50 | $225.63 |
| # AnalystsCovering analysts | 24 | 44 |
| Dividend YieldAnnual dividend ÷ price | — | — |
| Dividend StreakConsecutive years of raises | — | 2 |
| Dividend / ShareAnnual DPS | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | +4.2% |
Insufficient data to determine a leader in this category.
Key Takeaway
IQV leads in 2 of 6 categories (Valuation Metrics, Profitability & Efficiency). FOLD leads in 2 (Total Returns, Risk & Volatility). 1 tied.
Best OverallAmicus Therapeutics, Inc. (FOLD)Leads 2 of 6 categories
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FOLD vs IQV: Frequently Asked Questions
10 questions · data-driven answers · updated daily
01Is FOLD or IQV a better buy right now?
For growth investors, Amicus Therapeutics, Inc.
(FOLD) is the stronger pick with 32. 3% revenue growth year-over-year, versus 5. 9% for IQVIA Holdings Inc. (IQV). IQVIA Holdings Inc. (IQV) offers the better valuation at 22. 5x trailing P/E (13. 9x forward), making it the more compelling value choice. Analysts rate Amicus Therapeutics, Inc. (FOLD) a "Buy" — based on 24 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which has the better valuation — FOLD or IQV?
On forward P/E, IQVIA Holdings Inc.
is actually cheaper at 13. 9x.
03Which is the better long-term investment — FOLD or IQV?
Over the past 5 years, Amicus Therapeutics, Inc.
(FOLD) delivered a total return of +50. 9%, compared to -23. 7% for IQVIA Holdings Inc. (IQV). Over 10 years, the gap is even starker: IQV returned +167. 5% versus FOLD's +125. 0%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
04Which is safer — FOLD or IQV?
By beta (market sensitivity over 5 years), Amicus Therapeutics, Inc.
(FOLD) is the lower-risk stock at 0. 63β versus IQVIA Holdings Inc. 's 1. 33β — meaning IQV is approximately 111% more volatile than FOLD relative to the S&P 500. On balance sheet safety, Amicus Therapeutics, Inc. (FOLD) carries a lower debt/equity ratio of 2% versus 2% for IQVIA Holdings Inc. — giving it more financial flexibility in a downturn.
05Which is growing faster — FOLD or IQV?
By revenue growth (latest reported year), Amicus Therapeutics, Inc.
(FOLD) is pulling ahead at 32. 3% versus 5. 9% for IQVIA Holdings Inc. (IQV). On earnings-per-share growth, the picture is similar: Amicus Therapeutics, Inc. grew EPS 64. 7% year-over-year, compared to 4. 7% for IQVIA Holdings Inc.. Over a 3-year CAGR, FOLD leads at 20. 0% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.
06Which has better profit margins — FOLD or IQV?
IQVIA Holdings Inc.
(IQV) is the more profitable company, earning 8. 3% net margin versus -10. 6% for Amicus Therapeutics, Inc. — meaning it keeps 8. 3% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: IQV leads at 14. 0% versus 4. 7% for FOLD. At the gross margin level — before operating expenses — FOLD leads at 90. 0%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
07Is FOLD or IQV more undervalued right now?
On forward earnings alone, IQVIA Holdings Inc.
(IQV) trades at 13. 9x forward P/E versus 40. 6x for Amicus Therapeutics, Inc. — 26. 7x cheaper on a one-year earnings basis. Analyst consensus price targets imply the most upside for IQV: 27. 9% to $225. 63.
08Which pays a better dividend — FOLD or IQV?
None of the stocks in this comparison currently pay a material dividend.
All are effectively zero-yield and should be held for capital appreciation rather than income.
09Is FOLD or IQV better for a retirement portfolio?
For long-horizon retirement investors, Amicus Therapeutics, Inc.
(FOLD) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0. 63), +125. 0% 10Y return). Both have compounded well over 10 years (FOLD: +125. 0%, IQV: +167. 5%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
10What are the main differences between FOLD and IQV?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both.
In terms of investment character: FOLD is a small-cap high-growth stock; IQV is a mid-cap quality compounder stock. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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