GH vs TMO

For growth investors, Guardant Health, Inc.

(GH) is the stronger pick with 32. 9% revenue growth year-over-year, versus 3. 9% for Thermo Fisher Scientific Inc. (TMO). Thermo Fisher Scientific Inc. (TMO) offers the better valuation at 26. 7x trailing P/E (19. 0x forward), making it the more compelling value choice. Analysts rate Guardant Health, Inc. (GH) a "Buy" — based on 30 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.

Over the past 5 years, Thermo Fisher Scientific Inc.

(TMO) delivered a total return of +2. 1%, compared to -31. 5% for Guardant Health, Inc. (GH). Over 10 years, the gap is even starker: TMO returned +229. 1% versus GH's +186. 5%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.

By beta (market sensitivity over 5 years), Guardant Health, Inc.

(GH) is the lower-risk stock at 0. 86β versus Thermo Fisher Scientific Inc. 's 1. 10β — meaning TMO is approximately 27% more volatile than GH relative to the S&P 500.

By revenue growth (latest reported year), Guardant Health, Inc.

(GH) is pulling ahead at 32. 9% versus 3. 9% for Thermo Fisher Scientific Inc. (TMO). On earnings-per-share growth, the picture is similar: Thermo Fisher Scientific Inc. grew EPS 7. 3% year-over-year, compared to 6. 7% for Guardant Health, Inc.. Over a 3-year CAGR, GH leads at 29. 8% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.

Thermo Fisher Scientific Inc.

(TMO) is the more profitable company, earning 15. 1% net margin versus -42. 4% for Guardant Health, Inc. — meaning it keeps 15. 1% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: TMO leads at 18. 2% versus -44. 5% for GH. At the gross margin level — before operating expenses — GH leads at 64. 5%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.

Analyst consensus price targets imply the most upside for GH: 44.

3% to $133. 14.

In this comparison, TMO (0.

4% yield) pays a dividend. GH does not pay a meaningful dividend and should not be held primarily for income.

For long-horizon retirement investors, Guardant Health, Inc.

(GH) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0. 86), +186. 5% 10Y return). Both have compounded well over 10 years (GH: +186. 5%, TMO: +229. 1%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.

Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both.

In terms of investment character: GH is a mid-cap high-growth stock; TMO is a mid-cap quality compounder stock. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.