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Stock Comparison

HCWB vs RCUS vs IMVT vs AGEN

Revenue, margins, valuation, and 5-year total return — side by side.

Live fundamentals10-year financials5-year price chart
HCWB
HCW Biologics Inc.

Biotechnology

HealthcareNASDAQ • US
Market Cap$668K
5Y Perf.-99.8%
RCUS
Arcus Biosciences, Inc.

Biotechnology

HealthcareNYSE • US
Market Cap$2.50B
5Y Perf.-21.1%
IMVT
Immunovant, Inc.

Biotechnology

HealthcareNASDAQ • US
Market Cap$5.53B
5Y Perf.+160.2%
AGEN
Agenus Inc.

Biotechnology

HealthcareNASDAQ • US
Market Cap$132M
5Y Perf.-96.4%

HCWB vs RCUS vs IMVT vs AGEN — Key Financials

Market cap, revenue, margins, and valuation side-by-side.

Company Snapshot
HCWB logoHCWB
RCUS logoRCUS
IMVT logoIMVT
AGEN logoAGEN
IndustryBiotechnologyBiotechnologyBiotechnologyBiotechnology
Market Cap$668K$2.50B$5.53B$132M
Revenue (TTM)$54K$236M$0.00$114M
Net Income (TTM)$-8M$-369M$-464M$115K
Gross Margin-300.7%90.7%35.7%
Operating Margin-215.1%-168.6%-17.7%
Forward P/E1.8x
Total Debt$7M$99M$98K$10M
Cash & Equiv.$2M$222M$714M$3M

HCWB vs RCUS vs IMVT vs AGENLong-Term Stock Performance

Price return indexed to 100 at period start. Dividends excluded.

HCWB
RCUS
IMVT
AGEN
StockJul 21May 26Return
HCW Biologics Inc. (HCWB)1000.2-99.8%
Arcus Biosciences, … (RCUS)10078.9-21.1%
Immunovant, Inc. (IMVT)100260.2+160.2%
Agenus Inc. (AGEN)1003.6-96.4%

Price return only. Dividends and distributions are not included.

Quick Verdict: HCWB vs RCUS vs IMVT vs AGEN

Each card shows where this stock fits in a portfolio — not just who wins on paper.

Bottom line: IMVT and AGEN are tied at the top with 2 categories each — the right choice depends on your priorities. Agenus Inc. is the stronger pick specifically for growth and revenue expansion and operational efficiency and capital deployment. RCUS also leads in specific categories worth noting. As sector peers, any of these can serve as alternatives in the same allocation.
HCWB
HCW Biologics Inc.
The Secondary Option

HCWB lags the leaders in this set but could rank higher in a more targeted comparison.

Best for: healthcare exposure
RCUS
Arcus Biosciences, Inc.
The Momentum Pick

RCUS is the clearest fit if your priority is momentum.

  • +209.6% vs HCWB's -95.4%
Best for: momentum
IMVT
Immunovant, Inc.
The Income Pick

IMVT carries the broadest edge in this set and is the clearest fit for income & stability and long-term compounding.

  • beta 1.37
  • 173.6% 10Y total return vs RCUS's 45.9%
  • Lower volatility, beta 1.37, Low D/E 0.0%, current ratio 11.16x
  • Beta 1.37, current ratio 11.16x
Best for: income & stability and long-term compounding
AGEN
Agenus Inc.
The Growth Play

AGEN is the #2 pick in this set and the best alternative if growth exposure is your priority.

  • Rev growth 10.4%, EPS growth 100.0%, 3Y rev CAGR 5.2%
  • 10.4% revenue growth vs HCWB's -97.9%
  • 0.1% ROA vs IMVT's -44.1%
Best for: growth exposure
See the full category breakdown
CategoryWinnerWhy
GrowthAGEN logoAGEN10.4% revenue growth vs HCWB's -97.9%
Quality / MarginsIMVT logoIMVT3.2% margin vs HCWB's -146.8%
Stability / SafetyIMVT logoIMVTBeta 1.37 vs AGEN's 2.72
DividendsTieNone of these 4 stocks pay a meaningful dividend
Momentum (1Y)RCUS logoRCUS+209.6% vs HCWB's -95.4%
Efficiency (ROA)AGEN logoAGEN0.1% ROA vs IMVT's -44.1%

HCWB vs RCUS vs IMVT vs AGEN — Revenue Breakdown by Segment

How each company's revenue is distributed across its business units

HCWBHCW Biologics Inc.

Segment breakdown not available.

RCUSArcus Biosciences, Inc.
FY 2025
License And Development Services
87.4%$221M
Development Services
6.7%$17M
R&D Services
3.2%$8M
License
2.8%$7M
IMVTImmunovant, Inc.

Segment breakdown not available.

AGENAgenus Inc.
FY 2025
Non Cash Royalty Revenue
99.1%$109M
Other
0.9%$1M

HCWB vs RCUS vs IMVT vs AGEN — Financial Metrics

Side-by-side numbers across 4 stocks — who leads on profitability, valuation, growth, and risk.

BEST OVERALLIMVTLAGGINGRCUS

Income & Cash Flow (Last 12 Months)

AGEN leads this category, winning 5 of 6 comparable metrics.

RCUS and IMVT operate at a comparable scale, with $236M and $0 in trailing revenue. AGEN is the more profitable business, keeping 0.1% of every revenue dollar as net income compared to HCWB's -146.8%. On growth, AGEN holds the edge at +27.5% YoY revenue growth, suggesting stronger near-term business momentum.

MetricHCWB logoHCWBHCW Biologics Inc.RCUS logoRCUSArcus Biosciences…IMVT logoIMVTImmunovant, Inc.AGEN logoAGENAgenus Inc.
RevenueTrailing 12 months$54,231$236M$0$114M
EBITDAEarnings before interest/tax-$11M-$391M-$487M-$10M
Net IncomeAfter-tax profit-$8M-$369M-$464M$115,000
Free Cash FlowCash after capex-$13M-$489M-$423M-$159M
Gross MarginGross profit ÷ Revenue-3.0%+90.7%+35.7%
Operating MarginEBIT ÷ Revenue-215.1%-168.6%-17.7%
Net MarginNet income ÷ Revenue-146.8%-156.4%+0.1%
FCF MarginFCF ÷ Revenue-246.9%-2.1%-139.1%
Rev. Growth (YoY)Latest quarter vs prior year-93.2%-39.3%+27.5%
EPS Growth (YoY)Latest quarter vs prior year-21.1%+10.5%+19.7%+85.3%
AGEN leads this category, winning 5 of 6 comparable metrics.

Valuation Metrics

AGEN leads this category, winning 2 of 3 comparable metrics.
MetricHCWB logoHCWBHCW Biologics Inc.RCUS logoRCUSArcus Biosciences…IMVT logoIMVTImmunovant, Inc.AGEN logoAGENAgenus Inc.
Market CapShares × price$668,096$2.5B$5.5B$132M
Enterprise ValueMkt cap + debt − cash$6M$2.4B$4.8B$140M
Trailing P/EPrice ÷ TTM EPS-0.03x-7.54x-9.97x-1102.94x
Forward P/EPrice ÷ next-FY EPS est.1.79x
PEG RatioP/E ÷ EPS growth rate
EV / EBITDAEnterprise value multiple
Price / SalesMarket cap ÷ Revenue12.32x10.11x1.16x
Price / BookPrice ÷ Book value/share0.24x4.22x5.83x
Price / FCFMarket cap ÷ FCF
AGEN leads this category, winning 2 of 3 comparable metrics.

Profitability & Efficiency

IMVT leads this category, winning 4 of 9 comparable metrics.

IMVT delivers a -47.1% return on equity — every $100 of shareholder capital generates $-47 in annual profit, vs $-3 for HCWB. IMVT carries lower financial leverage with a 0.00x debt-to-equity ratio, signaling a more conservative balance sheet compared to HCWB's 2.46x. On the Piotroski fundamental quality scale (0–9), AGEN scores 6/9 vs RCUS's 0/9, reflecting solid financial health.

MetricHCWB logoHCWBHCW Biologics Inc.RCUS logoRCUSArcus Biosciences…IMVT logoIMVTImmunovant, Inc.AGEN logoAGENAgenus Inc.
ROE (TTM)Return on equity-2.9%-69.0%-47.1%
ROA (TTM)Return on assets-30.3%-35.3%-44.1%+0.1%
ROICReturn on invested capital-171.1%-64.1%
ROCEReturn on capital employed-5.5%-42.1%-66.1%
Piotroski ScoreFundamental quality 0–93026
Debt / EquityFinancial leverage2.46x0.16x0.00x
Net DebtTotal debt minus cash$5M-$123M-$714M$7M
Cash & Equiv.Liquid assets$2M$222M$714M$3M
Total DebtShort + long-term debt$7M$99M$98,000$10M
Interest CoverageEBIT ÷ Interest expense-8.05x-13.38x1.11x
IMVT leads this category, winning 4 of 9 comparable metrics.

Total Returns (Dividends Reinvested)

IMVT leads this category, winning 4 of 6 comparable metrics.

A $10,000 investment in IMVT five years ago would be worth $16,241 today (with dividends reinvested), compared to $13 for HCWB. Over the past 12 months, RCUS leads with a +209.6% total return vs HCWB's -95.4%. The 3-year compound annual growth rate (CAGR) favors IMVT at 12.1% vs HCWB's -82.2% — a key indicator of consistent wealth creation.

MetricHCWB logoHCWBHCW Biologics Inc.RCUS logoRCUSArcus Biosciences…IMVT logoIMVTImmunovant, Inc.AGEN logoAGENAgenus Inc.
YTD ReturnYear-to-date-71.4%+6.5%+5.1%+16.1%
1-Year ReturnPast 12 months-95.4%+209.6%+96.1%+27.1%
3-Year ReturnCumulative with dividends-99.4%+24.9%+40.9%-88.2%
5-Year ReturnCumulative with dividends-99.9%-18.6%+62.4%-93.9%
10-Year ReturnCumulative with dividends-99.9%+45.9%+173.6%-94.3%
CAGR (3Y)Annualised 3-year return-82.2%+7.7%+12.1%-51.0%
IMVT leads this category, winning 4 of 6 comparable metrics.

Risk & Volatility

IMVT leads this category, winning 2 of 2 comparable metrics.

IMVT is the less volatile stock with a 1.37 beta — it tends to amplify market swings less than AGEN's 2.72 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. IMVT currently trades 90.5% from its 52-week high vs HCWB's 1.8% drawdown — a narrower gap to the peak suggests stronger recent price momentum.

MetricHCWB logoHCWBHCW Biologics Inc.RCUS logoRCUSArcus Biosciences…IMVT logoIMVTImmunovant, Inc.AGEN logoAGENAgenus Inc.
Beta (5Y)Sensitivity to S&P 5001.54x1.95x1.37x2.72x
52-Week HighHighest price in past year$17.80$28.72$30.09$7.34
52-Week LowLowest price in past year$0.25$7.06$13.36$2.71
% of 52W HighCurrent price vs 52-week peak+1.8%+86.3%+90.5%+51.1%
RSI (14)Momentum oscillator 0–10041.660.560.248.8
Avg Volume (50D)Average daily shares traded10.8M1.2M1.4M814K
IMVT leads this category, winning 2 of 2 comparable metrics.

Analyst Outlook

Insufficient data to determine a leader in this category.

Analyst consensus: RCUS as "Buy", IMVT as "Buy", AGEN as "Buy". Consensus price targets imply 95.5% upside for AGEN (target: $7) vs 21.0% for RCUS (target: $30).

MetricHCWB logoHCWBHCW Biologics Inc.RCUS logoRCUSArcus Biosciences…IMVT logoIMVTImmunovant, Inc.AGEN logoAGENAgenus Inc.
Analyst RatingConsensus buy/hold/sellBuyBuyBuy
Price TargetConsensus 12-month target$30.00$45.50$7.33
# AnalystsCovering analysts182311
Dividend YieldAnnual dividend ÷ price
Dividend StreakConsecutive years of raises1
Dividend / ShareAnnual DPS
Buyback YieldShare repurchases ÷ mkt cap0.0%0.0%0.0%+0.1%
Insufficient data to determine a leader in this category.
Key Takeaway

IMVT leads in 3 of 6 categories (Profitability & Efficiency, Total Returns). AGEN leads in 2 (Income & Cash Flow, Valuation Metrics).

Best OverallImmunovant, Inc. (IMVT)Leads 3 of 6 categories
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HCWB vs RCUS vs IMVT vs AGEN: Key Questions Answered

9 questions · data-driven answers · updated daily

01

Is HCWB or RCUS or IMVT or AGEN a better buy right now?

For growth investors, Agenus Inc.

(AGEN) is the stronger pick with 10. 4% revenue growth year-over-year, versus -97. 9% for HCW Biologics Inc. (HCWB). Analysts rate Arcus Biosciences, Inc. (RCUS) a "Buy" — based on 18 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.

02

Which is the better long-term investment — HCWB or RCUS or IMVT or AGEN?

Over the past 5 years, Immunovant, Inc.

(IMVT) delivered a total return of +62. 4%, compared to -99. 9% for HCW Biologics Inc. (HCWB). Over 10 years, the gap is even starker: IMVT returned +173. 6% versus HCWB's -99. 9%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.

03

Which is safer — HCWB or RCUS or IMVT or AGEN?

By beta (market sensitivity over 5 years), Immunovant, Inc.

(IMVT) is the lower-risk stock at 1. 37β versus Agenus Inc. 's 2. 72β — meaning AGEN is approximately 98% more volatile than IMVT relative to the S&P 500. On balance sheet safety, Immunovant, Inc. (IMVT) carries a lower debt/equity ratio of 0% versus 2% for HCW Biologics Inc. — giving it more financial flexibility in a downturn.

04

Which is growing faster — HCWB or RCUS or IMVT or AGEN?

By revenue growth (latest reported year), Agenus Inc.

(AGEN) is pulling ahead at 10. 4% versus -97. 9% for HCW Biologics Inc. (HCWB). On earnings-per-share growth, the picture is similar: Agenus Inc. grew EPS 100. 0% year-over-year, compared to -1280. 5% for HCW Biologics Inc.. Over a 3-year CAGR, RCUS leads at 30. 2% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.

05

Which has better profit margins — HCWB or RCUS or IMVT or AGEN?

Agenus Inc.

(AGEN) is the more profitable company, earning 0. 1% net margin versus -146. 8% for HCW Biologics Inc. — meaning it keeps 0. 1% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: IMVT leads at 0. 0% versus -207. 6% for HCWB. At the gross margin level — before operating expenses — RCUS leads at 96. 0%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.

06

Is HCWB or RCUS or IMVT or AGEN more undervalued right now?

Analyst consensus price targets imply the most upside for AGEN: 95.

5% to $7. 33.

07

Which pays a better dividend — HCWB or RCUS or IMVT or AGEN?

None of the stocks in this comparison currently pay a material dividend.

All are effectively zero-yield and should be held for capital appreciation rather than income.

08

Is HCWB or RCUS or IMVT or AGEN better for a retirement portfolio?

For long-horizon retirement investors, Immunovant, Inc.

(IMVT) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (+173. 6% 10Y return). Agenus Inc. (AGEN) carries a higher beta of 2. 72 — meaning larger drawdowns in market downturns, which matters significantly when you cannot wait years for a recovery. Both have compounded well over 10 years (IMVT: +173. 6%, AGEN: -94. 3%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.

09

What are the main differences between HCWB and RCUS and IMVT and AGEN?

Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both.

These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.

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HCWB

Quality Business

  • Sector: Healthcare
  • Market Cap > $100B
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RCUS

Quality Business

  • Sector: Healthcare
  • Market Cap > $100B
  • Gross Margin > 54%
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IMVT

Quality Business

  • Sector: Healthcare
  • Market Cap > $100B
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AGEN

High-Growth Disruptor

  • Sector: Healthcare
  • Market Cap > $100B
  • Revenue Growth > 13%
  • Gross Margin > 21%
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Revenue Growth>
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(HCWB: -93.2% · RCUS: -39.3%)

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