Biotechnology
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Side-by-side financial analysisStock Comparison
MAZE vs LLY vs KO vs CRL vs PEP
Revenue, margins, valuation, and 5-year total return — side by side.
Drug Manufacturers - General
Beverages - Non-Alcoholic
Medical - Diagnostics & Research
Beverages - Non-Alcoholic
MAZE vs LLY vs KO vs CRL vs PEP — Key Financials
Market cap, revenue, margins, and valuation side-by-side.
| Company Snapshot | |||||
|---|---|---|---|---|---|
| Industry | Biotechnology | Drug Manufacturers - General | Beverages - Non-Alcoholic | Medical - Diagnostics & Research | Beverages - Non-Alcoholic |
| Market Cap | $1.33B | $1.07T | $355.61B | $9.03B | $197.17B |
| Revenue (TTM) | $20M | $72.25B | $49.28B | $4.03B | $93.92B |
| Net Income (TTM) | $-123M | $25.27B | $13.70B | $-185M | $8.24B |
| Gross Margin | 92.0% | 83.5% | 61.7% | 31.9% | 54.1% |
| Operating Margin | -6.7% | 45.9% | 29.3% | 11.8% | 12.2% |
| Forward P/E | — | 30.9x | 25.3x | 16.9x | 16.7x |
| Total Debt | $23M | $42.50B | $45.49B | $3.07B | $49.90B |
| Cash & Equiv. | $189M | $7.16B | $10.27B | $214M | $9.16B |
MAZE vs LLY vs KO vs CRL vs PEP — Long-Term Stock Performance
Price return indexed to 100 at period start. Dividends excluded.
| Stock | Jan 25 | Jun 26 | Return |
|---|---|---|---|
| Maze Therapeutics, … (MAZE) | 100 | 150.8 | +50.8% |
| Eli Lilly and Compa… (LLY) | 100 | 139.7 | +39.7% |
| The Coca-Cola Compa… (KO) | 100 | 130.2 | +30.2% |
| Charles River Labor… (CRL) | 100 | 113.8 | +13.8% |
| PepsiCo, Inc. (PEP) | 100 | 95.7 | -4.3% |
Price return only. Dividends and distributions are not included.
Quick Verdict: MAZE vs LLY vs KO vs CRL vs PEP
Each card shows where this stock fits in a portfolio — not just who wins on paper.
MAZE is the #2 pick in this set and the best alternative if sleep-well-at-night is your priority.
- Lower volatility, beta 1.13, Low D/E 6.6%, current ratio 15.50x
- +77.5% vs PEP's +13.4%
LLY carries the broadest edge in this set and is the clearest fit for growth exposure and long-term compounding.
- Rev growth 44.7%, EPS growth 96.0%, 3Y rev CAGR 31.7%
- 14.8% 10Y total return vs KO's 121.1%
- PEG 1.07 vs PEP's 5.11
- Beta 0.53, yield 0.5%, current ratio 1.58x
KO lags the leaders in this set but could rank higher in a more targeted comparison.
Among these 5 stocks, CRL doesn't own a clear edge in any measured category.
PEP ranks third and is worth considering specifically for income & stability.
- Dividend streak 54 yrs, beta -0.11, yield 3.9%
- 3.9% yield, 54-year raise streak, vs KO's 2.5%, (2 stocks pay no dividend)
See the full category breakdown
| Category | Winner | Why |
|---|---|---|
| Growth | 44.7% revenue growth vs MAZE's -100.0% | |
| Value | PEG 1.07 vs 2.26 | |
| Quality / Margins | 35.0% margin vs MAZE's -6.1% | |
| Stability / Safety | Beta 0.53 vs CRL's 1.39 | |
| Dividends | 3.9% yield, 54-year raise streak, vs KO's 2.5%, (2 stocks pay no dividend) | |
| Momentum (1Y) | +77.5% vs PEP's +13.4% | |
| Efficiency (ROA) | 22.7% ROA vs MAZE's -31.8%, ROIC 41.8% vs -99.4% |
MAZE vs LLY vs KO vs CRL vs PEP — Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
Segment breakdown not available.
MAZE vs LLY vs KO vs CRL vs PEP — Financial Metrics
Side-by-side numbers across 5 stocks — who leads on profitability, valuation, growth, and risk.
Who Leads Where
LLY leads in 3 of 6 categories
CRL leads 1 • KO leads 1 • MAZE leads 0 • PEP leads 0 • 1 tied
Explore the data ↓Income & Cash Flow (Last 12 Months)
LLY leads this category, winning 4 of 6 comparable metrics.
Income & Cash Flow (Last 12 Months)
PEP is the larger business by revenue, generating $93.9B annually — 4696.3x MAZE's $20M. LLY is the more profitable business, keeping 35.0% of every revenue dollar as net income compared to MAZE's -6.1%. On growth, LLY holds the edge at +55.5% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | |||||
|---|---|---|---|---|---|
| RevenueTrailing 12 months | $20M | $72.2B | $49.3B | $4.0B | $93.9B |
| EBITDAEarnings before interest/tax | -$132M | $34.7B | $15.5B | $824M | $14.3B |
| Net IncomeAfter-tax profit | -$123M | $25.3B | $13.7B | -$185M | $8.2B |
| Free Cash FlowCash after capex | -$122M | $13.6B | $12.6B | $391M | $7.7B |
| Gross MarginGross profit ÷ Revenue | +92.0% | +83.5% | +61.7% | +31.9% | +54.1% |
| Operating MarginEBIT ÷ Revenue | -6.7% | +45.9% | +29.3% | +11.8% | +12.2% |
| Net MarginNet income ÷ Revenue | -6.1% | +35.0% | +27.8% | -4.6% | +8.8% |
| FCF MarginFCF ÷ Revenue | -6.1% | +18.8% | +25.5% | +9.7% | +8.2% |
| Rev. Growth (YoY)Latest quarter vs prior year | — | +55.5% | +12.1% | +1.2% | +5.6% |
| EPS Growth (YoY)Latest quarter vs prior year | +39.9% | +169.9% | +18.2% | -160.0% | +66.7% |
Valuation Metrics
CRL leads this category, winning 4 of 7 comparable metrics.
Valuation Metrics
At 24.0x trailing earnings, PEP trades at a 51% valuation discount to LLY's 49.4x P/E. Adjusting for growth (PEG ratio), LLY offers better value at 1.71x vs PEP's 7.37x — a lower PEG means you pay less per unit of expected earnings growth.
| Metric | |||||
|---|---|---|---|---|---|
| Market CapShares × price | $1.3B | $1.07T | $355.6B | $9.0B | $197.2B |
| Enterprise ValueMkt cap + debt − cash | $1.2B | $1.11T | $390.8B | $11.9B | $237.9B |
| Trailing P/EPrice ÷ TTM EPS | -7.89x | 49.37x | 27.18x | -64.44x | 24.05x |
| Forward P/EPrice ÷ next-FY EPS est. | — | 30.95x | 25.27x | 16.90x | 16.68x |
| PEG RatioP/E ÷ EPS growth rate | — | 1.71x | 2.43x | — | 7.37x |
| EV / EBITDAEnterprise value multiple | — | 35.38x | 26.39x | 13.04x | 16.63x |
| Price / SalesMarket cap ÷ Revenue | — | 16.42x | 7.42x | 2.25x | 2.10x |
| Price / BookPrice ÷ Book value/share | 2.91x | 38.34x | 10.40x | 2.89x | 9.63x |
| Price / FCFMarket cap ÷ FCF | — | 119.31x | 67.15x | 17.42x | 25.70x |
Profitability & Efficiency
LLY leads this category, winning 6 of 9 comparable metrics.
Profitability & Efficiency
LLY delivers a 101.2% return on equity — every $100 of shareholder capital generates $101 in annual profit, vs $-37 for MAZE. MAZE carries lower financial leverage with a 0.07x debt-to-equity ratio, signaling a more conservative balance sheet compared to PEP's 2.43x. On the Piotroski fundamental quality scale (0–9), LLY scores 8/9 vs CRL's 4/9, reflecting strong financial health.
| Metric | |||||
|---|---|---|---|---|---|
| ROE (TTM)Return on equity | -36.6% | +101.2% | +41.1% | -5.7% | +40.1% |
| ROA (TTM)Return on assets | -31.8% | +22.7% | +13.1% | -2.5% | +7.7% |
| ROICReturn on invested capital | -99.4% | +41.8% | +15.8% | +6.3% | +14.9% |
| ROCEReturn on capital employed | -48.1% | +46.6% | +17.3% | +8.1% | +16.1% |
| Piotroski ScoreFundamental quality 0–9 | 4 | 8 | 7 | 4 | 5 |
| Debt / EquityFinancial leverage | 0.07x | 1.60x | 1.33x | 0.95x | 2.43x |
| Net DebtTotal debt minus cash | -$166M | $35.3B | $35.2B | $2.9B | $40.7B |
| Cash & Equiv.Liquid assets | $189M | $7.2B | $10.3B | $214M | $9.2B |
| Total DebtShort + long-term debt | $23M | $42.5B | $45.5B | $3.1B | $49.9B |
| Interest CoverageEBIT ÷ Interest expense | -148.24x | 35.68x | 10.70x | 4.29x | 10.34x |
Total Returns (Dividends Reinvested)
LLY leads this category, winning 4 of 6 comparable metrics.
Total Returns (Dividends Reinvested)
A $10,000 investment in LLY five years ago would be worth $51,207 today (with dividends reinvested), compared to $5,277 for CRL. Over the past 12 months, MAZE leads with a +77.5% total return vs PEP's +13.4%. The 3-year compound annual growth rate (CAGR) favors LLY at 37.2% vs PEP's -4.1% — a key indicator of consistent wealth creation.
| Metric | |||||
|---|---|---|---|---|---|
| YTD ReturnYear-to-date | -39.5% | +5.2% | +20.3% | -7.4% | +3.5% |
| 1-Year ReturnPast 12 months | +77.5% | +40.3% | +17.2% | +23.5% | +13.4% |
| 3-Year ReturnCumulative with dividends | +50.8% | +158.2% | +47.0% | -8.7% | -11.7% |
| 5-Year ReturnCumulative with dividends | +50.8% | +412.1% | +65.6% | -47.2% | +14.3% |
| 10-Year ReturnCumulative with dividends | +50.8% | +1484.6% | +121.1% | +122.4% | +82.3% |
| CAGR (3Y)Annualised 3-year return | +14.7% | +37.2% | +13.7% | -3.0% | -4.1% |
Risk & Volatility
KO leads this category, winning 2 of 2 comparable metrics.
Risk & Volatility
KO is the less volatile stock with a -0.20 beta — it tends to amplify market swings less than CRL's 1.39 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. KO currently trades 98.3% from its 52-week high vs MAZE's 44.8% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | |||||
|---|---|---|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 1.13x | 0.53x | -0.20x | 1.39x | -0.11x |
| 52-Week HighHighest price in past year | $53.65 | $1182.73 | $84.04 | $228.88 | $171.48 |
| 52-Week LowLowest price in past year | $9.83 | $623.78 | $65.35 | $143.06 | $127.60 |
| % of 52W HighCurrent price vs 52-week peak | +44.8% | +95.8% | +98.3% | +81.9% | +84.1% |
| RSI (14)Momentum oscillator 0–100 | 40.2 | 70.0 | 60.6 | 60.8 | 41.6 |
| Avg Volume (50D)Average daily shares traded | 642K | 2.6M | 12.7M | 767K | 6.0M |
Analyst Outlook
Evenly matched — KO and PEP each lead in 1 of 2 comparable metrics.
Analyst Outlook
Analyst consensus: MAZE as "Buy", LLY as "Buy", KO as "Buy", CRL as "Buy", PEP as "Hold". Consensus price targets imply 163.0% upside for MAZE (target: $63) vs 4.2% for KO (target: $86). For income investors, PEP offers the higher dividend yield at 3.86% vs LLY's 0.53%.
| Metric | |||||
|---|---|---|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Buy | Buy | Buy | Buy | Hold |
| Price TargetConsensus 12-month target | $63.25 | $1268.94 | $86.13 | $213.17 | $167.88 |
| # AnalystsCovering analysts | 6 | 45 | 48 | 37 | 45 |
| Dividend YieldAnnual dividend ÷ price | — | +0.5% | +2.5% | — | +3.9% |
| Dividend StreakConsecutive years of raises | — | 11 | 56 | 1 | 54 |
| Dividend / ShareAnnual DPS | — | $6.00 | $2.04 | — | $5.57 |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | +0.4% | +0.2% | +4.0% | +0.5% |
LLY leads in 3 of 6 categories (Income & Cash Flow, Profitability & Efficiency). CRL leads in 1 (Valuation Metrics). 1 tied.
MAZE vs LLY vs KO vs CRL vs PEP: Key Questions Answered
10 questions · data-driven answers · updated daily
01Is MAZE or LLY or KO or CRL or PEP a better buy right now?
For growth investors, Eli Lilly and Company (LLY) is the stronger pick with 44.
7% revenue growth year-over-year, versus -100. 0% for Maze Therapeutics, Inc. (MAZE). PepsiCo, Inc. (PEP) offers the better valuation at 24. 0x trailing P/E (16. 7x forward), making it the more compelling value choice. Analysts rate Maze Therapeutics, Inc. (MAZE) a "Buy" — based on 6 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which has the better valuation — MAZE or LLY or KO or CRL or PEP?
On trailing P/E, PepsiCo, Inc.
(PEP) is the cheapest at 24. 0x versus Eli Lilly and Company at 49. 4x. On forward P/E, PepsiCo, Inc. is actually cheaper at 16. 7x. The PEG ratio (P/E divided by earnings growth rate) is the most growth-adjusted single valuation metric: Eli Lilly and Company wins at 1. 07x versus PepsiCo, Inc. 's 5. 11x — a reasonable growth-adjusted valuation.
03Which is the better long-term investment — MAZE or LLY or KO or CRL or PEP?
Over the past 5 years, Eli Lilly and Company (LLY) delivered a total return of +412.
1%, compared to -47. 2% for Charles River Laboratories International, Inc. (CRL). Over 10 years, the gap is even starker: LLY returned +1485% versus MAZE's +50. 8%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
04Which is safer — MAZE or LLY or KO or CRL or PEP?
By beta (market sensitivity over 5 years), The Coca-Cola Company (KO) is the lower-risk stock at -0.
20β versus Charles River Laboratories International, Inc. 's 1. 39β — meaning CRL is approximately -792% more volatile than KO relative to the S&P 500. On balance sheet safety, Maze Therapeutics, Inc. (MAZE) carries a lower debt/equity ratio of 7% versus 2% for PepsiCo, Inc. — giving it more financial flexibility in a downturn.
05Which is growing faster — MAZE or LLY or KO or CRL or PEP?
By revenue growth (latest reported year), Eli Lilly and Company (LLY) is pulling ahead at 44.
7% versus -100. 0% for Maze Therapeutics, Inc. (MAZE). On earnings-per-share growth, the picture is similar: Eli Lilly and Company grew EPS 96. 0% year-over-year, compared to -40. 2% for Maze Therapeutics, Inc.. Over a 3-year CAGR, LLY leads at 31. 7% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.
06Which has better profit margins — MAZE or LLY or KO or CRL or PEP?
Eli Lilly and Company (LLY) is the more profitable company, earning 31.
7% net margin versus -612. 7% for Maze Therapeutics, Inc. — meaning it keeps 31. 7% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: LLY leads at 45. 6% versus -670. 3% for MAZE. At the gross margin level — before operating expenses — MAZE leads at 92. 0%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
07Is MAZE or LLY or KO or CRL or PEP more undervalued right now?
The PEG ratio (forward P/E divided by expected earnings growth rate) is the most precise measure of undervaluation relative to growth potential.
By this metric, Eli Lilly and Company (LLY) is the more undervalued stock at a PEG of 1. 07x versus PepsiCo, Inc. 's 5. 11x. A PEG below 1. 5 suggests fair-to-attractive pricing relative to expected growth. On forward earnings alone, PepsiCo, Inc. (PEP) trades at 16. 7x forward P/E versus 30. 9x for Eli Lilly and Company — 14. 3x cheaper on a one-year earnings basis. Analyst consensus price targets imply the most upside for MAZE: 163. 0% to $63. 25.
08Which pays a better dividend — MAZE or LLY or KO or CRL or PEP?
In this comparison, PEP (3.
9% yield), KO (2. 5% yield), LLY (0. 5% yield) pay a dividend. MAZE, CRL do not pay a meaningful dividend and should not be held primarily for income.
09Is MAZE or LLY or KO or CRL or PEP better for a retirement portfolio?
For long-horizon retirement investors, Eli Lilly and Company (LLY) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0.
53), 0. 5% yield, +1485% 10Y return). Both have compounded well over 10 years (LLY: +1485%, CRL: +122. 4%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
10What are the main differences between MAZE and LLY and KO and CRL and PEP?
These companies operate in different sectors (MAZE (Healthcare) and LLY (Healthcare) and KO (Consumer Defensive) and CRL (Healthcare) and PEP (Consumer Defensive)), which means they face different economic cycles, regulatory environments, and macro sensitivities — making direct comparison nuanced.
In terms of investment character: MAZE is a small-cap quality compounder stock; LLY is a mega-cap high-growth stock; KO is a large-cap quality compounder stock; CRL is a small-cap quality compounder stock; PEP is a mid-cap income-oriented stock. LLY, KO, PEP pay a dividend while MAZE, CRL do not, making them suitable for different income and tax situations. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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