← Back to Screener
ScreenerNewsCompareWatchlist
VCP ScannerFree US Stock Screener & Financial AnalysisFree US Stock Screener
ScreenerThemesNewsCompareWatchlist
AnalyzeValuationTotal ReturnDCA CalculatorInsider Activity

SYRS logoSyros Pharmaceuticals, Inc.(SYRS)Earnings, Financials & Key Ratios

SYRS•NASDAQ
$0.00
$10733 mkt cap·Price updated May 6, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryOncology Therapeutics Developers
AboutSyros Pharmaceuticals, Inc., a biopharmaceutical company, focuses on the development of treatments for cancer and monogenic diseases, and building a pipeline of gene control medicines. The company's lead product candidates are Tamibarotene, a selective retinoic acid receptor alpha agonist, which is in Phase III clinical trial for genomically defined subset of patients with myelodysplastic syndrome and Phase II clinical trial for patients with acute myeloid leukemia; SY-2101, a novel oral form of arsenic trioxide for treating patients with acute promyelocytic leukemia; and SY-5609, a cyclin-dependent kinase 7 inhibitor, which is in a Phase I clinical trial in patients with select advanced solid tumors. It has target discovery, research collaboration, and option agreement with Incyte Corporation to identify therapeutic targets with a focus on myeloproliferative neoplasms; and a license agreement with TMRC Co. Ltd. for the development and commercialization of tamibarotene. The company was formerly known as LS22, Inc. and changed its name to Syros Pharmaceuticals, Inc. in August 2012. Syros Pharmaceuticals, Inc. was incorporated in 2011 and is headquartered in Cambridge, Massachusetts.Show more
  • Revenue$10M-33.2%
  • EBITDA-$127M+4.6%
  • Net Income-$165M-73.9%
  • EPS (Diluted)-5.81+22.4%
  • Gross Margin77.33%-3.4%
  • EBITDA Margin-1275.52%-42.8%
  • Operating Margin-1298.19%-42.2%
  • Net Margin-1656.34%-160.4%
  • ROE-227.95%-156.4%
  • Debt/Equity3.73+648.6%
  • Interest Coverage-25.16+23.5%
Technical→

SYRS Key Insights

Syros Pharmaceuticals, Inc. (SYRS) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Strong 5Y sales CAGR of 37.1%
  • ✓Trading at only 0.0x book value

✗Weaknesses

  • ✗High debt to equity ratio of 3.7x
  • ✗Weak Piotroski F-Score: 1/9
  • ✗Negative free cash flow
  • ✗Weak momentum: RS Rating 6 (bottom 6%)
  • ✗Shares diluted 100.0% in last year
  • ✗Trading more than 30% below 52-week high

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

SYRS Price & Volume

Syros Pharmaceuticals, Inc. (SYRS) stock price & volume — 10-year historical chart

Loading chart...

SYRS Growth Metrics

Syros Pharmaceuticals, Inc. (SYRS) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years37.12%
3 Years-13.01%
TTM-90.54%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-53.44%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM-32.68%

Return on Capital

10 Years-67.75%
5 Years-66.8%
3 Years-69.44%
Last Year-74.73%

SYRS Peer Comparison

Syros Pharmaceuticals, Inc. (SYRS) competitors in Oncology Therapeutics Developers — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
KYMR logoKYMRKymera Therapeutics, Inc.Direct Competitor7.04B86.26-23.38-16.72%-6.12%-25.02%0.05
ARVN logoARVNArvinas, Inc.Direct Competitor656.24M10.26-8.02-0.3%-30.77%-14.25%0.02
IMVT logoIMVTImmunovant, Inc.Direct Competitor5.83B28.67-10.50-47.07%0.00
TNGX logoTNGXTango Therapeutics, Inc.Direct Competitor3.21B23.62-27.1548.29%-162.85%-50.3%0.10
PRAX logoPRAXPraxis Precision Medicines, Inc.Direct Competitor7.61B337.95-25.07-100%-58.74%0.00
RVMD logoRVMDRevolution Medicines, Inc.Direct Competitor32.12B151.07-25.39-83.22%0.10
BEAM logoBEAMBeam Therapeutics Inc.Product Competitor3.32B32.33-39.92120.01%-57.24%-7.31%0.24
EDIT logoEDITEditas Medicine, Inc.Product Competitor310.73M3.18-1.76-100%-5.23%0.66

Compare SYRS vs Peers

Syros Pharmaceuticals, Inc. (SYRS) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs KYMR

Most directly comparable listed peer for SYRS.

Scale Benchmark

vs TMO

Larger-name benchmark to compare SYRS against a more recognizable public peer.

Peer Set

Compare Top 5

vs KYMR, ARVN, IMVT, TNGX

SYRS Income Statement

Syros Pharmaceuticals, Inc. (SYRS) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
Line itemDec'15Dec'16Dec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23TTM
Sales/Revenue317K317K1.1M2.05M1.98M15.09M23.49M14.88M9.94M386K
Revenue Growth %-0%247.32%86.19%-3.32%661.5%55.62%-36.65%-33.23%-90.54%
Cost of Goods Sold602K01.53M00002.97M2.25M1.27M
COGS % of Revenue189.91%-138.69%----19.94%22.67%-
Gross Profit
-285K▲ 0%
317K▲ 211.2%
-426K▼ 234.4%
2.05M▲ 581.2%
1.98M▼ 3.3%
15.09M▲ 661.5%
23.49M▲ 55.6%
11.91M▼ 49.3%
7.68M▼ 35.5%
-883K▲ 0%
Gross Margin %-89.91%100%-38.69%100%100%100%100%80.06%77.33%-228.76%
Gross Profit Growth %-211.23%-234.38%581.22%-3.32%661.5%55.62%-49.28%-35.5%-
Operating Expenses30.14M48.28M55.79M66.35M79.72M97.39M122.91M38.81M30.77M111.3M
OpEx % of Revenue9506.94%15230.28%5066.94%3236.39%4022.35%645.27%523.28%260.81%309.69%-
Selling, General & Admin5.73M10.46M13.89M16.16M21.48M21.32M23.04M29.3M28.28M23.27M
SG&A % of Revenue1807.26%3300.63%1261.67%788.49%1083.65%141.29%98.08%196.9%284.64%-
Research & Development24.41M37.82M41.9M50.18M58.24M76.06M99.87M111.94M108.15M88.03M
R&D % of Revenue7699.68%11929.65%3805.27%2447.9%2938.7%503.98%425.2%752.31%1088.5%-
Other Operating Expenses2K220K676K0000-102.43M-105.66M0
Operating Income
-29.82M▲ 0%
-47.96M▼ 60.8%
-54.69M▼ 14.0%
-64.3M▼ 17.6%
-77.74M▼ 20.9%
-82.3M▼ 5.9%
-99.42M▼ 20.8%
-135.87M▼ 36.7%
-128.99M▲ 5.1%
-111.52M▲ 0%
Operating Margin %-9406.94%-15130.28%-4966.94%-3136.39%-3922.35%-545.27%-423.28%-913.13%-1298.19%-28892.23%
Operating Income Growth %-121.96%-60.84%-14.02%-17.57%-20.91%-5.86%-20.81%-36.67%5.07%-
EBITDA-29.22M-46.69M-53.16M-62.69M-75.02M-79.26M-96.4M-132.91M-126.74M-110.25M
EBITDA Margin %-9217.03%-14728.71%-4828.25%-3058.15%-3785.02%-525.16%-410.43%-893.19%-1275.52%-28563.47%
EBITDA Growth %-121.73%-59.8%-13.86%-17.93%-19.66%-5.66%-21.62%-37.87%4.64%18.39%
D&A (Non-Cash Add-back)602K1.27M1.53M1.6M2.72M3.04M3.02M2.97M2.25M1.27M
EBIT-29.82M-47.96M-54.69M-62.28M-75.44M-82.25M-82.65M-90.52M-159.45M-92.48M
Net Interest Income0002.02M2.3M-1.37M-3.82M-2M1.69M-623K
Interest Income0002.02M2.3M426K87K2.13M6.82M4.71M
Interest Expense0001K01.79M3.91M4.13M5.13M5.33M
Other Income/Expense2K220K676K2.02M2.3M-1.74M12.86M41.22M-35.59M13.84M
Pretax Income
-29.82M▲ 0%
-47.74M▼ 60.1%
-54.01M▼ 13.1%
-62.28M▼ 15.3%
-75.44M▼ 21.1%
-84.04M▼ 11.4%
-86.56M▼ 3.0%
-94.65M▼ 9.4%
-164.57M▼ 73.9%
-97.81M▲ 0%
Pretax Margin %-9406.31%-15060.88%-4905.54%-3038%-3806.16%-556.8%-368.52%-636.12%-1656.34%-25340.67%
Income Tax0000000000
Effective Tax Rate %0%0%0%0%0%0%0%0%0%0%
Net Income
-29.82M▲ 0%
-47.74M▼ 60.1%
-54.01M▼ 13.1%
-62.28M▼ 15.3%
-75.44M▼ 21.1%
-84.04M▼ 11.4%
-86.56M▼ 3.0%
-94.65M▼ 9.4%
-164.57M▼ 73.9%
-97.81M▲ 0%
Net Margin %-9406.31%-15060.88%-4905.54%-3038%-3806.16%-556.8%-368.52%-636.12%-1656.34%-25340.67%
Net Income Growth %-122.01%-60.11%-13.13%-15.31%-21.13%-11.4%-3%-9.35%-73.87%-53.44%
Net Income (Continuing)-29.82M-47.74M-54.01M-62.28M-75.44M-84.04M-86.56M-94.65M-164.57M-97.81M
Discontinued Operations0000000000
Minority Interest0000000000
EPS (Diluted)
-120.45▲ 0%
-37.60▲ 68.8%
-21.26▲ 43.5%
-19.07▲ 10.3%
-18.76▲ 1.6%
-18.25▲ 2.7%
-13.84▲ 24.2%
-7.49▲ 45.9%
-5.81▲ 22.4%
-2.49▲ 0%
EPS Growth %-122.03%68.78%43.46%10.3%1.63%2.72%24.16%45.88%22.43%-32.68%
EPS (Basic)-120.45-37.60-21.26-19.07-18.76-18.25-13.84-7.49-5.81-
Diluted Shares Outstanding247.56K1.27M2.54M3.27M4.02M4.61M6.25M12.63M28.33M39.34M
Basic Shares Outstanding247.56K1.27M2.54M3.27M4.02M4.61M6.25M12.63M28.33M39.27M
Dividend Payout Ratio----------

SYRS Balance Sheet

Syros Pharmaceuticals, Inc. (SYRS) balance sheet — assets, liabilities & shareholders' equity

Line itemDec'15Dec'16Dec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23TTM
Total Current Assets36.45M85.51M73.16M101.73M114.51M178.56M136.59M211.39M144.98M63.93M
Cash & Short-Term Investments35.91M83.59M72.05M99.68M91.42M173.98M130.37M202.3M139.53M58.27M
Cash Only35.91M58.59M32.2M49.89M41.44M173.98M92.3M167.47M139.53M58.27M
Short-Term Investments025M39.84M49.79M49.98M038.07M34.84M00
Accounts Receivable0867K0020.16M2.33M2.98M1.69M00
Days Sales Outstanding-998.28--3.71K56.3746.2941.55--
Inventory0000290K00000
Days Inventory Outstanding----------
Other Current Assets01.05M193K638K0007.39M5.45M5.66M
Total Non-Current Assets7.18M5.82M5.33M5.03M35.47M34.69M46.35M33.09M23.19M21.06M
Property, Plant & Equipment4.8M4.85M3.94M3.86M31.89M29.64M27.29M24.66M19.48M17.58M
Fixed Asset Turnover0.07x0.07x0.28x0.53x0.06x0.51x0.86x0.60x0.51x0.02x
Goodwill0000000000
Intangible Assets0000000000
Long-Term Investments483K483K290K290K3.09M3.09M13.04M3.09M2.12M8.48M
Other Non-Current Assets1.9M482K1.1M881K490K1.97M6.03M5.35M1.59M5.97M
Total Assets
43.63M▲ 0%
91.32M▲ 109.3%
78.49M▼ 14.1%
106.77M▲ 36.0%
149.98M▲ 40.5%
213.25M▲ 42.2%
182.94M▼ 14.2%
244.49M▲ 33.6%
168.17M▼ 31.2%
85M▲ 0%
Asset Turnover0.01x0.00x0.01x0.02x0.01x0.07x0.13x0.06x0.06x0.00x
Asset Growth %-29.05%109.31%-14.05%36.03%40.47%42.19%-14.22%33.65%-31.21%-149.12%
Total Current Liabilities7.96M9.57M12.41M19.53M23.52M28.62M31.51M30.78M36.68M28.39M
Accounts Payable5.04M2.42M2.28M3.31M5.85M3.6M3.69M6.41M11.54M9.65M
Days Payables Outstanding3.05K-545.71----788.681.87K2.88K
Short-Term Debt0168K47K9K1.28M1.73M006.67M0
Deferred Revenue (Current)0550K355K1.93M5.74M12.21M10.18M4.33M00
Other Current Liabilities284K4.36M7.54M11.29M5.19M3.99M9.28M9.44M6.99M0
Current Ratio4.58x8.94x5.89x5.21x4.87x6.24x4.33x6.87x3.95x3.95x
Quick Ratio4.58x8.94x5.89x5.21x4.86x6.24x4.33x6.87x3.95x3.95x
Cash Conversion Cycle----------
Total Non-Current Liabilities1.63M1.15M751K8.65M47.28M94.07M66.21M85.97M114.83M67.73M
Long-Term Debt0000039.55M40.26M40.65M34.56M41.08M
Capital Lease Obligations206K53K6K22K24.64M24.93M22.92M20.85M18.53M70.21M
Deferred Tax Liabilities000-22K-22.64M00000
Other Non-Current Liabilities1.42M1.1M745K353K019.71M3.03M24.47M61.75M136.99M
Total Liabilities9.58M10.72M13.16M28.18M70.79M122.7M97.72M116.75M151.51M96.12M
Total Debt339K221K53K31K25.92M66.21M65.19M63.57M62.08M60.23M
Net Debt-35.57M-58.37M-32.15M-49.85M-15.52M-107.77M-27.11M-103.9M-77.45M1.95M
Debt / Equity0.01x0.00x0.00x0.00x0.33x0.73x0.76x0.50x3.73x3.73x
Debt / EBITDA----------0.55x
Net Debt / EBITDA----------0.02x
Interest Coverage----64296.00x--45.92x-25.45x-32.87x-25.16x-17.35x
Total Equity
34.05M▲ 0%
80.6M▲ 136.7%
65.32M▼ 19.0%
78.59M▲ 20.3%
79.18M▲ 0.8%
90.55M▲ 14.4%
85.22M▼ 5.9%
127.74M▲ 49.9%
16.66M▼ 87.0%
-11.12M▲ 0%
Equity Growth %-43.48%136.72%-18.95%20.3%0.76%14.36%-5.89%49.89%-86.96%-412.16%
Book Value per Share137.5463.4825.7124.0619.6919.6613.6310.110.59-0.28
Total Shareholders' Equity34.05M80.6M65.32M78.59M79.18M90.55M85.22M127.74M16.66M-11.12M
Common Stock2K23K26K34K43K56K61K20K26K27K
Retained Earnings-53.51M-101.26M-155.27M-217.54M-292.98M-377.02M-463.58M-558.23M-722.81M-756.24M
Treasury Stock0000000000
Accumulated OCI-931K-9K-42K-3K24K0-79K102K00
Minority Interest0000000000

SYRS Cash Flow Statement

Syros Pharmaceuticals, Inc. (SYRS) cash flow — operating, investing & free cash flow history

Line itemDec'15Dec'16Dec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23TTM
Cash from Operations-23.03M-40.54M-44.73M-40.31M-60.25M-57.36M-99.54M-123.06M-109.71M-109.71M
Operating CF Margin %-7264.98%-12787.38%-4062.58%-1966.59%-3040.01%-380.07%-423.79%-827.05%-1104.14%-
Operating CF Growth %-92.41%-76.01%-10.34%9.87%-49.46%4.79%-73.52%-23.63%10.85%58.53%
Net Income-29.82M-47.74M-54.01M-62.28M-75.44M-84.04M-86.56M-94.65M-164.57M-97.81M
Depreciation & Amortization602K1.27M1.53M1.6M2.72M3.04M3.02M2.97M2.25M1.27M
Stock-Based Compensation3.23M4.23M4.42M6.61M9.84M10.94M10.35M11.41M10.43M7.25M
Deferred Taxes0000-1.13M326K-16.46M008.08M
Other Non-Cash Items17K10K-102K-642K7.24M2.32M706K-37.27M37.13M-22.18M
Working Capital Changes2.94M1.69M3.44M14.39M-3.48M10.05M-10.6M-5.52M5.05M3.38M
Change in Receivables0-317K867K0-20.16M19.99M7K1.28M1.69M1.67M
Change in Inventory02.69M3.3M0-4.36M-2.53M1.98M-1.28M029K
Change in Payables2.02M-404K141K888K1.49M-1.06M48K2.77M5.13M6.79M
Cash from Investing-1.18M-27.34M-15.59M-10.64M-11.73M46.66M-52.65M67.19M37.34M1.95M
Capital Expenditures-1.18M-2.32M-821K-1.38M-12.64M-3.34M-1.25M-1.24M-272K-67K
CapEx % of Revenue370.98%732.49%74.57%67.51%637.64%22.1%5.3%8.34%2.74%-
Acquisitions0009K110K00001.46M
Investments----------
Other Investing0-25.02M-14.77M9K00001.56M25.22M
Cash from Financing-278K90.56M33.94M69.08M65.99M142.95M70.51M131.04M43.46M43.16M
Debt Issued (Net)-50K-135K-168K-50K-205K39.38M-265K-291K-65K-3K
Equity Issued (Net)-228K1000K1000K1000K1000K1000K1000K1000K1000K1000K
Dividends Paid0000000000
Share Repurchases-620K000000-81K0115K
Other Financing0395K1.8M626K374K1.3M439K11.66M257K-111K
Net Change in Cash
-24.48M▲ 0%
22.68M▲ 192.6%
-26.38M▼ 216.3%
18.13M▲ 168.7%
-6M▼ 133.1%
132.25M▲ 2305.3%
-81.68M▼ 161.8%
75.17M▲ 192.0%
-28.91M▼ 138.5%
-53.94M▲ 0%
Free Cash Flow
-24.21M▲ 0%
-42.86M▼ 77.1%
-45.55M▼ 6.3%
-41.7M▲ 8.5%
-72.89M▼ 74.8%
-60.7M▲ 16.7%
-100.78M▼ 66.0%
-124.31M▼ 23.3%
-109.98M▲ 11.5%
-100.06M▲ 0%
FCF Margin %-7635.96%-13519.87%-4137.15%-2034.1%-3677.65%-402.17%-429.09%-835.39%-1106.87%-25921.5%
FCF Growth %-98.9%-77.06%-6.28%8.45%-74.8%16.73%-66.04%-23.34%11.53%18.74%
FCF per Share-97.78-33.76-17.93-12.77-18.12-13.18-16.12-9.84-3.88-3.88
FCF Conversion (FCF/Net Income)0.77x0.85x0.83x0.65x0.80x0.68x1.15x1.30x0.67x1.02x
Interest Paid0002K72K1.5M0000
Taxes Paid0007K29K7K0000

SYRS Key Ratios

Syros Pharmaceuticals, Inc. (SYRS) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric201520162017201820192020202120222023TTM
Return on Equity (ROE)-63.25%-83.28%-74.02%-86.55%-95.63%-99.02%-98.49%-88.9%-227.95%-2746.84%
Return on Invested Capital (ROIC)--347.32%-148.05%-155.8%-126.22%-265.81%-364.72%-248.71%-329.92%
Gross Margin-89.91%100%-38.69%100%100%100%100%80.06%77.33%-228.76%
Net Margin-9406.31%-15060.88%-4905.54%-3038%-3806.16%-556.8%-368.52%-636.12%-1656.34%-25340.67%
Debt / Equity0.01x0.00x0.00x0.00x0.33x0.73x0.76x0.50x3.73x3.73x
Interest Coverage----64296.00x--45.92x-25.45x-32.87x-25.16x-17.35x
FCF Conversion0.77x0.85x0.83x0.65x0.80x0.68x1.15x1.30x0.67x1.02x
Revenue Growth-0%247.32%86.19%-3.32%661.5%55.62%-36.65%-33.23%-90.54%

SYRS Frequently Asked Questions

Syros Pharmaceuticals, Inc. (SYRS) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Syros Pharmaceuticals, Inc. (SYRS) reported $0.4M in revenue for fiscal year 2023.

Syros Pharmaceuticals, Inc. (SYRS) saw revenue decline by 33.2% over the past year.

Syros Pharmaceuticals, Inc. (SYRS) reported a net loss of $97.8M for fiscal year 2023.

Dividend & Returns

Syros Pharmaceuticals, Inc. (SYRS) has a return on equity (ROE) of -227.9%. Negative ROE indicates the company is unprofitable.

Syros Pharmaceuticals, Inc. (SYRS) had negative free cash flow of $100.1M in fiscal year 2023, likely due to heavy capital investments.

Explore More SYRS

Syros Pharmaceuticals, Inc. (SYRS) financial analysis — history, returns, DCA and operating performance tools

Total Return Calculator

Historical returns with dividends reinvested

→

DCA Calculator

Dollar cost averaging vs lump sum

→

Dividend History

Yield, growth, payout safety & DRIP

→

Earnings History

EPS trends, net income & profitability

→

Price History

Long-term charts & historical price data

→

Revenue History

Sales growth patterns & revenue breakdown

→

Financial Ratios

30 years of market, efficiency and balance-sheet ratios

→

Valuation

DCF intrinsic value, peer multiples & estimates

→
VCP ScannerFree US Stock Screener & Financial Analysis

Find stocks. Verify deeply. Act with conviction.

Patterns find ideas. Fundamentals build conviction.

Data updated daily

Quick Links

  • Home
  • Screener
  • Themes
  • Market Valuation
  • Valuation
  • Compare
  • Total Return
  • DCA Calculator
  • News
  • Insights
  • Methodology
  • How It Works
  • Profile

Popular Screens

  • VCP Hot
  • VCP Warm
  • Value Screens
  • Growth Screens
  • Momentum Screens
  • Technical Screens
  • Quality Screens

Community

  • Follow @VCPScanner on X

Get weekly stock ideas — free

© 2026 VCP Scanner. All rights reserved.
About·Privacy Policy·Terms of Service
Not financial advice. Do your own research.