Syros Pharmaceuticals, Inc. (SYRS) Revenue History
Annual and quarterly revenue from 2013 to present
SYRS Revenue Over Time (2013–2023)
SYRS Revenue Growth History
4 of 8 years with positive growth- FY2013 revenue growth
- N/A
- FY2014 revenue growth
- N/A
- FY2015 revenue growth
- N/A
- FY2016 revenue growth
- +0.0%
- FY2017 revenue growth
- +247.3%
- FY2018 revenue growth
- +86.2%
- FY2019 revenue growth
- -3.3%
- FY2020 revenue growth
- +661.5%
- FY2021 revenue growth
- +55.6%
- FY2022 revenue growth
- -36.6%
- FY2023 revenue growth
- -33.2%
| Quarter | Revenue | YoY |
|---|---|---|
| Q3 2024 | $0 | -100.0% |
| Q2 2024 | $0 | -100.0% |
| Q1 2024 | $0 | -100.0% |
| Q4 2023 | $386K | +107.1% |
| Q3 2023 | $3.8M | -3.3% |
| Q2 2023 | $2.8M | -54.9% |
| Q1 2023 | $3.0M | -46.0% |
| Q4 2022 | $-5,467,000 | -170.1% |
Multi-year avg. share of annual revenue by fiscal quarter
SYRS Revenue Analysis (2013–2023)
Current Revenue & Growth
As of June 23, 2026, Syros Pharmaceuticals, Inc. (SYRS) generated trailing twelve-month (TTM) revenue of $386,000, reflecting significant decline in growth of -100.0% year-over-year. The most recent quarter (Q3 2024) recorded $0 in revenue
Historical Growth Trajectory
SYRS's 5-year compound annual growth rate (CAGR) stands at +37.1%, indicating outstanding long-term growth trajectory. The 3-year CAGR of -13.0% is below the 5-year average, signalling a growth deceleration in recent years. Syros Pharmaceuticals, Inc.'s highest annual revenue of $23.5 million was recorded in 2021.
Peer Comparison
Compared to Healthcare sector peers — including KYMR (-12.6% YoY), ARVN (-79.1% YoY), and TNGX (+39.0% YoY) — SYRS has underperformed the peer group in revenue growth. Compare SYRS vs KYMR →
SYRS Revenue vs Peers
Revenue metrics vs comparable public companies
| Company | TTM Revenue | YoY Growth | 5Y CAGR | Op. Margin | Compare |
|---|---|---|---|---|---|
| SYRSCurrent | $386,000 | -100.0% | +37.1% | -1298.2% | |
 KYMR | $39M | -12.6% | +2.9% | -891.3% | |
 ARVN | $263M | -79.1% | +58.9% | -43.8% | |
 TNGX | $62M | +39.0% | +52.1% | -178.4% |
SYRS Historical Revenue Data (2013–2023)
| Year | Revenue | YoY % | Gross Profit | Gross Margin | Op. Income | Op. Margin |
|---|---|---|---|---|---|---|
| 2023 | $9.9M | -33.2% | $7.7M | 77.3% | $-128,988,000 | -1298.2% |
| 2022 | $14.9M | -36.6% | $11.9M | 80.1% | $-135,873,000 | -913.1% |
| 2021 | $23.5M | +55.6% | $23.5M | 100.0% | $-99,420,000 | -423.3% |
| 2020 | $15.1M | +661.5% | $15.1M | 100.0% | $-82,297,000 | -545.3% |
| 2019 | $2.0M | -3.3% | $2.0M | 100.0% | $-77,741,000 | -3922.4% |
| 2018 | $2.0M | +86.2% | $2.0M | 100.0% | $-64,296,000 | -3136.4% |
| 2017 | $1.1M | +247.3% | $-426,000 | -38.7% | $-54,686,000 | -4966.9% |
| 2016 | $317K | +0.0% | $317K | 100.0% | $-47,963,000 | -15130.3% |
| 2015 | $317K | - | $-285,000 | -89.9% | $-29,820,000 | -9406.9% |
| 2014 | $0 | - | $0 | - | $-13,435,000 | - |
| 2013 | $0 | - | $0 | - | $-8,633,000 | - |
Intrinsic Valuation
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Historical Returns
13+ years return with dividends reinvested.
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Peer Comparison
Compare growth, multiples, and margins vs sector.
SYRS — Frequently Asked Questions
Quick answers to the most common questions about buying SYRS stock.
Is SYRS's revenue growth accelerating or slowing?
SYRS revenue is declining -100.0% year-over-year. TTM revenue fell to $386000.00, contrasting with the 5-year CAGR of +37.1%. The reversal reflects either macro headwinds or company-specific challenges.
What is SYRS's revenue history from 2013 to 2026?
Syros Pharmaceuticals, Inc. (SYRS) revenue history spans 2013 to 2026. TTM revenue as of 2026 is $386000.00, growing at -100.0% YoY. The 5-year CAGR is +37.1%. Complete annual and quarterly revenue figures are available on this page, including gross profit, operating income, and margin trends.
What is SYRS's long-term revenue growth rate (CAGR)?
Syros Pharmaceuticals, Inc.'s 5-year revenue CAGR of +37.1% reflects the variable nature of its business expansion. As of 2026, the current YoY growth rate of -100.0% is below this long-term average. CAGR is the most reliable measure of sustained revenue momentum for SYRS.
Why does SYRS's quarterly revenue fluctuate?
SYRS quarterly revenue can fluctuate significantly between periods. A quarter-over-quarter (QoQ) change does not always indicate a trend; comparing the same quarter year-over-year (YoY) is a more reliable signal for underlying growth. Syros Pharmaceuticals, Inc.'s revenue data from 2013 to 2026 shows full historical quarterly detail on this page.
How is SYRS's revenue distributed by segment?
SYRS reports revenue broken down by product line and geographic region. The segment breakdown on this page shows which business units contribute the most to total revenue as of the latest fiscal year. Concentration in a single segment above 50% indicates category dependence, while a diversified mix signals more resilient revenue streams.
How does SYRS's revenue compare to industry peers?
Syros Pharmaceuticals, Inc. (SYRS) with TTM revenue of $386000.00 and -100.0% YoY growth can be benchmarked against sector peers using the comparison table on this page. Revenue growth relative to peers indicates market share gains or losses. The peer section shows TTM revenue, YoY growth, and operating margin for direct comparisons.