Syros Pharmaceuticals, Inc. (SYRS) Stock Price History
Historical prices from 2016 to 2026
- 1M
- +0.0%
- 3M
- +100.0%
- YTD
- +100.0%
- 1Y
- -98.6%
- 3Y
- -94.9%
- 5Y
- -90.7%
Loading 10-year price history...
SYRS Historical Performance
SYRS Annual Returns
Year-by-year price performance · 2016–2026
- 2016 annual price return
- -33.0%
- 2017 annual price return
- -22.0%
- 2018 annual price return
- -44.2%
- 2019 annual price return
- +16.7%
- 2020 annual price return
- +52.2%
- 2021 annual price return
- -69.6%
- 2022 annual price return
- -90.6%
- 2023 annual price return
- +120.1%
- 2024 annual price return
- -97.1%
- 2025 annual price return
- -99.9%
- 2026 annual price return
- +0.0%
SYRS Stock Price Trajectory (2016–2026)
As of June 23, 2026, Syros Pharmaceuticals, Inc. (SYRS) trades at $0.00, representing a -98.6% return over the past year. The stock has delivered a -100.0% total return over five years (-90.7% CAGR), reflecting challenging market conditions.
The stock reached its all-time high of $243.75 on August 7, 2017. From this peak, SYRS has corrected -100.0%, currently trading 89% below its 200-day moving average, suggesting potential weakness.
When compared to Healthcare sector peers KYMR (+94.7% 1Y), ARVN (+2.7% 1Y), and IMVT (+122.8% 1Y), SYRS has underperformed the peer group average. Compare SYRS vs KYMR →
SYRS Historical Price Data · from 2016
Rows 1–50 of 2,493| Date | Open | High | Low | Close | Volume | Change % |
|---|---|---|---|---|---|---|
| 2026-06-22 | 0.00 | 0.00 | 0.00 | 0.00 | 20K | -75.00% |
| 2026-06-17 | 0.00 | 0.00 | 0.00 | 0.00 | 904 | +300.00% |
| 2026-06-16 | 0.00 | 0.00 | 0.00 | 0.00 | 904 | -75.00% |
| 2026-06-15 | 0.00 | 0.00 | 0.00 | 0.00 | 7K | +300.00% |
| 2026-06-12 | 0.00 | 0.00 | 0.00 | 0.00 | 105 | 0.00% |
| 2026-06-11 | 0.00 | 0.00 | 0.00 | 0.00 | 149 | 0.00% |
| 2026-06-10 | 0.00 | 0.00 | 0.00 | 0.00 | 2K | -50.00% |
| 2026-06-08 | 0.00 | 0.00 | 0.00 | 0.00 | 125 | 0.00% |
| 2026-06-05 | 0.00 | 0.00 | 0.00 | 0.00 | 245 | -50.00% |
| 2026-06-04 | 0.00 | 0.00 | 0.00 | 0.00 | 960 | +100.00% |
| 2026-06-03 | 0.00 | 0.00 | 0.00 | 0.00 | 2K | 0.00% |
| 2026-06-01 | 0.00 | 0.00 | 0.00 | 0.00 | 66K | 0.00% |
| 2026-05-29 | 0.00 | 0.00 | 0.00 | 0.00 | 1K | 0.00% |
| 2026-05-28 | 0.00 | 0.00 | 0.00 | 0.00 | 981 | 0.00% |
| 2026-05-27 | 0.00 | 0.00 | 0.00 | 0.00 | 2K | 0.00% |
| 2026-05-26 | 0.00 | 0.00 | 0.00 | 0.00 | 2K | 0.00% |
| 2026-05-21 | 0.00 | 0.00 | 0.00 | 0.00 | 3K | 0.00% |
| 2026-05-20 | 0.00 | 0.00 | 0.00 | 0.00 | 380 | 0.00% |
| 2026-05-19 | 0.00 | 0.00 | 0.00 | 0.00 | 904 | -50.00% |
| 2026-05-18 | 0.00 | 0.00 | 0.00 | 0.00 | 937 | +100.00% |
| 2026-05-15 | 0.00 | 0.00 | 0.00 | 0.00 | 489 | 0.00% |
| 2026-05-14 | 0.00 | 0.00 | 0.00 | 0.00 | 23K | 0.00% |
| 2026-05-13 | 0.00 | 0.00 | 0.00 | 0.00 | 1K | 0.00% |
| 2026-05-12 | 0.00 | 0.00 | 0.00 | 0.00 | 589 | 0.00% |
| 2026-05-11 | 0.00 | 0.00 | 0.00 | 0.00 | 1K | 0.00% |
| 2026-05-08 | 0.00 | 0.00 | 0.00 | 0.00 | 616 | -50.00% |
| 2026-05-06 | 0.00 | 0.01 | 0.00 | 0.00 | 7K | +100.00% |
| 2026-05-04 | 0.00 | 0.00 | 0.00 | 0.00 | 3K | 0.00% |
| 2026-05-01 | 0.00 | 0.00 | 0.00 | 0.00 | 113 | 0.00% |
| 2026-04-30 | 0.00 | 0.00 | 0.00 | 0.00 | 13K | 0.00% |
| 2026-04-29 | 0.00 | 0.00 | 0.00 | 0.00 | 2K | 0.00% |
| 2026-04-27 | 0.00 | 0.00 | 0.00 | 0.00 | 2K | 0.00% |
| 2026-04-24 | 0.00 | 0.00 | 0.00 | 0.00 | 2K | -50.00% |
| 2026-04-22 | 0.00 | 0.00 | 0.00 | 0.00 | 904 | +100.00% |
| 2026-04-21 | 0.00 | 0.00 | 0.00 | 0.00 | 782 | 0.00% |
| 2026-04-20 | 0.00 | 0.00 | 0.00 | 0.00 | 399 | -33.33% |
| 2026-04-17 | 0.00 | 0.00 | 0.00 | 0.00 | 3K | +50.00% |
| 2026-04-15 | 0.00 | 0.00 | 0.00 | 0.00 | 9K | -33.33% |
| 2026-04-13 | 0.00 | 0.00 | 0.00 | 0.00 | 925 | +50.00% |
| 2026-04-10 | 0.00 | 0.00 | 0.00 | 0.00 | 136 | 0.00% |
| 2026-04-09 | 0.00 | 0.00 | 0.00 | 0.00 | 14K | 0.00% |
| 2026-04-08 | 0.00 | 0.00 | 0.00 | 0.00 | 2K | 0.00% |
| 2026-04-07 | 0.00 | 0.00 | 0.00 | 0.00 | 493 | 0.00% |
| 2026-04-06 | 0.00 | 0.00 | 0.00 | 0.00 | 10K | 0.00% |
| 2026-04-02 | 0.00 | 0.00 | 0.00 | 0.00 | 114 | 0.00% |
| 2026-04-01 | 0.00 | 0.00 | 0.00 | 0.00 | 654 | 0.00% |
| 2026-03-31 | 0.00 | 0.00 | 0.00 | 0.00 | 44K | 0.00% |
| 2026-03-30 | 0.00 | 0.00 | 0.00 | 0.00 | 11K | -33.33% |
| 2026-03-26 | 0.00 | 0.00 | 0.00 | 0.00 | 904 | +50.00% |
| 2026-03-25 | 0.00 | 0.00 | 0.00 | 0.00 | 102 | 0.00% |
Intrinsic Valuation
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Historical Returns
10-year return with dividends reinvested.
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Peer Comparison
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SYRS — Frequently Asked Questions
Quick answers to the most common questions about buying SYRS stock.
How has SYRS stock performed recently?
SYRS declined -98.6% over the past year, below its 5-year annualized CAGR of -90.7%. The stock trades below its 200-day moving average, reflecting the downtrend.
What is SYRS's all-time high price?
Syros Pharmaceuticals, Inc. reached $243.75 on 2017-08-07. The 52-week high is $0.04. Current 1-year return of -98.6% places the stock further from historical peaks.
Where can I download SYRS historical price data?
This page provides SYRS daily OHLCV data with 50-day MA, 200-day MA, and RSI indicators. Data spans 2016-2026, downloadable in CSV format.