The company has generated zero revenue for nine consecutive quarters while reporting an operating loss of $9.9 million in 2026Q1, underscoring its status as a pre-commercial entity.
| Metric | TTM | Dec'25 | Dec'24 | Dec'23 | Dec'22 | Dec'21 | Dec'20 | Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|
| Sales/Revenue | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.76K | 40.14K | 632.56K | 481.84K | 1.5K | 0 | 0 |
| Revenue Growth % | - | - | - | - | - | - | - | - | - | - | -100% | -95.62% | -93.65% | 31.28% | 32022.8% | - | - | - |
| Cost of Goods Sold | 8K | 0 | 17K | 23K | 8K | 23K | 46.6K | 52.79K | 44.2K | 128.99K | 303.48K | 132.41K | 340.66K | 495.46K | 65.63K | 97.19K | 0 | 0 |
| COGS % of Revenue | - | - | - | - | - | - | - | - | - | - | - | 7531.91% | 848.72% | 78.33% | 13.62% | 6479.33% | - | - |
| Gross Profit | -8K | 0 | -17K | -23K | -8K | -23K | -46.6K | -52.79K | -44.2K | -128.99K | -303.48K | -130.65K | 40.14K | 137.09K | 416.21K | -95.69K | 0 | 0 |
| Gross Margin % | - | - | - | - | - | - | - | - | - | - | - | -7431.91% | 100% | 21.67% | 86.38% | -6379.33% | - | - |
| Gross Profit Growth % | - | 100% | 26.09% | -187.5% | 65.22% | 50.64% | 11.72% | -19.44% | 65.74% | 57.5% | -132.28% | -425.51% | -70.72% | -67.06% | 534.96% | - | - | - |
| Operating Expenses | 39.59M | 37.14M | 27.62M | 31.38M | 27.69M | 20.52M | 14.61M | 17.27M | 11.43M | 7.06M | 6.95M | 12.63M | 12.21M | 10.92M | 5.49M | 3.33M | 1.08M | 122.86K |
| OpEx % of Revenue | - | - | - | - | - | - | - | - | - | - | - | 718314.28% | 30422.96% | 1726.6% | 1138.39% | 222233.33% | - | - |
| Selling, General & Admin | 17.78M | 15.96M | 13.5M | 14.04M | 12.61M | 11.31M | 8M | 10.62M | 7.22M | 4.86M | 6.48M | 10.27M | 9.9M | 9.82M | 5.49M | 3.33M | 894.36K | 101.61K |
| SG&A % of Revenue | - | - | - | - | - | - | - | - | - | - | - | 584093.97% | 24658.98% | 1551.89% | 1138.39% | 222233.33% | - | - |
| Research & Development | 21.81M | 21.18M | 14.12M | 17.33M | 15.08M | 9.21M | 6.61M | 7.13M | 4.21M | 2.33M | 770.43K | 2.36M | 2.58M | 1.11M | 1.97K | 0 | 120K | 21.25K |
| R&D % of Revenue | - | - | - | - | - | - | - | - | - | - | - | 134220.31% | 6421.51% | 174.7% | 0.41% | - | - | - |
| Other Operating Expenses | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -486.55K | 0 | -128.99K | -303.48K | 0 | -263.92K | 0 | -1.97K | 0 | 63.64K | 0 |
| Operating Income | -39.6M | -37.14M | -27.62M | -31.38M | -27.69M | -20.52M | -14.61M | -17.27M | -11.43M | -7.19M | -7.25M | -12.76M | -12.17M | -10.78M | -5.07M | -3.43M | -1.08M | -122.86K |
| Operating Margin % | - | - | - | - | - | - | - | - | - | - | - | -725746.19% | -30322.96% | -1704.93% | -1052.01% | -228612.67% | - | - |
| Operating Income Growth % | - | -34.47% | 11.97% | -13.31% | -34.94% | -40.49% | 15.4% | -51% | -59.09% | 0.86% | 43.18% | -4.83% | -12.86% | -112.76% | -47.82% | -218.11% | -777.44% | - |
| EBITDA | -39.58M | -37.13M | -27.6M | -31.35M | -27.68M | -20.5M | -14.56M | -17.21M | -11.39M | -7.06M | -6.95M | -12.49M | -11.7M | -10.31M | -4.94M | -3.41M | -1.08M | -122.86K |
| EBITDA Margin % | - | - | - | - | - | - | - | - | - | - | - | -710238.4% | -29154.18% | -1630.16% | -1024.92% | -227571.13% | - | - |
| EBITDA Growth % | -41.16% | -34.49% | 11.96% | -13.26% | -35.05% | -40.78% | 15.41% | -51.12% | -61.37% | -1.62% | 44.37% | -6.7% | -13.48% | -108.8% | -44.67% | -216.79% | -777.07% | - |
| D&A (Non-Cash Add-back) | 16K | 16K | 17K | 23K | 8K | 23K | 47K | 52.79K | 44.2K | 128.99K | 303.48K | 272.63K | 469.13K | 472.93K | 130.55K | 15.62K | 455 | 0 |
| EBIT | -39.04M | -37.14M | -27.62M | -31.38M | -27.69M | -20.52M | -14.61M | -17.27M | -11.43M | -7.93M | -6.37M | -12.76M | -9.82M | -10.78M | -5.07M | -3.42M | -1.09M | -122.86K |
| Net Interest Income | 1.97M | 2.38M | 4.05M | 4.34M | 877K | 6K | 0 | 0 | 0 | -192.82K | 0 | 0 | -15.51K | -65 | -10.82K | -13.08K | -8.68K | 0 |
| Interest Income | 1.97M | 2.38M | 4.05M | 4.34M | 877K | 6K | 0 | 0 | 0 | 0 | 0 | 0 | 260 | 295 | 1.22K | 4.91K | 455 | 0 |
| Interest Expense | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 192.82K | 0 | 0 | 15.77K | 360 | 12.04K | 17.99K | 9.14K | 0 |
| Other Income/Expense | 1.96M | 2.37M | 2.12M | 1.28M | 731K | -85K | -3.22M | 25.65K | 29.3K | -935.13K | 880.74K | 431 | 260 | -65 | -10.82K | -13.08K | -8.68K | 0 |
| Pretax Income | -37.64M | -34.77M | -25.5M | -30.09M | -26.96M | -20.61M | -17.83M | -17.24M | -11.4M | -8.12M | -6.37M | -12.76M | -12.17M | -10.78M | -5.08M | -3.44M | -1.09M | -122.86K |
| Pretax Margin % | - | - | - | - | - | - | - | - | - | - | - | -725721.67% | -30322.31% | -1704.94% | -1054.26% | -229484.6% | - | - |
| Income Tax | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -29.3K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 250 | 0 |
| Effective Tax Rate % | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0.26% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | -0.02% | 0% |
| Net Income | -37.64M | -34.77M | -25.5M | -30.09M | -26.96M | -20.61M | -17.83M | -17.24M | -11.4M | -8.12M | -6.37M | -15.76M | -14.66M | -10.78M | -5.08M | -3.44M | -1.09M | -122.86K |
| Net Margin % | - | - | - | - | - | - | - | - | - | - | - | -896491.64% | -36518.83% | -1704.94% | -1054.26% | -229484.6% | - | - |
| Net Income Growth % | -42.88% | -36.33% | 15.25% | -11.62% | -30.84% | -15.58% | -3.41% | -51.16% | -40.41% | -27.54% | 59.59% | -7.52% | -35.91% | -112.3% | -47.57% | -216.7% | -784.71% | - |
| Net Income (Continuing) | -37.64M | -34.77M | -25.5M | -30.09M | -26.96M | -20.61M | -17.83M | -17.24M | -11.4M | -8.12M | -6.37M | -12.76M | -12.17M | -10.78M | -5.08M | -3.44M | -1.09M | -122.86K |
| Discontinued Operations | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2.33M | -2.49M | 0 | 0 | 0 | 0 | 0 |
| Minority Interest | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| EPS (Diluted) | -4.37 | -4.04 | -3.00 | -3.60 | -3.15 | -2.70 | -29.55 | -30.45 | -82.50 | -164.55 | -388.95 | -1433.10 | -1646.40 | -1880.55 | -1101.45 | -1019.40 | -488.70 | -36.30 |
| EPS Growth % | -40.2% | -34.67% | 16.67% | -14.29% | -16.67% | 90.86% | 2.96% | 63.09% | 49.86% | 57.69% | 72.86% | 12.96% | 12.45% | -70.73% | -8.05% | -108.59% | -1246.28% | - |
| EPS (Basic) | - | -4.04 | -3.00 | -3.60 | -3.15 | -2.70 | -29.55 | -30.45 | -82.50 | -164.55 | -388.95 | -1433.10 | -1646.40 | -1880.55 | -1101.45 | -1019.40 | -494.40 | -36.30 |
| Diluted Shares Outstanding | 8.62M | 8.61M | 8.39M | 8.41M | 8.44M | 7.8M | 753.9K | 566.46K | 277.18K | 64.98K | 16.37K | 10.53K | 8.9K | 5.74K | 4.61K | 3.38K | 2.22K | 3.38K |
| Basic Shares Outstanding | 8.62M | 8.61M | 8.39M | 8.41M | 8.44M | 7.8M | 753.9K | 566.46K | 277.18K | 64.98K | 16.37K | 10.53K | 8.9K | 5.74K | 4.61K | 3.38K | 2.2K | 3.38K |
| Dividend Payout Ratio | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Clinical trial funding dependency
As indicated by the company's financial statements, Atossa Therapeutics has generated zero revenue for nine consecutive quarters, confirming its status as a pre-commercial entity where growth metrics are currently irrelevant to the firm's fundamental valuation and long-term viability in the competitive oncology drug development landscape.
The lack of top-line growth underscores the company's total reliance on the successful clinical progression of (Z)-endoxifen. Investors should monitor the transition from R&D to potential commercialization, as the current revenue trajectory remains entirely dependent on future regulatory milestones rather than existing market demand.
Based on reported quarterly filings, R&D expenses have trended upward from $3.4 million in late 2024 to $6.2 million by the end of 2025, reflecting the intensifying capital requirements necessary to advance the company's primary clinical programs through critical Phase II trial stages.
This rising cost structure suggests that management is prioritizing clinical trial enrollment and data generation over immediate expense containment. The consistent increase in R&D spending warrants further investigation into whether these outlays are successfully accelerating the timeline to potential regulatory approval or merely extending the cash burn.
According to the provided income statement data, Atossa continues to report significant operating losses, with quarterly deficits reaching $11.4 million in 2025Q4, demonstrating that the company lacks the operational scale to offset its fixed overhead and clinical research costs through any form of revenue.
The absence of operating leverage is expected for a clinical-stage firm, yet the widening gap between R&D spending and income suggests a high sensitivity to capital market conditions. Without a commercial product, the company's operating efficiency is effectively measured by its ability to manage cash burn relative to clinical progress.
As reported in financial statements, the company consistently utilizes stock-based compensation, with quarterly charges reaching as high as $796,000 in 2025Q2, which serves to preserve cash reserves while simultaneously increasing the total share count and diluting the equity value for existing shareholders.
The reliance on equity-based incentives appears to be a strategic mechanism to manage liquidity in the absence of revenue. Investors should monitor the impact of these non-cash expenses on the overall share structure, as persistent dilution may offset potential gains from future clinical data readouts.
Based on the reported $41.3 million in cash and equivalents, the company faces a finite operational window, as the current quarterly burn rate suggests that Atossa may require additional capital infusions before reaching definitive Phase II clinical endpoints or securing a major pharmaceutical partnership.
The primary risk to the investment thesis is the potential for further equity dilution if the current cash balance proves insufficient to reach a value-inflection point. Market participants should remain cautious regarding the company's ability to fund its pipeline without significantly impacting the existing shareholder base.
Quick answers to the most common questions about buying ATOS stock.
For fiscal year 2025, Atossa Therapeutics, Inc. (ATOS) reported total revenue of $0.0M.
Atossa Therapeutics, Inc. (ATOS) reported a net loss of $34.8M for the fiscal year ending 2025.