Operational cash flow remains deeply negative, with quarterly outflows reaching $47.9 million in 2026Q1 and an OCF/NI ratio of -0.53, highlighting a persistent disconnect between accounting losses and actual cash burn.
| Cash from Operations | -159.52M | -157.24M | -119.19M | -97.38M | -105.45M | -67.75M | -41.38M | -17.81M | -9.8M |
| Operating CF Margin % | - | - | - | - | - | - | - | - | - |
| Operating CF Growth % | -66.14% | -31.93% | -22.4% | 7.66% | -55.66% | -63.71% | -132.3% | -81.75% | - |
| Net Income | -178.95M | -287.86M | -155.12M | -118.46M | -91.5M | -71.74M | -60.33M | -19.61M | -13.22M |
| Depreciation & Amortization | 179K | 216K | 233K | 242K | 330K | 175K | 112K | 63K | 22K |
| Stock-Based Compensation | 12.55M | 13.59M | 19.52M | 17.28M | 13.12M | 8.64M | 17.98M | 3.25M | 1.42M |
| Deferred Taxes | 0 | 0 | 0 | 0 | 0 | 22K | -221K | 0 | 0 |
| Other Non-Cash Items | 14.34M | 131.1M | 4.46M | 86K | 3.27M | 1.8M | 1.99M | 1.14M | 2.68M |
| Working Capital Changes | -7.8M | -14.28M | 11.72M | 3.48M | -30.67M | -6.64M | -912K | -2.66M | -704K |
| Change in Receivables | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Change in Inventory | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Change in Payables | 1.81M | 2.03M | 6.59M | 864K | 2.5M | -163K | 1.3M | 580K | -12K |
| Cash from Investing | 0 | 0 | 0 | -64K | -596K | -334K | -628K | -165K | -130K |
| Capital Expenditures | 0 | 0 | 0 | -66K | -596K | -334K | -131K | -165K | -130K |
| CapEx % of Revenue | - | - | - | - | - | - | - | - | - |
| Acquisitions | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Investments | - | - | - | - | - | - | - | - | - |
| Other Investing | 0 | 0 | 0 | 2K | 0 | 0 | 0 | 0 | 0 |
| Cash from Financing | 362.81M | 140.71M | 63.82M | 173.83M | 1.04M | 156.65M | 194.16M | 18.38M | 32.96M |
| Debt Issued (Net) | 18.55M | 0 | 0 | 29.59M | 0 | 0 | 0 | 18.43M | 0 |
| Equity Issued (Net) | 344.14M | 141.04M | 26.22M | 144.94M | 440K | 154.79M | 194.14M | 0 | 0 |
| Dividends Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Share Repurchases | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Financing | 115.87K | -328.82K | 37.6M | -690K | 600K | 1.85M | 16K | -55K | 32.96M |
| Net Change in Cash | 205.9M | -15.48M | -55.17M | 77.26M | -129.97M | 82.99M | 165.37M | 2.08M | 21.86M |
| Free Cash Flow | -159.52M | -157.24M | -119.19M | -97.44M | -106.05M | -68.08M | -41.51M | -17.98M | -9.93M |
| FCF Margin % | - | - | - | - | - | - | - | - | - |
| FCF Growth % | -10.77% | -31.93% | -22.31% | 8.11% | -55.77% | -64% | -130.9% | -81.03% | - |
| FCF per Share | -1.70 | -1.68 | -1.77 | -1.91 | -2.50 | -1.70 | -1.16 | -0.83 | -1.77 |
| FCF Conversion (FCF/Net Income) | 0.89x | 0.55x | 0.77x | 0.82x | 1.15x | 0.94x | 0.68x | 0.91x | 0.74x |
| Interest Paid | 0 | 0 | 3.07M | 1.25M | 0 | 0 | 0 | 0 | 0 |
| Taxes Paid | 0 | 0 | 1.12M | 2.44M | 0 | 0 | 0 | 0 | 0 |
Clinical trial cash runway
As reported in financial statements, the company's operating cash flow consistently trails net income, with the OCF/NI ratio exhibiting extreme volatility, including a 2026Q1 reading of -0.53, which highlights the disconnect between accounting losses and the actual cash required to sustain clinical development activities.
The wide variance between net income and operating cash flow suggests that non-cash items and working capital fluctuations are significantly distorting the perceived financial health of the firm. Investors should monitor this divergence, as it indicates that the company's reported losses may not fully capture the underlying cash-intensive nature of its ongoing Phase III clinical trials.
Based on quarterly data, COMPASS Pathways has maintained a consistent negative free cash flow trajectory, with quarterly outflows ranging from $20.8 million to $47.9 million, underscoring the company's total reliance on external financing to fund its research-heavy operational model prior to any commercial revenue generation.
The absence of positive free cash flow is expected for a pre-revenue biotech, yet the trend of deepening outflows suggests that the cost of clinical execution is rising. This trajectory warrants further investigation into whether the current cash reserves are sufficient to reach a definitive data readout without necessitating further dilutive capital raises.
According to recent SEC filings, working capital changes have been highly erratic, swinging from a $13.9 million inflow in 2025Q4 to a $17.6 million outflow in 2025Q1, which complicates the predictability of the company's short-term cash requirements and overall liquidity management during this critical development phase.
These fluctuations appear to be driven by the timing of clinical trial payments and vendor settlements rather than operational efficiency. Such volatility suggests that the company's cash position is sensitive to the timing of large-scale trial expenditures, which may create unexpected pressure on the balance sheet during periods of high activity.
As indicated by the provided financial data, stock-based compensation remains a persistent quarterly expense, averaging approximately $3.8 million, which effectively masks the true cash cost of retaining specialized scientific talent necessary to maintain the company's competitive position in the psychedelic-assisted therapy market.
While SBC is a non-cash expense, it represents a real economic cost to shareholders through dilution and should be factored into the total cost of operations. The reliance on equity-based incentives suggests that the company is managing its cash burn by shifting compensation burdens to future equity holders, a strategy that may become less effective if market sentiment toward the sector weakens.
Quick answers to the most common questions about buying CMPS stock.
COMPASS Pathways plc (CMPS) generated $-157.2M in net cash from operating activities in 2025. This reflects the cash generated directly from core business operations.
COMPASS Pathways plc (CMPS) reported negative free cash flow of $157.2M in 2025, indicating capital requirements exceeded cash from operations.
COMPASS Pathways plc (CMPS) spent $0.0M on capital expenditures in 2025. CapEx represents the cash invested in physical assets like property, plant, and equipment to maintain or grow the business.