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COYACoya Therapeutics, Inc.
$5.50$100M
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  4. Financial Ratios

Coya Therapeutics, Inc. (COYA) Financial Ratios

Latest Ratios: P/E Ratio -4.3x · EV/EBITDA N/A · ROE -51.4%. (2020–2025 historical series)

Income StatementBalance SheetCash FlowRatios
AnnualQuarterly

COYA Valuation Multiples

Price-based multiples — how expensive the stock is relative to earnings, sales, book value, and cash flow

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020
Market Cap$100M$97M$87M$75M$47M——
Enterprise Value$53M$50M$49M$43M$54M——
P/E Ratio →-4.33——————
P/S Ratio12.6012.2124.5712.55———
P/B Ratio2.142.262.212.11———
P/FCF———————
P/OCF———————

P/E links to full P/E history page with 30-year chart

COYA EV Ratios

Enterprise-value multiples — capital-structure-neutral measures of total business value

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020
EV / Revenue—6.3213.787.11———
EV / EBITDA———————
EV / EBIT———————
EV / FCF———————

COYA Profitability

Margins and return-on-capital ratios measuring operating efficiency

Margins

Full margin charts and quarterly trend are on the Earnings History page

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020
Gross Margin99.7%99.7%-233.9%8.3%———
Operating Margin-255.0%-255.0%-485.4%-131.7%———
Net Profit Margin-267.1%-267.1%-418.7%-133.1%———

Return on Capital

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020
ROE-51.4%-51.4%-39.6%-58.6%—-81.9%-13.2%
ROA-45.0%-45.0%-34.8%-32.2%-185.7%-72.3%-12.6%
ROIC——-609.4%-719.8%———
ROCE-47.9%-47.9%-45.0%-38.8%-238.9%-81.5%-12.6%

COYA Leverage & Debt

Solvency and debt-coverage ratios — lower is generally safer

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020
Debt / Equity———————
Debt / EBITDA———————
Net Debt / Equity—-1.09-0.97-0.92—-1.19-1.05
Net Debt / EBITDA———————
Debt / FCF———————
Interest Coverage——————-18.08

Net cash position: cash ($47M) exceeds total debt ($0)

COYA Liquidity & Efficiency

Short-term solvency ratios and asset-utilisation metrics

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020
Current Ratio8.508.5011.598.151.883.9919.57
Quick Ratio8.508.5011.598.151.883.9919.57
Cash Ratio7.977.9710.026.461.553.7819.50
Asset Turnover—0.160.080.15———
Inventory Turnover———————
Days Sales Outstanding——75.03456.08———

COYA Shareholder Yields

Earnings, FCF, buyback, and dividend yields — total returns to shareholders

Dividends

Full dividend history and growth charts are on the Dividend History page

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020
Dividend Yield———————
Payout Ratio———————

Total Shareholder Return Metrics

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020
Earnings Yield———————
FCF Yield———————
Buyback Yield0.0%0.0%0.0%0.0%0.0%——
Total Shareholder Yield0.0%0.0%0.0%0.0%0.0%——
Shares Outstanding—$17M$15M$10M$10M$7M$3M

Key Metrics

Growth RegimeMixed
ProfitabilityNegative
Balance SheetVulnerable
Cash FlowBurning
Top Statement Risk

Clinical Trial Execution Failure

Verified Source

Metrics are mathematically derived from official filings.

SEC 10-K (2026Q1)

Market Pricing Reflects High Uncertainty

Based on reported figures, Coya's P/S ratio of 12.60 suggests that investors are pricing the firm on speculative future milestone potential rather than current fundamentals, a valuation premium that appears elevated when compared to the broader neuro-inflammation peer group and the company's own historical trading ranges.

The current valuation multiple is heavily influenced by the market's anticipation of clinical readouts rather than tangible earnings, which are currently non-existent. Investors should monitor whether this premium holds as the company approaches critical data milestones, as any delay in trial progress could lead to a significant compression of these multiples.

Capital Efficiency Remains Deeply Negative

As reported in financial statements, Coya's ROE has consistently trended in negative territory, reaching -16.2% in 2025Q4, which highlights the company's inability to generate positive returns on invested capital while it remains in the high-expenditure, pre-commercial phase of its drug development lifecycle.

The lack of positive ROIC is a structural reality for a clinical-stage biotech, but the trend warrants investigation into how efficiently management deploys cash toward its primary pipeline candidates. The current negative returns suggest that capital is being consumed at a rate that far outpaces the value creation from its current partnership-driven revenue model.

Working Capital Dynamics Lack Predictability

According to recent SEC filings, Coya's asset turnover ratio has remained near zero, reflecting the company's status as a research-focused entity that lacks the revenue-generating asset base typically seen in mature industrial firms, thereby rendering traditional efficiency metrics largely inapplicable to its current operational model.

The extreme volatility in accounts payable and the absence of meaningful inventory turnover suggest that the company's working capital is entirely dictated by the timing of clinical trial payments and partnership milestones. Analysts should focus on the cash burn rate rather than traditional turnover ratios, as the latter fail to capture the true operational velocity of the firm.

Liquidity Buffer Faces Ongoing Erosion

Based on the provided balance sheet data, Coya's current ratio of 15.02 in 2026Q1 appears robust on the surface, yet this liquidity is primarily a function of cash reserves that are being rapidly depleted to fund ongoing R&D and clinical trial overhead.

While the current ratio suggests a comfortable short-term position, it masks the reality that the company has no recurring revenue to replenish these funds once they are exhausted. Investors should monitor the cash runway closely, as the current liquidity position is highly sensitive to the timing of future milestone payments from strategic partners.

Misapplication of Traditional Profitability Metrics

As indicated by historical financial data, the most commonly misapplied metric for Coya is the P/E ratio, which is fundamentally misleading for a pre-revenue biotech firm because it ignores the massive, non-recurring R&D investments that are necessary to build the company's long-term intellectual property moat.

Using P/E to evaluate Coya obscures the fact that current losses are a deliberate choice to fund future growth rather than a sign of operational failure. Analysts should instead utilize a risk-adjusted net present value (rNPV) approach to account for the probability of clinical success and the timing of future commercialization, which provides a more accurate picture of the firm's intrinsic value.

Download Financial Ratios Data

Includes 30+ ratios · 6 years · Updated daily

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COYA — Frequently Asked Questions

Quick answers to the most common questions about buying COYA stock.

What is Coya Therapeutics, Inc.'s P/E ratio?

Coya Therapeutics, Inc.'s current P/E ratio is -4.3x. This places it at the 50th percentile of its historical range.

What is Coya Therapeutics, Inc.'s ROE?

Coya Therapeutics, Inc.'s return on equity (ROE) is -51.4%. The historical average is -49.0%.

Is COYA stock overvalued?

Based on historical data, Coya Therapeutics, Inc. is trading at a P/E of -4.3x. This is at the 50th percentile of its historical P/E range. Compare with industry peers and growth rates for a complete picture.

What are Coya Therapeutics, Inc.'s profit margins?

Coya Therapeutics, Inc. has 99.7% gross margin and -255.0% operating margin.