Structural cash burn remains a critical concern, highlighted by a $23.5 million free cash flow deficit in 2025Q4 and a reliance on erratic milestone-driven working capital swings.
| Metric | Dec'25 | Dec'24 | Dec'23 | Dec'22 | Dec'21 | Dec'20 | Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 | Dec'08 | Dec'07 | Dec'06 | Dec'05 |
|---|
| Cash from Operations | -50.67M | -6.9M | -32.56M | -19.15M | -58.46M | -51.81M | 34.92M | -32.53M | -48.06M | -36.85M | 207.91M | -18.13M | -10.97M | -10.47M | 12.99M | -13.45M | -5.94M | -14.74M | -9.28M | 360K | -7.25M |
| Operating CF Margin % | -1818.19% | -54.64% | -62.73% | -33.21% | -482.64% | -74.25% | 50.63% | -40.72% | -147.28% | -65.62% | 1161.13% | -1999.34% | -87.95% | -100.94% | 110.61% | -311.32% | -76.93% | -114.06% | -64.95% | 5.81% | -557.62% |
| Operating CF Growth % | -634.82% | 78.82% | -69.98% | 67.23% | -12.84% | -248.34% | 207.36% | 32.31% | -30.42% | -117.72% | 1246.53% | -65.35% | -4.7% | -180.66% | 196.56% | -126.57% | 59.73% | -58.81% | -2678.33% | 104.97% | - |
| Net Income | -47.24M | -49.47M | -7.57M | -58.1M | -52.81M | -63.98M | -20.76M | 3.05M | -48.38M | 12.64M | -6.71M | -19.65M | -2.89M | -3.2M | -6.98M | -13.66M | -14.63M | -9.85M | -8.92M | -6.04M | -6.13M |
| Depreciation & Amortization | 1.33M | 1.99M | 5.09M | 45.41M | 4.6M | 56.8M | 16.53M | 7.4M | 4.39M | 3.26M | 2.65M | 2.34M | 880K | 839K | 901K | 1.1M | 1.02M | 539K | 536K | 298K | 301K |
| Stock-Based Compensation | 0 | 3.94M | 4.26M | 4.25M | 2.62M | 2.48M | 3.83M | 2.71M | 9.83M | 1.03M | 1.01M | 377K | 325K | 0 | 219K | 35K | 1.77M | 1.34M | 1.26M | 1.19M | 214K |
| Deferred Taxes | 0 | 0 | 0 | 0 | -1.68M | 2.65M | -4.14M | 1.16M | 3.17M | -2.61M | -586K | -78K | -9K | 0 | 0 | -259K | 1.06M | 0 | 0 | 49K | 1.64M |
| Other Non-Cash Items | 5.45M | -2.52M | -2.24M | 1.8M | -1.29M | -544K | -774K | 253K | -88K | -383K | 47K | 170K | 144K | 444K | -274K | -1K | -1.95M | 857K | 111K | 1K | -1.64M |
| Working Capital Changes | -10.21M | 39.16M | -32.09M | -12.5M | -9.88M | -49.2M | 40.25M | -47.1M | -16.98M | -50.79M | 211.49M | -1.3M | -9.41M | -8.56M | 19.12M | -666K | 6.78M | -7.63M | -2.27M | 4.87M | -1.64M |
| Change in Receivables | 0 | 0 | -13.67M | -4.2M | 3.39M | -22.92M | 110.3M | -130.7M | 10.98M | -16.17M | -6.14M | -2.07M | 379K | -2.01M | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Change in Inventory | 0 | 0 | 0 | 0 | -6.27M | 25.38M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Change in Payables | 0 | 0 | -3.89M | -7.66M | -946K | -6.53M | 1.39M | 34.34M | 4.39M | 7.89M | 9.23M | 1.66M | -5.52M | 969K | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Cash from Investing | 7M | 9.2M | 20.63M | 1.88M | -917K | -13.37M | -62.12M | 24.28M | -29.46M | 60.51M | -122.3M | -3.82M | -958K | -3.41M | 2.44M | -289K | 18.94M | 22.52M | 4.97M | -38.99M | -1.43M |
| Capital Expenditures | -134.47K | -391K | -351K | -1.12M | -1.33M | -11.28M | -65.4M | -1.43M | -6.03M | -9.39M | -7.4M | -2.34M | -433K | -1.23M | -322K | -408K | -511K | -1.9M | -1.3M | -752K | -112K |
| CapEx % of Revenue | 4.83% | 3.1% | 0.68% | 1.95% | 10.98% | 16.17% | 94.82% | 1.79% | 18.47% | 16.73% | 41.31% | 258.32% | 3.47% | 11.8% | 2.74% | 9.44% | 6.62% | 14.72% | 9.07% | 12.14% | 8.62% |
| Acquisitions | 4.8K | 0 | 0 | 0 | 7K | 9K | 0 | 22K | 3.06M | 8.04M | 0 | -60K | -120K | 0 | 0 | 0 | 0 | 375K | 0 | 0 | 0 |
| Investments | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Other Investing | -6.38M | 1K | -1.79M | -1K | 406K | 912K | 1.28M | 46K | -3.06M | -8.04M | 972K | 2K | 115K | -154K | 0 | 119K | 0 | -1.5M | 304K | 0 | 0 |
| Cash from Financing | 5.83M | -6.01M | -1.97M | -1.83M | 26.82M | -1.14M | 77.77M | 61.22M | 915K | -602K | 3.03M | 47.95M | 19.68M | -2.15M | -659K | -893K | 22.56M | 623K | 631K | 42.21M | 249K |
| Debt Issued (Net) | -8.56M | -8.94M | -2.36M | -2.03M | 26.63M | -885K | 11.92M | -1.34M | 537K | -685K | -452K | -613K | 314K | -2.26M | -719K | -789K | -257K | 623K | 339K | 712K | 249K |
| Equity Issued (Net) | 14.39M | 0 | 0 | 198K | 0 | 0 | 66.01M | 62.56M | 0 | 14K | 125K | 47.72M | 19.09M | 116K | 60K | -104K | 22.82M | 0 | 293K | 41.49M | 0 |
| Dividends Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -850K | 0 | 0 | 0 | 0 | -1.2M | 0 | 0 | 0 | 0 |
| Share Repurchases | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -70K | 0 | 0 | 0 | -112K | -300K | 0 | 0 | 0 | 0 |
| Other Financing | 0 | 2.93M | 395K | 0 | 187K | -251K | -159K | 8K | 378K | 69K | 3.36M | 1.7M | 278K | 0 | 0 | 0 | 1.2M | 0 | -1K | 1K | 0 |
| Net Change in Cash | -30.44M | -4.21M | -13.62M | -19.53M | -33.04M | -66.09M | 50.57M | 52.95M | -76.54M | 23.04M | 88.58M | 25.93M | 7.78M | -16.02M | 14.79M | -14.63M | 35.56M | 8.4M | -3.68M | 3.57M | -8.43M |
| Free Cash Flow | -50.81M | -7.29M | -34.91M | -20.28M | -59.79M | -63.09M | -30.48M | -33.96M | -54.09M | -46.24M | 200.51M | -20.48M | -11.4M | -11.7M | 12.66M | -13.86M | -6.45M | -16.64M | -10.58M | -392K | -7.36M |
| FCF Margin % | -1823.01% | -57.74% | -67.26% | -35.16% | -493.62% | -90.42% | -44.19% | -42.51% | -165.75% | -82.34% | 1119.82% | -2257.66% | -91.43% | -112.75% | 107.87% | -320.76% | -83.55% | -128.78% | -74.02% | -6.33% | -566.23% |
| FCF Growth % | -597.23% | 79.13% | -72.17% | 66.09% | 5.23% | -107.01% | 10.26% | 37.21% | -16.96% | -123.06% | 1079.22% | -79.62% | 2.56% | -192.39% | 191.39% | -114.94% | 61.26% | -57.34% | -2598.47% | 94.67% | - |
| FCF per Share | -0.57 | -0.09 | -0.42 | -0.25 | -0.75 | -0.80 | -0.46 | -0.58 | -1.00 | -0.86 | 3.75 | -0.41 | -0.29 | -0.31 | 0.34 | -0.37 | -0.25 | -0.65 | -0.42 | -0.02 | -0.49 |
| FCF Conversion (FCF/Net Income) | 1.03x | 0.14x | 4.30x | 0.33x | 1.11x | 0.81x | -1.68x | -10.67x | 0.99x | -2.92x | -31.00x | 0.92x | 3.79x | 3.27x | -1.86x | 0.98x | 0.41x | 1.50x | 1.04x | -0.06x | 1.18x |
| Interest Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Taxes Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Binary clinical trial dependency
As reported in recent financial statements, the relationship between net income and operating cash flow remains highly erratic, with the OCF/NI ratio fluctuating between 0.31 and 6.67, suggesting that accounting accruals and milestone recognition timing significantly distort the underlying cash reality of the business.
The wide variance in the OCF/NI ratio indicates that net income is a poor proxy for the company's actual liquidity position. Investors should monitor how non-cash items and deferred revenue adjustments create these swings, as they often obscure the persistent cash outflows required to fund ongoing clinical development.
Based on historical cash flow data, Innate Pharma has struggled to maintain positive free cash flow, with the most recent quarter showing a $23.5 million outflow, highlighting a structural inability to self-fund operations through its current milestone-dependent revenue model without recurring external capital injections.
The consistent negative FCF trajectory underscores the high-risk nature of the company's clinical-stage business model. Without a shift toward recurring royalty streams, the company appears perpetually reliant on the timing of unpredictable partnership payments to bridge the gap between R&D spending and commercial viability.
According to quarterly cash flow disclosures, working capital changes have been a primary driver of liquidity fluctuations, with a notable $31.3 million swing in 2024Q2, reflecting the lumpy nature of milestone-based receivables and the company's reliance on partner-driven cash inflows to manage its short-term obligations.
The extreme volatility in working capital suggests that the company's cash position is highly sensitive to the timing of contractual payments from partners like AstraZeneca. This dependency creates significant uncertainty for cash forecasting, as any delay in clinical milestones directly impacts the firm's ability to fund operations.
As indicated by the provided financial data, capital expenditures remain negligible, often representing less than 5% of revenue, which confirms that the company's cash burn is driven almost entirely by R&D and clinical trial expenses rather than investments in physical infrastructure or manufacturing capacity.
The low capital intensity is typical for a licensing-focused biotech, yet it highlights that the company lacks the asset-heavy moat that might otherwise provide stability. Consequently, the cash flow statement serves primarily as a tracker for R&D efficiency rather than a measure of capital asset replacement.
Quick answers to the most common questions about buying IPHA stock.
Innate Pharma S.A. (IPHA) generated $-50.7M in net cash from operating activities in 2025. This reflects the cash generated directly from core business operations.
Innate Pharma S.A. (IPHA) reported negative free cash flow of $50.8M in 2025, indicating capital requirements exceeded cash from operations.
Innate Pharma S.A. (IPHA) spent $0.1M on capital expenditures in 2025. CapEx represents the cash invested in physical assets like property, plant, and equipment to maintain or grow the business.